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Runt-related transcription factor

 M3YM57_MUSPF            Unreviewed;       507 AA.
M3YM57;
01-MAY-2013, integrated into UniProtKB/TrEMBL.
01-MAY-2013, sequence version 1.
22-NOV-2017, entry version 26.
RecName: Full=Runt-related transcription factor {ECO:0000256|PIRNR:PIRNR009374};
Name=RUNX2 {ECO:0000313|Ensembl:ENSMPUP00000012414};
Mustela putorius furo (European domestic ferret) (Mustela furo).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
Mustelinae; Mustela.
NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000012414, ECO:0000313|Proteomes:UP000000715};
[1] {ECO:0000313|Ensembl:ENSMPUP00000012414}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000012414};
Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
Walker B.J., Young S., Birren B., Lindblad-Toh K.;
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSMPUP00000012414}
IDENTIFICATION.
Ensembl;
Submitted (MAR-2013) to UniProtKB.
-!- FUNCTION: CBF binds to the core site, 5'-PYGPYGGT-3', of a number
of enhancers and promoters. {ECO:0000256|PIRNR:PIRNR009374}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR009374}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSMPUP00000012414}.
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EMBL; AEYP01006028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEYP01006029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9669.ENSMPUP00000012414; -.
Ensembl; ENSMPUT00000012615; ENSMPUP00000012414; ENSMPUG00000012508.
eggNOG; KOG3982; Eukaryota.
eggNOG; ENOG4111J4Y; LUCA.
GeneTree; ENSGT00390000016964; -.
InParanoid; M3YM57; -.
OMA; SDPRQFT; -.
OrthoDB; EOG091G0CXB; -.
Proteomes; UP000000715; Unassembled WGS sequence.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005667; C:transcription factor complex; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:InterPro.
GO; GO:0043425; F:bHLH transcription factor binding; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
GO; GO:0070491; F:repressing transcription factor binding; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IEA:Ensembl.
GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
GO; GO:0048469; P:cell maturation; IEA:Ensembl.
GO; GO:0002063; P:chondrocyte development; IEA:Ensembl.
GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
GO; GO:0035115; P:embryonic forelimb morphogenesis; IEA:Ensembl.
GO; GO:0001958; P:endochondral ossification; IEA:Ensembl.
GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0002076; P:osteoblast development; IEA:Ensembl.
GO; GO:0002051; P:osteoblast fate commitment; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0032332; P:positive regulation of chondrocyte differentiation; IEA:Ensembl.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
GO; GO:1901522; P:positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; IEA:Ensembl.
GO; GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
GO; GO:0030217; P:T cell differentiation; IEA:Ensembl.
Gene3D; 2.60.40.720; -; 1.
Gene3D; 4.10.770.10; -; 1.
InterPro; IPR000040; AML1_Runt.
InterPro; IPR008967; p53-like_TF_DNA-bd.
InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd_sf.
InterPro; IPR013524; Runt_dom.
InterPro; IPR027384; Runx_central_dom_sf.
InterPro; IPR013711; RunxI_C_dom.
InterPro; IPR016554; TF_Runt-rel_RUNX.
PANTHER; PTHR11950; PTHR11950; 1.
Pfam; PF00853; Runt; 1.
Pfam; PF08504; RunxI; 1.
PIRSF; PIRSF009374; TF_Runt-rel_RUNX; 1.
PRINTS; PR00967; ONCOGENEAML1.
SUPFAM; SSF49417; SSF49417; 1.
PROSITE; PS51062; RUNT; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000000715};
DNA-binding {ECO:0000256|PIRNR:PIRNR009374};
Reference proteome {ECO:0000313|Proteomes:UP000000715};
Transcription {ECO:0000256|PIRNR:PIRNR009374};
Transcription regulation {ECO:0000256|PIRNR:PIRNR009374}.
DOMAIN 89 215 Runt. {ECO:0000259|PROSITE:PS51062}.
BINDING 149 149 Chloride 1.
{ECO:0000256|PIRSR:PIRSR009374-1}.
BINDING 153 153 Chloride 1; via amide nitrogen.
{ECO:0000256|PIRSR:PIRSR009374-1}.
BINDING 176 176 Chloride 2.
{ECO:0000256|PIRSR:PIRSR009374-1}.
BINDING 207 207 Chloride 2; via amide nitrogen.
{ECO:0000256|PIRSR:PIRSR009374-1}.
SEQUENCE 507 AA; 55292 MW; 8436EB4065421FDF CRC64;
DPSTSRRFSP PSSSLQPGKM SDVSPVVAAQ QQQQQQQQQG GCRRREPQQR PGRLRVQGLE
PLAVAGCVST ARSRFPRADL VRLRSPQDDY TRILIICLYS ACCVRTDTFL CCACKCNKKG
SMETTFKVVA LGEVPDGTVV TVMAGNDENY SAELRNASAV MKNQVARFND LRFVGRSGRG
KSFTLTITVF TNPPQVATYH RAIKVTVDGP REPRRHRQKL DDSKPSLFSD RLSDLGRIPH
PSMRVGVPPQ NPRPSLNSAP SPFNPQGQSQ ITDPRQAQSS PPWSYDQSYP SYLSQMTSPS
IHSTTPLSST RGTGLPAITD VPRRISGADT STSDFCLWPS TLSKKSQAGA SELGPFSDPR
QFPSISSLTE SRFSNPRMHY PATFTYTPPV TSGMSLGMSA TTHYHTYLPP PYPGSSQSQS
GPFQTSSTPY LYYGTSSGSY QFPMVPGGDR SPSRMLPPCT TTSNGSTLLN PNLPNQNDGV
DADGSHSSSP TVLNSSGRMD ESVWRPY


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