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SPG11, spatacsin vesicle trafficking associated

 G1SQS2_RABIT            Unreviewed;      2435 AA.
G1SQS2;
19-OCT-2011, integrated into UniProtKB/TrEMBL.
19-OCT-2011, sequence version 1.
30-AUG-2017, entry version 30.
SubName: Full=SPG11, spatacsin vesicle trafficking associated {ECO:0000313|Ensembl:ENSOCUP00000005471};
Name=SPG11 {ECO:0000313|Ensembl:ENSOCUP00000005471};
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
Oryctolagus.
NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000005471, ECO:0000313|Proteomes:UP000001811};
[1] {ECO:0000313|Ensembl:ENSOCUP00000005471, ECO:0000313|Proteomes:UP000001811}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
PubMed=21993624; DOI=10.1038/nature10530;
Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
Pedersen J.S., Lander E.S., Kellis M.;
"A high-resolution map of human evolutionary constraint using 29
mammals.";
Nature 478:476-482(2011).
[2] {ECO:0000313|Ensembl:ENSOCUP00000005471}
IDENTIFICATION.
STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000005471};
Ensembl;
Submitted (SEP-2011) to UniProtKB.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000005471}.
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EMBL; AAGW02024623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9986.ENSOCUP00000005471; -.
Ensembl; ENSOCUT00000006326; ENSOCUP00000005471; ENSOCUG00000006317.
eggNOG; KOG1884; Eukaryota.
eggNOG; ENOG410XR4T; LUCA.
GeneTree; ENSGT00390000016791; -.
InParanoid; G1SQS2; -.
OMA; TCHMEGI; -.
OrthoDB; EOG091G008H; -.
TreeFam; TF325171; -.
Proteomes; UP000001811; Chromosome 17.
Bgee; ENSOCUG00000006317; -.
GO; GO:0030424; C:axon; IEA:Ensembl.
GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0030425; C:dendrite; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO; GO:0005730; C:nucleolus; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0045202; C:synapse; IEA:Ensembl.
GO; GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO; GO:0048675; P:axon extension; IEA:Ensembl.
GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
GO; GO:0090389; P:phagosome-lysosome fusion involved in apoptotic cell clearance; IEA:Ensembl.
GO; GO:0048489; P:synaptic vesicle transport; IEA:Ensembl.
GO; GO:0090659; P:walking behavior; IEA:Ensembl.
Gene3D; 2.130.10.10; -; 1.
InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
InterPro; IPR028103; Spatacsin.
InterPro; IPR028107; Spatacsin_C_dom.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
PANTHER; PTHR13650; PTHR13650; 1.
Pfam; PF14649; Spatacsin_C; 1.
SUPFAM; SSF50998; SSF50998; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000001811};
Reference proteome {ECO:0000313|Proteomes:UP000001811}.
DOMAIN 2088 2379 Spatacsin_C. {ECO:0000259|Pfam:PF14649}.
SEQUENCE 2435 AA; 277076 MW; 7E075E663590BFB4 CRC64;
MSAKQVPGSA DGAGLSCGSE TMERVLPMLL VPVPAEATRR LGSRAQLHGR QEALASLTDA
GSLQILCLGC CLEGPFHQSV WEDCHNSSTP TDKPKLLALS KNHELFVYEF NLKDGRCDTA
VVYSYSGDKL QKLIEDQGIS ISLLSLQILS FRSNTSLLFI NKYLILHIVF PERGDEVSVL
GCFTLPLPAQ TVDAIVDVQS CRGVLFVLSS GGWIYIFDTA DGTQVAQVDL TLHQEDTGNE
QHQEPATICS FTSLKVSQDL DVVVIVSSSN SAIALNLNLY FRLHPGHLLC ERMLEDSPIQ
GPKGIDEDDP VNSEYNMKLT SFSFQVDRSW KGQLSSLNET IKNSKLEASC CAPWFQGILP
LESPESGNCS TSVPSWTFMP QDIMCGQYNW SQEDCAKASD PGRPWKIMHI TEEEDPLELK
CMSVTRFTAL FTWTVKRTGC TIGLWDLETQ GMQCFSLGKK CVPVDSSGDQ QLCFVLAENG
LSLILFGLTQ EEFLNRLMIH GSASTVDFIC HLNGWGRCSI PIHALEAGIA NRQLDTVDFF
LKSKENLFNP SSESSVPDEF DHFSSHLYLR NVEDLTPALD LLCSAIRESD SEAQSKHFSE
QLLNLTLSFL NKQIKELFVR SEELDEHLQK GVNILTSYIN ELRTFMIKFP WKLTEAVDEY
DVNEDLPKIK ESDVWEKISF EEVIADAILN NKIPEAQIFF RINGHSAQRL EELIRIGLDL
VFDNLKKKNM KEASELLKNM GFDVKDQLLK ICFCTTDKNV RDFLVEILKE KNYFSDKEKR
TIDFMHQVEK SYSGHSQENT QIHSFSRYWI KEHDFFKHKS VLDSFLKYYK DEFNKQDHRI
ALSWAQWWDQ LTQESILLPR ISPEEYKLYS PKALWRYLTA RHDWLSIVSW IGEFQTQDSY
VPHHQNKWPS LTVDVIDQDT CCNSYTRNRI LDTLGRNGIF LTSELEDFEL FLLRLSRIGG
VIQVTLPVHN YTSKEGWDFH SHFILYCLEH GLQHLLYVYL DYYRLSPENC PFLEKRELHE
AHPWFEFLVQ CRKVSSNLTD IEKSIIGYNL KQAQKIYETF EEPIYSALVS PQTLLALATT
MYAPGGISQV IQNEDTESCL KKVDPQLLKM ALPAYPRLKA ALFPQCTALS VLPPDITLYH
LIQSLSPFDP SRLFGWQPAN TLAVGDASGR LPHFSSPDLV NKYAIVERLN FAYYLYHGRP
SFAFGTFLVQ ELIKSKTPKQ LIQQVGNEAY VLGLSSFHIP SIGAACVCFL ELLGLDSLRL
RVDMKVANVI LNYKCRNEEA PYSFVRESLG EKLSKLADGE KATIEELLVL LEEGTWHSIQ
QQEVKRLSSE SSSQWALVVQ FCRLHNMKLS TSYLKECAKA DDWLQFLIHS QLYNYQPEEV
KPLLQYFNPV LQDHLRLAFE NLPPVSNSRM EGDQVCSKFP QEFQKNKEHG TDVFDILLQC
PEEPSSWRWL LAEAVRQQAP VLSILASCLQ GASAVPCLCV WIITSVEHSV GAEAMGHIQG
SIEDHTWDLE DLSVIWRTLL TRQKSKTLTR GFRLFFKDSP LLLMMEMYEL CMLFKNYKEA
EVKLLEFQKS LETLDTAATK IHPFFPATWL KDQVCFLLKL MPQQCQTQYE LGKVLELSIG
IQHLFSDGPD VKKLYALSQI LKDTSIAISH RIITSYSIEN FQHECRSILE RLQTDGQFAL
ARRVAELAEL PVDNLVIKEV TQEMQTLKHV QQWSLTQARI DFWKKCHDNF KKNSVSSKAA
SSFFSAQALA VCEHPSGQSS IEERHLLLTL AGHWLAKDDP VCLDKLEALE KQIWLCRISQ
HTLRGNQEEM EPRFSRQIAA SGELSFDSLA SEFSFSKLDA LNSSKYLELH GLPSRETCEP
RLDWKEQDSL NFLVGRLLDD GCVHEASRVC RYFHLYNRDV ALVLHCRALA SGQASVDDLH
PEIRALLQSA ELLEGEEHAV PPRRVQSTSS LDSQPLVVVP PSDEVVLSLE TLTSKCLHGK
NYCRQIICLY ELAKELGCSY TDVATQDGEA TLRAILASCQ SDRCTRAQAF ISTQGLEPDT
VAELVAEAVT RELLTPSEGT GRKPVCSPAE QSQLCLQLVA LCPDRTLVGM KLLDKISSVP
HGELSCTTEL LILAHHCFTL SCHMEGIIQV LQAARMLTDN HLAPNEEYGL VVRLLTGIGR
YNEMTYIFDL LHKKHYFEVL MRKKLDPSGT LKTALLDYIK RCRPGDSEKH NMIALCFSMC
REIGENHEAA ACIQLKLIES QPWEDSLKEG HQLKQLLLKA LTLMVDAAES YAKDSCVRKA
QHCHRLTKLI TLQIHFLNTG QNTMLINLSR HKLPDCIMAL PRFYQASIVA EAYDFVPDWA
EILYQKVILR GDFNYLEEFK QQRLLKPSIF EEISKKYKQH QPADMVTENL KKLLTYCEDI
YLHYKLAYEH KFYEIVNVLL KDPQTGCCLK DMLAG


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