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Runt-related transcription factor

 Q8UVG3_CHICK            Unreviewed;       472 AA.
Q8UVG3;
01-MAR-2002, integrated into UniProtKB/TrEMBL.
01-MAR-2002, sequence version 1.
22-NOV-2017, entry version 93.
RecName: Full=Runt-related transcription factor {ECO:0000256|PIRNR:PIRNR009374};
Name=RUNX2 {ECO:0000313|Ensembl:ENSGALP00000050655};
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031 {ECO:0000313|EMBL:AAL62328.1};
[1] {ECO:0000313|EMBL:AAL62328.1}
NUCLEOTIDE SEQUENCE.
Iwamoto M., Enomoto-Iwamoto M.;
"Requirement of Cbfa-1 in differentiation of chondrocytes.";
Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSGALP00000050655, ECO:0000313|Proteomes:UP000000539}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000050655,
ECO:0000313|Proteomes:UP000000539};
PubMed=15592404; DOI=10.1038/nature03154;
International Chicken Genome Sequencing Consortium;
Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C.,
Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E.,
Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W.,
Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A., Kremitzki C.,
Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E.,
Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J.,
Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M.,
Paton B., Smith J., Morrice D., Daniels L., Tempest H.G.,
Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V.,
Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J.,
van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J.,
Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H.,
Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S.,
Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J.,
Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H.,
Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C.,
Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C.,
Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P.,
King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S.,
Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S.,
Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S.,
Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z.,
Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J.,
Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z.,
Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J.,
Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G.,
Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D.,
Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G.,
Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A.,
Mardis E.R., Wilson R.K.;
"Sequence and comparative analysis of the chicken genome provide
unique perspectives on vertebrate evolution.";
Nature 432:695-716(2004).
[3] {ECO:0000313|Ensembl:ENSGALP00000050655}
IDENTIFICATION.
STRAIN=Red jungle fowl {ECO:0000313|Ensembl:ENSGALP00000050655};
Ensembl;
Submitted (OCT-2016) to UniProtKB.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR009374}.
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EMBL; AADN04000287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AF450085; AAL62328.1; -; mRNA.
RefSeq; NP_989459.1; NM_204128.1.
UniGene; Gga.157; -.
PaxDb; Q8UVG3; -.
Ensembl; ENSGALT00000077870; ENSGALP00000050655; ENSGALG00000040276.
GeneID; 373919; -.
CTD; 860; -.
eggNOG; KOG3982; Eukaryota.
eggNOG; ENOG4111J4Y; LUCA.
GeneTree; ENSGT00390000016964; -.
HOGENOM; HOG000045616; -.
HOVERGEN; HBG060268; -.
Reactome; R-GGA-8878166; Transcriptional regulation by RUNX2.
Reactome; R-GGA-8939902; Regulation of RUNX2 expression and activity.
Reactome; R-GGA-8940973; RUNX2 regulates osteoblast differentiation.
Reactome; R-GGA-8941326; RUNX2 regulates bone development.
Proteomes; UP000000539; Chromosome 3.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IDA:AgBase.
GO; GO:0005667; C:transcription factor complex; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:InterPro.
GO; GO:0043425; F:bHLH transcription factor binding; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
GO; GO:0070491; F:repressing transcription factor binding; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IEA:Ensembl.
GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
GO; GO:0060317; P:cardiac epithelial to mesenchymal transition; IMP:AgBase.
GO; GO:1990079; P:cartilage homeostasis; IMP:AgBase.
GO; GO:0048469; P:cell maturation; IEA:Ensembl.
GO; GO:0060591; P:chondroblast differentiation; IMP:AgBase.
GO; GO:0002063; P:chondrocyte development; IEA:Ensembl.
GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
GO; GO:0035115; P:embryonic forelimb morphogenesis; IEA:Ensembl.
GO; GO:0001958; P:endochondral ossification; IEA:Ensembl.
GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0002076; P:osteoblast development; IEA:Ensembl.
GO; GO:0001649; P:osteoblast differentiation; IMP:AgBase.
GO; GO:0002051; P:osteoblast fate commitment; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0032332; P:positive regulation of chondrocyte differentiation; TAS:AgBase.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
GO; GO:1901522; P:positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; IEA:Ensembl.
GO; GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IEA:Ensembl.
GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
GO; GO:0030217; P:T cell differentiation; IEA:Ensembl.
Gene3D; 2.60.40.720; -; 1.
Gene3D; 4.10.770.10; -; 1.
InterPro; IPR000040; AML1_Runt.
InterPro; IPR008967; p53-like_TF_DNA-bd.
InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd_sf.
InterPro; IPR013524; Runt_dom.
InterPro; IPR027384; Runx_central_dom_sf.
InterPro; IPR013711; RunxI_C_dom.
InterPro; IPR016554; TF_Runt-rel_RUNX.
PANTHER; PTHR11950; PTHR11950; 1.
Pfam; PF00853; Runt; 1.
Pfam; PF08504; RunxI; 1.
PIRSF; PIRSF009374; TF_Runt-rel_RUNX; 1.
PRINTS; PR00967; ONCOGENEAML1.
SUPFAM; SSF49417; SSF49417; 1.
PROSITE; PS51062; RUNT; 1.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000000539};
DNA-binding {ECO:0000256|PIRNR:PIRNR009374};
Reference proteome {ECO:0000313|Proteomes:UP000000539};
Transcription {ECO:0000256|PIRNR:PIRNR009374};
Transcription regulation {ECO:0000256|PIRNR:PIRNR009374}.
DOMAIN 74 202 Runt. {ECO:0000259|PROSITE:PS51062}.
BINDING 136 136 Chloride 1.
{ECO:0000256|PIRSR:PIRSR009374-1}.
BINDING 140 140 Chloride 1; via amide nitrogen.
{ECO:0000256|PIRSR:PIRSR009374-1}.
BINDING 163 163 Chloride 2.
{ECO:0000256|PIRSR:PIRSR009374-1}.
BINDING 194 194 Chloride 2; via amide nitrogen.
{ECO:0000256|PIRSR:PIRSR009374-1}.
SEQUENCE 472 AA; 51690 MW; 3DCA14639939C11E CRC64;
MASNSLFSSV TPCQQNFFWD PSTSRRFSPP SSSLQPGKMS EVSPVVVAQQ QQQQQQQQQQ
EAAVPRLRPH DNRTMVEIIA DHPAELVRTD SPNFLCSVLP SHWRCNKTLP VAFKVVALGE
VPDGTVVTVM AGNDENYSAE LRNASAVMKN QVARFNDLRF VGRSGRGKSF TLTITVLTNP
PQVATYHRAI KVTVDGPREP RRHRQKLDDS KPSLFPERLS DLGRIPHPSM RVGVPTQSPR
PSLNSAPSPF NPQGQSQITD PRQAQSSPPW SYDQSYPSYL SQMTSPSIHS TTPLSSTRGT
GLPAITDVPR RLSGASELGP FSDPRQFTSI SSLTESRFSN PRMHYPATFT YTPPVTSGMS
LGMSATTHYH TYLPPPYPGS SQNQSGPFQT SSTPYLYYGT SSGSYQFPMV PGGDRSPSRM
LPPCTTTSNG STLLNPNLPN QSDGVEADGS HSSSPTVLNS SGRMDESVWR PY


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