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SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2)

 SMRC2_MOUSE             Reviewed;        1213 AA.
Q6PDG5; Q6P6P3;
04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
04-JAN-2005, sequence version 2.
12-SEP-2018, entry version 143.
RecName: Full=SWI/SNF complex subunit SMARCC2;
AltName: Full=BRG1-associated factor 170;
Short=BAF170;
AltName: Full=SWI/SNF complex 170 kDa subunit;
AltName: Full=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2;
Name=Smarcc2; Synonyms=Baf170;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-347, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryonic brain;
PubMed=15345747; DOI=10.1074/mcp.M400085-MCP200;
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
"Phosphoproteomic analysis of the developing mouse brain.";
Mol. Cell. Proteomics 3:1093-1101(2004).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=16452087; DOI=10.1074/mcp.T500041-MCP200;
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,
Burlingame A.L.;
"Comprehensive identification of phosphorylation sites in postsynaptic
density preparations.";
Mol. Cell. Proteomics 5:914-922(2006).
[4]
FUNCTION OF THE NBAF AND NPBAF COMPLEXES, IDENTIFICATION BY MASS
SPECTROMETRY, IDENTIFICATION IN THE NBAF AND NPBAF COMPLEXES, AND
DEVELOPMENTAL STAGE.
PubMed=17640523; DOI=10.1016/j.neuron.2007.06.019;
Lessard J., Wu J.I., Ranish J.A., Wan M., Winslow M.M., Staahl B.T.,
Wu H., Aebersold R., Graef I.A., Crabtree G.R.;
"An essential switch in subunit composition of a chromatin remodeling
complex during neural development.";
Neuron 55:201-215(2007).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283; SER-286 AND
SER-347, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
TISSUE=Liver;
PubMed=17242355; DOI=10.1073/pnas.0609836104;
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283; SER-286; SER-302;
SER-304; SER-347 AND SER-387, AND IDENTIFICATION BY MASS SPECTROMETRY
[LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
Pancreas, Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
[8]
INTERACTION WITH KDM6B.
PubMed=21095589; DOI=10.1016/j.molcel.2010.10.028;
Miller S.A., Mohn S.E., Weinmann A.S.;
"Jmjd3 and UTX play a demethylase-independent role in chromatin
remodeling to regulate T-box family member-dependent gene
expression.";
Mol. Cell 40:594-605(2010).
[9]
REVIEW ON SWI/SNF CHROMATIN REMODELING COMPLEXES.
PubMed=22952240; DOI=10.1074/jbc.R111.309302;
Euskirchen G., Auerbach R.K., Snyder M.;
"SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse
functions.";
J. Biol. Chem. 287:30897-30905(2012).
[10]
REVIEW ON SWI/SNF CHROMATIN REMODELING COMPLEXES.
PubMed=26601204; DOI=10.1126/sciadv.1500447;
Kadoch C., Crabtree G.R.;
"Mammalian SWI/SNF chromatin remodeling complexes and cancer:
Mechanistic insights gained from human genomics.";
Sci. Adv. 1:E1500447-E1500447(2015).
[11]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=28369036; DOI=10.1038/ng.3833;
Witzel M., Petersheim D., Fan Y., Bahrami E., Racek T., Rohlfs M.,
Puchalka J., Mertes C., Gagneur J., Ziegenhain C., Enard W.,
Stray-Pedersen A., Arkwright P.D., Abboud M.R., Pazhakh V.,
Lieschke G.J., Krawitz P.M., Dahlhoff M., Schneider M.R., Wolf E.,
Horny H.P., Schmidt H., Schaeffer A.A., Klein C.;
"Chromatin-remodeling factor SMARCD2 regulates transcriptional
networks controlling differentiation of neutrophil granulocytes.";
Nat. Genet. 49:742-752(2017).
-!- FUNCTION: Involved in transcriptional activation and repression of
select genes by chromatin remodeling (alteration of DNA-nucleosome
topology). Component of SWI/SNF chromatin remodeling complexes
that carry out key enzymatic activities, changing chromatin
structure by altering DNA-histone contacts within a nucleosome in
an ATP-dependent manner. Can stimulate the ATPase activity of the
catalytic subunit of these complexes. May be required for CoREST
dependent repression of neuronal specific gene promoters in non-
neuronal cells. Belongs to the neural progenitors-specific
chromatin remodeling complex (npBAF complex) and the neuron-
specific chromatin remodeling complex (nBAF complex). During
neural development a switch from a stem/progenitor to a
postmitotic chromatin remodeling mechanism occurs as neurons exit
the cell cycle and become committed to their adult state. The
transition from proliferating neural stem/progenitor cells to
postmitotic neurons requires a switch in subunit composition of
the npBAF and nBAF complexes. As neural progenitors exit mitosis
and differentiate into neurons, npBAF complexes which contain
ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous
alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits
in neuron-specific complexes (nBAF). The npBAF complex is
essential for the self-renewal/proliferative capacity of the
multipotent neural stem cells. The nBAF complex along with CREST
plays a role regulating the activity of genes essential for
dendrite growth (PubMed:17640523). Critical regulator of myeloid
differentiation, controlling granulocytopoiesis and the expression
of genes involved in neutrophil granule formation
(PubMed:28369036). {ECO:0000269|PubMed:17640523,
ECO:0000269|PubMed:28369036, ECO:0000303|PubMed:22952240,
ECO:0000303|PubMed:26601204}.
-!- SUBUNIT: Component of the multiprotein chromatin-remodeling
complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related
complexes. The canonical complex contains a catalytic subunit
(either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least
SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and
SMARCB1/SNF5/BAF47. Other subunits specific to each of the
complexes may also be present permitting several possible
combinations developmentally and tissue specific (Probable).
Component of the BAF complex, which includes at least actin
(ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1,
ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155,
SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A,
SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF
complex also contains DPF3. Component of neural progenitors-
specific chromatin remodeling complex (npBAF complex) composed of
at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A,
SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A,
SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170,
PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-
specific chromatin remodeling complex (nBAF complex) composed of
at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A,
SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A,
SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170,
DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin
(PubMed:17640523). Component of the SWI/SNF-B (PBAF) chromatin
remodeling complex, at least composed of SMARCA4/BRG1,
SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57,
SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C,
SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and
actin (PubMed:22952240, PubMed:26601204). May also interact with
the SIN3A histone deacetylase transcription repressor complex in
conjunction with SMARCA2 and SMARCA4. Interacts with SMARD1 (By
similarity). Interacts with KDM6B (PubMed:21095589). Interaction
with RCOR1 (By similarity). {ECO:0000250|UniProtKB:Q8TAQ2,
ECO:0000269|PubMed:17640523, ECO:0000269|PubMed:21095589,
ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q6PDG5-1; Sequence=Displayed;
Name=2;
IsoId=Q6PDG5-2; Sequence=VSP_012492;
-!- DEVELOPMENTAL STAGE: Expressed ubiquitously throughout the
developing spinal cord, brain and other embryonic tissues at
E10.5-E16.5. {ECO:0000269|PubMed:17640523}.
-!- DISRUPTION PHENOTYPE: SMARCD2 knockout mice show aberrant
hematopoiesis, characterized by defective myeloid and erythroid
differentiation, a reduction in granulocyte/macrophage progenitors
as well as reduced neutrophil granulocytes and monocytes. Knockout
embryos die late during fetal development and are characterized by
reduced size, pallor, and decreased temporal vascularization.
{ECO:0000269|PubMed:28369036}.
-!- SIMILARITY: Belongs to the SMARCC family. {ECO:0000305}.
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EMBL; BC058720; AAH58720.1; -; mRNA.
EMBL; BC062102; AAH62102.1; -; mRNA.
CCDS; CCDS24278.1; -. [Q6PDG5-2]
CCDS; CCDS48727.1; -. [Q6PDG5-1]
RefSeq; NP_001107568.1; NM_001114096.1.
RefSeq; NP_001107569.1; NM_001114097.1. [Q6PDG5-1]
RefSeq; NP_937803.1; NM_198160.2. [Q6PDG5-2]
UniGene; Mm.417338; -.
ProteinModelPortal; Q6PDG5; -.
SMR; Q6PDG5; -.
BioGrid; 212652; 13.
ComplexPortal; CPX-1232; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant.
ComplexPortal; CPX-1233; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant.
ComplexPortal; CPX-1234; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant.
ComplexPortal; CPX-1235; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant.
ComplexPortal; CPX-1236; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant.
ComplexPortal; CPX-1237; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant.
ComplexPortal; CPX-1238; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant.
ComplexPortal; CPX-1239; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant.
ComplexPortal; CPX-1240; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant.
ComplexPortal; CPX-1241; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant.
ComplexPortal; CPX-1242; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant.
ComplexPortal; CPX-1243; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant.
ComplexPortal; CPX-1244; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant.
ComplexPortal; CPX-1245; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant.
ComplexPortal; CPX-1246; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant.
ComplexPortal; CPX-1247; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant.
ComplexPortal; CPX-1248; Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant.
ComplexPortal; CPX-1250; Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant.
ComplexPortal; CPX-1252; Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant.
ComplexPortal; CPX-1253; Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant.
ComplexPortal; CPX-1254; Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant.
ComplexPortal; CPX-1255; Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant.
ComplexPortal; CPX-1256; Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant.
ComplexPortal; CPX-1257; Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant.
ComplexPortal; CPX-1258; Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant.
ComplexPortal; CPX-1259; Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant.
ComplexPortal; CPX-1261; Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant.
ComplexPortal; CPX-1262; Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant.
ComplexPortal; CPX-1263; Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant.
ComplexPortal; CPX-1264; Brain-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant.
CORUM; Q6PDG5; -.
DIP; DIP-48884N; -.
IntAct; Q6PDG5; 13.
MINT; Q6PDG5; -.
STRING; 10090.ENSMUSP00000100868; -.
iPTMnet; Q6PDG5; -.
PhosphoSitePlus; Q6PDG5; -.
SwissPalm; Q6PDG5; -.
PaxDb; Q6PDG5; -.
PeptideAtlas; Q6PDG5; -.
PRIDE; Q6PDG5; -.
Ensembl; ENSMUST00000026433; ENSMUSP00000026433; ENSMUSG00000025369. [Q6PDG5-2]
Ensembl; ENSMUST00000105235; ENSMUSP00000100868; ENSMUSG00000025369. [Q6PDG5-1]
GeneID; 68094; -.
KEGG; mmu:68094; -.
UCSC; uc007hmw.2; mouse. [Q6PDG5-2]
UCSC; uc007hmx.2; mouse. [Q6PDG5-1]
CTD; 6601; -.
MGI; MGI:1915344; Smarcc2.
eggNOG; KOG1279; Eukaryota.
eggNOG; COG5259; LUCA.
GeneTree; ENSGT00390000018166; -.
HOGENOM; HOG000047736; -.
HOVERGEN; HBG054849; -.
InParanoid; Q6PDG5; -.
KO; K11649; -.
OMA; FLGPLGC; -.
OrthoDB; EOG091G06AJ; -.
PhylomeDB; Q6PDG5; -.
TreeFam; TF314710; -.
Reactome; R-MMU-3214858; RMTs methylate histone arginines.
Reactome; R-MMU-8939243; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.
ChiTaRS; Smarcc2; mouse.
PRO; PR:Q6PDG5; -.
Proteomes; UP000000589; Chromosome 10.
Bgee; ENSMUSG00000025369; Expressed in 252 organ(s), highest expression level in brain.
ExpressionAtlas; Q6PDG5; baseline and differential.
Genevisible; Q6PDG5; MM.
GO; GO:0071565; C:nBAF complex; IDA:UniProtKB.
GO; GO:0071564; C:npBAF complex; IDA:UniProtKB.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0016514; C:SWI/SNF complex; IDA:MGI.
GO; GO:0003682; F:chromatin binding; IDA:MGI.
GO; GO:0003677; F:DNA binding; IEA:InterPro.
GO; GO:0006338; P:chromatin remodeling; ISO:MGI.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IGI:MGI.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
GO; GO:0006337; P:nucleosome disassembly; ISO:MGI.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
GO; GO:0021882; P:regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment; IMP:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00024; CHROMO; 1.
CDD; cd00167; SANT; 1.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR036420; BRCT_dom_sf.
InterPro; IPR000953; Chromo/chromo_shadow_dom.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR001005; SANT/Myb.
InterPro; IPR017884; SANT_dom.
InterPro; IPR038044; SMARCC2.
InterPro; IPR032451; SMARCC_C.
InterPro; IPR032450; SMARCC_N.
InterPro; IPR007526; SWIRM.
InterPro; IPR032448; SWIRM-assoc.
InterPro; IPR036388; WH-like_DNA-bd_sf.
PANTHER; PTHR12802:SF38; PTHR12802:SF38; 1.
Pfam; PF00249; Myb_DNA-binding; 1.
Pfam; PF04433; SWIRM; 1.
Pfam; PF16495; SWIRM-assoc_1; 1.
Pfam; PF16496; SWIRM-assoc_2; 1.
Pfam; PF16498; SWIRM-assoc_3; 1.
SMART; SM00298; CHROMO; 1.
SMART; SM00717; SANT; 1.
SUPFAM; SSF46689; SSF46689; 2.
SUPFAM; SSF52113; SSF52113; 2.
PROSITE; PS51293; SANT; 1.
PROSITE; PS50934; SWIRM; 1.
1: Evidence at protein level;
Acetylation; Alternative splicing; Chromatin regulator; Coiled coil;
Complete proteome; Isopeptide bond; Neurogenesis; Nucleus;
Phosphoprotein; Reference proteome; Transcription;
Transcription regulation; Ubl conjugation.
CHAIN 1 1213 SWI/SNF complex subunit SMARCC2.
/FTId=PRO_0000197118.
DOMAIN 424 521 SWIRM. {ECO:0000255|PROSITE-
ProRule:PRU00247}.
DOMAIN 596 647 SANT. {ECO:0000255|PROSITE-
ProRule:PRU00624}.
COILED 907 934 {ECO:0000255}.
COMPBIAS 186 189 Poly-Glu.
COMPBIAS 747 855 Glu-rich.
COMPBIAS 861 870 Poly-Ala.
COMPBIAS 956 961 Poly-Gln.
COMPBIAS 962 1212 Pro-rich.
MOD_RES 283 283 Phosphoserine.
{ECO:0000244|PubMed:17242355,
ECO:0000244|PubMed:19144319,
ECO:0000244|PubMed:21183079}.
MOD_RES 286 286 Phosphoserine.
{ECO:0000244|PubMed:17242355,
ECO:0000244|PubMed:21183079}.
MOD_RES 302 302 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 304 304 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 306 306 Phosphoserine.
{ECO:0000250|UniProtKB:Q8TAQ2}.
MOD_RES 326 326 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q8TAQ2}.
MOD_RES 347 347 Phosphoserine.
{ECO:0000244|PubMed:15345747,
ECO:0000244|PubMed:17242355,
ECO:0000244|PubMed:21183079}.
MOD_RES 387 387 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 813 813 Phosphoserine.
{ECO:0000250|UniProtKB:Q8TAQ2}.
CROSSLNK 564 564 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q8TAQ2}.
CROSSLNK 566 566 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q8TAQ2}.
CROSSLNK 568 568 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q8TAQ2}.
CROSSLNK 592 592 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q8TAQ2}.
CROSSLNK 704 704 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q8TAQ2}.
CROSSLNK 787 787 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q8TAQ2}.
CROSSLNK 848 848 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:Q8TAQ2}.
VAR_SEQ 1075 1188 Missing (in isoform 2).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_012492.
CONFLICT 550 550 Missing (in Ref. 1; AAH62102).
{ECO:0000305}.
SEQUENCE 1213 AA; 132604 MW; 6239489440320676 CRC64;
MAVRKKDGGP NVKYYEAADT VTQFDNVRLW LGKNYKKYIQ AEPPTNKSLS SLVVQLLQFQ
EEVFGKHVSN APLTKLPIKC FLDFKAGGSL CHILAAAYKF KSDQGWRRYD FQNPSRMDRN
VEMFMTIEKS LVQNNCLSRP NIFLCPEIEP KLLGKLKDIV KRHQGTISED KSNASHVVYP
VPGNLEEEEW VRPVMKRDKQ VLLHWGYYPD SYDTWIPASE IEASVEDAPT PEKPRKVHAK
WILDTDTFNE WMNEEDYEVS DDKSPVSRRK KISAKTLTDE VNSPDSDRRD KKGGNYKKRK
RSPSPSPTPE AKKKNAKKGP STPYTKSKRG HREEEQEDLT KDMDEPSPVP NVEEVTLPKT
VNTKKDSESA PVKGGTMTDL DEQDDESMET TGKDEDENST GNKGEQTKNP DLHEDNVTEQ
THHIIIPSYA AWFDYNSVHA IERRALPEFF NGKNKSKTPE IYLAYRNFMI DTYRLNPQEY
LTSTACRRNL AGDVCAIMRV HAFLEQWGLI NYQVDAESRP TPMGPPPTSH FHVLADTPSG
LVPLQPKPPQ QSSASQQMLN FPEKGKEKPA DMQNFGLRTD MYTKKNVPSK SKAAASATRE
WTEQETLLLL EALEMYKDDW NKVSEHVGSR TQDECILHFL RLPIEDPYLE DSEASLGPLA
YQPIPFSQSG NPVMSTVAFL ASVVDPRVAS AAAKSALEEF SKMKEEVPTA LVEAHVRKVE
EAAKVTGKAD PAFGLESSGI AGTASDEPER IEESGTEEAR PEGQAADEKK EPKEPREGGG
AVEEEAKEEI SEVPKKDEEK GKEGDSEKES EKSDGDPIVD PEKDKEPTEG QEEVLKEVAE
PEGERKTKVE RDIGEGNLST AAAAALAAAA VKAKHLAAVE ERKIKSLVAL LVETQMKKLE
IKLRHFEELE TIMDREREAL EYQRQQLLAD RQAFHMEQLK YAEMRARQQH FQQMHQQQQQ
QPPTLPPGSQ PIPPTGAAGP PTVHGLAVPP AAVASAPPGS GAPPGSLGPS EQIGQAGTTA
GPQQPQQAGA PQPGAVPPGV PPPGPHGPSP FPNQPTPPSM MPGAVPGSGH PGVAGNAPLG
LPFGMPPPPP AAPSVIPFGS LADSISINLP PPPNLHGHHH HLPFAPGTIP PPNLPVSMAN
PLHPNLPATT TMPSSLPLGP GLGSAAAQSP AIVAAVQGNL LPSASPLPDP GTPLPPDPTA
PSPGTVTPVP PPQ


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