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Ribonuclease pancreatic (EC 3.1.27.5) (RNase 1) (RNase A)

 RNAS1_CAPHI             Reviewed;         124 AA.
P67926; P00661; P04420;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
13-AUG-1987, sequence version 1.
25-OCT-2017, entry version 57.
RecName: Full=Ribonuclease pancreatic;
EC=3.1.27.5;
AltName: Full=RNase 1;
AltName: Full=RNase A;
Name=RNASE1; Synonyms=RNS1;
Capra hircus (Goat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Capra.
NCBI_TaxID=9925;
[1]
PROTEIN SEQUENCE, AND GLYCOSYLATION AT ASN-34.
TISSUE=Pancreas;
PubMed=4855010; DOI=10.1016/0014-5793(74)80953-1;
Welling G.W., Scheffer A.J., Beintema J.J.;
"The primary structure of goat and sheep pancreatic ribonucleases.";
FEBS Lett. 41:58-61(1974).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8587129; DOI=10.1007/BF00173164;
Confalone E., Beintema J.J., Sasso M.P., Carsana A., Palmieri M.,
Vento M.T., Furia A.;
"Molecular evolution of genes encoding ribonucleases in ruminant
species.";
J. Mol. Evol. 41:850-858(1995).
-!- FUNCTION: Endonuclease that catalyzes the cleavage of RNA on the
3' side of pyrimidine nucleotides. Acts on single-stranded and
double-stranded RNA (By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: Endonucleolytic cleavage to nucleoside 3'-
phosphates and 3'-phosphooligonucleotides ending in Cp or Up with
2',3'-cyclic phosphate intermediates.
-!- SUBUNIT: Monomer. Interacts with and forms tight 1:1 complexes
with RNH1. Dimerization of two such complexes may occur.
Interaction with RNH1 inhibits this protein (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Pancreas.
-!- SIMILARITY: Belongs to the pancreatic ribonuclease family.
{ECO:0000305}.
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EMBL; S81742; AAB36136.1; -; Genomic_DNA.
PIR; A00810; NRGT.
UniGene; Chi.34468; -.
ProteinModelPortal; P67926; -.
SMR; P67926; -.
iPTMnet; P67926; -.
HOVERGEN; HBG008396; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO; GO:0004522; F:ribonuclease A activity; IEA:UniProtKB-EC.
Gene3D; 3.10.130.10; -; 1.
InterPro; IPR001427; RNaseA.
InterPro; IPR036816; RNaseA-like_dom_sf.
InterPro; IPR023411; RNaseA_AS.
InterPro; IPR023412; RNaseA_domain.
PANTHER; PTHR11437; PTHR11437; 1.
Pfam; PF00074; RnaseA; 1.
PRINTS; PR00794; RIBONUCLEASE.
ProDom; PD000535; RNaseA; 1.
SMART; SM00092; RNAse_Pc; 1.
SUPFAM; SSF54076; SSF54076; 1.
PROSITE; PS00127; RNASE_PANCREATIC; 1.
1: Evidence at protein level;
Direct protein sequencing; Disulfide bond; Endonuclease; Glycoprotein;
Hydrolase; Nuclease; Secreted.
CHAIN 1 124 Ribonuclease pancreatic.
/FTId=PRO_0000057187.
REGION 41 45 Substrate binding.
ACT_SITE 12 12 Proton acceptor.
ACT_SITE 119 119 Proton donor.
BINDING 7 7 Substrate.
BINDING 10 10 Substrate.
BINDING 66 66 Substrate.
BINDING 85 85 Substrate.
CARBOHYD 34 34 N-linked (GlcNAc...) asparagine; partial.
{ECO:0000269|PubMed:4855010}.
DISULFID 26 84
DISULFID 40 95
DISULFID 58 110
DISULFID 65 72
SEQUENCE 124 AA; 13707 MW; 3570EC14528EDDFA CRC64;
KESAAAKFER QHMDSSTSSA SSSNYCNQMM KSRNLTQDRC KPVNTFVHES LADVQAVCSQ
KNVACKNGQT NCYQSYSTMS ITDCRETGSS KYPNCAYKTT QAEKHIIVAC EGNPYVPVHF
DASV


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