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S-arrestin (48 kDa protein) (Retinal S-antigen) (S-AG) (Rod photoreceptor arrestin)

 ARRS_CANLF              Reviewed;         405 AA.
Q28281;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 1.
10-MAY-2017, entry version 93.
RecName: Full=S-arrestin;
AltName: Full=48 kDa protein;
AltName: Full=Retinal S-antigen;
Short=S-AG;
AltName: Full=Rod photoreceptor arrestin;
Name=SAG; Synonyms=ARR, SAG1;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Beagle X Briard; TISSUE=Retina;
PubMed=9088745; DOI=10.1076/ceyr.16.3.270.15413;
Veske A., Nafstroem K., Finckh U., Sargan D.R., Nilsson S.E.G.,
Gal A.;
"Isolation of canine retinal arrestin cDNA and exclusion of three
candidate genes for Swedish Briard retinal dystrophy.";
Curr. Eye Res. 16:270-274(1997).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS CYS-14; VAL-101;
THR-103; TYR-257 AND GLU-377.
PubMed=12123530; DOI=10.1186/1471-2156-3-12;
Dekomien G., Epplen J.T.;
"Screening of the arrestin gene in dogs afflicted with generalized
progressive retinal atrophy.";
BMC Genet. 3:12-12(2002).
-!- FUNCTION: Arrestin is one of the major proteins of the ros
(retinal rod outer segments); it binds to photoactivated-
phosphorylated rhodopsin, thereby apparently preventing the
transducin-mediated activation of phosphodiesterase.
-!- TISSUE SPECIFICITY: Retina and pineal gland.
-!- DISEASE: Note=S-antigen induces autoimmune uveitis.
-!- DISEASE: Note=Defects in SAG may be the cause of generalized
progressive retinal atrophy (gPRA) in some breeds.
-!- MISCELLANEOUS: Arrestin binds calcium. {ECO:0000250}.
-!- SIMILARITY: Belongs to the arrestin family. {ECO:0000305}.
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EMBL; X98460; CAA67100.1; -; mRNA.
EMBL; AJ426068; CAD19827.1; -; Genomic_DNA.
EMBL; AJ426069; CAD19827.1; JOINED; Genomic_DNA.
EMBL; AJ426070; CAD19827.1; JOINED; Genomic_DNA.
EMBL; AJ426071; CAD19827.1; JOINED; Genomic_DNA.
EMBL; AJ426072; CAD19827.1; JOINED; Genomic_DNA.
EMBL; AJ426073; CAD19827.1; JOINED; Genomic_DNA.
EMBL; AJ426074; CAD19827.1; JOINED; Genomic_DNA.
EMBL; AJ426075; CAD19827.1; JOINED; Genomic_DNA.
EMBL; AJ426076; CAD19827.1; JOINED; Genomic_DNA.
EMBL; AJ426077; CAD19827.1; JOINED; Genomic_DNA.
EMBL; AJ426078; CAD19827.1; JOINED; Genomic_DNA.
RefSeq; NP_001003230.1; NM_001003230.1.
UniGene; Cfa.3764; -.
ProteinModelPortal; Q28281; -.
SMR; Q28281; -.
STRING; 9615.ENSCAFP00000017366; -.
PaxDb; Q28281; -.
GeneID; 403906; -.
KEGG; cfa:403906; -.
CTD; 6295; -.
eggNOG; KOG3865; Eukaryota.
eggNOG; ENOG410XR0F; LUCA.
HOGENOM; HOG000231319; -.
HOVERGEN; HBG002399; -.
InParanoid; Q28281; -.
KO; K19627; -.
Proteomes; UP000002254; Unplaced.
GO; GO:0007165; P:signal transduction; IEA:InterPro.
GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
Gene3D; 2.60.40.840; -; 1.
InterPro; IPR000698; Arrestin.
InterPro; IPR011021; Arrestin-like_N.
InterPro; IPR011022; Arrestin_C-like.
InterPro; IPR017864; Arrestin_CS.
InterPro; IPR014753; Arrestin_N.
InterPro; IPR014756; Ig_E-set.
PANTHER; PTHR11792; PTHR11792; 1.
Pfam; PF02752; Arrestin_C; 1.
Pfam; PF00339; Arrestin_N; 1.
PRINTS; PR00309; ARRESTIN.
SMART; SM01017; Arrestin_C; 1.
SUPFAM; SSF81296; SSF81296; 2.
PROSITE; PS00295; ARRESTINS; 1.
2: Evidence at transcript level;
Autoimmune uveitis; Calcium; Complete proteome; Disulfide bond;
Phosphoprotein; Polymorphism; Reference proteome;
Sensory transduction; Vision.
CHAIN 1 405 S-arrestin.
/FTId=PRO_0000205185.
MOD_RES 234 234 Phosphothreonine.
{ECO:0000250|UniProtKB:P15887}.
DISULFID 132 147 {ECO:0000305}.
VARIANT 14 14 H -> C (requires 2 nucleotide
substitutions).
{ECO:0000269|PubMed:12123530}.
VARIANT 101 101 A -> V. {ECO:0000269|PubMed:12123530}.
VARIANT 103 103 A -> T. {ECO:0000269|PubMed:12123530}.
VARIANT 257 257 D -> Y. {ECO:0000269|PubMed:12123530}.
VARIANT 377 377 A -> E. {ECO:0000269|PubMed:12123530}.
SEQUENCE 405 AA; 45177 MW; CDDE31B82FEDEBE6 CRC64;
MAASGKTSKS ASNHVIFKKI SRDKSVTIYL GKRDYIDHVE QVEPVDGIVL VDPELVKGKK
VYVSLTCAFR YGQEDIDVIG LSFRRDLYFS QVQVFPPVEA AGAPTKLQES LMKKLGGNTY
PFLLTFPDYL PCSVMLQPAP QDMGKCCGVD FEVKAFARDS TEDEEDKVPK KSSVRLLIRK
VQHAPSKMGP QPRAEAAWQF FMSDKPLHLA VSLSKEIYFH GEPITVTVTV TNNTEKTVKK
IKALVEQVAN VVLYSSDYYT KPVAQEETQE KVPPNSTLTT TLTLVPLLAN NRERRGIALD
GKIKHEDTNL ASSTIIKEGI DRTVLGILVS YHIKVKLTVS GFLGELTSSE VATEVPFRLM
HPQPEDPATA KESFQDANLV FEEFARQNLK DFAEEGKKDR EAMDE


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