GENTAUR Molecular Products.

 A0A0M1EL65_STEMA        Unreviewed;       319 AA.
 A0A0M1EL65;
 11-NOV-2015, integrated into UniProtKB/TrEMBL.
 11-NOV-2015, sequence version 1.
 28-MAR-2018, entry version 26.
 RecName: Full=Ribose-phosphate pyrophosphokinase {ECO:0000256|HAMAP-Rule:MF_00583};
          Short=RPPK {ECO:0000256|HAMAP-Rule:MF_00583};
          EC=2.7.6.1 {ECO:0000256|HAMAP-Rule:MF_00583};
 AltName: Full=5-phospho-D-ribosyl alpha-1-diphosphate {ECO:0000256|HAMAP-Rule:MF_00583};
 AltName: Full=Phosphoribosyl diphosphate synthase {ECO:0000256|HAMAP-Rule:MF_00583};
 AltName: Full=Phosphoribosyl pyrophosphate synthase {ECO:0000256|HAMAP-Rule:MF_00583};
          Short=P-Rib-PP synthase {ECO:0000256|HAMAP-Rule:MF_00583};
          Short=PRPP synthase {ECO:0000256|HAMAP-Rule:MF_00583};
          Short=PRPPase {ECO:0000256|HAMAP-Rule:MF_00583};
 Name=prs {ECO:0000256|HAMAP-Rule:MF_00583};
 ORFNames=ABW44_14450 {ECO:0000313|EMBL:KOQ72738.1},
 ABW45_09965 {ECO:0000313|EMBL:KOQ77262.1},
 AR275_04030 {ECO:0000313|EMBL:KUJ02395.1},
 ARC23_13705 {ECO:0000313|EMBL:KRG49705.1},
 B9Y56_02905 {ECO:0000313|EMBL:PJL45014.1},
 B9Y57_18460 {ECO:0000313|EMBL:PJL00919.1},
 B9Y61_02595 {ECO:0000313|EMBL:PJL74523.1},
 B9Y64_03930 {ECO:0000313|EMBL:PJL34638.1},
 B9Y71_03700 {ECO:0000313|EMBL:PJL23702.1},
 B9Y76_03350 {ECO:0000313|EMBL:PJL05101.1},
 B9Y82_02090 {ECO:0000313|EMBL:PJL60992.1},
 B9Y88_02195 {ECO:0000313|EMBL:PJL80590.1},
 BB780_19215 {ECO:0000313|EMBL:OHY63190.1},
 BWP19_12915 {ECO:0000313|EMBL:OOD13640.1},
 CEE63_04395 {ECO:0000313|EMBL:OWQ77423.1},
 CEK00_01615 {ECO:0000313|EMBL:PAM74821.1},
 SmaCSM2_03835 {ECO:0000313|EMBL:AUI09695.1},
 VL23_12740 {ECO:0000313|EMBL:KOO84688.1};
 Stenotrophomonas maltophilia (Pseudomonas maltophilia) (Xanthomonas
 maltophilia).
 Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales;
 Xanthomonadaceae; Stenotrophomonas;
 Stenotrophomonas maltophilia group.
 NCBI_TaxID=40324 {ECO:0000313|EMBL:KOQ72738.1, ECO:0000313|Proteomes:UP000037272};
 [1] {ECO:0000313|Proteomes:UP000037632}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=ISMMS6 {ECO:0000313|Proteomes:UP000037632};
 PubMed=26324280; DOI=10.1128/AAC.01723-15;
 Pak T.R., Altman D.R., Attie O., Sebra R., Hamula C.L., Lewis M.,
 Deikus G., Newman L.C., Fang G., Hand J., Papel G., Wallach F.,
 Schadt E.E., Huprikar S., van Bakel H., Kasarskis A., Bashir A.;
 "Whole-Genome Sequencing Identifies Emergence of a Quinolone
 Resistance Mutation in a Case of Stenotrophomonas maltophilia
 Bacteremia.";
 Antimicrob. Agents Chemother. 59:7117-7120(2015).
 [2] {ECO:0000313|EMBL:KOO84688.1}
 NUCLEOTIDE SEQUENCE.
 STRAIN=ISMMS6 {ECO:0000313|EMBL:KOO84688.1};
 Pak T.R., Altman D.R., Attie O., Sebra R., Hamula C.L., Lewis M.,
 Deikus G., Newman L.C., Fang G., Hand J., Papel G., Wallach F.,
 Schadt E.E., Huprikar S., van Bakel H., Kasarskis A., Bashir A.;
 "Whole-genome sequencing identifes emergence of a quinolone resistance
 mutation in a case of Stenotrophomonas maltophilia bacteremia.";
 Antimicrob. Agents Chemother. 0:0-0(2015).
 [3] {ECO:0000313|Proteomes:UP000037059, ECO:0000313|Proteomes:UP000037272}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=B5 {ECO:0000313|Proteomes:UP000037272}, and
 C11 {ECO:0000313|Proteomes:UP000037059};
 Ormerod K.L., Fraser J.A., Wainwright C., Hugenholtz P.;
 "Comparative genomics of non-pseudomonal bacterial species colonizing
 pediatric cystic fibrosis patients.";
 Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
 [4] {ECO:0000313|EMBL:KOQ72738.1}
 NUCLEOTIDE SEQUENCE.
 STRAIN=B5 {ECO:0000313|EMBL:KOQ72738.1}, and
 C11 {ECO:0000313|EMBL:KOQ77262.1};
 Michener P.S., Gardner A.G., Jabaily R.S., Sessa E.;
 "Utilizing next-generation sequencing to resolve the backbone and
 inform taxonomy of the Core Goodeniaceae.";
 Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
 [5] {ECO:0000313|EMBL:KRG49705.1, ECO:0000313|Proteomes:UP000051757}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=LMG 978 {ECO:0000313|EMBL:KRG49705.1,
 ECO:0000313|Proteomes:UP000051757};
 Patil P.P., Midha S., Patil P.B.;
 "Genome sequencing and analysis of members of genus
 Stenotrophomonas.";
 Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
 [6] {ECO:0000313|Proteomes:UP000053200}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=SM41 {ECO:0000313|Proteomes:UP000053200};
 Rizek C.;
 "Stenotrophomonas maltophilia genome sequencing and assembly.";
 Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
 [7] {ECO:0000313|EMBL:KUJ02395.1}
 NUCLEOTIDE SEQUENCE.
 STRAIN=SM41 {ECO:0000313|EMBL:KUJ02395.1};
 McClelland M., Jain A., Saraogi P., Mendelson R., Westerman R.,
 SanMiguel P., Csonka L.;
 Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
 [8] {ECO:0000313|EMBL:OHY63190.1, ECO:0000313|Proteomes:UP000179972}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=R5G {ECO:0000313|EMBL:OHY63190.1,
 ECO:0000313|Proteomes:UP000179972};
 Chan K.G., Goh S.Y.;
 "Stenotrophomonas maltophilia Genome sequencing and assembly.";
 Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
 [9] {ECO:0000313|Proteomes:UP000229595, ECO:0000313|Proteomes:UP000229667, ECO:0000313|Proteomes:UP000229718}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=E301 {ECO:0000313|EMBL:PJL60992.1,
 ECO:0000313|Proteomes:UP000229595}, E729 {ECO:0000313|EMBL:PJL80590.1,
 ECO:0000313|Proteomes:UP000230546}, E824 {ECO:0000313|EMBL:PJL45014.1,
 ECO:0000313|Proteomes:UP000230978}, E999 {ECO:0000313|EMBL:PJL74523.1,
 ECO:0000313|Proteomes:UP000229667}, EA1 {ECO:0000313|EMBL:PJL34638.1,
 ECO:0000313|Proteomes:UP000230167}, EA21 {ECO:0000313|EMBL:PJL05101.1,
 ECO:0000313|Proteomes:UP000229718}, EA23 {ECO:0000313|EMBL:PJL23702.1,
 ECO:0000313|Proteomes:UP000230986}, and
 EA63 {ECO:0000313|EMBL:PJL00919.1, ECO:0000313|Proteomes:UP000230476};
 PubMed=29170656; DOI=.3389/fmicb.2017.02190;
 Lira F., Berg G., Martinez J.L.;
 "Double-Face Meets the Bacterial World: The Opportunistic Pathogen
 Stenotrophomonas maltophilia.";
 Front. Microbiol. 8:2190-2190(2017).
 [10] {ECO:0000313|EMBL:OOD13640.1, ECO:0000313|Proteomes:UP000189183}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=ATCC 13637 {ECO:0000313|EMBL:OOD13640.1,
 ECO:0000313|Proteomes:UP000189183};
 Kozyreva V.K., Truong C.-L., Greninger A.L., Mukhopadhyay R.,
 Crandall J., Chaturvedi V.;
 "Validation and Implementation of CLIA-Compliant Whole Genome
 Sequencing (WGS) in Public Health Laboratory.";
 Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
 [11] {ECO:0000313|EMBL:PAM74821.1, ECO:0000313|Proteomes:UP000216433}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=DF07 {ECO:0000313|EMBL:PAM74821.1,
 ECO:0000313|Proteomes:UP000216433};
 Iyer R.;
 "Genome sequencing and assembly of Stenotrophomonas maltophilia
 DF07.";
 Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
 [12] {ECO:0000313|EMBL:OWQ77423.1, ECO:0000313|Proteomes:UP000197090}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=594 {ECO:0000313|EMBL:OWQ77423.1,
 ECO:0000313|Proteomes:UP000197090};
 Kim H.J., Triplett B.A.;
 Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
 [13] {ECO:0000313|EMBL:AUI09695.1, ECO:0000313|Proteomes:UP000234414}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=CSM2 {ECO:0000313|EMBL:AUI09695.1,
 ECO:0000313|Proteomes:UP000234414};
 Castro-Jaimes S., Lopez-Leal G., Barberena Jonas C., Bustos P.,
 Perez-Oseguera A., Cevallos M.A.;
 "Complete Genome Sequence of Stenotrophomonas maltophilia CSM2.";
 Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
 -!- FUNCTION: Involved in the biosynthesis of the central metabolite
     phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of
     pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate
     (Rib-5-P). {ECO:0000256|HAMAP-Rule:MF_00583}.
 -!- CATALYTIC ACTIVITY: ATP + D-ribose 5-phosphate = AMP + 5-phospho-
     alpha-D-ribose 1-diphosphate. {ECO:0000256|HAMAP-Rule:MF_00583,
     ECO:0000256|SAAS:SAAS00956745}.
 -!- COFACTOR:
     Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
       Evidence={ECO:0000256|HAMAP-Rule:MF_00583};
     Note=Binds 2 Mg(2+) ions per subunit. {ECO:0000256|HAMAP-
     Rule:MF_00583};
 -!- PATHWAY: Metabolic intermediate biosynthesis; 5-phospho-alpha-D-
     ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-
     diphosphate from D-ribose 5-phosphate (route I): step 1/1.
     {ECO:0000256|HAMAP-Rule:MF_00583, ECO:0000256|SAAS:SAAS00956751}.
 -!- SUBUNIT: Homohexamer. {ECO:0000256|HAMAP-Rule:MF_00583}.
 -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00583}.
 -!- SIMILARITY: Belongs to the ribose-phosphate pyrophosphokinase
     family. Class I subfamily. {ECO:0000256|HAMAP-Rule:MF_00583}.
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 EMBL; CP025298; AUI09695.1; -; Genomic_DNA.
 EMBL; JZIW01000001; KOO84688.1; -; Genomic_DNA.
 EMBL; LDVS01000086; KOQ72738.1; -; Genomic_DNA.
 EMBL; LDVT01000033; KOQ77262.1; -; Genomic_DNA.
 EMBL; LLXV01000042; KRG49705.1; -; Genomic_DNA.
 EMBL; LQIG01000789; KUJ02395.1; -; Genomic_DNA.
 EMBL; MJAS01000039; OHY63190.1; -; Genomic_DNA.
 EMBL; MTGD01000040; OOD13640.1; -; Genomic_DNA.
 EMBL; NIVX01000034; OWQ77423.1; -; Genomic_DNA.
 EMBL; NJGC01000001; PAM74821.1; -; Genomic_DNA.
 EMBL; NEQP01000006; PJL00919.1; -; Genomic_DNA.
 EMBL; NEQQ01000003; PJL05101.1; -; Genomic_DNA.
 EMBL; NEQT01000009; PJL23702.1; -; Genomic_DNA.
 EMBL; NEQV01000001; PJL34638.1; -; Genomic_DNA.
 EMBL; NEQY01000004; PJL45014.1; -; Genomic_DNA.
 EMBL; NERD01000002; PJL60992.1; -; Genomic_DNA.
 EMBL; NERF01000003; PJL74523.1; -; Genomic_DNA.
 EMBL; NERH01000003; PJL80590.1; -; Genomic_DNA.
 RefSeq; WP_005415400.1; NZ_NJGC01000001.1.
 EnsemblBacteria; KOO84688; KOO84688; VL23_12740.
 EnsemblBacteria; KOQ63752; KOQ63752; ABW42_11475.
 EnsemblBacteria; KOQ72738; KOQ72738; ABW44_14450.
 EnsemblBacteria; KOQ77262; KOQ77262; ABW45_09965.
 EnsemblBacteria; KRG49705; KRG49705; ARC23_13705.
 EnsemblBacteria; KUJ02395; KUJ02395; AR275_04030.
 EnsemblBacteria; KZE43665; KZE43665; AVW14_18750.
 EnsemblBacteria; OBU64750; OBU64750; A9J40_14605.
 GeneID; 6392388; -.
 PATRIC; fig|40324.126.peg.797; -.
 UniPathway; UPA00087; UER00172.
 Proteomes; UP000037059; Unassembled WGS sequence.
 Proteomes; UP000037272; Unassembled WGS sequence.
 Proteomes; UP000037632; Unassembled WGS sequence.
 Proteomes; UP000051757; Unassembled WGS sequence.
 Proteomes; UP000053200; Unassembled WGS sequence.
 Proteomes; UP000179972; Unassembled WGS sequence.
 Proteomes; UP000189183; Unassembled WGS sequence.
 Proteomes; UP000197090; Unassembled WGS sequence.
 Proteomes; UP000216433; Unassembled WGS sequence.
 Proteomes; UP000229595; Unassembled WGS sequence.
 Proteomes; UP000229667; Unassembled WGS sequence.
 Proteomes; UP000229718; Unassembled WGS sequence.
 Proteomes; UP000230167; Unassembled WGS sequence.
 Proteomes; UP000230476; Unassembled WGS sequence.
 Proteomes; UP000230546; Unassembled WGS sequence.
 Proteomes; UP000230978; Unassembled WGS sequence.
 Proteomes; UP000230986; Unassembled WGS sequence.
 Proteomes; UP000234414; Chromosome.
 GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
 GO; GO:0004749; F:ribose phosphate diphosphokinase activity; IEA:UniProtKB-UniRule.
 GO; GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO; GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
 GO; GO:0009165; P:nucleotide biosynthetic process; IEA:UniProtKB-KW.
 GO; GO:0009156; P:ribonucleoside monophosphate biosynthetic process; IEA:UniProtKB-UniRule.
 CDD; cd06223; PRTases_typeI; 1.
 HAMAP; MF_00583_B; RibP_PPkinase_B; 1.
 InterPro; IPR000842; PRib_PP_synth_CS.
 InterPro; IPR029099; Pribosyltran_N.
 InterPro; IPR000836; PRibTrfase_dom.
 InterPro; IPR029057; PRTase-like.
 InterPro; IPR005946; Rib-P_diPkinase.
 InterPro; IPR037515; Rib-P_diPkinase_bac.
 Pfam; PF14572; Pribosyl_synth; 1.
 Pfam; PF13793; Pribosyltran_N; 1.
 SUPFAM; SSF53271; SSF53271; 1.
 TIGRFAMs; TIGR01251; ribP_PPkin; 1.
 PROSITE; PS00114; PRPP_SYNTHASE; 1.
 3: Inferred from homology;
 ATP-binding {ECO:0000256|HAMAP-Rule:MF_00583,
 ECO:0000256|SAAS:SAAS00956731};
 Complete proteome {ECO:0000313|Proteomes:UP000037059,
 ECO:0000313|Proteomes:UP000037272, ECO:0000313|Proteomes:UP000037632,
 ECO:0000313|Proteomes:UP000051757};
 Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00583};
 Kinase {ECO:0000256|HAMAP-Rule:MF_00583,
 ECO:0000256|SAAS:SAAS00956744, ECO:0000313|EMBL:KOQ72738.1};
 Magnesium {ECO:0000256|HAMAP-Rule:MF_00583,
 ECO:0000256|SAAS:SAAS00956743};
 Metal-binding {ECO:0000256|HAMAP-Rule:MF_00583,
 ECO:0000256|SAAS:SAAS00956748};
 Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00583,
 ECO:0000256|SAAS:SAAS00956760};
 Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00583,
 ECO:0000256|SAAS:SAAS00956731};
 Transferase {ECO:0000256|HAMAP-Rule:MF_00583,
 ECO:0000256|SAAS:SAAS00956744, ECO:0000313|EMBL:KOQ72738.1}.
 DOMAIN        8    124       Pribosyltran_N.
                              {ECO:0000259|Pfam:PF13793}.
 NP_BIND      40     42       ATP. {ECO:0000256|HAMAP-Rule:MF_00583}.
 NP_BIND      99    100       ATP. {ECO:0000256|HAMAP-Rule:MF_00583}.
 REGION      228    232       Ribose-5-phosphate binding.
                              {ECO:0000256|HAMAP-Rule:MF_00583}.
 ACT_SITE    198    198       {ECO:0000256|HAMAP-Rule:MF_00583}.
 METAL       134    134       Magnesium. {ECO:0000256|HAMAP-
                              Rule:MF_00583}.
 METAL       174    174       Magnesium. {ECO:0000256|HAMAP-
                              Rule:MF_00583}.
 BINDING     200    200       Ribose-5-phosphate. {ECO:0000256|HAMAP-
                              Rule:MF_00583}.
 BINDING     224    224       Ribose-5-phosphate. {ECO:0000256|HAMAP-
                              Rule:MF_00583}.
 SEQUENCE   319 AA;  34414 MW;  96EB2A6F0371089C CRC64;
 MQESPNLLVF SGNANKRLAQ NICKELGVRP GKALVSHFSD GEVQVEIEEN VRKQDVFVIQ
 PTCAPSAENL MELLVLIDAL KRASVASVTA VVPYFGYSRQ DRRMRSSRVP ITAKLAAKMF
 STAGADRVLT VDLHADQIQG FFDIPVDNVY ASPLLLADIW RAYGTENLIV VSPDVGGVVR
 ARAVAKRLDD ADLAIIDKRR PRANVSTVMN IIGDVEGKTC VMVDDIVDTA GTLCAAAAAL
 KARGALKVAA YCTHAVLSGP AVDNITNSQL DELVVTDTIP LKDAARVCSK IRQLSVAEML
 AETMRRIAFG ESVSSLYVD

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