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SPG11, spatacsin vesicle trafficking associated

 G3WWJ8_SARHA            Unreviewed;      2200 AA.
G3WWJ8;
16-NOV-2011, integrated into UniProtKB/TrEMBL.
16-NOV-2011, sequence version 1.
30-AUG-2017, entry version 27.
SubName: Full=SPG11, spatacsin vesicle trafficking associated {ECO:0000313|Ensembl:ENSSHAP00000019803};
Name=SPG11 {ECO:0000313|Ensembl:ENSSHAP00000019803};
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000019803, ECO:0000313|Proteomes:UP000007648};
[1] {ECO:0000313|Ensembl:ENSSHAP00000019803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=21709235; DOI=10.1073/pnas.1102838108;
Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
"Genetic diversity and population structure of the endangered
marsupial Sarcophilus harrisii (Tasmanian devil).";
Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
[2] {ECO:0000313|Ensembl:ENSSHAP00000019803}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000019803}.
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EMBL; AEFK01010500; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEFK01010501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEFK01010502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEFK01010503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEFK01010504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9305.ENSSHAP00000019803; -.
Ensembl; ENSSHAT00000019960; ENSSHAP00000019803; ENSSHAG00000016808.
eggNOG; KOG1884; Eukaryota.
eggNOG; ENOG410XR4T; LUCA.
GeneTree; ENSGT00390000016791; -.
InParanoid; G3WWJ8; -.
OMA; TCHMEGI; -.
OrthoDB; EOG091G008H; -.
TreeFam; TF325171; -.
Proteomes; UP000007648; Unassembled WGS sequence.
GO; GO:0030424; C:axon; IEA:Ensembl.
GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0030425; C:dendrite; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO; GO:0005730; C:nucleolus; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0045202; C:synapse; IEA:Ensembl.
GO; GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO; GO:0048675; P:axon extension; IEA:Ensembl.
GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
GO; GO:0090389; P:phagosome-lysosome fusion involved in apoptotic cell clearance; IEA:Ensembl.
GO; GO:0048489; P:synaptic vesicle transport; IEA:Ensembl.
GO; GO:0090659; P:walking behavior; IEA:Ensembl.
Gene3D; 2.130.10.10; -; 1.
InterPro; IPR028103; Spatacsin.
InterPro; IPR028107; Spatacsin_C_dom.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
PANTHER; PTHR13650; PTHR13650; 1.
Pfam; PF14649; Spatacsin_C; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000007648};
Reference proteome {ECO:0000313|Proteomes:UP000007648}.
DOMAIN 2097 2196 Spatacsin_C. {ECO:0000259|Pfam:PF14649}.
SEQUENCE 2200 AA; 250681 MW; A9633B6BEFC032C8 CRC64;
MAAPEGAGSG CDSRASPTGA MERVLPVLLV PVPAETRAGL GPRAQLHREQ GALGSLTASG
SLQLLSLAPG GRGGRGCSLA GPFRHFVWEN SQPSDPPTDK PKLLTLSDNN ELFVYEFKIK
DGKCDVTTLC SCSGEMLKKL IEDKNIRISS LLYIKILSFQ NTSSLLLINR CVVLHVAFPG
RDTEVKTLNC FSLALPPQVL EKITDSQLCR GFLFVLDSSG WIYIFDAADG TYLAQMDLTR
HQAETCDEQL TDISSFTTMK VSQELDVVVV ISCSGSAIAV DLNVYFRLHP EHILCERKLE
NLRIKVPQGM DEDDPANSVY NMKLTRFSFQ VDRSWKTQLS ELYNSTKKPR LKLVSCVPWF
QDLLHFDPSE SSSHPTQEQI WTFIPQDLTR VQHSHPWRDH VKSDDLKKLW KVMPIGEQEG
IAKLKCVSVT GFTVLFTWLV ESTGWTVVLW DLETQNVHRV FLGKNCIPVD CSENQQLCLV
LTENGLSLIL FGLTQEEFLN RLMIHGSAST VDTLCHLNAW GRCSIPIHAL EAGLENRQLD
TVDFFLKSKE NLFNPSSISS EPDQSARLPS HLYLKSVKEL IPALDLLCSA IRENDSETQS
KHFSEQLLKL TLSFLNKQIR EIFAHTEELD EHLQNGVDIL TNYIIELRTF MIKFPRKPAD
SVNVYIDEDI PRINENEMWR KLTPEQVIAN AILNNKIPEA QTFFRITNHA AQNLDKLIQI
GLHLVFDRLL KSNIKEASEL LKNMGFNVKD ELHKICFYTT EKNTRDFLVG ILKEENYFSE
EEKRTIEYVY QVEKLYSEPL KENKKTQPCS FRSWRKEDDF SKHRSVLDFL KFSEKDEICK
QDHGIILSWA QWWESLTRET ILLPRRSTEE LKSCSPQVLW MHITARHDWL SIFSWMEELK
IQDGCVSLQQ AKWPHLTVDI IDHHTCCNNY LRNEILDKLA RHGIFLKSEL EDFELLLLRL
SRIGGVMQDP LPVQNYTSCD GLDFHARFLL YCLEHNLQHL LYVYLDYYKL NPLNCPFLEK
KELHETYPWF EFLVRCRQVT SNLTDPKLIF QASLANAQIL IPSNQASVSS MLLEGHTLLA
LATTAYASGG LSQVVQKEEG EICLRKVDPQ LLKMALTPYP KLRAALFPQN AVPSILPHDI
TLYHLIQSLS PFDPSKLFGW QATNTLAIAD TSSDLPHFSS SDLVNKYAIM ERLNFAYYLR
HGRPSFAFGT FLIQELAKSK SPKQLIQQVG NEAYMLALSF FHMPSVGAAC VCFLELLGID
SLKLRVDMKV ASIILSYKCR NEEAQYNCIK ESLAEKLVKL ANGKKAATEE LLSLLEEGIW
DSIQQQGISR TSSESGRQWA LVVQFCRLHN VRLSTAYLKE CSKANDWLQF IVHSQLHNYP
LEEVRSLLCY FSPILQDHLQ LAFENLSSFS NSKVHDRQTC GRPLQETQRR QEGISIDLFQ
ILLQCPEAPN SWRYLLAEAM RQRAPILSIL ASCFKDANVV PCLSVWIITS VEDRVAAEAT
SHIQGSVEDH EWDLEDLSLI WRMLLTRKKS RTLTRSFQLF LKDSALLLMM EIYELCMLWK
NYKGAKAKLL ELQKNLETIE KADNTATLAI PVLWLKCQVN LLWKLMLQQC KTQYELRKLL
QLFSEIDHFT DGPDVKKLCL LSEILKDTSI VINHSIITSY STENFQEECR SIVERLQTEG
QFALARKVAG LAELPVDSLV IEEITQEMQT LKHIGQWYLK QARIEFWKKC HENFKKNSIF
KKVASDFFLA QATVTSESSA DKKQCNIMER HLLLTLAGHW LAQEDPVPLG KLEELEKQIW
LCRITKQIHS SDQEVVESRL SRQISTSGDL SFDSLATEFS FSKLPALNAS KYLEINGFPS
KEASESRLDK NEAESLNFLI GHLLDDGSVH EASRICHYFH FYNQDAFLVL HCRALASGEA
SIDDLHPEIQ GILRDAELLL EKEEEQVGVP IRRFQSTSSL DSQSFVVVTH GDEIALHLET
LISRCLHGKN YCRQVLCLYE LAKELGCTYR KISVQDSTSV LQAILSSQQS DRCKRAQAFI
TTQGLTAEQV AELVAEEVMR ELLAASAEKG QKQVSSPAEE GLMFLQLTAL CQDRTLVGMK
LLDKISSVPP GELACTTELL ILAHQCFTLT CHMEGIIRVL QAARLLTDNH LAPNDEYGLV
VRLLTGIGRY NEMTYIFDLL HRKHYFEVLM RKKLDPVRSG


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