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Runt-related transcription factor

 F6YLA1_ORNAN            Unreviewed;       380 AA.
F6YLA1;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
22-NOV-2017, entry version 43.
RecName: Full=Runt-related transcription factor {ECO:0000256|PIRNR:PIRNR009374};
Name=RUNX2 {ECO:0000313|Ensembl:ENSOANP00000013130};
Ornithorhynchus anatinus (Duckbill platypus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000013130, ECO:0000313|Proteomes:UP000002279};
[1] {ECO:0000313|Ensembl:ENSOANP00000013130}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000013130};
PubMed=8919867; DOI=10.1007/BF02198841;
Janke A., Gemmell N.J., Feldmaier-Fuchs G., von Haeseler A., Paabo S.;
"The mitochondrial genome of a monotreme--the platypus
(Ornithorhynchus anatinus).";
J. Mol. Evol. 42:153-159(1996).
[2] {ECO:0000313|Proteomes:UP000002279}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
PubMed=18464734; DOI=10.1038/nature06936;
Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
Wilson R.K.;
"Genome analysis of the platypus reveals unique signatures of
evolution.";
Nature 453:175-183(2008).
[3] {ECO:0000313|Ensembl:ENSOANP00000013130}
IDENTIFICATION.
STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000013130};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- FUNCTION: CBF binds to the core site, 5'-PYGPYGGT-3', of a number
of enhancers and promoters. {ECO:0000256|PIRNR:PIRNR009374}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR009374}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSOANP00000013130}.
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STRING; 9258.ENSOANP00000013130; -.
Ensembl; ENSOANT00000013132; ENSOANP00000013130; ENSOANG00000008265.
eggNOG; KOG3982; Eukaryota.
eggNOG; ENOG4111J4Y; LUCA.
GeneTree; ENSGT00390000016964; -.
InParanoid; F6YLA1; -.
OMA; SDPRQFT; -.
OrthoDB; EOG091G0CXB; -.
TreeFam; TF321496; -.
Proteomes; UP000002279; Unplaced.
Bgee; ENSOANG00000008265; -.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0005667; C:transcription factor complex; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:InterPro.
GO; GO:0043425; F:bHLH transcription factor binding; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
GO; GO:0070491; F:repressing transcription factor binding; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IEA:Ensembl.
GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
GO; GO:0048469; P:cell maturation; IEA:Ensembl.
GO; GO:0002063; P:chondrocyte development; IEA:Ensembl.
GO; GO:0002062; P:chondrocyte differentiation; IBA:GO_Central.
GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
GO; GO:0035115; P:embryonic forelimb morphogenesis; IEA:Ensembl.
GO; GO:0001958; P:endochondral ossification; IEA:Ensembl.
GO; GO:0030097; P:hemopoiesis; IBA:GO_Central.
GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0001503; P:ossification; IBA:GO_Central.
GO; GO:0002076; P:osteoblast development; IEA:Ensembl.
GO; GO:0002051; P:osteoblast fate commitment; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0032332; P:positive regulation of chondrocyte differentiation; IEA:Ensembl.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
GO; GO:1901522; P:positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; IEA:Ensembl.
GO; GO:0045595; P:regulation of cell differentiation; IBA:GO_Central.
GO; GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IBA:GO_Central.
GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
GO; GO:0030217; P:T cell differentiation; IEA:Ensembl.
Gene3D; 2.60.40.720; -; 1.
Gene3D; 4.10.770.10; -; 1.
InterPro; IPR000040; AML1_Runt.
InterPro; IPR008967; p53-like_TF_DNA-bd.
InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd_sf.
InterPro; IPR013524; Runt_dom.
InterPro; IPR027384; Runx_central_dom_sf.
InterPro; IPR013711; RunxI_C_dom.
InterPro; IPR016554; TF_Runt-rel_RUNX.
PANTHER; PTHR11950; PTHR11950; 1.
Pfam; PF00853; Runt; 1.
Pfam; PF08504; RunxI; 1.
PIRSF; PIRSF009374; TF_Runt-rel_RUNX; 1.
PRINTS; PR00967; ONCOGENEAML1.
SUPFAM; SSF49417; SSF49417; 1.
PROSITE; PS51062; RUNT; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000002279};
DNA-binding {ECO:0000256|PIRNR:PIRNR009374};
Reference proteome {ECO:0000313|Proteomes:UP000002279};
Transcription {ECO:0000256|PIRNR:PIRNR009374};
Transcription regulation {ECO:0000256|PIRNR:PIRNR009374}.
DOMAIN 1 88 Runt. {ECO:0000259|PROSITE:PS51062}.
BINDING 22 22 Chloride 1.
{ECO:0000256|PIRSR:PIRSR009374-1}.
BINDING 26 26 Chloride 1; via amide nitrogen.
{ECO:0000256|PIRSR:PIRSR009374-1}.
BINDING 49 49 Chloride 2.
{ECO:0000256|PIRSR:PIRSR009374-1}.
BINDING 80 80 Chloride 2; via amide nitrogen.
{ECO:0000256|PIRSR:PIRSR009374-1}.
SEQUENCE 380 AA; 41516 MW; 40FFB605FD851523 CRC64;
VVALGEVPDG TVVTVMAGND ENYSAELRNA SAVMKNQVAR FNDLRFVGRS GRGKSFTLTI
TVFTNPPQVA TYHRAIKVTV DGPREPRRHR QKLDDSKPSL FSERLSDLGR IPHPSMRVGV
PTQNPRPSLN SAPSPFNPQG QSQITDPRQT QSSPPWSYDQ SYPSYLSQMT SPSIHSTTPL
SSTRGTGLPA ITDVPRRISV TDWLTNVYIL SPSQLTKNSL AGSQNWGPFS DPRQFTSISS
LTESRFSNPR MHYPATFTYT PPVTSGMSLG MSATTHYHTY LPPPYPGFSQ NQSGPFQTSS
TPYLYYGTSS GSYQFPMVPG GDRSPSRMLP PCTTTSNGSA LLNPNLPNQN DGVDADGSHS
SSPTVLNSSG RMDESVWRPY


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