GENTAUR Molecular Products.

 STIL_HUMAN              Reviewed;        1287 AA.
 Q15468; Q5T0C5; Q68CN9;
 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
 09-JAN-2007, sequence version 2.
 28-MAR-2018, entry version 133.
 RecName: Full=SCL-interrupting locus protein;
 AltName: Full=TAL-1-interrupting locus protein;
 Name=STIL; Synonyms=SIL;
 Homo sapiens (Human).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
 Catarrhini; Hominidae; Homo.
 NCBI_TaxID=9606;
 [1]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHROMOSOMAL REARRANGEMENT, AND
 TISSUE SPECIFICITY.
 TISSUE=Bone marrow;
 PubMed=1922059; DOI=10.1128/MCB.11.11.5462;
 Aplan P.D., Lombardi D.P., Kirsch I.R.;
 "Structural characterization of SIL, a gene frequently disrupted in T-
 cell acute lymphoblastic leukemia.";
 Mol. Cell. Biol. 11:5462-5469(1991).
 [2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1),
 AND VARIANTS VAL-86 AND ARG-1012.
 PubMed=12438740; DOI=10.1159/000064057;
 Karkera J.D., Izraeli S., Roessler E., Dutra A., Kirsch I.R.,
 Muenke M.;
 "The genomic structure, chromosomal localization, and analysis of SIL
 as a candidate gene for holoprosencephaly.";
 Cytogenet. Genome Res. 97:62-67(2002).
 [3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS
 VAL-86 AND ARG-984.
 TISSUE=Uterus;
 PubMed=17974005; DOI=10.1186/1471-2164-8-399;
 Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
 Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H.,
 Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K.,
 Ottenwaelder B., Poustka A., Wiemann S., Schupp I.;
 "The full-ORF clone resource of the German cDNA consortium.";
 BMC Genomics 8:399-399(2007).
 [4]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 PubMed=16710414; DOI=10.1038/nature04727;
 Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
 Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
 Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
 McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
 Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
 Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
 Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
 Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
 Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
 Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
 Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
 Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
 Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
 Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
 Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
 Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
 Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
 Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
 Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
 Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
 Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
 Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
 Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
 Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
 Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
 Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
 Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
 Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
 Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
 Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
 Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
 Beck S., Rogers J., Bentley D.R.;
 "The DNA sequence and biological annotation of human chromosome 1.";
 Nature 441:315-321(2006).
 [5]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
 PubMed=15489334; DOI=10.1101/gr.2596504;
 The MGC Project Team;
 "The status, quality, and expansion of the NIH full-length cDNA
 project: the Mammalian Gene Collection (MGC).";
 Genome Res. 14:2121-2127(2004).
 [6]
 CHROMOSOMAL REARRANGEMENT.
 PubMed=2209547;
 Brown L., Cheng J.-T., Chen Q., Siciliano M.J., Crist W., Buchanan G.,
 Baer R.;
 "Site-specific recombination of the tal-1 gene is a common occurrence
 in human T cell leukemia.";
 EMBO J. 9:3343-3351(1990).
 [7]
 CHROMOSOMAL REARRANGEMENT.
 PubMed=2255914; DOI=10.1126/science.2255914;
 Aplan P.D., Lombardi D.P., Ginsberg A.M., Cossman J., Bertness V.L.,
 Kirsch I.R.;
 "Disruption of the human SCL locus by 'illegitimate' V-(D)-J
 recombinase activity.";
 Science 250:1426-1429(1990).
 [8]
 CHROMOSOMAL REARRANGEMENT.
 PubMed=1311214;
 Aplan P.D., Lombardi D.P., Reaman G.H., Sather H.N., Hammond G.D.,
 Kirsch I.R.;
 "Involvement of the putative hematopoietic transcription factor SCL in
 T-cell acute lymphoblastic leukemia.";
 Blood 79:1327-1333(1992).
 [9]
 FUNCTION, AND INDUCTION.
 PubMed=9372240;
 Izraeli S., Colaizzo-Anas T., Bertness V.L., Mani K., Aplan P.D.,
 Kirsch I.R.;
 "Expression of the SIL gene is correlated with growth induction and
 cellular proliferation.";
 Cell Growth Differ. 8:1171-1179(1997).
 [10]
 CHROMOSOMAL REARRANGEMENT.
 PubMed=11390401; DOI=10.1074/jbc.M103797200;
 Raghavan S.C., Kirsch I.R., Lieber M.R.;
 "Analysis of the V(D)J recombination efficiency at lymphoid
 chromosomal translocation breakpoints.";
 J. Biol. Chem. 276:29126-29133(2001).
 [11]
 CHROMOSOMAL REARRANGEMENT.
 PubMed=12681356; DOI=10.1016/S0145-2126(02)00260-6;
 Curry J.D., Smith M.T.;
 "Measurement of SIL-TAL1 fusion gene transcripts associated with human
 T-cell lymphocytic leukemia by real-time reverse transcriptase-PCR.";
 Leuk. Res. 27:575-582(2003).
 [12]
 CHROMOSOMAL REARRANGEMENT.
 PubMed=14504110; DOI=10.1182/blood-2003-05-1495;
 Cave H., Suciu S., Preudhomme C., Poppe B., Robert A., Uyttebroeck A.,
 Malet M., Boutard P., Benoit Y., Mauvieux L., Lutz P., Mechinaud F.,
 Grardel N., Mazingue F., Dupont M., Margueritte G., Pages M.-P.,
 Bertrand Y., Plouvier E., Brunie G., Bastard C., Plantaz D.,
 Vande Velde I., Hagemeijer A., Speleman F., Lessard M., Otten J.,
 Vilmer E., Dastugue N.;
 "Clinical significance of HOX11L2 expression linked to
 t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in
 childhood T-cell malignancies: results of EORTC studies 58881 and
 58951.";
 Blood 103:442-450(2004).
 [13]
 TISSUE SPECIFICITY.
 PubMed=15107824; DOI=10.1038/sj.onc.1207685;
 Erez A., Perelman M., Hewitt S.M., Cojacaru G., Goldberg I.,
 Shahar I., Yaron P., Muler I., Campaner S., Amariglio N., Rechavi G.,
 Kirsch I.R., Krupsky M., Kaminski N., Izraeli S.;
 "Sil overexpression in lung cancer characterizes tumors with increased
 mitotic activity.";
 Oncogene 23:5371-5377(2004).
 [14]
 FUNCTION, AND PHOSPHORYLATION.
 PubMed=16024801; DOI=10.1128/MCB.25.15.6660-6672.2005;
 Campaner S., Kaldis P., Izraeli S., Kirsch I.R.;
 "Sil phosphorylation in a Pin1 binding domain affects the duration of
 the spindle checkpoint.";
 Mol. Cell. Biol. 25:6660-6672(2005).
 [15]
 PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-753, AND IDENTIFICATION
 BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
 TISSUE=Cervix carcinoma;
 PubMed=18669648; DOI=10.1073/pnas.0805139105;
 Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
 Elledge S.J., Gygi S.P.;
 "A quantitative atlas of mitotic phosphorylation.";
 Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
 [16]
 INVOLVEMENT IN MCPH7.
 PubMed=19215732; DOI=10.1016/j.ajhg.2009.01.017;
 Kumar A., Girimaji S.C., Duvvari M.R., Blanton S.H.;
 "Mutations in STIL, encoding a pericentriolar and centrosomal protein,
 cause primary microcephaly.";
 Am. J. Hum. Genet. 84:286-290(2009).
 [17]
 PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1135, AND IDENTIFICATION
 BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
 TISSUE=Leukemic T-cell;
 PubMed=19690332; DOI=10.1126/scisignal.2000007;
 Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
 Rodionov V., Han D.K.;
 "Quantitative phosphoproteomic analysis of T cell receptor signaling
 reveals system-wide modulation of protein-protein interactions.";
 Sci. Signal. 2:RA46-RA46(2009).
 [18]
 FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, INTERACTION WITH CENPJ,
 FORMATION OF A COMPLEX WITH CENPJ AND SASS6, AND UBIQUITINATION.
 PubMed=22020124; DOI=10.1038/emboj.2011.378;
 Tang C.J., Lin S.Y., Hsu W.B., Lin Y.N., Wu C.T., Lin Y.C.,
 Chang C.W., Wu K.S., Tang T.K.;
 "The human microcephaly protein STIL interacts with CPAP and is
 required for procentriole formation.";
 EMBO J. 30:4790-4804(2011).
 [19]
 ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY
 MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
 PubMed=22814378; DOI=10.1073/pnas.1210303109;
 Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
 Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
 Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
 Aldabe R.;
 "N-terminal acetylome analyses and functional insights of the N-
 terminal acetyltransferase NatB.";
 Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
 [20]
 PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-395; SER-779 AND
 SER-1135, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
 ANALYSIS].
 TISSUE=Cervix carcinoma, and Erythroleukemia;
 PubMed=23186163; DOI=10.1021/pr300630k;
 Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
 Mohammed S.;
 "Toward a comprehensive characterization of a human cancer cell
 phosphoproteome.";
 J. Proteome Res. 12:260-271(2013).
 [21]
 SUBCELLULAR LOCATION, AND INTERACTION WITH RBM14 AND CENPJ.
 PubMed=25385835; DOI=10.15252/embj.201488979;
 Shiratsuchi G., Takaoka K., Ashikawa T., Hamada H., Kitagawa D.;
 "RBM14 prevents assembly of centriolar protein complexes and maintains
 mitotic spindle integrity.";
 EMBO J. 34:97-114(2015).
 [22]
 VARIANT MCPH7 TRP-798.
 PubMed=22989186; DOI=10.1111/j.1399-0004.2012.01949.x;
 Papari E., Bastami M., Farhadi A., Abedini S.S., Hosseini M.,
 Bahman I., Mohseni M., Garshasbi M., Moheb L.A., Behjati F.,
 Kahrizi K., Ropers H.H., Najmabadi H.;
 "Investigation of primary microcephaly in Bushehr province of Iran:
 novel STIL and ASPM mutations.";
 Clin. Genet. 83:488-490(2013).
 -!- FUNCTION: Immediate-early gene. Plays an important role in
     embryonic development as well as in cellular growth and
     proliferation; its long-term silencing affects cell survival and
     cell cycle distribution as well as decreases CDK1 activity
     correlated with reduced phosphorylation of CDK1. Plays a role as a
     positive regulator of the sonic hedgehog pathway, acting
     downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an
     important role in the regulation of centriole duplication.
     Required for the onset of procentriole formation and proper
     mitotic progression. During procentriole formation, is essential
     for the correct loading of SASS6 and CENPJ to the base of the
     procentriole to initiate procentriole assembly (PubMed:22020124).
     {ECO:0000269|PubMed:16024801, ECO:0000269|PubMed:22020124,
     ECO:0000269|PubMed:9372240}.
 -!- SUBUNIT: Homodimer (PubMed:22020124). Interacts with PIN1 via its
     WW domain. This interaction is dependent on STIL mitotic
     phosphorylation (By similarity). Interacts with CENPJ
     (PubMed:22020124, PubMed:25385835). Interacts with RBM14 and this
     interaction interferes with the interaction of STIL with CENPJ
     (PubMed:25385835). Forms a complex with CENPJ and SASS6
     (PubMed:22020124). {ECO:0000250|UniProtKB:Q60988,
     ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:25385835}.
 -!- INTERACTION:
     Q9HC77:CENPJ; NbExp=15; IntAct=EBI-7488405, EBI-946194;
     Q6UVJ0:SASS6; NbExp=4; IntAct=EBI-7488405, EBI-1570153;
 -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
     {ECO:0000250|UniProtKB:Q60988}. Cytoplasm, cytoskeleton,
     microtubule organizing center, centrosome, centriole
     {ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:25385835}.
 -!- ALTERNATIVE PRODUCTS:
     Event=Alternative splicing; Named isoforms=2;
     Name=1;
       IsoId=Q15468-1; Sequence=Displayed;
     Name=2;
       IsoId=Q15468-2; Sequence=VSP_022301;
       Note=No experimental confirmation available.;
 -!- TISSUE SPECIFICITY: Expressed in all hematopoietic tissues and
     cell lines. Highly expressed in a variety of tumors characterized
     by increased mitotic activity with highest expression in lung
     cancer. {ECO:0000269|PubMed:15107824, ECO:0000269|PubMed:1922059}.
 -!- INDUCTION: Down-regulated when cell proliferation ceased.
     Accumulates during G2 phase and falls at completion of the cell
     cycle. {ECO:0000269|PubMed:9372240}.
 -!- PTM: Ubiquitinated. {ECO:0000269|PubMed:22020124}.
 -!- PTM: Phosphorylated following the activation of the mitotic
     checkpoint. {ECO:0000269|PubMed:16024801}.
 -!- DISEASE: Note=A chromosomal aberration involving STIL may be a
     cause of some T-cell acute lymphoblastic leukemias (T-ALL). A
     deletion at 1p32 between STIL and TAL1 genes leads to STIL/TAL1
     fusion mRNA with STIL exon 1 splicing to TAL1 exon 3. As both STIL
     exon 1 and TAL1 exon 3 are 5'-untranslated exons, STIL/TAL1 fusion
     mRNA predicts a full-length TAL1 protein under the control of the
     STIL promoter, leading to inappropriate TAL1 expression. In
     childhood T-cell malignancies (T-ALL), a type of defect such as
     STIL/TAL1 fusion is associated with a good prognosis. In cultured
     lymphocytes from healthy adults, STIL/TAL1 fusion mRNA may be
     detected after 7 days of culture. {ECO:0000269|PubMed:11390401,
     ECO:0000269|PubMed:12681356, ECO:0000269|PubMed:1311214,
     ECO:0000269|PubMed:14504110, ECO:0000269|PubMed:1922059,
     ECO:0000269|PubMed:2209547, ECO:0000269|PubMed:2255914}.
 -!- DISEASE: Microcephaly 7, primary, autosomal recessive (MCPH7)
     [MIM:612703]: A disease defined as a head circumference more than
     3 standard deviations below the age-related mean. Brain weight is
     markedly reduced and the cerebral cortex is disproportionately
     small. Despite this marked reduction in size, the gyral pattern is
     relatively well preserved, with no major abnormality in cortical
     architecture. Affected individuals are mentally retarded. Primary
     microcephaly is further defined by the absence of other syndromic
     features or significant neurological deficits due to degenerative
     brain disorder. {ECO:0000269|PubMed:19215732,
     ECO:0000269|PubMed:22989186}. Note=The disease is caused by
     mutations affecting the gene represented in this entry.
 -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
     and Haematology;
     URL="http://atlasgeneticsoncology.org/Genes/SILID524ch1p32.html";
 -----------------------------------------------------------------------
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 EMBL; M74558; AAA60550.1; -; mRNA.
 EMBL; AF349657; AAK51418.1; -; Genomic_DNA.
 EMBL; AF349642; AAK51418.1; JOINED; Genomic_DNA.
 EMBL; AF349643; AAK51418.1; JOINED; Genomic_DNA.
 EMBL; AF349645; AAK51418.1; JOINED; Genomic_DNA.
 EMBL; AF349647; AAK51418.1; JOINED; Genomic_DNA.
 EMBL; AF349649; AAK51418.1; JOINED; Genomic_DNA.
 EMBL; AF349651; AAK51418.1; JOINED; Genomic_DNA.
 EMBL; AF349653; AAK51418.1; JOINED; Genomic_DNA.
 EMBL; AF349656; AAK51418.1; JOINED; Genomic_DNA.
 EMBL; AF349655; AAK51418.1; JOINED; Genomic_DNA.
 EMBL; AF349654; AAK51418.1; JOINED; Genomic_DNA.
 EMBL; AF349652; AAK51418.1; JOINED; Genomic_DNA.
 EMBL; AF349650; AAK51418.1; JOINED; Genomic_DNA.
 EMBL; AF349648; AAK51418.1; JOINED; Genomic_DNA.
 EMBL; AF349646; AAK51418.1; JOINED; Genomic_DNA.
 EMBL; AF349644; AAK51418.1; JOINED; Genomic_DNA.
 EMBL; CR749851; CAH18699.1; -; mRNA.
 EMBL; AL513322; CAI13468.1; -; Genomic_DNA.
 EMBL; AL135960; CAI13468.1; JOINED; Genomic_DNA.
 EMBL; AL135960; CAI19733.1; -; Genomic_DNA.
 EMBL; AL513322; CAI19733.1; JOINED; Genomic_DNA.
 EMBL; BC126223; AAI26224.1; -; mRNA.
 CCDS; CCDS41329.1; -. [Q15468-2]
 CCDS; CCDS548.1; -. [Q15468-1]
 PIR; A41685; A41685.
 RefSeq; NP_001041631.1; NM_001048166.1. [Q15468-2]
 RefSeq; NP_001269865.1; NM_001282936.1. [Q15468-1]
 RefSeq; NP_001269866.1; NM_001282937.1.
 RefSeq; NP_001269867.1; NM_001282938.1.
 RefSeq; NP_001269868.1; NM_001282939.1.
 RefSeq; NP_003026.2; NM_003035.2. [Q15468-1]
 RefSeq; XP_006710897.1; XM_006710834.3. [Q15468-2]
 RefSeq; XP_011540293.1; XM_011541991.2. [Q15468-2]
 RefSeq; XP_011540294.1; XM_011541992.2. [Q15468-2]
 UniGene; Hs.525198; -.
 PDB; 4YYP; X-ray; 2.60 A; B=720-751.
 PDB; 5LHW; X-ray; 0.91 A; A=726-750.
 PDB; 5LHZ; X-ray; 2.51 A; D/E/F=726-750.
 PDBsum; 4YYP; -.
 PDBsum; 5LHW; -.
 PDBsum; 5LHZ; -.
 ProteinModelPortal; Q15468; -.
 SMR; Q15468; -.
 BioGrid; 112382; 97.
 DIP; DIP-60580N; -.
 IntAct; Q15468; 71.
 MINT; Q15468; -.
 STRING; 9606.ENSP00000360944; -.
 iPTMnet; Q15468; -.
 PhosphoSitePlus; Q15468; -.
 BioMuta; STIL; -.
 DMDM; 122070597; -.
 MaxQB; Q15468; -.
 PaxDb; Q15468; -.
 PeptideAtlas; Q15468; -.
 PRIDE; Q15468; -.
 DNASU; 6491; -.
 Ensembl; ENST00000360380; ENSP00000353544; ENSG00000123473. [Q15468-1]
 Ensembl; ENST00000371877; ENSP00000360944; ENSG00000123473. [Q15468-2]
 GeneID; 6491; -.
 KEGG; hsa:6491; -.
 UCSC; uc001crd.2; human. [Q15468-1]
 CTD; 6491; -.
 DisGeNET; 6491; -.
 EuPathDB; HostDB:ENSG00000123473.15; -.
 GeneCards; STIL; -.
 GeneReviews; STIL; -.
 HGNC; HGNC:10879; STIL.
 HPA; HPA046543; -.
 MalaCards; STIL; -.
 MIM; 181590; gene.
 MIM; 612703; phenotype.
 neXtProt; NX_Q15468; -.
 OpenTargets; ENSG00000123473; -.
 Orphanet; 2512; Autosomal recessive primary microcephaly.
 Orphanet; 99861; Precursor T-cell acute lymphoblastic leukemia.
 PharmGKB; PA35780; -.
 eggNOG; ENOG410IF1P; Eukaryota.
 eggNOG; ENOG4111HAF; LUCA.
 GeneTree; ENSGT00390000007310; -.
 HOGENOM; HOG000231284; -.
 HOVERGEN; HBG079548; -.
 InParanoid; Q15468; -.
 KO; K16724; -.
 OMA; SPNNMSF; -.
 OrthoDB; EOG091G0KB1; -.
 PhylomeDB; Q15468; -.
 TreeFam; TF331178; -.
 SIGNOR; Q15468; -.
 ChiTaRS; STIL; human.
 GeneWiki; STIL; -.
 GenomeRNAi; 6491; -.
 PRO; PR:Q15468; -.
 Proteomes; UP000005640; Chromosome 1.
 Bgee; ENSG00000123473; -.
 CleanEx; HS_STIL; -.
 ExpressionAtlas; Q15468; baseline and differential.
 Genevisible; Q15468; HS.
 GO; GO:0005814; C:centriole; IDA:UniProtKB.
 GO; GO:0005813; C:centrosome; IDA:UniProtKB.
 GO; GO:0005737; C:cytoplasm; IDA:MGI.
 GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO; GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO; GO:0051298; P:centrosome duplication; IDA:MGI.
 GO; GO:0007368; P:determination of left/right symmetry; ISS:BHF-UCL.
 GO; GO:0000578; P:embryonic axis specification; ISS:BHF-UCL.
 GO; GO:0033504; P:floor plate development; ISS:BHF-UCL.
 GO; GO:0030900; P:forebrain development; ISS:BHF-UCL.
 GO; GO:0001947; P:heart looping; ISS:BHF-UCL.
 GO; GO:0001701; P:in utero embryonic development; ISS:BHF-UCL.
 GO; GO:0007052; P:mitotic spindle organization; IMP:MGI.
 GO; GO:0035264; P:multicellular organism growth; ISS:BHF-UCL.
 GO; GO:0043066; P:negative regulation of apoptotic process; ISS:BHF-UCL.
 GO; GO:0001843; P:neural tube closure; ISS:BHF-UCL.
 GO; GO:0021915; P:neural tube development; ISS:BHF-UCL.
 GO; GO:0030903; P:notochord development; ISS:BHF-UCL.
 GO; GO:0071539; P:protein localization to centrosome; IMP:MGI.
 GO; GO:0046599; P:regulation of centriole replication; IMP:UniProtKB.
 GO; GO:0007224; P:smoothened signaling pathway; ISS:BHF-UCL.
 InterPro; IPR026123; Sil.
 PANTHER; PTHR15128; PTHR15128; 1.
 Pfam; PF15253; STIL_N; 1.
 1: Evidence at protein level;
 3D-structure; Acetylation; Alternative splicing;
 Chromosomal rearrangement; Complete proteome; Cytoplasm; Cytoskeleton;
 Developmental protein; Disease mutation; Mental retardation;
 Phosphoprotein; Polymorphism; Primary microcephaly; Proto-oncogene;
 Reference proteome; Ubl conjugation.
 CHAIN         1   1287       SCL-interrupting locus protein.
                              /FTId=PRO_0000271332.
 REGION        1   1018       Interaction with RBM14.
                              {ECO:0000269|PubMed:25385835}.
 REGION      231    781       Interaction with CENPJ.
                              {ECO:0000269|PubMed:22020124,
                              ECO:0000269|PubMed:25385835}.
 REGION      584    779       PIN1-binding. {ECO:0000250}.
 MOD_RES       1      1       N-acetylmethionine.
                              {ECO:0000244|PubMed:22814378}.
 MOD_RES     395    395       Phosphoserine.
                              {ECO:0000244|PubMed:23186163}.
 MOD_RES     753    753       Phosphoserine.
                              {ECO:0000244|PubMed:18669648}.
 MOD_RES     779    779       Phosphoserine.
                              {ECO:0000244|PubMed:23186163}.
 MOD_RES    1135   1135       Phosphoserine.
                              {ECO:0000244|PubMed:19690332,
                              ECO:0000244|PubMed:23186163}.
 VAR_SEQ     872    872       N -> NS (in isoform 2).
                              {ECO:0000303|PubMed:17974005}.
                              /FTId=VSP_022301.
 VARIANT      86     86       A -> V (in dbSNP:rs3125630).
                              {ECO:0000269|PubMed:12438740,
                              ECO:0000269|PubMed:17974005}.
                              /FTId=VAR_029870.
 VARIANT     798    798       L -> W (in MCPH7; dbSNP:rs398122976).
                              {ECO:0000269|PubMed:22989186}.
                              /FTId=VAR_072404.
 VARIANT     984    984       H -> R (in dbSNP:rs13376679).
                              {ECO:0000269|PubMed:17974005}.
                              /FTId=VAR_029871.
 VARIANT    1012   1012       P -> R. {ECO:0000269|PubMed:12438740}.
                              /FTId=VAR_029872.
 VARIANT    1145   1145       A -> V (in dbSNP:rs3766317).
                              /FTId=VAR_051386.
 CONFLICT     70     71       KQ -> NE (in Ref. 1; AAA60550 and 2;
                              AAK51418). {ECO:0000305}.
 HELIX       726    746       {ECO:0000244|PDB:5LHW}.
 SEQUENCE   1287 AA;  142955 MW;  7F15BEDA8717659C CRC64;
 MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY RNPKLVVTEK
 TIRLAYRHAK QNKKNSSCFL LGSLTADEDE EGVTLTVDRF DPGREVPECL EITPTASLPG
 DFLIPCKVHT QELCSREMIV HSVDDFSSAL KALQCHICSK DSLDCGKLLS LRVHITSRES
 LDSVEFDLHW AAVTLANNFK CTPVKPIPII PTALARNLSS NLNISQVQGT YKYGYLTMDE
 TRKLLLLLES DPKVYSLPLV GIWLSGITHI YSPQVWACCL RYIFNSSVQE RVFSESGNFI
 IVLYSMTHKE PEFYECFPCD GKIPDFRFQL LTSKETLHLF KNVEPPDKNP IRCELSAESQ
 NAETEFFSKA SKNFSIKRSS QKLSSGKMPI HDHDSGVEDE DFSPRPIPSP HPVSQKISKI
 QPSVPELSLV LDGNFIESNP LPTPLEMVNN ENPPLINHLE HLKPLQPQLY DEKHSPEVEA
 GEPSLRGIPN QLNQDKPALL RHCKVRQPPA YKKGNPHTRN SIKPSSHNGP SHDIFEKLQT
 VSAGNVQNEE YPIRPSTLNS RQSSLAPQSQ PHDFVFSPHN SGRPMELQIP TPPLPSYCST
 NVCRCCQHHS HIQYSPLNSW QGANTVGSIQ DVQSEALQKH SLFHPSGCPA LYCNAFCSSS
 SPIALRPQGD MGSCSPHSNI EPSPVARPPS HMDLCNPQPC TVCMHTPKTE SDNGMMGLSP
 DAYRFLTEQD RQLRLLQAQI QRLLEAQSLM PCSPKTTAVE DTVQAGRQME LVSVEAQSSP
 GLHMRKGVSI AVSTGASLFW NAAGEDQEPD SQMKQDDTKI SSEDMNFSVD INNEVTSLPG
 SASSLKAVDI PSFEESNIAV EEEFNQPLSV SNSSLVVRKE PDVPVFFPSG QLAESVSMCL
 QTGPTGGASN NSETSEEPKI EHVMQPLLHQ PSDNQKIYQD LLGQVNHLLN SSSKETEQPS
 TKAVIISHEC TRTQNVYHTK KKTHHSRLVD KDCVLNATLK QLRSLGVKID SPTKVKKNAH
 NVDHASVLAC ISPEAVISGL NCMSFANVGM SGLSPNGVDL SMEANAIALK YLNENQLSQL
 SVTRSNQNNC DPFSLLHINT DRSTVGLSLI SPNNMSFATK KYMKRYGLLQ SSDNSEDEEE
 PPDNADSKSE YLLNQNLRSI PEQLGGQKEP SKNDHEIINC SNCESVGTNA DTPVLRNITN
 EVLQTKAKQQ LTEKPAFLVK NLKPSPAVNL RTGKAEFTQH PEKENEGDIT IFPESLQPSE
 TLKQMNSMNS VGTFLDVKRL RQLPKLF

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