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SPG11, spatacsin vesicle trafficking associated

 H0WQH6_OTOGA            Unreviewed;      2444 AA.
H0WQH6;
22-FEB-2012, integrated into UniProtKB/TrEMBL.
22-FEB-2012, sequence version 1.
22-NOV-2017, entry version 27.
SubName: Full=SPG11, spatacsin vesicle trafficking associated {ECO:0000313|Ensembl:ENSOGAP00000004205};
Name=SPG11 {ECO:0000313|Ensembl:ENSOGAP00000004205};
Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
Lorisiformes; Galagidae; Otolemur.
NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000004205, ECO:0000313|Proteomes:UP000005225};
[1] {ECO:0000313|Ensembl:ENSOGAP00000004205}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
The Broad Institute Genome Sequencing Platform;
Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
Walker B.J., Sharpe T., Hall G.;
"Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSOGAP00000004205}
IDENTIFICATION.
Ensembl;
Submitted (JAN-2012) to UniProtKB.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSOGAP00000004205}.
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EMBL; AAQR03085006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAQR03085007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAQR03085008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAQR03085009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAQR03085010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAQR03085011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAQR03085012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAQR03085013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAQR03085014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAQR03085015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 30611.ENSOGAP00000004205; -.
Ensembl; ENSOGAT00000004706; ENSOGAP00000004205; ENSOGAG00000004699.
eggNOG; KOG1884; Eukaryota.
eggNOG; ENOG410XR4T; LUCA.
GeneTree; ENSGT00390000016791; -.
InParanoid; H0WQH6; -.
OMA; TCHMEGI; -.
OrthoDB; EOG091G008H; -.
TreeFam; TF325171; -.
Proteomes; UP000005225; Unassembled WGS sequence.
GO; GO:0030424; C:axon; IEA:Ensembl.
GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0030425; C:dendrite; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO; GO:0005730; C:nucleolus; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0045202; C:synapse; IEA:Ensembl.
GO; GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO; GO:0048675; P:axon extension; IEA:Ensembl.
GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
GO; GO:0090389; P:phagosome-lysosome fusion involved in apoptotic cell clearance; IEA:Ensembl.
GO; GO:0048489; P:synaptic vesicle transport; IEA:Ensembl.
GO; GO:0090659; P:walking behavior; IEA:Ensembl.
Gene3D; 2.130.10.10; -; 1.
InterPro; IPR028103; Spatacsin.
InterPro; IPR028107; Spatacsin_C_dom.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
PANTHER; PTHR13650; PTHR13650; 1.
Pfam; PF14649; Spatacsin_C; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000005225};
Reference proteome {ECO:0000313|Proteomes:UP000005225}.
DOMAIN 2097 2387 Spatacsin_C. {ECO:0000259|Pfam:PF14649}.
SEQUENCE 2444 AA; 279441 MW; 1E2FEB96BD538FE5 CRC64;
MAAEEGAGKA VSAGCSSCPV AMERVLPMLL VSVPAEATGK LGSRAQLHRE QEAVGSLTAE
GCLRVISLTP GGRGGGRCCL EGPFQQFMWE ESHNSTPTDK PRLLALGENY ELFIYEFNLK
DGQCDATILY SYSGKILQKL IEDQDISISL LSLKILSFHN NTSLLFINKC VVLHITFPER
DAEIRLLNCF TLPLPAHSVD MIVDAQLCRG ILFVLSCLGW IYIFDIVDGT HVAHVDLVLH
QEDMCNEQQQ EPAKISSFTS LRVSQDLDVV VIVSSSNSAI ALNLNLYFRQ YPGHLLFERM
LEDLPIQGPK GIDEDDPVNS DYNMKLTKFS FQVDRSWKAQ LSSLNETIKS SKLEASCCAP
WFQDILHLEF PESGNHSISV PNWVFIPQDI MHKEYNCQQK DHAKTSDPRR SWKIMHVSEQ
EEPTEFKCMS VTGFTVLFTL TVERTGCTIV LWDLETQGMQ CFSLGKKCIP VDSSGDQQLC
LVLTVENGLS LILFGLTQEE FLNRLMIHGS ASTVDSLCHL NGWGRCSIPI HALEAGIENR
QLDTVDFFLK SKENLFNSSS KSSVPDRFDH FSSHLYLRNV EELTPALDLL CSAIRESDSE
TQSKHFSEQL LNLTLSFLNK QIKELFIHTE ELDEHLQKGV NILTRYINEL RTFMIKFPWK
LTDAVDEYDV NENIPKGKES DMWEKLSTEE VIASAILNNR IPEAQTFFRI NSHSAQRLEE
VIRIGLDLVF DNLKKNNIKE ASEFLKNMAF DVKDQLLKIC VYTTDKNIRD FLVEILKEKS
CFSEKQKRTI DFVHQVEKLY LEHFPENMQI QAFPRYLIKE QDFFKHRCVL DSFLKYDHKD
EFNKQDDRIV LNWALWWDQL TQDRILLPKI SPEEYKSYSP EALWRFLTTR HDWLNITLWI
GEFQTQDNYA SLQQNKWPPL SVDVISQNTC CNNYMRNEIL DKLARNGIFL VSELEDFECF
LLRLSRIGGV IQDTLPVQKY KSKEGWDFHS HFILYCLEHS LQHLLYVYLD CYRLSPENCP
LLEKKELREV HPWFEFLVQC RQVSGNLTDP KLMFHASLAN AQILIPTNQA SVSSMLLEGH
TLLALATTMY APGGVSQVIQ NEENENCLKK VDPQLLKMAL TPYPKLKTAL FPQCTAPSVL
PPDITLYHLI QSLSPFDPSR LFGWQSANTL AIGDALSHLP HFSSPDLINK YAIVERLNFA
YYLHHGRPSF AFGTFLVQEL TKSKTPKQLI QQVGNEAYVL GLSSFHIPSV GAACVCFLEL
LGLDSLKLRV DMKVANIILS YKCRNEDAQY SFIRESLAEK LPKLADGEKA TIEELLVLLE
EGIWNSIQQQ EIKRLSSESS SQWALVVQFC RLHNMKLSMS YLQECAKAND WLQFVIHSQL
HNYHPEEVKS LIKYFSPVLQ DHLRLAFENL SSVSTSRMDS DQVCNKSPQE LQRNNEEMTD
FFEILLRCSE EPDSWHWLLA EAVKHQAPVL SVLASCLQDA SAIPCLCVWI VTSVEDSVAA
EAMKHIQGST EGHTWDLEDL SVIWRTLLIR QKSKTLTRGF QLFFKDSPLL LMMEIYELCM
FFKNYKEAKA KLLEFQKNLE TLDMASTGVH HVIPATWLKD QVCFLLKFML QQCKTQYELG
KLLQLFVGIE HLFSEGLDVK KLCLLSQILK DTSIAINRVI ITNYSIENFQ HECRSVLERL
QTDGQFALAR RVAELAELPV DNLVIEEITQ EMQTLKHIEQ WSLKQARIDF WKRCHENFKK
NCISSKAAAS FFSAQALVAC DYPTGRSSIE ERHLLLTLSG HWLAQEDLVP LDKLEELEKQ
IWLCRITQHS LGGNQEEMEP RFSQQISASG ELSFDSLANE FSFSKFAALN TSKYFELNGL
PSKETCENSL DWKEQESLNF LIGRLLDDDC VHEASRVCRY FHFYNQDVAL VLHCRALASG
EASVNDLHPE IRSLLQSAEL LEEEEEPSIP LGKVQGTSSL DSQSFVVVPS GDAVVTHLQT
LTSRCLHGKN YCRQVLCLYE LAKELGCSYT DVAAQDGEAM LQAILASQQP DRCKRAQAFI
STQGLKPDTV AELVAEEVTR ELLALSEGTG HKQMFSPAEE SQMFLQLTTL CQDRTLVGLK
LLDKISSVPH GELSCTTELL ILAHHCFTLT CHMEGIMRVL QAARMLTDNH LAPNEEYGLV
VRLLTGIGRY NEMTYIFDLL HKKHYFEVLM RKKLDPSGTL KTALLDYIKR CHPGDSEKHN
MIALCFSMCR EIGENHEAAA CIQLKLIESQ SWEDSLKDVY QLKQLLLKAL TLMLDAAESY
AKDSCVRQAL HCHRLTKLIT LQIHFLNTGQ NTMLINLGRH KLMDCIVTLP RFYQASIVAE
AYDFVPDWAE ILYQHVILKG DFNYMEEFKQ QRLLRPSIFE EISKKCKQHQ PTDIVMENLK
KLLTYCEDIY LYYKLAYEHK FYEIVNVLLK DPQTGCCLKD MLAG


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