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Ribonuclease mitogillin (EC 3.1.27.-) (Allergen Asp f I) (Allergen I/a) (IgE-binding ribotoxin) (Major allergen Asp f 1) (allergen Asp f 1)

 RNMG_ASPFU              Reviewed;         176 AA.
P67875; P04389; P19792; Q4WEA6;
20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
11-OCT-2004, sequence version 1.
10-MAY-2017, entry version 83.
RecName: Full=Ribonuclease mitogillin;
EC=3.1.27.-;
AltName: Full=Allergen Asp f I;
AltName: Full=Allergen I/a;
AltName: Full=IgE-binding ribotoxin;
AltName: Full=Major allergen Asp f 1;
AltName: Allergen=Asp f 1;
Flags: Precursor;
Name=mitF; Synonyms=aspF1; ORFNames=AFUA_5G02330;
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
A1100) (Aspergillus fumigatus).
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
NCBI_TaxID=330879;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=CBS 143.89;
PubMed=1943712; DOI=10.1111/j.1365-2958.1991.tb01930.x;
Lamy B., Moutaouakil M., Latge J.P., Davies J.;
"Secretion of a potential virulence factor, a fungal ribonucleotoxin,
during human aspergillosis infections.";
Mol. Microbiol. 5:1811-1815(1991).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1431110;
Arruda L.K., Mann B.J., Chapman M.D.;
"Selective expression of a major allergen and cytotoxin, Asp f I, in
Aspergillus fumigatus. Implications for the immunopathogenesis of
Aspergillus-related diseases.";
J. Immunol. 149:3354-3359(1992).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
PubMed=16372009; DOI=10.1038/nature04332;
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S.,
Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W.,
Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S.,
Farman M.L., Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R.,
Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A.,
Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J.,
Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J.,
Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S.,
Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A.,
Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M.,
Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I.,
Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
Ronning C.M., Rutter S., Salzberg S.L., Sanchez M.,
Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S.,
Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J.,
White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K.,
Machida M., Hall N., Barrell B.G., Denning D.W.;
"Genomic sequence of the pathogenic and allergenic filamentous fungus
Aspergillus fumigatus.";
Nature 438:1151-1156(2005).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 28-176.
PubMed=1624793;
Moser M., Crameri R., Menz G., Schneider T., Dudler T., Virchow C.,
Gmachl M., Blaser K., Suter M.;
"Cloning and expression of recombinant Aspergillus fumigatus allergen
I/a (rAsp f I/a) with IgE binding and type I skin test activity.";
J. Immunol. 149:454-460(1992).
[5]
PRELIMINARY PROTEIN SEQUENCE OF 28-176.
STRAIN=5167;
PubMed=2230656; DOI=10.1084/jem.172.5.1529;
Arruda L.K., Platts-Mills T.A.E., Fox J.W., Chapman M.D.;
"Aspergillus fumigatus allergen I, a major IgE-binding protein, is a
member of the mitogillin family of cytotoxins.";
J. Exp. Med. 172:1529-1532(1990).
[6]
PROTEIN SEQUENCE OF 28-48.
STRAIN=AF-285 / Indian isolate;
Sarma P.U., Bir N., Fairwell T.;
Submitted (AUG-1999) to UniProtKB.
-!- FUNCTION: This purine-specific ribonuclease cleaves 28S RNA in
eukaryotic ribosomes, inhibits protein synthesis, and shows
antitumor activity.
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE. May
promote colonization through cytotoxic activity and by causing
inflammatory reactions involving IgE antibodies. Binds also to
IgG.
-!- SIMILARITY: Belongs to the ribonuclease U2 family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; X58278; CAA41217.1; -; Genomic_DNA.
EMBL; M83781; AAB07779.1; -; Genomic_DNA.
EMBL; AAHF01000011; EAL86071.1; -; Genomic_DNA.
EMBL; S39330; AAB22442.1; -; mRNA.
PIR; A46497; A46497.
RefSeq; XP_748109.1; XM_743016.1.
ProteinModelPortal; P67875; -.
SMR; P67875; -.
Allergome; 3107; Asp f 1.0101.
Allergome; 62; Asp f 1.
PRIDE; P67875; -.
EnsemblFungi; CADAFUAT00002637; CADAFUAP00002637; CADAFUAG00002637.
GeneID; 3505541; -.
KEGG; afm:AFUA_5G02330; -.
EuPathDB; FungiDB:Afu5g02330; -.
HOGENOM; HOG000216956; -.
InParanoid; P67875; -.
KO; K01171; -.
OMA; SSYPHWF; -.
OrthoDB; EOG092C597G; -.
Proteomes; UP000002530; Chromosome 5.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0004521; F:endoribonuclease activity; IEA:InterPro.
GO; GO:0019863; F:IgE binding; IDA:AspGD.
GO; GO:0004540; F:ribonuclease activity; IDA:AspGD.
GO; GO:0003723; F:RNA binding; IEA:InterPro.
GO; GO:0017148; P:negative regulation of translation; IEA:UniProtKB-KW.
GO; GO:0060300; P:regulation of cytokine activity; IMP:AspGD.
InterPro; IPR004025; Fun_ribotoxin.
InterPro; IPR000026; Gua-sp_ribonuclease_N1/T1/U2.
InterPro; IPR016191; Ribonuclease/ribotoxin.
PIRSF; PIRSF037430; RNase_U2; 1.
PRINTS; PR01704; FUNRIBOTOXIN.
SUPFAM; SSF53933; SSF53933; 1.
1: Evidence at protein level;
Allergen; Complete proteome; Direct protein sequencing;
Disulfide bond; Hydrolase; Nuclease; Protein synthesis inhibitor;
Reference proteome; Secreted; Signal.
SIGNAL 1 27 {ECO:0000269|Ref.6}.
CHAIN 28 176 Ribonuclease mitogillin.
/FTId=PRO_0000030837.
ACT_SITE 76 76 {ECO:0000250}.
ACT_SITE 122 122 Proton acceptor. {ECO:0000250}.
ACT_SITE 163 163 Proton donor. {ECO:0000250}.
DISULFID 32 174
DISULFID 102 158
CONFLICT 52 52 S -> N (in Ref. 2; CAA41217/AAB07779).
{ECO:0000305}.
SEQUENCE 176 AA; 19595 MW; AAD431C57939E42C CRC64;
MVAIKNLFLL AATAVSVLAA PSPLDARATW TCINQQLNPK TNKWEDKRLL YSQAKAESNS
HHAPLSDGKT GSSYPHWFTN GYDGNGKLIK GRTPIKFGKA DCDRPPKHSQ NGMGKDDHYL
LEFPTFPDGH DYKFDSKKPK EDPGPARVIY TYPNKVFCGI VAHQRGNQGD LRLCSH


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