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SPG11, spatacsin vesicle trafficking associated

 H2NN35_PONAB            Unreviewed;      2431 AA.
H2NN35;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
09-JAN-2013, sequence version 2.
25-OCT-2017, entry version 30.
SubName: Full=SPG11, spatacsin vesicle trafficking associated {ECO:0000313|Ensembl:ENSPPYP00000007288};
Name=SPG11 {ECO:0000313|Ensembl:ENSPPYP00000007288};
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pongo.
NCBI_TaxID=9601 {ECO:0000313|Ensembl:ENSPPYP00000007288, ECO:0000313|Proteomes:UP000001595};
[1] {ECO:0000313|Ensembl:ENSPPYP00000007288, ECO:0000313|Proteomes:UP000001595}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Wilson R.K., Mardis E.;
"A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSPPYP00000007288}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSPPYP00000007288}.
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EMBL; ABGA01183115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01183116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01183117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01183118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01183119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01183120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01183121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01183122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01183123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; ABGA01183124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9601.ENSPPYP00000007288; -.
Ensembl; ENSPPYT00000007590; ENSPPYP00000007288; ENSPPYG00000006432.
eggNOG; KOG1884; Eukaryota.
eggNOG; ENOG410XR4T; LUCA.
GeneTree; ENSGT00390000016791; -.
InParanoid; H2NN35; -.
OMA; TCHMEGI; -.
OrthoDB; EOG091G008H; -.
TreeFam; TF325171; -.
Proteomes; UP000001595; Chromosome 15.
GO; GO:0030424; C:axon; IEA:Ensembl.
GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0030425; C:dendrite; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO; GO:0005730; C:nucleolus; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0045202; C:synapse; IEA:Ensembl.
GO; GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO; GO:0048675; P:axon extension; IEA:Ensembl.
GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
GO; GO:0090389; P:phagosome-lysosome fusion involved in apoptotic cell clearance; IEA:Ensembl.
GO; GO:0048489; P:synaptic vesicle transport; IEA:Ensembl.
GO; GO:0090659; P:walking behavior; IEA:Ensembl.
Gene3D; 2.130.10.10; -; 1.
InterPro; IPR028103; Spatacsin.
InterPro; IPR028107; Spatacsin_C_dom.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
PANTHER; PTHR13650; PTHR13650; 2.
Pfam; PF14649; Spatacsin_C; 2.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000001595};
Reference proteome {ECO:0000313|Proteomes:UP000001595}.
DOMAIN 2141 2240 Spatacsin_C. {ECO:0000259|Pfam:PF14649}.
DOMAIN 2242 2375 Spatacsin_C. {ECO:0000259|Pfam:PF14649}.
SEQUENCE 2431 AA; 277187 MW; 22DB3B4D668F99AE CRC64;
MESTGDSREV SAGVTRPSVS RSVHRACPRR SQVPAKVTGS NRRAKMAAEE GVASAASAGG
SWGVAAMGRV LPMLLVPVPA EVMGQLGSRA QLHTQQEALG SLTAAGSLQV LSLEPGSRGG
GRCCLEGPFW HFIWEDSRDS STPTEKPKLL AVGENYELLI YEFNLKDGRC DATILYSCSG
EALQKLIEDQ DISISLLSLR ILSFHNNTSL LFINKCVILH IIFPERDAAI RVLNCFTLPL
PAQAVDMIID TQLCRGILFV LSSLGWIYIF DVVDGTYVAH VDLALHKEDM CNEQRQEPAK
ISSFTSLKVS QDLDVVVIVS SSNSAVALNL NLYFRQHPGH LLCERILEDL PIQGPKGIDE
DDPVNSAYNM KLTKFSFQID RSWKAQLSSL NETIKKSKLE VSCCAPWFQD ILHLESPKSG
NHSTSVQSWA FIPQDIMHGQ YNVLQKDHAK TSDPGRSWKI MHISEQEEPI ELKCVSVTGF
TALFTWEVER MGYTITLWDL ETQGMQCFSL GTKCIPVDSS GDQQLCFVLT ENGLSLILFG
LTQEEFLNRL MIHGSASTVD TLCHLNGWGR CSIPIHALEA GIENRQLDTV NFFLKSKENL
FNPSSKSSVS DQFDHLSSHL YLRNVEELIP ALDLLCSAIR ESYSEPQSKH FSEQLLNLTL
SFLNNQIKEL FIHTEELDEH LQKGVNILTS YINELRTFMI KFPWKLTDAI DEYDIHENVP
KVKESSIWKK LSFEEVIASA ILNNKIPEAQ TFFRIDSHSA QKLEELIGIG LNLVFDNLKK
NNIKEASELL KNMGFDVKGQ LLKICFYTTN KNIRDFLVEI LKEKNYFSEK EKRTIDFVHQ
VEKLYLGHFQ ENMQIQSFPR YWIKEQDFFK HKSVLDSFLK YDCKDEFNKQ DHRIVLNWAL
WWDQLTQESI LLPRISPEEY KSYSPEALWR YLTARHDWLN IILWIGEFQT QHSYASLQQN
KWPLLTVDVI NQNTSCNNYM RNEILDKLAR NGVFLASELE DFECFLLRLS RIGGVIQDTL
PVQNYKTKEG WDFHSHFILY CLEHSLQHLL YVYLDCYKLS PENCPFLEKK ELHEAHPWFE
FLVQCRQVAS DLTDPKLIFQ ASLANAQILI PTNQASVSSM LLEGHTLLAL ATTMYSPGGV
SQVVQNEENE NCLKKVDPQL LKMALTPYPK LKTALFPQCT PPSVLPSDIT LYHLTQSLSP
FDPSRLFGWQ SANTLAIGDA WSHLPHFSSP DLVNKYAIVE RLNFAYYLHN GRPSFAFGTF
LVQELIKSKT PKQLIQQVGN EAFVIGLSSF HIPSIGAACV CFLELLGLDS LKLRVDMKVA
NIILSYKCRN EDAQYSFIRE SLAEKLSKLA DGEKTTTEEL LVLLEEGTWN SIQQQEIKRL
SSESSSQWAL VVQFCRLHNM KLSISYLREC AKANDWLQFI IHSQLHNYHP AEVKSLIQYF
SPVVQDHLRL AFENLPSVPT SKMDSDQVCN KSPQELQGSK EEMTDLFEIL LQCSEEPDSW
HWLLVEAVKQ QAPILSVLAS CLQGASAISC LCVWIITSVE DSVATEAMGH IQDSTEDHTW
NLEDLSVIWR TLLTRQKSKT LIRGFHLFFK DSPLLLVMEM YELCMFFRNY KEAEAKLLEF
QKSLETLNTA ATKVHPVIPA MWLEDQVCFL LKLMLQQCKT QYELGKLLQL FVEREHLFSD
GPDVKKLCVL CQILKDTSIA INHTIITSYS IENFQHECRS ILEKLQTDGQ FALARRVAEL
AELPVDDLVI KEITQEMQTL KHIEQWSLKQ ARIDFWKKCH ENFKKNSISS KAASSFFSTQ
AHVACEHPTG WSSIEERHLL LTLSGHWLAQ EDVVPLDKLE ELEKQIWLCR ITQHTLGRNQ
EETEPKFSRQ ISTSGELSFD SLASEFSFSK LAALNTSKYL ELNSLPSKET CENRLDWKEQ
ESLNFLIGHL LDDGCVHEAS RVCRYFHFYN RDVALVLHCR ALASGEASME DLHPEIHALL
QSAELLEEEA PDIPLRRVHS TSSLDSQKFV TVPSSDEVVT NLEVLTSKCL HGKNYCRQVL
CLYDLAKELG CSYTDVAAQD GEAMLREILA SQQPDRCKRA QAFISTQGLK PDTVAELVAE
EVTRELLTSS QGTGHKQMFS PTEESQTFLQ LTTLCQDRTL VGMKLLDKIS SVPHGELSCT
TELLILAHHC FTLTCHMEGI IRVLQAAQML TDNHLAPSEE YGLVVRLLTG IGRYNEMTYI
FDLLHKKHYF EVLMRKKLDP DSLKDGHQLK QLLLKALTLM LDAAESYAKD SCVRQAQHCQ
RLTKLITLQI HFLNTGQNIM LINLGRHKLM DCILALPRFY QASIVAEAYD FVPDWAEILY
QQVILKGDFN YLEEFKQQRL LKSSIFEEIS KKYKQHQPTD MAMENLKKLL TYCEDVYLYY
KLAYEHKFYE IVNVLLKDPQ TGCCLKDMLA G


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