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SRY-box 9

 W5PWD8_SHEEP            Unreviewed;       383 AA.
W5PWD8;
16-APR-2014, integrated into UniProtKB/TrEMBL.
16-APR-2014, sequence version 1.
27-SEP-2017, entry version 26.
SubName: Full=SRY-box 9 {ECO:0000313|Ensembl:ENSOARP00000014771};
Name=SOX9 {ECO:0000313|Ensembl:ENSOARP00000014771};
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000014771, ECO:0000313|Proteomes:UP000002356};
[1] {ECO:0000313|Ensembl:ENSOARP00000014771, ECO:0000313|Proteomes:UP000002356}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000014771};
PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
Wang J., Wang W., Xun X.;
"The sheep genome reference sequence: a work in progress.";
Anim. Genet. 41:449-453(2010).
[2] {ECO:0000313|Ensembl:ENSOARP00000014771}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2014) to UniProtKB.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSOARP00000014771}.
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EMBL; AMGL01019514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AMGL01019515; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AMGL01019516; -; NOT_ANNOTATED_CDS; Genomic_DNA.
Ensembl; ENSOART00000014989; ENSOARP00000014771; ENSOARG00000013779.
GeneTree; ENSGT00760000118988; -.
OMA; VGAHAWM; -.
OrthoDB; EOG091G0EKD; -.
Proteomes; UP000002356; Chromosome 11.
GO; GO:0044798; C:nuclear transcription factor complex; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0001046; F:core promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001158; F:enhancer sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0097157; F:pre-mRNA intronic binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
GO; GO:0004672; F:protein kinase activity; IEA:Ensembl.
GO; GO:0003705; F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; IEA:Ensembl.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IEA:Ensembl.
GO; GO:0060018; P:astrocyte fate commitment; IEA:Ensembl.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0060532; P:bronchus cartilage development; IEA:Ensembl.
GO; GO:0019933; P:cAMP-mediated signaling; IEA:Ensembl.
GO; GO:0001502; P:cartilage condensation; IEA:Ensembl.
GO; GO:0001708; P:cell fate specification; IEA:Ensembl.
GO; GO:0071364; P:cellular response to epidermal growth factor stimulus; IEA:Ensembl.
GO; GO:0071504; P:cellular response to heparin; IEA:Ensembl.
GO; GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO; GO:0071300; P:cellular response to retinoic acid; IEA:Ensembl.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
GO; GO:0003413; P:chondrocyte differentiation involved in endochondral bone morphogenesis; IEA:Ensembl.
GO; GO:0003415; P:chondrocyte hypertrophy; IEA:Ensembl.
GO; GO:0006338; P:chromatin remodeling; IEA:Ensembl.
GO; GO:0090103; P:cochlea morphogenesis; IEA:Ensembl.
GO; GO:0007010; P:cytoskeleton organization; IEA:Ensembl.
GO; GO:0003203; P:endocardial cushion morphogenesis; IEA:Ensembl.
GO; GO:0031018; P:endocrine pancreas development; IEA:Ensembl.
GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0060517; P:epithelial cell proliferation involved in prostatic bud elongation; IEA:Ensembl.
GO; GO:0001837; P:epithelial to mesenchymal transition; IEA:Ensembl.
GO; GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IEA:Ensembl.
GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
GO; GO:0001942; P:hair follicle development; IEA:Ensembl.
GO; GO:0070384; P:Harderian gland development; IEA:Ensembl.
GO; GO:0003188; P:heart valve formation; IEA:Ensembl.
GO; GO:0060729; P:intestinal epithelial structure maintenance; IEA:Ensembl.
GO; GO:0035622; P:intrahepatic bile duct development; IEA:Ensembl.
GO; GO:0032808; P:lacrimal gland development; IEA:Ensembl.
GO; GO:0060174; P:limb bud formation; IEA:Ensembl.
GO; GO:0060487; P:lung epithelial cell differentiation; IEA:Ensembl.
GO; GO:0061145; P:lung smooth muscle development; IEA:Ensembl.
GO; GO:0019100; P:male germ-line sex determination; IEA:Ensembl.
GO; GO:0030879; P:mammary gland development; IEA:Ensembl.
GO; GO:0072289; P:metanephric nephron tubule formation; IEA:Ensembl.
GO; GO:0030502; P:negative regulation of bone mineralization; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0032331; P:negative regulation of chondrocyte differentiation; IEA:Ensembl.
GO; GO:0030857; P:negative regulation of epithelial cell differentiation; IEA:Ensembl.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:0002683; P:negative regulation of immune system process; IEA:Ensembl.
GO; GO:2001054; P:negative regulation of mesenchymal cell apoptotic process; IEA:Ensembl.
GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
GO; GO:0046533; P:negative regulation of photoreceptor cell differentiation; IEA:Ensembl.
GO; GO:1902894; P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0014032; P:neural crest cell development; IEA:Ensembl.
GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
GO; GO:0030903; P:notochord development; IEA:Ensembl.
GO; GO:0006334; P:nucleosome assembly; IEA:Ensembl.
GO; GO:0048709; P:oligodendrocyte differentiation; IEA:Ensembl.
GO; GO:0001503; P:ossification; IEA:Ensembl.
GO; GO:0030916; P:otic vesicle formation; IEA:Ensembl.
GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:2000138; P:positive regulation of cell proliferation involved in heart morphogenesis; IEA:Ensembl.
GO; GO:0032332; P:positive regulation of chondrocyte differentiation; IEA:Ensembl.
GO; GO:0030858; P:positive regulation of epithelial cell differentiation; IEA:Ensembl.
GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
GO; GO:1901203; P:positive regulation of extracellular matrix assembly; IEA:Ensembl.
GO; GO:2000020; P:positive regulation of male gonad development; IEA:Ensembl.
GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Ensembl.
GO; GO:2000741; P:positive regulation of mesenchymal stem cell differentiation; IEA:Ensembl.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:Ensembl.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0006461; P:protein complex assembly; IEA:Ensembl.
GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
GO; GO:0034504; P:protein localization to nucleus; IEA:Ensembl.
GO; GO:0061046; P:regulation of branching involved in lung morphogenesis; IEA:Ensembl.
GO; GO:0030155; P:regulation of cell adhesion; IEA:Ensembl.
GO; GO:0010564; P:regulation of cell cycle process; IEA:Ensembl.
GO; GO:0060784; P:regulation of cell proliferation involved in tissue homeostasis; IEA:Ensembl.
GO; GO:2000794; P:regulation of epithelial cell proliferation involved in lung morphogenesis; IEA:Ensembl.
GO; GO:0072034; P:renal vesicle induction; IEA:Ensembl.
GO; GO:0060221; P:retinal rod cell differentiation; IEA:Ensembl.
GO; GO:0060009; P:Sertoli cell development; IEA:Ensembl.
GO; GO:0016337; P:single organismal cell-cell adhesion; IEA:Ensembl.
GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
GO; GO:0060534; P:trachea cartilage development; IEA:Ensembl.
GO; GO:0072197; P:ureter morphogenesis; IEA:Ensembl.
GO; GO:0072193; P:ureter smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0072190; P:ureter urothelium development; IEA:Ensembl.
Gene3D; 1.10.30.10; -; 1.
InterPro; IPR009071; HMG_box_dom.
InterPro; IPR029548; SOX-9.
InterPro; IPR022151; Sox_N.
PANTHER; PTHR10270:SF272; PTHR10270:SF272; 1.
Pfam; PF00505; HMG_box; 1.
Pfam; PF12444; Sox_N; 1.
SMART; SM00398; HMG; 1.
SUPFAM; SSF47095; SSF47095; 1.
PROSITE; PS50118; HMG_BOX_2; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000002356};
DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
Reference proteome {ECO:0000313|Proteomes:UP000002356}.
DOMAIN 58 126 HMG box. {ECO:0000259|PROSITE:PS50118}.
DNA_BIND 58 126 HMG box. {ECO:0000256|PROSITE-
ProRule:PRU00267}.
SEQUENCE 383 AA; 42146 MW; 1D917EF1DD7E79CB CRC64;
PGSNTFPKGE PDLKKESEED KFPVCIREAV SQVLKGYDWT LVPMPVRVNG SSKNKPHVKR
PMNAFMVWAQ AARRKLADQY PHLHNAELSK TLGKLSRLLN ESEKRPFVEE AERLRVQHKK
DHPDYKYQPR RRKSVKNGQA EAEEAPEQTH ISPNAIFKAL QADSPHSSSG MSEVHSPGEH
SGEPPPAPGP SRQPPPPRGT LPPGPRAPRG GDKLSPAPTQ FSPRCPGPQG PTKSLDTHNT
PPNPCILTGK MPLQLYRASP LFPFAAPPPK HTQGFSTSSN VVFRTLRGLG PSPDKRGLPS
VYPRVNHSMP YLGRSAPTSR TRGGRYSHAA GQGSGLYSTF SYMSPAQRPM YTPIADTSGV
PSIPQTHSPQ HWEQPVYTQL TRP


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