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SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine)

 SPRC_BOVIN              Reviewed;         303 AA.
P13213; A5D9C9; Q3B7N5;
01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
31-OCT-2006, sequence version 2.
28-MAR-2018, entry version 140.
RecName: Full=SPARC;
AltName: Full=Basement-membrane protein 40;
Short=BM-40;
AltName: Full=Osteonectin;
Short=ON;
AltName: Full=Secreted protein acidic and rich in cysteine;
Flags: Precursor;
Name=SPARC;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2834720; DOI=10.1073/pnas.85.9.2919;
Bolander M.E., Young M.F., Fisher L.W., Yamada Y., Termine J.D.;
"Osteonectin cDNA sequence reveals potential binding regions for
calcium and hydroxyapatite and shows homologies with both a basement
membrane protein (SPARC) and a serine proteinase inhibitor
(ovomucoid).";
Proc. Natl. Acad. Sci. U.S.A. 85:2919-2923(1988).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=16305752; DOI=10.1186/1471-2164-6-166;
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
"Characterization of 954 bovine full-CDS cDNA sequences.";
BMC Genomics 6:166-166(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Fetal liver;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-69.
PubMed=2835093; DOI=10.1021/bi00405a013;
Findlay D.M., Fisher L.W., McQuillan C.I., Termine J.D., Young M.F.;
"Isolation of the osteonectin gene: evidence that a variable region of
the osteonectin molecule is encoded within one exon.";
Biochemistry 27:1483-1489(1988).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 18-36.
PubMed=3012473; DOI=10.1093/nar/14.11.4483;
Young M.F., Bolander M.E., Day A.A., Ramis C.I., Robey P.G.,
Yamada Y., Termine J.D.;
"Osteonectin mRNA: distribution in normal and transformed cells.";
Nucleic Acids Res. 14:4483-4497(1986).
[6]
PROTEIN SEQUENCE OF 18-55, AND CHARACTERIZATION.
PubMed=3421938; DOI=10.1042/bj2530139;
Domenicucci C., Goldberg H.A., Hofmann T., Isenman D., Wasi S.,
Sodek J.;
"Characterization of porcine osteonectin extracted from foetal
calvariae.";
Biochem. J. 253:139-151(1988).
[7]
PROTEIN SEQUENCE OF 19-36, CALCIUM-BINDING, SUBCELLULAR LOCATION, AND
CHARACTERIZATION.
PubMed=2982834;
Romberg R.W., Werness P.G., Lollar P., Riggs B.L., Mann K.G.;
"Isolation and characterization of native adult osteonectin.";
J. Biol. Chem. 260:2728-2736(1985).
-!- FUNCTION: Appears to regulate cell growth through interactions
with the extracellular matrix and cytokines. Binds calcium and
copper, several types of collagen, albumin, thrombospondin, PDGF
and cell membranes. There are two calcium binding sites; an acidic
domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand
loop that binds a Ca(2+) ion with a high affinity.
-!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
matrix, basement membrane {ECO:0000269|PubMed:2982834}. Note=In or
around the basement membrane. {ECO:0000250}.
-!- DEVELOPMENTAL STAGE: Expressed at high levels in tissues
undergoing morphogenesis, remodeling and wound repair.
-!- SIMILARITY: Belongs to the SPARC family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; J03233; AAA30678.1; -; mRNA.
EMBL; BT030548; ABQ12988.1; -; mRNA.
EMBL; BC107529; AAI07530.1; -; mRNA.
EMBL; M18876; AAA51416.1; -; Genomic_DNA.
EMBL; M18874; AAA51416.1; JOINED; Genomic_DNA.
EMBL; M18875; AAA51416.1; JOINED; Genomic_DNA.
EMBL; M31318; AAA30677.1; -; mRNA.
PIR; A31333; GEBON.
RefSeq; NP_776889.1; NM_174464.2.
UniGene; Bt.48850; -.
ProteinModelPortal; P13213; -.
SMR; P13213; -.
STRING; 9913.ENSBTAP00000019758; -.
PaxDb; P13213; -.
PeptideAtlas; P13213; -.
PRIDE; P13213; -.
Ensembl; ENSBTAT00000019758; ENSBTAP00000019758; ENSBTAG00000014835.
GeneID; 282077; -.
KEGG; bta:282077; -.
CTD; 6678; -.
VGNC; VGNC:35171; SPARC.
eggNOG; KOG4004; Eukaryota.
eggNOG; ENOG41101WW; LUCA.
GeneTree; ENSGT00510000046787; -.
HOGENOM; HOG000088654; -.
HOVERGEN; HBG002746; -.
InParanoid; P13213; -.
OMA; KDFPRRM; -.
OrthoDB; EOG091G0CPG; -.
TreeFam; TF319356; -.
Reactome; R-BTA-114608; Platelet degranulation.
Reactome; R-BTA-3000178; ECM proteoglycans.
Reactome; R-BTA-3000497; Scavenging by Class H Receptors.
Proteomes; UP000009136; Chromosome 7.
Bgee; ENSBTAG00000014835; -.
GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
GO; GO:0031092; C:platelet alpha granule membrane; IEA:Ensembl.
GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
GO; GO:0005518; F:collagen binding; IBA:GO_Central.
GO; GO:0050840; F:extracellular matrix binding; IBA:GO_Central.
GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
GO; GO:0060348; P:bone development; IEA:Ensembl.
GO; GO:0071363; P:cellular response to growth factor stimulus; IEA:Ensembl.
GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
GO; GO:0001937; P:negative regulation of endothelial cell proliferation; IEA:Ensembl.
GO; GO:0043473; P:pigmentation; IEA:Ensembl.
GO; GO:0010595; P:positive regulation of endothelial cell migration; IEA:Ensembl.
GO; GO:0022604; P:regulation of cell morphogenesis; IEA:Ensembl.
GO; GO:0007165; P:signal transduction; IEA:InterPro.
InterPro; IPR011992; EF-hand-dom_pair.
InterPro; IPR018247; EF_Hand_1_Ca_BS.
InterPro; IPR003645; Fol_N.
InterPro; IPR015369; Follistatin/Osteonectin_EGF.
InterPro; IPR002350; Kazal_dom.
InterPro; IPR036058; Kazal_dom_sf.
InterPro; IPR001999; Osteonectin_CS.
InterPro; IPR037641; SPARC.
InterPro; IPR019577; SPARC/Testican_Ca-bd-dom.
PANTHER; PTHR13866; PTHR13866; 1.
Pfam; PF09289; FOLN; 1.
Pfam; PF00050; Kazal_1; 1.
Pfam; PF10591; SPARC_Ca_bdg; 1.
SMART; SM00274; FOLN; 1.
SMART; SM00280; KAZAL; 1.
SUPFAM; SSF100895; SSF100895; 1.
SUPFAM; SSF47473; SSF47473; 1.
PROSITE; PS00018; EF_HAND_1; 1.
PROSITE; PS51465; KAZAL_2; 1.
PROSITE; PS00612; OSTEONECTIN_1; 1.
PROSITE; PS00613; OSTEONECTIN_2; 1.
1: Evidence at protein level;
Basement membrane; Calcium; Complete proteome; Copper;
Direct protein sequencing; Disulfide bond; Extracellular matrix;
Glycoprotein; Metal-binding; Reference proteome; Secreted; Signal.
SIGNAL 1 17 {ECO:0000269|PubMed:3421938}.
CHAIN 18 303 SPARC.
/FTId=PRO_0000020303.
DOMAIN 71 93 Follistatin-like.
DOMAIN 89 151 Kazal-like. {ECO:0000255|PROSITE-
ProRule:PRU00798}.
DOMAIN 261 296 EF-hand.
CA_BIND 274 285 {ECO:0000250}.
COMPBIAS 22 69 Asp/Glu-rich (acidic; binds calcium).
CARBOHYD 116 116 N-linked (GlcNAc...) asparagine.
{ECO:0000305}.
DISULFID 72 83 {ECO:0000255|PROSITE-ProRule:PRU00798}.
DISULFID 77 93 {ECO:0000255|PROSITE-ProRule:PRU00798}.
DISULFID 95 130 {ECO:0000255|PROSITE-ProRule:PRU00798}.
DISULFID 101 123 {ECO:0000255|PROSITE-ProRule:PRU00798}.
DISULFID 112 149 {ECO:0000255|PROSITE-ProRule:PRU00798}.
DISULFID 155 265 {ECO:0000255|PROSITE-ProRule:PRU00798}.
DISULFID 273 289 {ECO:0000255|PROSITE-ProRule:PRU00798}.
CONFLICT 209 209 G -> GC (in Ref. 1; AAA30678).
{ECO:0000305}.
SEQUENCE 303 AA; 34613 MW; BD54FA0F727054D5 CRC64;
MRAWIFFLLC LAGRALAAPQ QEALPDETEV VEETVAEVAE VPVGANPVQV EVGEFDDGAE
ETEEEVVAEN PCQNHHCKHG KVCELDENNT PMCVCQDPTS CPAPIGEFEK VCSNDNKTFD
SSCHFFATKC TLEGTKKGHK LHLDYIGPCK YIPPCLDSEL TEFPLRMRDW LKNVLVTLYE
RDEDNNLLTE KQKLRVKKIH ENEKRLEAGD HPVELLARDF EKNYNMYIFP VHWQFGQLDQ
HPIDGYLSHT ELAPLRAPLI PMEHCTTRFF ETCDLDNDKY IALDEWAGCF GIKEKDIDKD
LVI


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