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Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small subunit)

 Q99CY2_BHV4             Unreviewed;       305 AA.
Q99CY2;
01-JUN-2001, integrated into UniProtKB/TrEMBL.
01-JUN-2001, sequence version 1.
28-FEB-2018, entry version 78.
RecName: Full=Ribonucleoside-diphosphate reductase small subunit {ECO:0000256|HAMAP-Rule:MF_04028};
EC=1.17.4.1 {ECO:0000256|HAMAP-Rule:MF_04028};
AltName: Full=Ribonucleotide reductase small subunit {ECO:0000256|HAMAP-Rule:MF_04028};
Name=ORF 60 {ECO:0000313|EMBL:AEL29804.1};
Synonyms=RIR2 {ECO:0000256|HAMAP-Rule:MF_04028};
Bovine herpesvirus 4 (BoHV-4) (Movar virus).
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
Gammaherpesvirinae; Rhadinovirus.
NCBI_TaxID=10385 {ECO:0000313|EMBL:AAK07979.1, ECO:0000313|Proteomes:UP000109731};
NCBI_TaxID=9913; Bos taurus (Bovine).
NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
NCBI_TaxID=9689; Panthera leo (Lion).
[1] {ECO:0000313|EMBL:AAK07979.1, ECO:0000313|Proteomes:UP000109731}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=11152491; DOI=10.1128/JVI.75.3.1186-1194.2001;
Zimmermann W., Broll H., Ehlers B., Buhk H.-J., Rosenthal A.,
Goltz M.;
"Genome sequence of bovine herpesvirus 4, a bovine Rhadinovirus, and
identification of an origin of DNA replication.";
J. Virol. 75:1186-1194(2001).
[2] {ECO:0000313|EMBL:AEL29804.1}
NUCLEOTIDE SEQUENCE.
STRAIN=V.test {ECO:0000313|EMBL:AEL29804.1};
PubMed=21846388;
Palmeira L., Machiels B., Lete C., Vanderplasschen A., Gillet L.;
"Sequencing of Bovine herpesvirus 4 V.test strain reveals important
genome features.";
Virol. J. 8:406-406(2011).
[3] {ECO:0000313|EMBL:AIA82805.1}
NUCLEOTIDE SEQUENCE.
STRAIN=FMV09-1180503 {ECO:0000313|EMBL:AIA82805.1};
Music N., Laroche J., Tremblay D., Mandeville I., Bellehumeur C.,
Charette S.J., Gagnon C.A.;
"Seroprevalence against a Canadian isolate of bovine herpesvirus 4
(BHV4) is higher in various diseases affected bovine dairy herds
compared to healthy herds.";
Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Ribonucleoside-diphosphate reductase holoenzyme provides
the precursors necessary for viral DNA synthesis. Allows virus
growth in non-dividing cells, as well as reactivation from latency
in infected hosts. Catalyzes the biosynthesis of
deoxyribonucleotides from the corresponding ribonucleotides.
{ECO:0000256|HAMAP-Rule:MF_04028}.
-!- CATALYTIC ACTIVITY: 2'-deoxyribonucleoside diphosphate +
thioredoxin disulfide + H(2)O = ribonucleoside diphosphate +
thioredoxin. {ECO:0000256|HAMAP-Rule:MF_04028}.
-!- COFACTOR:
Name=Fe cation; Xref=ChEBI:CHEBI:24875;
Evidence={ECO:0000256|HAMAP-Rule:MF_04028};
-!- PATHWAY: Genetic information processing; DNA replication.
{ECO:0000256|HAMAP-Rule:MF_04028}.
-!- SUBUNIT: Heterotetramer composed of a homodimer of the large
subunit (R1) and a homodimer of the small subunit (R2). Larger
multisubunit protein complex are also active, composed of
(R1)n(R2)n. {ECO:0000256|HAMAP-Rule:MF_04028}.
-!- SUBCELLULAR LOCATION: Host membrane {ECO:0000256|HAMAP-
Rule:MF_04028}; Single-pass membrane protein {ECO:0000256|HAMAP-
Rule:MF_04028}.
-!- SIMILARITY: Belongs to the ribonucleoside diphosphate reductase
small chain family. {ECO:0000256|HAMAP-Rule:MF_04028}.
-----------------------------------------------------------------------
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EMBL; AF318573; AAK07979.1; -; Genomic_DNA.
EMBL; JN133502; AEL29804.1; -; Genomic_DNA.
EMBL; KC999113; AIA82805.1; -; Genomic_DNA.
RefSeq; NP_076552.1; NC_002665.1.
GeneID; 1684946; -.
KEGG; vg:1684946; -.
UniPathway; UPA00326; -.
Proteomes; UP000109731; Genome.
GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
GO; GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:UniProtKB-UniRule.
GO; GO:0009186; P:deoxyribonucleoside diphosphate metabolic process; IEA:UniProtKB-UniRule.
GO; GO:0009263; P:deoxyribonucleotide biosynthetic process; IEA:InterPro.
GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
CDD; cd01049; RNRR2; 1.
Gene3D; 1.10.620.20; -; 1.
HAMAP; MF_04028; HSV_RIR2; 1.
InterPro; IPR009078; Ferritin-like_SF.
InterPro; IPR034715; HSV_RIR2.
InterPro; IPR012348; RNR-like.
InterPro; IPR033909; RNR_small.
InterPro; IPR030475; RNR_small_AS.
InterPro; IPR000358; RNR_small_fam.
PANTHER; PTHR23409; PTHR23409; 1.
Pfam; PF00268; Ribonuc_red_sm; 1.
SUPFAM; SSF47240; SSF47240; 1.
PROSITE; PS00368; RIBORED_SMALL; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000109731};
DNA replication {ECO:0000256|HAMAP-Rule:MF_04028};
Host membrane {ECO:0000256|HAMAP-Rule:MF_04028};
Iron {ECO:0000256|HAMAP-Rule:MF_04028};
Membrane {ECO:0000256|HAMAP-Rule:MF_04028};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_04028};
Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_04028};
Reference proteome {ECO:0000313|Proteomes:UP000109731};
Transmembrane {ECO:0000256|HAMAP-Rule:MF_04028};
Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_04028}.
TRANSMEM 150 171 Helical. {ECO:0000256|HAMAP-
Rule:MF_04028}.
ACT_SITE 101 101 {ECO:0000256|HAMAP-Rule:MF_04028}.
METAL 64 64 Iron 1. {ECO:0000256|HAMAP-
Rule:MF_04028}.
METAL 94 94 Iron 1. {ECO:0000256|HAMAP-
Rule:MF_04028}.
METAL 94 94 Iron 2. {ECO:0000256|HAMAP-
Rule:MF_04028}.
METAL 97 97 Iron 1. {ECO:0000256|HAMAP-
Rule:MF_04028}.
METAL 157 157 Iron 2. {ECO:0000256|HAMAP-
Rule:MF_04028}.
METAL 191 191 Iron 2. {ECO:0000256|HAMAP-
Rule:MF_04028}.
METAL 194 194 Iron 2. {ECO:0000256|HAMAP-
Rule:MF_04028}.
SEQUENCE 305 AA; 35548 MW; 352EFE84B987EBDE CRC64;
MDNVKKFLYS CDHQGFLKLL HETWQNRWFP SQVSLHGDVN HLKSLNVQDR EFYKFLFTFL
GMAESLVNFN IEDIIKQFES HDMLHYYTEQ MAMENIHARM YENILNMFFN NDPAEMYRYT
QMIINDRALI RKLDWLHSRI KSVSNKAEKV LLFLLVEGIF FVSSFYSIGL LRVRGMFNGV
CLANDYISRD ELLHTRAAAL LYNTMVSGAD KPHMLWVHNL FKEAVEVEHE FILVKSSGVS
AVNVDDIRSF LEATADRILK SINLPPIYGT PPPPKCPLVY TGCVKNVNFF ERDNSDYTSS
IKDDL


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