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STAR protein (Steroidogenic acute regulator, isoform CRA_a) (Steroidogenic acute regulatory protein isoform 1) (Testis secretory sperm-binding protein Li 241mP) (cDNA, FLJ96085, highly similar to Homo sapiens steroidogenic acute regulator (STAR), mRNA)

 Q6IBK0_HUMAN            Unreviewed;       285 AA.
Q6IBK0;
10-MAY-2005, integrated into UniProtKB/TrEMBL.
10-MAY-2005, sequence version 1.
05-DEC-2018, entry version 131.
RecName: Full=Steroidogenic acute regulatory protein, mitochondrial {ECO:0000256|RuleBase:RU365007};
Short=StAR {ECO:0000256|RuleBase:RU365007};
AltName: Full=START domain-containing protein 1 {ECO:0000256|RuleBase:RU365007};
Name=STAR {ECO:0000313|EMBL:CAG33084.1};
ORFNames=hCG_23102 {ECO:0000313|EMBL:EAW63334.1};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606 {ECO:0000313|EMBL:CAG33084.1};
[1] {ECO:0000313|EMBL:EAW63334.1}
NUCLEOTIDE SEQUENCE.
PubMed=11181995; DOI=10.1126/science.1058040;
Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
"The sequence of the human genome.";
Science 291:1304-1351(2001).
[2] {ECO:0000313|EMBL:CAG46648.1}
NUCLEOTIDE SEQUENCE.
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,
Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,
Korn B., Zuo D., Hu Y., LaBaer J.;
"Cloning of human full open reading frames in Gateway(TM) system entry
vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:CAG33084.1}
NUCLEOTIDE SEQUENCE.
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry
vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:EAW63334.1}
NUCLEOTIDE SEQUENCE.
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|EMBL:BAG37577.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Testis {ECO:0000313|EMBL:BAG37577.1};
Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y.,
Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R.,
Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N.,
Isogai T.;
"NEDO functional analysis of protein and research application
project.";
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
[6] {ECO:0000313|EMBL:AEE61251.1}
NUCLEOTIDE SEQUENCE.
Li J.Y.;
"Human testis protein.";
Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
[7] {ECO:0000313|EMBL:ALQ33795.1}
NUCLEOTIDE SEQUENCE.
PubMed=26871637; DOI=10.1016/j.cell.2016.01.029;
Yang X., Coulombe-Huntington J., Kang S., Sheynkman G.M., Hao T.,
Richardson A., Sun S., Yang F., Shen Y.A., Murray R., Spirohn K.,
Begg B.E., Duran-Frigola M., MacWilliams A., Pevzner S.J., Zhong Q.,
Trigg S.A., Tam S., Ghamsari L., Sahni N., Yi S., Rodriguez M.D.,
Balcha D., Tan G., Costanzo M., Andrews B., Boone C., Zhou X.J.,
Salehi-Ashtiani K., Charloteaux B., Chen A., Calderwood M.A., Aloy P.,
Roth F.P., Hill D.E., Iakoucheva L.M., Xia Y., Vidal M.;
"Widespread Expansion of Protein Interaction Capabilities by
Alternative Splicing.";
Cell 164:805-817(2016).
-!- FUNCTION: Plays a key role in steroid hormone synthesis by
enhancing the metabolism of cholesterol into pregnenolone.
Mediates the transfer of cholesterol from the outer mitochondrial
membrane to the inner mitochondrial membrane where it is cleaved
to pregnenolone. {ECO:0000256|RuleBase:RU365007}.
-!- PATHWAY: Steroid metabolism; cholesterol metabolism.
{ECO:0000256|RuleBase:RU365007}.
-!- SUBCELLULAR LOCATION: Mitochondrion
{ECO:0000256|RuleBase:RU365007}.
-----------------------------------------------------------------------
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EMBL; HM005654; AEE61251.1; -; mRNA.
EMBL; KU178337; ALQ33795.1; -; mRNA.
EMBL; AK315122; BAG37577.1; -; mRNA.
EMBL; CR456803; CAG33084.1; -; mRNA.
EMBL; CR541850; CAG46648.1; -; mRNA.
EMBL; CH471080; EAW63334.1; -; Genomic_DNA.
EMBL; CH471080; EAW63335.1; -; Genomic_DNA.
RefSeq; NP_000340.2; NM_000349.2.
UniGene; Hs.521535; -.
SMR; Q6IBK0; -.
GeneID; 6770; -.
KEGG; hsa:6770; -.
UCSC; uc003xkv.2; human.
CTD; 6770; -.
EuPathDB; HostDB:ENSG00000147465.11; -.
PharmGKB; PA36181; -.
eggNOG; KOG3845; Eukaryota.
eggNOG; ENOG41100B5; LUCA.
HOVERGEN; HBG010529; -.
KO; K16931; -.
OMA; QQGEEAM; -.
OrthoDB; EOG091G06RM; -.
UniPathway; UPA00296; -.
ChiTaRS; STAR; human.
GenomeRNAi; 6770; -.
Bgee; ENSG00000147465; Expressed in 118 organ(s), highest expression level in metanephros.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0030061; C:mitochondrial crista; IEA:Ensembl.
GO; GO:0005758; C:mitochondrial intermembrane space; IEA:Ensembl.
GO; GO:0043005; C:neuron projection; IEA:Ensembl.
GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO; GO:0015485; F:cholesterol binding; IEA:Ensembl.
GO; GO:0017127; F:cholesterol transporter activity; IEA:InterPro.
GO; GO:0006699; P:bile acid biosynthetic process; IEA:Ensembl.
GO; GO:0018879; P:biphenyl metabolic process; IEA:Ensembl.
GO; GO:0007420; P:brain development; IEA:Ensembl.
GO; GO:0071312; P:cellular response to alkaloid; IEA:Ensembl.
GO; GO:0071236; P:cellular response to antibiotic; IEA:Ensembl.
GO; GO:0071276; P:cellular response to cadmium ion; IEA:Ensembl.
GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
GO; GO:0071549; P:cellular response to dexamethasone stimulus; IEA:Ensembl.
GO; GO:0071872; P:cellular response to epinephrine stimulus; IEA:Ensembl.
GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEA:Ensembl.
GO; GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEA:Ensembl.
GO; GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO; GO:0071378; P:cellular response to growth hormone stimulus; IEA:Ensembl.
GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
GO; GO:0035457; P:cellular response to interferon-alpha; IEA:Ensembl.
GO; GO:0071346; P:cellular response to interferon-gamma; IEA:Ensembl.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
GO; GO:0071373; P:cellular response to luteinizing hormone stimulus; IEA:Ensembl.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-UniPathway.
GO; GO:0042747; P:circadian sleep/wake cycle, REM sleep; IEA:Ensembl.
GO; GO:0018894; P:dibenzo-p-dioxin metabolic process; IEA:Ensembl.
GO; GO:0016101; P:diterpenoid metabolic process; IEA:Ensembl.
GO; GO:0006703; P:estrogen biosynthetic process; IEA:Ensembl.
GO; GO:0008211; P:glucocorticoid metabolic process; IEA:Ensembl.
GO; GO:0017143; P:insecticide metabolic process; IEA:Ensembl.
GO; GO:0032367; P:intracellular cholesterol transport; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:0018958; P:phenol-containing compound metabolic process; IEA:Ensembl.
GO; GO:0018963; P:phthalate metabolic process; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0050769; P:positive regulation of neurogenesis; IEA:Ensembl.
GO; GO:0048168; P:regulation of neuronal synaptic plasticity; IEA:Ensembl.
GO; GO:0050810; P:regulation of steroid biosynthetic process; IEA:Ensembl.
GO; GO:0014823; P:response to activity; IEA:Ensembl.
GO; GO:0051412; P:response to corticosterone; IEA:Ensembl.
GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
GO; GO:0060992; P:response to fungicide; IEA:Ensembl.
GO; GO:0009635; P:response to herbicide; IEA:Ensembl.
GO; GO:0042542; P:response to hydrogen peroxide; IEA:Ensembl.
GO; GO:0010212; P:response to ionizing radiation; IEA:Ensembl.
GO; GO:0010288; P:response to lead ion; IEA:Ensembl.
GO; GO:0044321; P:response to leptin; IEA:Ensembl.
GO; GO:0035094; P:response to nicotine; IEA:Ensembl.
GO; GO:0007584; P:response to nutrient; IEA:Ensembl.
GO; GO:0061370; P:testosterone biosynthetic process; IEA:Ensembl.
CDD; cd08905; START_STARD1-like; 1.
Gene3D; 3.30.530.20; -; 1.
InterPro; IPR029866; StAR.
InterPro; IPR000799; StAR-like.
InterPro; IPR023393; START-like_dom_sf.
InterPro; IPR002913; START_lipid-bd_dom.
PANTHER; PTHR12136:SF9; PTHR12136:SF9; 1.
Pfam; PF01852; START; 1.
PRINTS; PR00978; STARPROTEIN.
SMART; SM00234; START; 1.
PROSITE; PS50848; START; 1.
2: Evidence at transcript level;
Lipid transport {ECO:0000256|RuleBase:RU365007};
Lipid-binding {ECO:0000256|RuleBase:RU365007};
Mitochondrion {ECO:0000256|RuleBase:RU365007};
Steroidogenesis {ECO:0000256|RuleBase:RU365007};
Transit peptide {ECO:0000256|RuleBase:RU365007};
Transport {ECO:0000256|RuleBase:RU365007}.
DOMAIN 67 280 START. {ECO:0000259|PROSITE:PS50848}.
NON_TER 285 285 {ECO:0000313|EMBL:ALQ33795.1}.
SEQUENCE 285 AA; 31914 MW; 2683086C20DE88AB CRC64;
MLLATFKLCA GSSYRHMRNM KGLRQQAVMA ISQELNRRAL GGPTPSTWIN QVRRRSSLLG
SRLEETLYSD QELAYLQQGE EAMQKALGIL SNQEGWKKES QQDNGDKVMS KVVPDVGKVF
RLEVVVDQPM ERLYEELVER MEAMGEWNPN VKEIKVLQKI GKDTFITHEL AAEAAGNLVG
PRDFVSVRCA KRRGSTCVLA GMATDFGNMP EQKGVIRAEH GPTCMVLHPL AGSPSKTKLT
WLLSIDLKGW LPKSIINQVL SQTQVDFANH LRKRLESHPA SEARC


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