Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Ryanodine receptor 3 (RYR-3) (RyR3) (Brain ryanodine receptor-calcium release channel) (Brain-type ryanodine receptor) (Type 3 ryanodine receptor)

 RYR3_RABIT              Reviewed;        4872 AA.
Q9TS33;
22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
10-MAY-2017, entry version 116.
RecName: Full=Ryanodine receptor 3;
Short=RYR-3;
Short=RyR3;
AltName: Full=Brain ryanodine receptor-calcium release channel;
AltName: Full=Brain-type ryanodine receptor;
AltName: Full=Type 3 ryanodine receptor;
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
Oryctolagus.
NCBI_TaxID=9986;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
TISSUE=Brain;
PubMed=1330694; DOI=10.1016/0014-5793(92)80941-9;
Hakamata Y., Nakai J., Takeshima H., Imoto K.;
"Primary structure and distribution of a novel ryanodine
receptor/calcium release channel from rabbit brain.";
FEBS Lett. 312:229-235(1992).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), FUNCTION, SUBCELLULAR
LOCATION, REGULATION BY RYANODINE; CALMODULIN; CALCIUM LEVELS;
MAGNESIUM; ATP; CAFFEINE AND RUTHENIUM RED, AND TISSUE SPECIFICITY.
TISSUE=Uterus;
PubMed=9305876; DOI=10.1074/jbc.272.39.24234;
Chen S.R., Li X., Ebisawa K., Zhang L.;
"Functional characterization of the recombinant type 3 Ca2+ release
channel (ryanodine receptor) expressed in HEK293 cells.";
J. Biol. Chem. 272:24234-24246(1997).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), ALTERNATIVE
SPLICING, FUNCTION, SUBUNIT, INTERACTION WITH RYR2, AND TISSUE
SPECIFICITY.
TISSUE=Uterus;
PubMed=12471029; DOI=10.1074/jbc.M210410200;
Jiang D., Xiao B., Li X., Chen S.R.;
"Smooth muscle tissues express a major dominant negative splice
variant of the type 3 Ca2+ release channel (ryanodine receptor).";
J. Biol. Chem. 278:4763-4769(2003).
[4]
FUNCTION, SUBUNIT, AND MUTAGENESIS OF GLU-3885.
PubMed=9614063; DOI=10.1074/jbc.273.24.14675;
Chen S.R., Ebisawa K., Li X., Zhang L.;
"Molecular identification of the ryanodine receptor Ca2+ sensor.";
J. Biol. Chem. 273:14675-14678(1998).
[5]
FUNCTION, SUBUNIT, DOMAIN, INTERACTION WITH FKBP1A, SUBCELLULAR
LOCATION, MEMBRANE TOPOLOGY, ELECTRON MICROSCOPY, REGULATION BY
RYANODINE; CALCIUM LEVELS; MAGNESIUM; ATP AND CAFFEINE, AND TISSUE
SPECIFICITY.
PubMed=10358090; DOI=10.1074/jbc.274.24.17297;
Murayama T., Oba T., Katayama E., Oyamada H., Oguchi K., Kobayashi M.,
Otsuka K., Ogawa Y.;
"Further characterization of the type 3 ryanodine receptor (RyR3)
purified from rabbit diaphragm.";
J. Biol. Chem. 274:17297-17308(1999).
[6]
INTERACTION WITH RYR2, AND FUNCTION.
PubMed=12213830; DOI=10.1074/jbc.M208210200;
Xiao B., Masumiya H., Jiang D., Wang R., Sei Y., Zhang L.,
Murayama T., Ogawa Y., Lai F.A., Wagenknecht T., Chen S.R.;
"Isoform-dependent formation of heteromeric Ca2+ release channels
(ryanodine receptors).";
J. Biol. Chem. 277:41778-41785(2002).
[7]
SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=16176801; DOI=10.1016/j.bbrc.2005.09.027;
Conti A., Reggiani C., Sorrentino V.;
"Selective expression of the type 3 isoform of ryanodine receptor Ca2+
release channel (RyR3) in a subset of slow fibers in diaphragm and
cephalic muscles of adult rabbits.";
Biochem. Biophys. Res. Commun. 337:195-200(2005).
[8]
FUNCTION, INTERACTION WITH CALM, SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
PubMed=16274254; DOI=10.1021/bi051251t;
Yamaguchi N., Xu L., Pasek D.A., Evans K.E., Chen S.R., Meissner G.;
"Calmodulin regulation and identification of calmodulin binding region
of type-3 ryanodine receptor calcium release channel.";
Biochemistry 44:15074-15081(2005).
[9]
INTERACTION WITH SELENON, AND SUBCELLULAR LOCATION.
PubMed=18713863; DOI=10.1073/pnas.0806015105;
Jurynec M.J., Xia R., Mackrill J.J., Gunther D., Crawford T.,
Flanigan K.M., Abramson J.J., Howard M.T., Grunwald D.J.;
"Selenoprotein N is required for ryanodine receptor calcium release
channel activity in human and zebrafish muscle.";
Proc. Natl. Acad. Sci. U.S.A. 105:12485-12490(2008).
-!- FUNCTION: Calcium channel that mediates the release of Ca(2+) from
the sarcoplasmic reticulum into the cytoplasm in muscle and
thereby plays a role in triggering muscle contraction. May
regulate Ca(2+) release by other calcium channels. Calcium channel
that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic
reticulum in non-muscle cells. Plays a role in cellular calcium
signaling. Contributes to cellular calcium ion homeostasis.
Isoform 2 lacks a predicted transmembrane segment and does not
form functional calcium channels by itself; however, it can form
tetramers with isoforms that contain the full complement of
transmembrane segments and modulate their activity.
{ECO:0000269|PubMed:10358090, ECO:0000269|PubMed:12213830,
ECO:0000269|PubMed:12471029, ECO:0000269|PubMed:16274254,
ECO:0000269|PubMed:9305876, ECO:0000269|PubMed:9614063}.
-!- SUBUNIT: Homotetramer. Isoform 2 can form tetramers with isoform
1. Heterotetramer with RYR2. Interacts with FKBP1A. Interacts with
CALM. Interacts with SELENON (PubMed:18713863).
{ECO:0000269|PubMed:10358090, ECO:0000269|PubMed:12213830,
ECO:0000269|PubMed:12471029, ECO:0000269|PubMed:16274254,
ECO:0000269|PubMed:18713863, ECO:0000269|PubMed:9614063}.
-!- INTERACTION:
Self; NbExp=2; IntAct=EBI-9542578, EBI-9542578;
-!- SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane; Multi-pass
membrane protein. Membrane; Multi-pass membrane protein. Microsome
membrane; Multi-pass membrane protein. Sarcoplasmic reticulum
{ECO:0000269|PubMed:18713863}. Note=The number of predicted
transmembrane domains varies between orthologs, but both N-
terminus and C-terminus seem to be cytoplasmic. {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Comment=Additional isoforms seem to exist.;
Name=1;
IsoId=Q9TS33-1; Sequence=Displayed;
Name=2; Synonyms=AS-8a;
IsoId=Q9TS33-2; Sequence=VSP_042306;
Note=Lacks a predicted transmembrane segment and does not form
functional calcium channels.;
Name=3;
IsoId=Q9TS33-3; Sequence=VSP_042305;
Name=4;
IsoId=Q9TS33-4; Sequence=VSP_042307;
-!- TISSUE SPECIFICITY: Detected in skeletal muscle from young rabbits
and in adult diaphragm muscle (at protein level). Detected in
brain, especially in corpus striatum, thalamus and hippocampus.
Detected in taenia coli, uterus, vas deferens, aorta, stomach,
small intestine, heart, diaphragm and ureter. Isoform 2 is highly
expressed in uterus and aorta, and at much lower levels in heart,
brain and diaphragm. {ECO:0000269|PubMed:10358090,
ECO:0000269|PubMed:12471029, ECO:0000269|PubMed:1330694,
ECO:0000269|PubMed:16176801, ECO:0000269|PubMed:16274254,
ECO:0000269|PubMed:9305876}.
-!- DEVELOPMENTAL STAGE: Ubiquitous in skeletal muscle in neonates and
in 15 day old rabbits. In adult, detected in diaphragm muscle, and
in a subset of skeletal muscles including digastricus,
pterygoideus, tongue and masseter. {ECO:0000269|PubMed:16176801}.
-!- DOMAIN: The calcium release channel activity resides in the C-
terminal region while the remaining part of the protein resides in
the cytoplasm. {ECO:0000305|PubMed:10358090}.
-!- MISCELLANEOUS: Channel activity is modulated by the alkaloid
ryanodine that binds to the open calcium-release channel with high
affinity. At low concentrations, ryanodine maintains the channel
in an open conformation. High ryanodine concentrations inhibit
channel activity. Channel activity is regulated by calmodulin
(CALM). The calcium release is activated by elevated cytoplasmic
calcium levels in the micromolar range, by caffeine and adenine
nucleotides, such as AMP and ATP. Inhibited by Mg(2+) and
ruthenium red.
-!- SIMILARITY: Belongs to the ryanodine receptor (TC 1.A.3.1) family.
RYR3 subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; X68650; CAC16153.1; -; mRNA.
PIR; S27272; S27272.
RefSeq; NP_001076231.1; NM_001082762.1. [Q9TS33-1]
UniGene; Ocu.3278; -.
ProteinModelPortal; Q9TS33; -.
STRING; 9986.ENSOCUP00000024658; -.
GeneID; 100009545; -.
KEGG; ocu:100009545; -.
CTD; 6263; -.
eggNOG; KOG2243; Eukaryota.
eggNOG; ENOG410YCNW; LUCA.
HOGENOM; HOG000231428; -.
HOVERGEN; HBG006699; -.
KO; K04963; -.
Proteomes; UP000001811; Unplaced.
GO; GO:0016021; C:integral component of membrane; IDA:UniProtKB.
GO; GO:0016529; C:sarcoplasmic reticulum; IDA:UniProtKB.
GO; GO:0033017; C:sarcoplasmic reticulum membrane; IDA:UniProtKB.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IDA:UniProtKB.
GO; GO:0070588; P:calcium ion transmembrane transport; IDA:UniProtKB.
GO; GO:0006874; P:cellular calcium ion homeostasis; TAS:UniProtKB.
GO; GO:0071318; P:cellular response to ATP; IDA:UniProtKB.
GO; GO:0071313; P:cellular response to caffeine; IDA:UniProtKB.
GO; GO:0071277; P:cellular response to calcium ion; IDA:UniProtKB.
GO; GO:0071286; P:cellular response to magnesium ion; IDA:UniProtKB.
GO; GO:0006936; P:muscle contraction; NAS:UniProtKB.
GO; GO:0051289; P:protein homotetramerization; IDA:UniProtKB.
InterPro; IPR001870; B30.2/SPRY.
InterPro; IPR013320; ConA-like_dom.
InterPro; IPR011992; EF-hand-dom_pair.
InterPro; IPR002048; EF_hand_dom.
InterPro; IPR014821; Ins145_P3_rcpt.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR016093; MIR_motif.
InterPro; IPR013662; RIH_assoc-dom.
InterPro; IPR000699; RIH_dom.
InterPro; IPR013333; Ryan_recept.
InterPro; IPR003032; Ryanodine_rcpt.
InterPro; IPR015925; Ryanodine_recept-rel.
InterPro; IPR009460; Ryanrecept_TM4-6.
InterPro; IPR003877; SPRY_dom.
PANTHER; PTHR13715; PTHR13715; 1.
Pfam; PF08709; Ins145_P3_rec; 1.
Pfam; PF00520; Ion_trans; 1.
Pfam; PF02815; MIR; 1.
Pfam; PF08454; RIH_assoc; 1.
Pfam; PF06459; RR_TM4-6; 1.
Pfam; PF01365; RYDR_ITPR; 2.
Pfam; PF02026; RyR; 4.
Pfam; PF00622; SPRY; 3.
PRINTS; PR00795; RYANODINER.
SMART; SM00472; MIR; 4.
SMART; SM00449; SPRY; 3.
SUPFAM; SSF100909; SSF100909; 2.
SUPFAM; SSF47473; SSF47473; 1.
SUPFAM; SSF49899; SSF49899; 3.
SUPFAM; SSF82109; SSF82109; 2.
PROSITE; PS50188; B302_SPRY; 3.
PROSITE; PS50919; MIR; 5.
1: Evidence at protein level;
Alternative splicing; Calcium; Calcium channel; Calcium transport;
Calmodulin-binding; Complete proteome; Endoplasmic reticulum;
Ion channel; Ion transport; Ligand-gated ion channel; Membrane;
Microsome; Receptor; Reference proteome; Repeat;
Sarcoplasmic reticulum; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 4872 Ryanodine receptor 3.
/FTId=PRO_0000415649.
TOPO_DOM 1 4188 Cytoplasmic. {ECO:0000255}.
TRANSMEM 4189 4209 Helical. {ECO:0000255}.
TRANSMEM 4412 4432 Helical. {ECO:0000255}.
TRANSMEM 4487 4507 Helical. {ECO:0000255}.
TRANSMEM 4612 4632 Helical. {ECO:0000255}.
TRANSMEM 4635 4655 Helical. {ECO:0000255}.
TRANSMEM 4674 4694 Helical. {ECO:0000255}.
INTRAMEM 4725 4734 Pore-forming. {ECO:0000250}.
TRANSMEM 4755 4775 Helical. {ECO:0000255}.
TOPO_DOM 4776 4872 Cytoplasmic. {ECO:0000255}.
DOMAIN 100 155 MIR 1. {ECO:0000255|PROSITE-
ProRule:PRU00131}.
DOMAIN 162 207 MIR 2. {ECO:0000255|PROSITE-
ProRule:PRU00131}.
DOMAIN 215 269 MIR 3. {ECO:0000255|PROSITE-
ProRule:PRU00131}.
DOMAIN 275 333 MIR 4. {ECO:0000255|PROSITE-
ProRule:PRU00131}.
DOMAIN 343 400 MIR 5. {ECO:0000255|PROSITE-
ProRule:PRU00131}.
DOMAIN 585 796 B30.2/SPRY 1. {ECO:0000255|PROSITE-
ProRule:PRU00548}.
REPEAT 840 953 1.
REPEAT 954 1068 2.
DOMAIN 1012 1208 B30.2/SPRY 2. {ECO:0000255|PROSITE-
ProRule:PRU00548}.
DOMAIN 1254 1466 B30.2/SPRY 3. {ECO:0000255|PROSITE-
ProRule:PRU00548}.
REPEAT 2592 2710 3.
REPEAT 2711 2823 4.
REGION 840 2823 4 X approximate repeats.
REGION 2325 2338 Interaction with FKBP1A. {ECO:0000250}.
REGION 3472 3501 Interaction with CALM.
{ECO:0000269|PubMed:16274254}.
SITE 3885 3885 Important for activation by Ca(2+).
VAR_SEQ 3341 3345 Missing (in isoform 3).
{ECO:0000303|PubMed:12471029,
ECO:0000303|PubMed:9305876}.
/FTId=VSP_042305.
VAR_SEQ 4406 4434 Missing (in isoform 2).
{ECO:0000303|PubMed:12471029}.
/FTId=VSP_042306.
VAR_SEQ 4791 4841 Missing (in isoform 4).
{ECO:0000303|PubMed:12471029}.
/FTId=VSP_042307.
MUTAGEN 3885 3885 E->A: Reduces calcium-sensitivity by over
10000-fold. {ECO:0000269|PubMed:9614063}.
SEQUENCE 4872 AA; 551929 MW; D1DC6B85CD6B93E6 CRC64;
MAEGGEGGED EIQFLRTEDE VVLQCIATVH KEQRKFCLAA EGLGNRLCFL EPTSEAKFIP
PDLCVCNFVL EQSLSVRALQ EMLANTGENG GEGAAQGGGH RTLLYGHAIL LRHSFSGMYL
TCLTTSRSQT DKLAFDVGLR EHATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER
YLHLSISNGN IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD
QNDSQHRRIF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED
QGLLLQDRGK ADTKSTAFSF RPSKETKEKL DSSHKRDIEG MGVPEIKYGD SVCFVQHIAS
GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC QREESQAARI IRNTTALFSQ
FVSGNNRTAA PVTLPIEEVL QTLHDLIAYF QPPEEEMQHE DKQNKLRSLK NRQNLFKEEG
MLALVLNCID RLNIYNSVAH FAGIAREESG MAWKEVLSLL YKLLAALIRG NRNTCAQFSN
NLDWLISKLD RLESSSGILE VLHCILIESP EALNLIAEGH IKSIISLLDK HGRNHKVLDV
LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV AEGSAQYKKW
YFELIIDQVD PFLTAEPTHL RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW
SGRIPRAVAS INQHLLKSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVMS
FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD AEGVRDLLGT
TQFLSQASFI PCPIDTSQVV LPPHLEKIRD RLAENIHELW GMNKIELGWT FGKMRDDNKR
QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK VKLPKNYMMS
NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV
PYALLDERTK KSNRDSLREA VRTFVGYGYN IEPSDQELAD PAVEKVSIDK IRFFRVERSY
AVRSGKWYFE FEVVTGGDMR VGWARPGCRP DIELGPMTKP LCLKAAGASV GTKVVGILGV
PWQPGDVVGC MINLDDASMI FTLNGELLIT NKGSELAFAD YEIENGFVPI CSLGLSQIGR
MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAMWFSKR LPTFVNVPKD HPHIEVVRID
GTMDSPPCLK VTHKTFGTQN SNANMIYCRL SMPVECHSSF SHSPCLDSEA FQKRKQMQEI
LSHTTTQCFY SIRIFAGQDP SCVWVGWVTP DYHLYSEKFD LNKNCTVTVT LGDERGRVHE
SVKRSNCYMV WGGDVVASSQ RSSRSNVDLE IGCLVDLAMG MLSFSANGKE LGTCYQVEPN
TKVFPAVFLQ PTSTSLFQFE LGKLKNAMPL SAAIFKSEEK NPVPQCPPRL DVQTIQPVLW
SRMPNSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE QEDLMQFHYH
TLRLYSAVCA LGNSRVAYAL CSHVDLSQLF HAIDNKYLPG LLRSGFYDLL ISIHLANAKE
RKLMMKNEYI IPITSTTRNI RLYPDESKKH GLPGVGPRTC LKPGFKFSTP CFVVTNEERQ
KQSPEIPLEI LKMKALSMLT EAVQCSGAHI RDPVGGSVEF QFVPVLKLVG TLLVMGVFCD
DDVRQILLLI DPSVFGEHSA DTEEGAEKEE VSQVEEKAVE AGEKTSKEAR KEAPVRGLLQ
TRLPESVKLQ MCELLSYLCD CELQHRVEAI VAFGDIYVSK LQANQKFRYN ELMQALNMSA
ALTARKTREF RSPPQEQINM LLNFQLGENC PCPEEIREEL YDFHEDLLVH CGVPLEEEEE
EEEDTSWTGK LRTLVYKIKG PPKPEKEQPT EEEERCPTTL KELISQTMIR WAQEDQIQDA
ELVRMMFNLL RRQYDSIGEL LQALRKTYTI SHASVSDTIN LLAALGQIRS LLSVRMGREE
ELLMINGLGD IMNNKVFYQH PNLMRVLGMH ETVMEVMVNV LGTEKSQIAF PKMVASCCRF
LCYFCRISRQ NQKAMFEHLS YLLENSSVGL ASPSMRGSTP LDVAASSVMD NNELALGLEE
PDLEKVVTYL AGCGLQSCPM LLAKGYPDVG WNPIEGERYL SFLRFAVFVN SESVEENASV
VVKLLIRRPE CFGPALRGEG GNGLLAAMQG AIKISESPAL DLPSQGYKRE VPEDGEEEEE
IVHMGNAIMS FYSALIDLLG RCAPEMHLIQ TGKGEAIRIR SILRSLVPTE DLVGIISIPL
KLPSLNKDGS VSEPDMAANF CPDHKAPMVL FLDRVYGIKD QTFLLHLLEV GFLPDLRASA
SLDTVALSTT ESALALNRYI CSAVLPLLTR CAPLFAGTEH YTSLIDSTLQ TIYRLSKGRS
LTKAQRDTIE ECLLAICNHL RPSMLQQLLR RLVFDVPQLN DYCKMPLKLL TNHFEQCWKY
YCLPSGWGSY GLAVEEELHL TEKLFWGIFD SLSHKKYDPD LFRMSLPCLS AIAGALPPDY
LDTRITATLE KQVSVDADGN FDPKPINTIN FSLPEKLEYI VTKYAEHSHD KWACEKSQSG
WKYGISLDEN VKTHPLIRPF KTLTEKEKEI YRWPARESLK TMLAVGWTVE RTKEGEALVQ
LRENEKLRSV SQTSQGNSYN PAPLDLSNVV LSRELQGMVE VVAENYHNIW AKKKKLELES
KGGGSHPLLV PYDTLTAKEK FRDREKAQDL FKFLQVNGVI VSRGMKDMEL DAFSMEKRFA
YKFLKKILKY VDSAQEFIAH LEAIVSSGKT EKSPHDQEIK FFAKVLLPLV DQYFTNHRLY
FLSSPLKPLS SSGYASHKEK EMVASLFCKL AALVRHRISL FGSDSTTMVS CLHILAQTLD
TRTVMKSGSE LVKAGLRAFF ESAAEDLEKT SENLKLGKFT HSRTQIKGVS QNINYTTVAL
LPILTSIFEH VAQHQFGVDL LLGDVQISCY RILCSLYSLG TGKNIYVERQ RPALGECLAS
LAAAIPVAFL EPTLNRYNAL SVFNTKTPRE RSILGMPDTV EEMCPDIPQL EGLMKEINDL
AESGARYTEM PHVIEVILPM LCNYLSYWWE RGPENLSPST GPCCSKVTSE HLSLILGNIL
KIINNNLGID EASWMKRIAV YAQPIISKAR PDLLRSHFIP TLEKLKKKAV KTVQEEEQLK
ADGKGDTQEA ELLILDEFAI LCRDLYAFYP MLIRYVDNNR SNWLKSPDGD SDQLFRMVAE
VFILWCKSHN FKREEQNFVI QNEINNLAFL TGDSKSKMSK AMQVKSGGQD QERKKTKRRG
DLYSIQTSLI VAALKKMLPI GLNMCTPGDQ ELISLAKSRY SYRDTDEEVK EHLRNNLHLQ
EKSDDPAVKW QLNLYKDVLK SEEPSNPEKT VERVQRISAA VFHLEQVEQP LRSKKAVWHK
LLSKQRKRAV VACFRMAPLY NLPRHRSINL FLHGYQRFWI ETEEYSFEEK LVQDLAKSPK
VEEEEEEEME KQPDPLHQII LHFSRNALTE RSKLEDDPLY TSYSSMMAKS CQSGEDEEEE
DKEKTFEEKE MEKQKTLYQQ ARLHERGAAE MVLQMISASK GEMSPMVVET LKLGIAILNG
GNAGVQQKML DYLKVKKDAG FFQSLSGLMQ SCSVLDLNAF ERQNKAEGLG MVTEEGTLIV
RERGEKVLQN DEFTRDLFRF LQLLCEGHNS DFQNFLRTQM GNTTTVNVII STVDYLLRLQ
ESISDFYWYY SGKDIIDESG QHNFSKALAV TKQIFNSLTE YIQGPCIGNQ QSLAHSRLWD
AVVGFLHVFA NMQMKLSQDS SQIELLKELL DLLQDMVVML LSLLEGNVVN GTIGKQMVDT
LVESSTNVEM ILKFFDMFLK LKDLTSSDTF KEYDPDGKGI ISKKEFQKAM EGQKQYTQSE
IDFLLSCAEA DENDMFNYID FVDRFHEPAK DIGFNVAVLL TNLSEHMPND SRLKCLLDPA
ESVLNYFEPY LGRIEIMGGA KKIERVYFEI SESSRTQWEK PQVKESKRQF IFDVVNEGGE
QEKMELFVNF CEDTIFEMQL ASQISESDSA DRPEEEEGDE ESSYVLEING EEEEDKSFES
ASAFAMACAS LKRNITNLLR KATLKNLRKQ YRNVKKMTAK ELVKVFFSFF WMLFVGLFQL
FFTIVGGIFQ ILWSTVFGGG LVEGAKNIRV TKILGDMPDP TQFGIHDDAM EAERAEVAEA
GITTELVHFV KGERGDTELM SDLFGLHPKK EGGVKHGPEV GLGDLSEIIG KDEPPTLEST
VRKKRKAQAA ETKAEHEAEG KVESEKADLE DGEKEDKAKE EERAEYLWAE VTKKKKRRRG
QKVEKPEAFM ANFFKGLEIY QTKLLHYLAR NFYNLRFLAL FVAFAINFIL LFYKVTEEPL
EEETEDVANL WNSLNDEEEE EAMVFFVLQE STGYMAPTLR ALAVVHTIIS LVCVVGYYCL
KVPLVVFKRE KEIARKLEFD GLYITEQPSE DDIKGQWDRL VINTPSFPHN YWDKFVKRKV
INKYGDLYGA ERIAELLGLD KNALDFSPVE ETTAEAASLV SWLSSIDMKY HIWKLGVVFT
DNSFLYLAWY TTMSVLGHYN NFFFAAHLLD IAMGFKTLRT ILSSVTHNGK QLVLTVGLLA
VVVYLYTVVA FNFFRKFYNK SEDDDEPDMK CDDMMTCYLF HMYVGVRAGG GIGDEIEDPA
GDPYEMYRIV FDITFFFFVI VILLAIIQGL IIDAFGELRD QQEQVREDME TKCFICGIGN
DYFDTTPHGF ETHTLQEHNL ANYLFFLMYL INKDETEHTG QESYVWKMYQ ERCWDFFPAG
DCFRKQYEDQ LG


Related products :

Catalog number Product name Quantity
EIAAB36521 Brain ryanodine receptor-calcium release channel,Brain-type ryanodine receptor,HBRR,Homo sapiens,Human,Ryanodine receptor 3,RyR3,RYR3,RYR-3
EIAAB36519 Cardiac muscle ryanodine receptor-calcium release channel,Cardiac muscle-type ryanodine receptor,Homo sapiens,hRYR-2,Human,Ryanodine receptor 2,RyR2,RYR2,RYR-2
EIAAB36520 Cardiac muscle ryanodine receptor-calcium release channel,Cardiac muscle-type ryanodine receptor,Oryctolagus cuniculus,Rabbit,Ryanodine receptor 2,RyR2,RYR2,RYR-2
EIAAB36518 Homo sapiens,Human,Ryanodine receptor 1,RYDR,RyR1,RYR1,RYR-1,Skeletal muscle calcium release channel,Skeletal muscle-type ryanodine receptor
EIAAB36517 Oryctolagus cuniculus,Rabbit,Ryanodine receptor 1,RyR1,RYR1,RYR-1,Skeletal muscle calcium release channel,Skeletal muscle-type ryanodine receptor
EIAAB36516 CRC,Pig,Ryanodine receptor 1,RyR1,RYR1,RYR-1,Skeletal muscle calcium release channel,Skeletal muscle-type ryanodine receptor,Sus scrofa
CSB-EQ027244HU Human anti-ryanodine receptor(RyR) calcium release channel antibody ELISA kit , Species , Sample Type 96T
OBT1818 MOUSE ANTI HUMAN RYANODINE RECEPTOR, Product Type Monoclonal Antibody, Specificity RYANODINE RECEPTOR, Target Species Human, Host Mouse, Format Purified, Isotypes IgG2b, Applications C, E, F, I 50 µg
SCH-OBT1818 MOUSE ANTI HUMAN RYANODINE RECEPTOR, Product Type Monoclonal Antibody, Specificity RYANODINE RECEPTOR, Target Species Human, Host Mouse, Format Purified, Isotypes IgG2b, Applications C, E, F, I 50 µg
CSB-E13357h Human anti-ryanodine receptor calcium release channel antibodies ELISA Kit 96T
CSB-E13357h Human anti-ryanodine receptor calcium release channel antibodies ELISA Kit, Species Human, Sample Type serum, plasma 96T
G8633 Ryanodine receptor 3 (RYR3), Human, ELISA Kit 96T
CSB-EL020621HU Human Ryanodine receptor 3(RYR3) ELISA kit 96T
E3159Hu Human Ryanodine receptor 3,RyR3 ELISA kit 48T
QY-E02416 Human Ryanodine Receptor 3(RYR3)ELISA Kit 96T
201-12-4841 Human Ryanodine Receptor 3(RYR3)ELISA Kit 96T
E3159Hu Human Ryanodine receptor 3,RyR3 ELISA kit 96T
Y050674 Anti-RYR3(Ryanodine receptor 3) Antibody 100ug
UB-E02416 Human Ryanodine Receptor 3(RYR3)ELISA Kit 96T
E3158Hu Human Ryanodine receptor 3,RyR3 ELISA kit 48T
YHB2617Hu Human Ryanodine receptor 3,RyR3 ELISA kit 48T
YHB2617Hu Human Ryanodine receptor 3,RyR3 ELISA kit 96T
'AP32428SU-N Ryanodine receptor 3 RYR3 antibody Ab host: Rabbit 0.1 ml
CSB-EL020621HU Human Ryanodine receptor 3(RYR3) ELISA kit SpeciesHuman 96T
CSB-EL020621HU Human ryanodine receptor 3 (RYR3) ELISA kit, Species Human, Sample Type serum, plasma 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur