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S-fimbrial adhesin protein SfaS

 SFAS_ECOL5              Reviewed;         163 AA.
P13430; Q0TL48;
01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
01-JAN-1990, sequence version 1.
05-JUL-2017, entry version 104.
RecName: Full=S-fimbrial adhesin protein SfaS;
Flags: Precursor;
Name=sfaS; OrderedLocusNames=ECP_0298;
Escherichia coli O6:K15:H31 (strain 536 / UPEC).
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=362663;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 23-63,
SUBCELLULAR LOCATION, IDENTIFICATION IN FIMBRIAE COMPLEX, AND
DISRUPTION PHENOTYPE.
PubMed=2576095; DOI=10.1111/j.1365-2958.1989.tb00159.x;
Schmoll T., Hoschuetzky H., Morschhaeuser J., Lottspeich F., Jann K.,
Hacker J.;
"Analysis of genes coding for the sialic acid-binding adhesin and two
other minor fimbrial subunits of the S-fimbrial adhesin determinant of
Escherichia coli.";
Mol. Microbiol. 3:1735-1744(1989).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=536 / UPEC;
PubMed=16879640; DOI=10.1111/j.1365-2958.2006.05255.x;
Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U.,
Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.;
"Role of pathogenicity island-associated integrases in the genome
plasticity of uropathogenic Escherichia coli strain 536.";
Mol. Microbiol. 61:584-595(2006).
[3]
MUTAGENESIS OF LYS-138; ARG-140 AND LYS-144.
PubMed=2194961;
Morschhaeuser J., Hoschuetzky H., Jann K., Hacker J.;
"Functional analysis of the sialic acid-binding adhesin SfaS of
pathogenic Escherichia coli by site-specific mutagenesis.";
Infect. Immun. 58:2133-2138(1990).
-!- FUNCTION: Fimbriae (also called pili), polar filaments radiating
from the surface of the bacterium to a length of 0.5-1.5
micrometers and numbering 100-300 per cell, enable bacteria to
colonize the epithelium of specific host organs.
-!- FUNCTION: A minor fimbrial subunit, this protein is necessary for
full expression of S-specific binding. S-fimbrial adhesins enable
pathogenic E.coli causing urinary-tract infections or newborn
meningitis to attach to glycoproteins terminating with alpha-
sialic acid-(2-3)-beta-Gal. This protein binds to the alpha-sialic
acid-(2-3)-beta-Gal and is thus responsible for erythrocyte
recognition and hemagglutination.
-!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000269|PubMed:2576095}.
-!- DISRUPTION PHENOTYPE: Deletion prevents hemagglutination
(erythrocyte recognition), although cells are still poorly
fimbriated. {ECO:0000269|PubMed:2576095}.
-!- SIMILARITY: Belongs to the fimbrial protein family. {ECO:0000305}.
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EMBL; X16664; CAA34653.1; -; Genomic_DNA.
EMBL; CP000247; ABG68333.1; -; Genomic_DNA.
PIR; S15926; S15926.
RefSeq; WP_000767892.1; NC_008253.1.
ProteinModelPortal; P13430; -.
SMR; P13430; -.
EnsemblBacteria; ABG68333; ABG68333; ECP_0298.
KEGG; ecp:ECP_0298; -.
HOGENOM; HOG000260127; -.
OMA; WITFHIN; -.
GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
GO; GO:0007155; P:cell adhesion; IEA:InterPro.
Gene3D; 2.60.40.1090; -; 1.
InterPro; IPR008966; Adhesion_dom.
InterPro; IPR000259; Adhesion_dom_fimbrial.
Pfam; PF00419; Fimbrial; 1.
SUPFAM; SSF49401; SSF49401; 1.
1: Evidence at protein level;
Direct protein sequencing; Disulfide bond; Fimbrium; Signal.
SIGNAL 1 22 {ECO:0000269|PubMed:2576095}.
CHAIN 23 163 S-fimbrial adhesin protein SfaS.
/FTId=PRO_0000009202.
REGION 138 144 Involved in sialic acid binding.
DISULFID 38 75 {ECO:0000305}.
MUTAGEN 138 138 K->T: No change in S-binding.
{ECO:0000269|PubMed:2194961}.
MUTAGEN 140 140 R->S: No hemagglutination, weak reaction
with antiadhesin-specific antibody A1.
{ECO:0000269|PubMed:2194961}.
MUTAGEN 144 144 K->T: No hemagglutination, no reaction
with antiadhesin-specific antibody A1.
{ECO:0000269|PubMed:2194961}.
SEQUENCE 163 AA; 17183 MW; 0BF1333BF8B2DE4F CRC64;
MKLKAIILAT GLINCIAFSA QAVDTTITVT GNVLQRTCNV PGNVDVSLGN LYVSDFPNAG
SGSPWVNFDL SLTGCQNMNT VRATFSGTAD GQTYYANTGN AGGIKIEIQD RDGSNASYHN
GMFKTLNVQN NNATFNLKAR AVSKGQVTPG NISSVITVTY TYA


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