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SPG11, spatacsin vesicle trafficking associated

 H2Q9C1_PANTR            Unreviewed;      2371 AA.
H2Q9C1;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
21-MAR-2012, sequence version 1.
30-AUG-2017, entry version 27.
SubName: Full=SPG11, spatacsin vesicle trafficking associated {ECO:0000313|Ensembl:ENSPTRP00000011993};
Name=SPG11 {ECO:0000313|Ensembl:ENSPTRP00000011993};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000011993, ECO:0000313|Proteomes:UP000002277};
[1] {ECO:0000313|Ensembl:ENSPTRP00000011993, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the
human genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136134; DOI=10.1038/nature04101;
Hughes J.F., Skaletsky H., Pyntikova T., Minx P.J., Graves T.,
Rozen S., Wilson R.K., Page D.C.;
"Conservation of Y-linked genes during human evolution revealed by
comparative sequencing in chimpanzee.";
Nature 437:100-103(2005).
[3] {ECO:0000313|Ensembl:ENSPTRP00000011993}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSPTRP00000011993}.
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EMBL; AACZ03101778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ03101959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ03101960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ03101961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ03101962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ03101963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ03101964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ03101965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ03101966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ03101967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9598.ENSPTRP00000011993; -.
PaxDb; H2Q9C1; -.
Ensembl; ENSPTRT00000012952; ENSPTRP00000011993; ENSPTRG00000007016.
eggNOG; KOG1884; Eukaryota.
eggNOG; ENOG410XR4T; LUCA.
GeneTree; ENSGT00390000016791; -.
InParanoid; H2Q9C1; -.
OMA; TCHMEGI; -.
OrthoDB; EOG091G008H; -.
TreeFam; TF325171; -.
Proteomes; UP000002277; Chromosome 15.
Bgee; ENSPTRG00000007016; -.
GO; GO:0030424; C:axon; IEA:Ensembl.
GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0030425; C:dendrite; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO; GO:0005730; C:nucleolus; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0045202; C:synapse; IEA:Ensembl.
GO; GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO; GO:0048675; P:axon extension; IEA:Ensembl.
GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
GO; GO:0090389; P:phagosome-lysosome fusion involved in apoptotic cell clearance; IEA:Ensembl.
GO; GO:0048489; P:synaptic vesicle transport; IEA:Ensembl.
GO; GO:0090659; P:walking behavior; IEA:Ensembl.
Gene3D; 2.130.10.10; -; 1.
InterPro; IPR028103; Spatacsin.
InterPro; IPR028107; Spatacsin_C_dom.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
PANTHER; PTHR13650; PTHR13650; 1.
Pfam; PF14649; Spatacsin_C; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000002277};
Reference proteome {ECO:0000313|Proteomes:UP000002277}.
DOMAIN 2024 2315 Spatacsin_C. {ECO:0000259|Pfam:PF14649}.
SEQUENCE 2371 AA; 270822 MW; B12DC2D8DA8EECEF CRC64;
MAAEEGVASA ASAGGSWGTA AMGRVLPMLL VPVPAEAMGQ LGSRAQLRTQ PEALGSLTAA
GSLQVLSLTP GSRGGGRCCL EGPFWHFIWE DSRNSSTPTE KPKLLALGEN YELLIYEFNL
KDGRCDATIL YSCSREALQK LIDDQDISIS LLSLRILSFH NNTSLLFINK CVILHIIFPE
RDAAIRVLNC FTLPLPAQAV DMIIDTQLCR GILFVLSSLG WIYIFDVVDG TYVAHVDLAL
HKEDMCNEQQ QEPAKISSFT SLKVSQDLDV VVIVSSSNSA VALNLNLYFR QHPGHLLCER
ILEDLPIQGP KGIDEDDPVN SAYNMKLTKF SFQIDRSWKA QLSSLNETIK NSKLEVSCCA
PWFQDILHLE SPESGNHSTS VQSWAFIPQD IMHGQYNVLQ KDHAKTSDPG RSWKIMHISE
QEEPIELKCV SVTGFTALFT WEVERMGYTI TLWDLETQGM QCFSLGTKCI PVDSSGDQQL
CFVLTENGLS LILFGLTQEE FLNRLMIHGS ASTVDTLCHL NGWGRCSIPI HALEAGIENR
QLDTVNFFLK SKENLFNPSS KSSVSDQFDH LSSHLYLRNV EELIPALDLL CSAIRESYSE
PQSKHFSEQL LNLTLSFLNN QIKELFIHTE ELDEHLQKGV NILTSYINEL RTFMIKFPWK
LTDAIDEYDV HENVPKVKES NIWKKLSFEE VIASAILNNK IPEAQTFFRI DSHSAQKLEE
LIGIGLNLVF DNLKKNNIKE ASELLKNMGF DVKGQLLKIC FYTTNKNIRD FLVEILKEKN
YFSEKEKRTI DFVHQVEKLY LGHFQENMQI QSFPRYWIKE QDFFKHKSVL DSFLKYDCKD
EFNKQDHRIV LNWALWWDQL TQESILLPRI SPEEYKSYSP EALWRYLTAR HDWLNIILWI
GEFQTQHSYA SLQQNKWPLL TVDVINQNTS CNNYMRNEIL DKLARNGVFL ASELEDFECF
LLRLSRIGGV IQDTLPVQNY KTKEGWDFHS QFILYCLEHS LQHLLYVYLD CYKLSPENCP
FLEKKELHEA HPWFEFLVQC RQVASNLTDP KLIFQASLAN AQILIPTNQA SVSSMLLEGH
TLLALATTMY SPGGVSQVVQ NEENENCLKK VDPQLLKMAL TPYPKLKTAL FPQCTPPSIL
PSDITLYHLI QSLSPFDPSR LFGWQSANTL AIGDAWSYLP HFSSPDLVNK YAIVERLNFA
YYLHNGRPSF AFGTFLVQEL IKSKTPKQLI QQVGNEAYAT GLSSFHIPSI GAACVCFLEL
LGLDSLKLRV DMKVANIILS YKCRNEDAQY SFIRESLAEK LSKLADGEKT TTEELLVLLE
EGTWNSIQQQ EIKRLSSESS SQWALVVQFC RLHNMKLSIS YLRECAKAND WLQFIIHSQL
HNYHPAEVKS LIQYFSPVVQ DHLRLAFENL PSVPTSKMDS DQVCNKCPQE LQGSKQEMTD
LFEILLQCSE EPDSWHWLLV EAVKQQAPIL SVLASCLQGA SAISCLCVWI ITSVEDSVAT
EAMGHIQDST EDHTWNLEDL SVIWRTLLTR QKSKTLIRGF QLFFKDSPLL LVMEMYELCM
FFRNYKEAEA KLLEFQKSLE TLNTAATKVH PVIPAMWLED QVCFLLKLML QQCKTQYELG
KLLQLFVERE HLFSDITQEM QTLKHIEQWS LKQARIDFWK KCHENFKKNS ISSKAASSFF
STQAHVACEH PTGWSSMEER HLLLTLAGHW LAQEDVVPLD KLEELEKQIW LCRITQHTLG
RNQEETEPRF SRQISTSGEL SFDSLASEFS FSKLAALNTS KYLELNSLPS KETCENRLDW
KEQESLNFLI GRLLDDGCVH EASRVCRYFH FYNPDVALVL HCRALASGEA SMEDLHPEIH
ALLQSAELLE EEAPDIPLRR VHSTSSLDSQ KFVTVPSSDE VVTNLEVLTS KCLHGKNYCR
QVLCLYDLAK ELGCSYTDVA AQDGEAMLRE ILASQQPDRC KRAQAFISTQ GLKPDTVAEL
VAEEVTRELL TSSQGTGHKQ MFNPTEESQT FLQLTTLCQD RTLVGMKLLD KISSVPHGEL
SCTTELLILA HHCFTLTCHM EGIIRVLQAA QMLTDNHLAP SEEYGLVVRL LTGIGRYNEM
TYIFDLLHKK HYFEVLMRKK LDPSGTLKTA LLDYIKRCRP GDSEKHNMIA LCFSMCREIG
ENHEAAARIQ LKLIESQPWE DSLKDGHQLK QLLLKALTLM LDAAESYAKD SCVRQAQHCQ
RLTKLITLQI HFLNTGQNTM LINLGRHKLM DCILALPRFY QASIVAEAYD FVPDWAEILY
QQVILKGDFN YLEEFKQQRL LKSSIFEEIS KKYKQHQPTD MVMENLKKLL TYCEDVYLYY
KLAYEHKFYE IVNVLLKDPQ TGCCLKDMLA G


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