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SPG11, spatacsin vesicle trafficking associated

 M3YHB6_MUSPF            Unreviewed;      2444 AA.
M3YHB6;
01-MAY-2013, integrated into UniProtKB/TrEMBL.
01-MAY-2013, sequence version 1.
30-AUG-2017, entry version 24.
SubName: Full=SPG11, spatacsin vesicle trafficking associated {ECO:0000313|Ensembl:ENSMPUP00000010723};
Name=SPG11 {ECO:0000313|Ensembl:ENSMPUP00000010723};
Mustela putorius furo (European domestic ferret) (Mustela furo).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae;
Mustelinae; Mustela.
NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000010723, ECO:0000313|Proteomes:UP000000715};
[1] {ECO:0000313|Ensembl:ENSMPUP00000010723}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000010723};
Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E.,
Przyblyski D., Ribeiro F., Russell P., Sharpe T., Turner-Maier J.,
Walker B.J., Young S., Birren B., Lindblad-Toh K.;
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSMPUP00000010723}
IDENTIFICATION.
Ensembl;
Submitted (MAR-2013) to UniProtKB.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSMPUP00000010723}.
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EMBL; AEYP01028433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEYP01028434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEYP01028435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEYP01028436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEYP01028437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEYP01028438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AEYP01028439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_004751343.1; XM_004751286.2.
STRING; 9669.ENSMPUP00000010723; -.
Ensembl; ENSMPUT00000010902; ENSMPUP00000010723; ENSMPUG00000010811.
GeneID; 101673468; -.
CTD; 80208; -.
eggNOG; KOG1884; Eukaryota.
eggNOG; ENOG410XR4T; LUCA.
GeneTree; ENSGT00390000016791; -.
InParanoid; M3YHB6; -.
OMA; TCHMEGI; -.
OrthoDB; EOG091G008H; -.
Proteomes; UP000000715; Unassembled WGS sequence.
GO; GO:0030424; C:axon; IEA:Ensembl.
GO; GO:0031410; C:cytoplasmic vesicle; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0030425; C:dendrite; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
GO; GO:0005730; C:nucleolus; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0045202; C:synapse; IEA:Ensembl.
GO; GO:0008088; P:axo-dendritic transport; IEA:Ensembl.
GO; GO:0048675; P:axon extension; IEA:Ensembl.
GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
GO; GO:0090389; P:phagosome-lysosome fusion involved in apoptotic cell clearance; IEA:Ensembl.
GO; GO:0048489; P:synaptic vesicle transport; IEA:Ensembl.
GO; GO:0090659; P:walking behavior; IEA:Ensembl.
Gene3D; 2.130.10.10; -; 1.
InterPro; IPR028103; Spatacsin.
InterPro; IPR028107; Spatacsin_C_dom.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
PANTHER; PTHR13650; PTHR13650; 1.
Pfam; PF14649; Spatacsin_C; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000000715};
Reference proteome {ECO:0000313|Proteomes:UP000000715}.
DOMAIN 2096 2388 Spatacsin_C. {ECO:0000259|Pfam:PF14649}.
SEQUENCE 2444 AA; 278034 MW; 6D75BCD500314A00 CRC64;
MATEKAARGA AACGTCSAKA MERVLPMLLV PVPVEATGRL GCRAQLHREQ EVLGSLTAAG
SLQVLSLAPG GRSGGACCLN GPFRHFVWED SRNSSSPTDK PKLLALSESY ELLIYEFDLK
DGRCDATILY SCSEETLQKL IGDQNINISL LSLRILSFHN NTSLLFINKC IVLHIVFPER
DAEIGVLNCF TLPLPTQAVD RIIDVQLCRG ILFILSSLGW IYIFDTVDGT HVAHVDLALH
QEDVCDEQQQ EPAKISSFTS LKVSQDLDVV VIVSSSNSAI AVNLNLYFRQ HPGHLLCERT
LEDIPIEGPK GIDEDDPVNS DYNMKLTKFS FQVDRSWKAQ LSSLNETIKS SKLEVSYCAP
WFQNILHLES PESGNHNTSM LGWTFIPQDI MHSHYKFPQK DHANTNEPGR SWKIMNISEQ
EEPVELTCMS VTGFSALFTW AVEGMGCTIG LWDLETQGMQ CFSLGRKCIP IDAGGDKQLC
LVLTENGLSL ILFGLTQEEF LNRLMIHGSA STVDSLCHLN GWGRCSIPIH ALEAGIENRQ
LDTVDFFLKS KENLLNPSSK SSVPDQLDDF PSYLYLRNVE KLIPALDLLC SAIRESDSET
QSKHFSEQLL NLTLSFLNKQ IKELFVHNEE LDEHLQKGVN ILTSYINELR TFMIKFPWKT
IDTVDDYDVN ENIPKVRESS MWEKLSIEEV IASAVLDNKI PEAQTFFRIN NHSAQRLEEL
IRIGLNLVFD NLKRNNIKEA SELLKNMGFD VKDQLLKICF YTTDTNIRDF LVEILKEKNY
ISENEKRTID FVHQVEKFYS GQFQENVQIQ SFARYWIKEQ DFFKHKSVLD SLLKYDPKDK
CNKQDHKVVL NWAQWWNQLT QESILLPRIS PEEYKSYSPE ALWSYLTARH DWSSVILWIG
EFQTQNSCAL LEKNRWPLLT VDVIDRHTCC SSYMRNEILD QLARNGIFLE SELEDFELLL
LRLTRIGGVM QDAVPVQNYR AQEGWDFHSH FILYCLEHGL QYLLYVYLDC YKLSPSNCPF
LEKKELHEAY PWFEFLVQCR QVSSNLTDPK LIFHASLANA QILIPSNQAS VSSMLLEGHT
LLALATTMYA PGGVSQVVQN DENETCLKKV DPQLLKMALT PYPKLKTALF PQYTASNVLP
PDITLYHLIQ SLLPFDPSRL FGWQCANTLA IGDAVSHLPH FSSPDLVNKY AIVERLNFAY
YLQHGRPSFA FGTFLVQELT KSKTPKQLIQ QVGNEAYVLG LSSFYVPSVG AACVCFLELL
GLDSLKLRVD MKVANIILSC KCRNEDARSS YIRESLAEKL SKLAVGEKAT IEELLILLEE
GIWNSIQQQE IKRLSSESSS QWALAVQFCR LHNVKLSTSY LRECAEANDW LQFIIHSQLH
NYHPEEVKSL LQYFSPVLQD HLRLAFENLT SVSNSKMDSD PVCNRVPQEL QRNKEEMTDL
FEVLLQCSEE PDSWCWLLAE AVKQRAPILS VLASCLQDAS TIPCLCVWIV TSVEDTVAAE
ATEHIQGSME EHIWDLQDLS VIWRTLLTRQ KSKTLIRGFQ LFFKDSPLLL MMEMYELCMF
FKNYKEAKAK LLEFQKSFET VETAATGVHA TIPAPWLKEH VCFLLKLMLQ QCGTQYELGK
LLQLFVGIEN LFSDGPDVKK LFVLSQILKD TSIAINHVII SSYSLENFQH ECKSILEKLE
TEGRFALARR VAELAELPVD NLVIEEITQE MQTLQHTDQW ALKQARIDFW TKCHENFKKN
AISSRAAASF FSAQAQESPE APGEGGPPGL EERRLLLTLA AHWLAQEAPG PEEELEELEK
QIWHCRISQH ALREKQEDAE PRFPQHISTS GEPSFDSVAH KFSLSMLAAL NTAKYLELNG
LPPKETCESR LDWKEQESLN SLIGRLLDDG CVHEASRVCR YFHFYNQDVT LVLHCRALAA
GEASVDGLHP EIRAILQSTQ RLEEEEPGTP LRRVQSTSSL DSQSFVMLPP SDEVVTNLET
LTSKCLHGKN YCRQVLCLYE LAKELGCSYT DVATQDGETM LRAILASRQP DRCRRAQAFI
STQGLEPDTV AELVAEEVTR ELLTPSEGTG QKQMFAPAEE SQTFLQLTTL CQDRTLIGMK
LLDKISSVPH GELSCTAELL ILAHHCFTLT CHMEGIIRVL QAARLLTDKH LAPSEEYGLM
VRLLTGIGRY NEMTYIFDLL HKKHYFEVLM RKKLDPSGTL KTALLDYIKR CRPGDSEKHN
MIALCFSMCR EIGENHEAAA CIQLKLIESQ PWEDSLKDGQ HLKLLLLKAL TLMLDAAESY
AKDSCVRQAL HCHRLTKLIT LQIHFLNTGQ NTMLINLGRH RLMDCLMALP RFYQASIVAE
AYDFVPDWAE ILYQRVILKG DFNYLEEFKQ QRLLRSSIFE EISKKYKQHQ LADTAVKNLK
KLLTYCEDVY LYYKLAYEHK FFDIVNVLLK DPQTGCCLKD MLAG


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