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SPG21 isoform 1 (SPG21 isoform 11) (SPG21 isoform 3) (SPG21, maspardin) (Spastic paraplegia 21 (Autosomal recessive, Mast syndrome))

 H2Q9L5_PANTR            Unreviewed;       308 AA.
H2Q9L5; A0A2J8NRK6;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
21-MAR-2012, sequence version 1.
23-MAY-2018, entry version 48.
SubName: Full=SPG21 isoform 1 {ECO:0000313|EMBL:PNI74371.1};
SubName: Full=SPG21 isoform 11 {ECO:0000313|EMBL:PNI74378.1};
SubName: Full=SPG21 isoform 3 {ECO:0000313|EMBL:PNI74372.1};
SubName: Full=SPG21, maspardin {ECO:0000313|Ensembl:ENSPTRP00000012254};
SubName: Full=Spastic paraplegia 21 (Autosomal recessive, Mast syndrome) {ECO:0000313|EMBL:JAA11213.1};
Name=SPG21 {ECO:0000313|EMBL:JAA11213.1,
ECO:0000313|Ensembl:ENSPTRP00000012254};
ORFNames=CK820_G0008304 {ECO:0000313|EMBL:PNI74371.1};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000012254, ECO:0000313|Proteomes:UP000002277};
[1] {ECO:0000313|Ensembl:ENSPTRP00000012254, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the
human genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|Ensembl:ENSPTRP00000012254}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[3] {ECO:0000313|EMBL:JAA11213.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA11213.1},
Skeletal muscle {ECO:0000313|EMBL:JAA41815.1},
Skin {ECO:0000313|EMBL:JAA25402.1}, and
Smooth vascular {ECO:0000313|EMBL:JAA18989.1};
Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
"De novo assembly of the reference chimpanzee transcriptome from
NextGen mRNA sequences.";
Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:PNI74371.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI74371.1};
TISSUE=Blood {ECO:0000313|EMBL:PNI74371.1};
Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
Haussler D., Eichler E.;
"High-resolution comparative analysis of great ape genomes.";
Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
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EMBL; AACZ04064619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ04064620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; GABC01000125; JAA11213.1; -; mRNA.
EMBL; GABF01003156; JAA18989.1; -; mRNA.
EMBL; GABD01007698; JAA25402.1; -; mRNA.
EMBL; GABE01002924; JAA41815.1; -; mRNA.
EMBL; NBAG03000224; PNI74371.1; -; Genomic_DNA.
EMBL; NBAG03000224; PNI74372.1; -; Genomic_DNA.
EMBL; NBAG03000224; PNI74378.1; -; Genomic_DNA.
RefSeq; XP_003314760.1; XM_003314712.3.
RefSeq; XP_009427621.1; XM_009429346.2.
RefSeq; XP_510477.3; XM_510477.4.
STRING; 9598.ENSPTRP00000012254; -.
ESTHER; pantr-h2q9l5; Maspardin-ACP33-SPG21_like.
Ensembl; ENSPTRT00000013226; ENSPTRP00000012254; ENSPTRG00000007170.
GeneID; 453510; -.
KEGG; ptr:453510; -.
CTD; 51324; -.
eggNOG; ENOG410IETY; Eukaryota.
eggNOG; ENOG410XPCG; LUCA.
GeneTree; ENSGT00390000007857; -.
KO; K19367; -.
OMA; GIDFMVD; -.
OrthoDB; EOG091G0GY0; -.
TreeFam; TF105253; -.
Proteomes; UP000002277; Chromosome 15.
Bgee; ENSPTRG00000007170; -.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
GO; GO:0030140; C:trans-Golgi network transport vesicle; IEA:Ensembl.
GO; GO:0042609; F:CD4 receptor binding; IEA:Ensembl.
Gene3D; 3.40.50.1820; -; 1.
InterPro; IPR029058; AB_hydrolase.
InterPro; IPR000073; AB_hydrolase_1.
InterPro; IPR026151; Maspardin.
PANTHER; PTHR15913; PTHR15913; 1.
Pfam; PF00561; Abhydrolase_1; 1.
SUPFAM; SSF53474; SSF53474; 1.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000002277};
Reference proteome {ECO:0000313|Proteomes:UP000002277}.
DOMAIN 87 159 AB hydrolase-1.
{ECO:0000259|Pfam:PF00561}.
SEQUENCE 308 AA; 34960 MW; 83C4F7B4B3EDEC7C CRC64;
MGEIKVSPDY NWFRGTVPLK KIIVDDDDSK IWSLYDAGPR SIRCPLIFLP PVSGTADVFF
RQILALTGWG YRVIALQYPV YWDHLEFCDG FRKLLDHLQL DKVHLFGASL GGFLAQKFAE
YTHKSPRVHS LILCNSFSDT SIFNQTWTAN SFWLMPAFML KKIVLGNFSS GPVDPMMADA
IDFMVDRLES LGQSELASRL TLNCQNSYVE PHKIRDIPVT IMDVFDQSAL STEAKEEMYK
LYPNARRAHL KTGGNFPYLC RSAEVNLYVQ IHLLQFHGTK YAAIDPSMVS AEELEVQKGS
LGISQEEQ


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