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Rosmarinate synthase (MoRAS) (EC 2.3.1.140) (Hydroxycinnamoyl-CoA:hydroxyphenyllactate hydroxycinnamoyltransferase)

 RAS_MELOI               Reviewed;         427 AA.
G0LD36;
29-MAY-2013, integrated into UniProtKB/Swiss-Prot.
19-OCT-2011, sequence version 1.
27-SEP-2017, entry version 16.
RecName: Full=Rosmarinate synthase;
Short=MoRAS;
EC=2.3.1.140;
AltName: Full=Hydroxycinnamoyl-CoA:hydroxyphenyllactate hydroxycinnamoyltransferase;
Name=RAS;
Melissa officinalis (Lemon balm).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae;
Mentheae; Melissa.
NCBI_TaxID=39338;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY, AND
BIOPHYSICOCHEMICAL PROPERTIES.
PubMed=21354582; DOI=10.1016/j.phytochem.2011.01.039;
Weitzel C., Petersen M.;
"Cloning and characterisation of rosmarinic acid synthase from Melissa
officinalis L.";
Phytochemistry 72:572-578(2011).
-!- FUNCTION: Catalyzes the formation of rosmarinic acid using
caffeoyl-CoA and 3.4-dihydroxyphenyllactate as substrates. Can
also use 4-coumaroyl-CoA and 4-hydroxyphenyllactate as substrates.
Rosmarinic acid is an ester of caffeic acid and 3,4-
dihydroxyphenyllactic acid. {ECO:0000269|PubMed:21354582}.
-!- CATALYTIC ACTIVITY: Caffeoyl-CoA + (R)-3-(3,4-
dihydroxyphenyl)lactate = CoA + rosmarinate.
{ECO:0000269|PubMed:21354582}.
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=4.8 uM for 4-coumaroyl-CoA (with 4-hydroxyphenyllactate as
acceptor substrate) {ECO:0000269|PubMed:21354582};
KM=5.8 uM for caffeoyl-CoA (with 4-hydroxyphenyllactate as
acceptor substrate) {ECO:0000269|PubMed:21354582};
KM=7.3 uM for 4-coumaroyl-CoA (with 3,4-dihydroxyphenyllactic
acid as acceptor substrate) {ECO:0000269|PubMed:21354582};
KM=5.2 uM for caffeoyl-CoA (with 3,4-dihydroxyphenyllactic acid
as acceptor substrate) {ECO:0000269|PubMed:21354582};
pH dependence:
Optimum pH is 7.1. {ECO:0000269|PubMed:21354582};
Temperature dependence:
Optimum temperature is 45 degrees Celsius.
{ECO:0000269|PubMed:21354582};
-!- SIMILARITY: Belongs to the plant acyltransferase family.
{ECO:0000305}.
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EMBL; FR670523; CBW35684.1; -; Genomic_DNA.
SMR; G0LD36; -.
KEGG; ag:CBW35684; -.
KO; K21425; -.
GO; GO:0050266; F:rosmarinate synthase activity; IDA:UniProtKB.
GO; GO:0008152; P:metabolic process; IDA:UniProtKB.
InterPro; IPR003480; Transferase.
Pfam; PF02458; Transferase; 1.
1: Evidence at protein level;
Acyltransferase; Transferase.
CHAIN 1 427 Rosmarinate synthase.
/FTId=PRO_0000422583.
ACT_SITE 152 152 Proton acceptor. {ECO:0000255}.
ACT_SITE 374 374 Proton acceptor. {ECO:0000255}.
SEQUENCE 427 AA; 47161 MW; 4B4383045C3AB9E2 CRC64;
MRIDIKDSTM VKPAAETPGG SVWLTNLDLL SPANYHTLSV HFYHHDGSEN FFDAAALKEA
LSRALVDFYP YAGRLKLKDN RLEIDCNGEG VLLVEAESDG ALAELGEFAP RPDLNLIPQV
DYAKGISTYP LMLFQLTRFK CGGVGLGVAN EHHLSDGVAA LHFINTWAHL ARGVPAPSPP
PVFDRRSLSA RNPPKPQFSH AEYQPPPTLP TPLTDTAIAY SKLKVTRDQL GALKAKCLAG
DPSGKPRSTF EVLAGHIWRC VCAARGLPED QETKLHIPFD GRAKLRLPPG YFGNAIFFAT
PVATCGEIES NSLAHAVKRV GDAIARLDED YLRSSIDFLE LQEDISKLAQ GAHSFRCPNL
WVISWVRLPV YEPDFGWGKA VYMGPWAAPF EGKSYLLPNP DNDGSLFVAI TLHTQHMERF
EKLFYEI


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