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Ribosome-inactivating protein gelonin (EC 3.2.2.22) (rRNA N-glycosidase)

 RIPG_SURMU              Reviewed;         316 AA.
P33186;
01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 2.
25-OCT-2017, entry version 80.
RecName: Full=Ribosome-inactivating protein gelonin;
EC=3.2.2.22;
AltName: Full=rRNA N-glycosidase;
Flags: Precursor;
Name=GEL;
Suregada multiflora (False lime) (Gelonium multiflorum).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae;
Crotonoideae; Gelonieae; Suregada.
NCBI_TaxID=3979;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7916721; DOI=10.1016/0378-1119(93)90097-M;
Nolan P.A., Garrison D.A., Better M.;
"Cloning and expression of a gene encoding gelonin, a ribosome-
inactivating protein from Gelonium multiflorum.";
Gene 134:223-227(1993).
[2]
PROTEIN SEQUENCE OF 47-93.
TISSUE=Seed;
PubMed=2753596;
Montecucchi P.-C., Lazzarini A.M., Barbieri L., Stirpe F., Soria M.,
Lappi D.;
"N-terminal sequence of some ribosome-inactivating proteins.";
Int. J. Pept. Protein Res. 33:263-267(1989).
[3]
X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
PubMed=7608981; DOI=10.1006/jmbi.1995.0383;
Hosur M.V., Nair B., Satyamurthy P., Misquith S., Surolia A.,
Kannan K.K.;
"X-ray structure of gelonin at 1.8-A resolution.";
J. Mol. Biol. 250:368-380(1995).
-!- CATALYTIC ACTIVITY: Endohydrolysis of the N-glycosidic bond at one
specific adenosine on the 28S rRNA.
-!- SUBUNIT: Homodimer.
-!- SIMILARITY: Belongs to the ribosome-inactivating protein family.
Type 1 RIP subfamily. {ECO:0000305}.
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EMBL; L12243; AAA16312.1; -; mRNA.
PIR; JT0753; JT0753.
PDB; 3KTZ; X-ray; 1.60 A; A/B=47-297.
PDB; 3KU0; X-ray; 1.90 A; A/B=47-297.
PDBsum; 3KTZ; -.
PDBsum; 3KU0; -.
ProteinModelPortal; P33186; -.
SMR; P33186; -.
Allergome; 2798; Gel m RIP.
EvolutionaryTrace; P33186; -.
GO; GO:0030598; F:rRNA N-glycosylase activity; IEA:UniProtKB-EC.
GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
GO; GO:0017148; P:negative regulation of translation; IEA:UniProtKB-KW.
Gene3D; 3.40.420.10; -; 1.
Gene3D; 4.10.470.10; -; 1.
InterPro; IPR036041; Ribosome-inact_prot_sf.
InterPro; IPR017989; Ribosome_inactivat_1/2.
InterPro; IPR001574; Ribosome_inactivat_prot.
InterPro; IPR017988; Ribosome_inactivat_prot_CS.
InterPro; IPR016138; Ribosome_inactivat_prot_sub1.
InterPro; IPR016139; Ribosome_inactivat_prot_sub2.
Pfam; PF00161; RIP; 1.
PRINTS; PR00396; SHIGARICIN.
SUPFAM; SSF56371; SSF56371; 1.
PROSITE; PS00275; SHIGA_RICIN; 1.
1: Evidence at protein level;
3D-structure; Direct protein sequencing; Disulfide bond; Glycoprotein;
Hydrolase; Plant defense; Protein synthesis inhibitor; Signal; Toxin.
SIGNAL 1 26 {ECO:0000255}.
PROPEP 27 46 {ECO:0000269|PubMed:2753596}.
/FTId=PRO_0000030786.
CHAIN 47 297 Ribosome-inactivating protein gelonin.
/FTId=PRO_0000030787.
PROPEP 298 316 Removed in mature form.
/FTId=PRO_0000030788.
ACT_SITE 212 212
CARBOHYD 235 235 N-linked (GlcNAc...) asparagine.
DISULFID 90 96
CONFLICT 90 90 C -> K (in Ref. 2; AA sequence).
{ECO:0000305}.
CONFLICT 93 93 P -> D (in Ref. 2; AA sequence).
{ECO:0000305}.
STRAND 49 54 {ECO:0000244|PDB:3KTZ}.
HELIX 60 73 {ECO:0000244|PDB:3KTZ}.
STRAND 78 80 {ECO:0000244|PDB:3KTZ}.
STRAND 83 85 {ECO:0000244|PDB:3KTZ}.
TURN 93 95 {ECO:0000244|PDB:3KTZ}.
STRAND 96 103 {ECO:0000244|PDB:3KTZ}.
STRAND 109 115 {ECO:0000244|PDB:3KTZ}.
TURN 116 118 {ECO:0000244|PDB:3KTZ}.
STRAND 121 126 {ECO:0000244|PDB:3KTZ}.
STRAND 129 132 {ECO:0000244|PDB:3KTZ}.
HELIX 138 143 {ECO:0000244|PDB:3KTZ}.
STRAND 147 152 {ECO:0000244|PDB:3KTZ}.
HELIX 159 163 {ECO:0000244|PDB:3KTZ}.
TURN 164 166 {ECO:0000244|PDB:3KTZ}.
HELIX 169 171 {ECO:0000244|PDB:3KTZ}.
HELIX 176 188 {ECO:0000244|PDB:3KTZ}.
STRAND 191 193 {ECO:0000244|PDB:3KTZ}.
HELIX 196 209 {ECO:0000244|PDB:3KTZ}.
HELIX 211 215 {ECO:0000244|PDB:3KTZ}.
HELIX 217 224 {ECO:0000244|PDB:3KTZ}.
TURN 225 228 {ECO:0000244|PDB:3KTZ}.
HELIX 235 252 {ECO:0000244|PDB:3KTZ}.
STRAND 259 267 {ECO:0000244|PDB:3KTZ}.
STRAND 273 278 {ECO:0000244|PDB:3KTZ}.
HELIX 279 282 {ECO:0000244|PDB:3KTZ}.
HELIX 283 285 {ECO:0000244|PDB:3KTZ}.
SEQUENCE 316 AA; 35419 MW; 1252F3E710901B85 CRC64;
MKGNMKVYWI KIAVATWFCC TTIVLGSTAR IFSLPTNDEE ETSKTLGLDT VSFSTKGATY
ITYVNFLNEL RVKLKPEGNS HGIPLLRKKC DDPGKCFVLV ALSNDNGQLA EIAIDVTSVY
VVGYQVRNRS YFFKDAPDAA YEGLFKNTIK TRLHFGGSYP SLEGEKAYRE TTDLGIEPLR
IGIKKLDENA IDNYKPTEIA SSLLVVIQMV SEAARFTFIE NQIRNNFQQR IRPANNTISL
ENKWGKLSFQ IRTSGANGMF SEAVELERAN GKKYYVTAVD QVKPKIALLK FVDKDPKTSL
AAELIIQNYE SLVGFD


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