Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (60 kDa BRG-1/Brm-associated factor subunit A) (BRG1-associated factor 60A) (BAF60A) (SWI/SNF complex 60 kDa subunit)

 SMRD1_HUMAN             Reviewed;         515 AA.
Q96GM5; A6NN27; Q92924; Q9Y635;
17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
26-MAY-2009, sequence version 2.
10-OCT-2018, entry version 163.
RecName: Full=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1;
AltName: Full=60 kDa BRG-1/Brm-associated factor subunit A;
AltName: Full=BRG1-associated factor 60A;
Short=BAF60A;
AltName: Full=SWI/SNF complex 60 kDa subunit;
Name=SMARCD1 {ECO:0000312|EMBL:AAD23390.1};
Synonyms=BAF60A {ECO:0000303|PubMed:8804307};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1] {ECO:0000305, ECO:0000312|EMBL:AAD23390.1}
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR
LOCATION, AND TISSUE SPECIFICITY.
TISSUE=Peripheral blood;
PubMed=8804307; DOI=10.1101/gad.10.17.2117;
Wang W., Xue Y., Zhou S., Kuo A., Cairns B.R., Crabtree G.R.;
"Diversity and specialization of mammalian SWI/SNF complexes.";
Genes Dev. 10:2117-2130(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16541075; DOI=10.1038/nature04569;
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
Kucherlapati R., Weinstock G., Gibbs R.A.;
"The finished DNA sequence of human chromosome 12.";
Nature 440:346-351(2006).
[3] {ECO:0000305, ECO:0000312|EMBL:AAH09368.3}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Muscle;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4] {ECO:0000305}
SUBUNIT.
PubMed=8895581;
Wang W., Cote J., Xue Y., Zhou S., Khavari P.A., Biggar S.R.,
Muchardt C., Kalpana G.V., Goff S.P., Yaniv M., Workman J.L.,
Crabtree G.R.;
"Purification and biochemical heterogeneity of the mammalian SWI-SNF
complex.";
EMBO J. 15:5370-5382(1996).
[5] {ECO:0000305}
FUNCTION, AND INTERACTION WITH THE VITAMIN D RECEPTOR HETERODIMER
COMPLEX.
PubMed=14698202; DOI=10.1016/j.jsbmb.2003.09.006;
Koszewski N.J., Henry K.W., Lubert E.J., Gravatte H., Noonan D.J.;
"Use of a modified yeast one-hybrid screen to identify BAF60a
interactions with the Vitamin D receptor heterodimer.";
J. Steroid Biochem. Mol. Biol. 87:223-231(2003).
[6] {ECO:0000305}
FUNCTION, AND INTERACTION WITH ESR1; NR3C1; NR1H4; PGR; SMARCA4;
SMARCC1 AND SMARCC2.
PubMed=12917342; DOI=10.1128/MCB.23.17.6210-6220.2003;
Hsiao P.W., Fryer C.J., Trotter K.W., Wang W., Archer T.K.;
"BAF60a mediates critical interactions between nuclear receptors and
the BRG1 chromatin-remodeling complex for transactivation.";
Mol. Cell. Biol. 23:6210-6220(2003).
[7]
IDENTIFICATION IN THE BAF COMPLEX, AND IDENTIFICATION BY MASS
SPECTROMETRY.
PubMed=18765789; DOI=10.1101/gad.471408;
Lange M., Kaynak B., Forster U.B., Toenjes M., Fischer J.J., Grimm C.,
Schlesinger J., Just S., Dunkel I., Krueger T., Mebus S., Lehrach H.,
Lurz R., Gobom J., Rottbauer W., Abdelilah-Seyfried S., Sperling S.;
"Regulation of muscle development by DPF3, a novel histone acetylation
and methylation reader of the BAF chromatin remodeling complex.";
Genes Dev. 22:2370-2384(2008).
[8]
SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-101, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=28112733; DOI=10.1038/nsmb.3366;
Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
Nielsen M.L.;
"Site-specific mapping of the human SUMO proteome reveals co-
modification with phosphorylation.";
Nat. Struct. Mol. Biol. 24:325-336(2017).
[9]
REVIEW ON SWI/SNF CHROMATIN REMODELING COMPLEXES.
PubMed=22952240; DOI=10.1074/jbc.R111.309302;
Euskirchen G., Auerbach R.K., Snyder M.;
"SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse
functions.";
J. Biol. Chem. 287:30897-30905(2012).
[10]
REVIEW ON SWI/SNF CHROMATIN REMODELING COMPLEXES.
PubMed=26601204; DOI=10.1126/sciadv.1500447;
Kadoch C., Crabtree G.R.;
"Mammalian SWI/SNF chromatin remodeling complexes and cancer:
Mechanistic insights gained from human genomics.";
Sci. Adv. 1:E1500447-E1500447(2015).
[11]
FUNCTION, AND IDENTIFICATION IN THE GBAF COMPLEX.
PubMed=29374058; DOI=10.1074/jbc.RA117.001065;
Alpsoy A., Dykhuizen E.C.;
"Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its
paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.";
J. Biol. Chem. 293:3892-3903(2018).
-!- FUNCTION: Involved in transcriptional activation and repression of
select genes by chromatin remodeling (alteration of DNA-nucleosome
topology). Component of SWI/SNF chromatin remodeling complexes
that carry out key enzymatic activities, changing chromatin
structure by altering DNA-histone contacts within a nucleosome in
an ATP-dependent manner (PubMed:8804307, PubMed:29374058). Belongs
to the neural progenitors-specific chromatin remodeling complex
(npBAF complex) and the neuron-specific chromatin remodeling
complex (nBAF complex). During neural development a switch from a
stem/progenitor to a postmitotic chromatin remodeling mechanism
occurs as neurons exit the cell cycle and become committed to
their adult state. The transition from proliferating neural
stem/progenitor cells to postmitotic neurons requires a switch in
subunit composition of the npBAF and nBAF complexes. As neural
progenitors exit mitosis and differentiate into neurons, npBAF
complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are
exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B
or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The
npBAF complex is essential for the self-renewal/proliferative
capacity of the multipotent neural stem cells. The nBAF complex
along with CREST plays a role regulating the activity of genes
essential for dendrite growth (By similarity). Has a strong
influence on vitamin D-mediated transcriptional activity from an
enhancer vitamin D receptor element (VDRE). May be a link between
mammalian SWI-SNF-like chromatin remodeling complexes and the
vitamin D receptor (VDR) heterodimer (PubMed:14698202). Mediates
critical interactions between nuclear receptors and the
BRG1/SMARCA4 chromatin-remodeling complex for transactivation
(PubMed:12917342). {ECO:0000250|UniProtKB:Q61466,
ECO:0000269|PubMed:12917342, ECO:0000269|PubMed:14698202,
ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:8804307,
ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
-!- SUBUNIT: Component of the multiprotein chromatin-remodeling
complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related
complexes. The canonical complex contains a catalytic subunit
(either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B), and at least
SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and
SMARCB1/SNF5/BAF47. Other subunits specific to each of the
complexes may also be present permitting several possible
combinations developmentally and tissue specific (PubMed:8895581).
Component of the BAF complex, which includes at least actin
(ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM,
SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57,
SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more
SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C
(PubMed:18765789). In muscle cells, the BAF complex also contains
DPF3. Component of neural progenitors-specific chromatin
remodeling complex (npBAF complex) composed of at least,
ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C,
SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47,
SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A,
ACTL6A/BAF53A and actin. Component of neuron-specific chromatin
remodeling complex (nBAF complex) composed of at least,
ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C,
SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47,
SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B,
DPF3/BAF45C, ACTL6B/BAF53B and actin (By similarity). Component of
the SWI/SNF-B (PBAF) chromatin remodeling complex, at least
composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or
ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B,
perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170,
PBRM1/BAF180, ARID2/BAF200 and actin (ACTB) (PubMed:22952240,
PubMed:26601204). Component of SWI/SNF (GBAF) subcomplex, which
includes at least BICRA or BICRAL (mutually exclusive), BRD9,
SS18, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53,
SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058). Specifically
interacts with the VDR heterodimer complex (PubMed:14698202).
Interacts with ESR1, NR3C1, NR1H4, PGR, SMARCA4, SMARCC1 and
SMARCC2 (PubMed:12917342). {ECO:0000250|UniProtKB:Q61466,
ECO:0000269|PubMed:12917342, ECO:0000269|PubMed:14698202,
ECO:0000269|PubMed:18765789, ECO:0000269|PubMed:29374058,
ECO:0000269|PubMed:8895581, ECO:0000303|PubMed:22952240,
ECO:0000303|PubMed:26601204}.
-!- INTERACTION:
P19012:KRT15; NbExp=3; IntAct=EBI-358489, EBI-739566;
O95751:LDOC1; NbExp=3; IntAct=EBI-358489, EBI-740738;
Q9NPJ6:MED4; NbExp=5; IntAct=EBI-358489, EBI-394607;
P06536:Nr3c1 (xeno); NbExp=2; IntAct=EBI-358489, EBI-1187143;
P51532:SMARCA4; NbExp=7; IntAct=EBI-358489, EBI-302489;
Q92922:SMARCC1; NbExp=4; IntAct=EBI-358489, EBI-355653;
Q8N6Y0:USHBP1; NbExp=3; IntAct=EBI-358489, EBI-739895;
Q9H9H4:VPS37B; NbExp=6; IntAct=EBI-358489, EBI-4400866;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8804307,
ECO:0000305}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1 {ECO:0000269|PubMed:8804307};
IsoId=Q96GM5-1; Sequence=Displayed;
Name=2 {ECO:0000269|PubMed:8804307};
IsoId=Q96GM5-2; Sequence=VSP_004179;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Expressed in all tissues tested, including
brain, heart, kidney, liver, lung, muscle, pancreas and placenta.
{ECO:0000269|PubMed:8804307}.
-!- SIMILARITY: Belongs to the SMARCD family. {ECO:0000255}.
-!- SEQUENCE CAUTION:
Sequence=AAC50695.1; Type=Frameshift; Positions=30; Evidence={ECO:0000305};
Sequence=AAD23390.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Sequence=AAH09368.3; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF109733; AAD23390.1; ALT_INIT; mRNA.
EMBL; U66617; AAC50695.1; ALT_FRAME; mRNA.
EMBL; AC025154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC009368; AAH09368.3; ALT_INIT; mRNA.
CCDS; CCDS8797.2; -. [Q96GM5-1]
CCDS; CCDS8798.2; -. [Q96GM5-2]
RefSeq; NP_003067.3; NM_003076.4. [Q96GM5-1]
RefSeq; NP_620710.2; NM_139071.2. [Q96GM5-2]
UniGene; Hs.79335; -.
ProteinModelPortal; Q96GM5; -.
SMR; Q96GM5; -.
BioGrid; 112486; 117.
ComplexPortal; CPX-1164; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant.
ComplexPortal; CPX-1194; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant.
ComplexPortal; CPX-1195; Embryonic stem cell-specific SWI/SNF ATP-dependent chromatin remodeling complex.
ComplexPortal; CPX-1196; Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B variant.
ComplexPortal; CPX-1199; Polybromo-associated SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A variant.
ComplexPortal; CPX-1201; Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant.
ComplexPortal; CPX-1202; Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant.
ComplexPortal; CPX-1204; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant.
ComplexPortal; CPX-1205; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant.
ComplexPortal; CPX-1206; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant.
ComplexPortal; CPX-1207; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant.
ComplexPortal; CPX-1209; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant.
ComplexPortal; CPX-1210; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant.
ComplexPortal; CPX-1211; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant.
ComplexPortal; CPX-1212; Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant.
ComplexPortal; CPX-1213; Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant.
ComplexPortal; CPX-1215; Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant.
ComplexPortal; CPX-1216; Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant.
ComplexPortal; CPX-1217; Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant.
ComplexPortal; CPX-1218; Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant.
ComplexPortal; CPX-1222; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant.
ComplexPortal; CPX-1223; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant.
ComplexPortal; CPX-1224; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant.
ComplexPortal; CPX-1225; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant.
ComplexPortal; CPX-1226; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant.
ComplexPortal; CPX-1227; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant.
ComplexPortal; CPX-1228; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant.
CORUM; Q96GM5; -.
DIP; DIP-33390N; -.
IntAct; Q96GM5; 160.
MINT; Q96GM5; -.
STRING; 9606.ENSP00000378414; -.
iPTMnet; Q96GM5; -.
PhosphoSitePlus; Q96GM5; -.
BioMuta; SMARCD1; -.
DMDM; 238054318; -.
EPD; Q96GM5; -.
MaxQB; Q96GM5; -.
PaxDb; Q96GM5; -.
PeptideAtlas; Q96GM5; -.
PRIDE; Q96GM5; -.
ProteomicsDB; 76645; -.
ProteomicsDB; 76646; -. [Q96GM5-2]
DNASU; 6602; -.
Ensembl; ENST00000381513; ENSP00000370924; ENSG00000066117. [Q96GM5-2]
Ensembl; ENST00000394963; ENSP00000378414; ENSG00000066117. [Q96GM5-1]
GeneID; 6602; -.
KEGG; hsa:6602; -.
UCSC; uc001rvx.5; human. [Q96GM5-1]
CTD; 6602; -.
DisGeNET; 6602; -.
EuPathDB; HostDB:ENSG00000066117.14; -.
GeneCards; SMARCD1; -.
HGNC; HGNC:11106; SMARCD1.
HPA; HPA004101; -.
MIM; 601735; gene.
neXtProt; NX_Q96GM5; -.
OpenTargets; ENSG00000066117; -.
PharmGKB; PA35956; -.
eggNOG; KOG2570; Eukaryota.
eggNOG; COG5531; LUCA.
GeneTree; ENSGT00390000017809; -.
HOGENOM; HOG000240746; -.
HOVERGEN; HBG054046; -.
InParanoid; Q96GM5; -.
KO; K11650; -.
OMA; FRLPWVE; -.
OrthoDB; EOG091G06WW; -.
PhylomeDB; Q96GM5; -.
TreeFam; TF106486; -.
Reactome; R-HSA-3214858; RMTs methylate histone arginines.
Reactome; R-HSA-8939243; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.
SIGNOR; Q96GM5; -.
ChiTaRS; SMARCD1; human.
GeneWiki; SMARCD1; -.
GenomeRNAi; 6602; -.
PRO; PR:Q96GM5; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000066117; Expressed in 218 organ(s), highest expression level in left adrenal gland.
CleanEx; HS_SMARCD1; -.
ExpressionAtlas; Q96GM5; baseline and differential.
Genevisible; Q96GM5; HS.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO; GO:0071565; C:nBAF complex; ISS:UniProtKB.
GO; GO:0071564; C:npBAF complex; ISS:UniProtKB.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0016514; C:SWI/SNF complex; IDA:UniProtKB.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0032947; F:protein-containing complex scaffold activity; IDA:UniProtKB.
GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
GO; GO:0003713; F:transcription coactivator activity; NAS:BHF-UCL.
GO; GO:0071398; P:cellular response to fatty acid; IEA:Ensembl.
GO; GO:0006338; P:chromatin remodeling; IDA:BHF-UCL.
GO; GO:0048096; P:chromatin-mediated maintenance of transcription; IMP:UniProtKB.
GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
GO; GO:0006337; P:nucleosome disassembly; IDA:BHF-UCL.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; NAS:BHF-UCL.
Gene3D; 1.10.245.10; -; 1.
InterPro; IPR038041; SMARCD1.
InterPro; IPR019835; SWIB_domain.
InterPro; IPR036885; SWIB_MDM2_dom_sf.
InterPro; IPR003121; SWIB_MDM2_domain.
PANTHER; PTHR13844:SF1; PTHR13844:SF1; 1.
Pfam; PF02201; SWIB; 1.
SMART; SM00151; SWIB; 1.
SUPFAM; SSF47592; SSF47592; 1.
1: Evidence at protein level;
Acetylation; Alternative splicing; Chromatin regulator; Coiled coil;
Complete proteome; Isopeptide bond; Methylation; Neurogenesis;
Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation.
CHAIN 1 515 SWI/SNF-related matrix-associated actin-
dependent regulator of chromatin
subfamily D member 1.
/FTId=PRO_0000071983.
DOMAIN 291 390 SWIB.
REGION 43 167 Interaction with ESR1, NR1H4, NR3C1, PGR
and SMARCA4.
{ECO:0000269|PubMed:12917342}.
REGION 168 474 Interaction with SMARCC1 and SMARCC2.
{ECO:0000269|PubMed:12917342}.
REGION 180 515 Necessary for GR/NR3C1-mediated
remodeling and transcription from
chromatin; required for GR/NR3C1
interaction with the BRG1/SMARCA4 complex
in vivo.
COILED 412 440 {ECO:0000255}.
COMPBIAS 124 127 Poly-Lys.
MOD_RES 68 68 Asymmetric dimethylarginine.
{ECO:0000250|UniProtKB:Q92925}.
MOD_RES 88 88 Asymmetric dimethylarginine.
{ECO:0000250|UniProtKB:Q61466}.
MOD_RES 203 203 Phosphothreonine.
{ECO:0000250|UniProtKB:Q92925}.
MOD_RES 223 223 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q61466}.
CROSSLNK 101 101 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000244|PubMed:28112733}.
VAR_SEQ 423 463 Missing (in isoform 2).
{ECO:0000303|PubMed:8804307}.
/FTId=VSP_004179.
CONFLICT 349 349 S -> T (in Ref. 1; AAC50695).
{ECO:0000305}.
SEQUENCE 515 AA; 58233 MW; E683AA1E345DA400 CRC64;
MAARAGFQSV APSGGAGASG GAGAAAALGP GGTPGPPVRM GPAPGQGLYR SPMPGAAYPR
PGMLPGSRMT PQGPSMGPPG YGGNPSVRPG LAQSGMDQSR KRPAPQQIQQ VQQQAVQNRN
HNAKKKKMAD KILPQRIREL VPESQAYMDL LAFERKLDQT IMRKRLDIQE ALKRPIKQKR
KLRIFISNTF NPAKSDAEDG EGTVASWELR VEGRLLEDSA LSKYDATKQK RKFSSFFKSL
VIELDKDLYG PDNHLVEWHR TATTQETDGF QVKRPGDVNV RCTVLLMLDY QPPQFKLDPR
LARLLGIHTQ TRPVIIQALW QYIKTHKLQD PHEREFVICD KYLQQIFESQ RMKFSEIPQR
LHALLMPPEP IIINHVISVD PNDQKKTACY DIDVEVDDTL KTQMNSFLLS TASQQEIATL
DNKIHETIET INQLKTQREF MLSFARDPQG FINDWLQSQC RDLKTMTDVV GNPEEERRAE
FYFQPWAQEA VCRYFYSKVQ QRRQELEQAL GIRNT


Related products :

Catalog number Product name Quantity
18-003-43476 SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 - 60 kDa BRG-1_Brm-associated factor subunit B; BRG1-associated factor 60B Polyclonal 0.05 mg Aff Pur
18-003-43138 SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 - 60 kDa BRG-1_Brm-associated factor subunit C; BRG1-associated factor 60C Polyclonal 0.05 mg Aff Pur
EIAAB38867 60 kDa BRG-1_Brm-associated factor subunit B,BAF60B,Bos taurus,Bovine,BRG1-associated factor 60B,SMARCD2,SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2
EIAAB38862 60 kDa BRG-1_Brm-associated factor subunit A,BAF60A,BAF60A,Bos taurus,Bovine,BRG1-associated factor 60A,SMARCD1,SWI_SNF complex 60 kDa subunit,SWI_SNF-related matrix-associated actin-dependent regulat
EIAAB38864 60 kDa BRG-1_Brm-associated factor subunit A,BAF60A,BAF60A,BRG1-associated factor 60A,Homo sapiens,Human,SMARCD1,SWI_SNF complex 60 kDa subunit,SWI_SNF-related matrix-associated actin-dependent regula
EIAAB38868 60 kDa BRG-1_Brm-associated factor subunit B,BAF60B,Baf60b,BRG1-associated factor 60B,Mouse,Mus musculus,Smarcd2,SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D me
EIAAB38865 60 kDa BRG-1_Brm-associated factor subunit B,BAF60B,Baf60b,BRG1-associated factor 60B,Rat,Rattus norvegicus,Smarcd2,SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D
EIAAB38870 60 kDa BRG-1_Brm-associated factor subunit C,BAF60C,BAF60C,BRG1-associated factor 60C,Homo sapiens,Human,SMARCD3,SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D me
18-003-43477 SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 - BRG1-associated factor 57 Polyclonal 0.05 mg Aff Pur
EIAAB38869 60 kDa BRG-1_Brm-associated factor subunit C,BAF60C,Baf60c,BRG1-associated factor 60C,mBAF60c,Mouse,Mus musculus,Smarcd3,SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfam
EIAAB38951 BAF47,BAF47,Bos taurus,Bovine,BRG1-associated factor 47,SMARCB1,SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
EIAAB38784 BAF57,Baf57,BRG1-associated factor 57,Mouse,Mus musculus,Smarce1,SWI_SNF-related matrix-associated actin-dependent regulator chromatin subfamily E member 1
EIAAB38866 60 kDa BRG-1_Brm-associated factor subunit B,BAF60B,BAF60B,BRG1-associated factor 60B,Homo sapiens,Human,PRO2451,SMARCD2,SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfam
EIAAB38785 BAF57,BAF57,BRG1-associated factor 57,Homo sapiens,Human,SMARCE1,SWI_SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
EIAAB38863 60 kDa BRG-1_Brm-associated factor subunit A,BAF60A,Baf60a,BRG1-associated factor 60A,D15Kz1,Mouse,Mus musculus,Protein D15KZ1,Smarcd1,SWI_SNF complex 60 kDa subunit,SWI_SNF-related matrix-associated
EIAAB38858 BAF170,BAF170,BRG1-associated factor 170,Homo sapiens,Human,SMARCC2,SWI_SNF complex 170 kDa subunit,SWI_SNF complex subunit SMARCC2,SWI_SNF-related matrix-associated actin-dependent regulator of chrom
EIAAB38857 BAF155,BAF155,BRG1-associated factor 155,Homo sapiens,Human,SMARCC1,SWI_SNF complex 155 kDa subunit,SWI_SNF complex subunit SMARCC1,SWI_SNF-related matrix-associated actin-dependent regulator of chrom
EIAAB38856 BAF155,Baf155,BRG1-associated factor 155,Mouse,Mus musculus,Smarcc1,Srg3,SWI_SNF complex 155 kDa subunit,SWI_SNF complex subunit SMARCC1,SWI_SNF-related matrix-associated actin-dependent regulator of
EIAAB38859 BAF170,Baf170,BRG1-associated factor 170,Mouse,Mus musculus,Smarcc2,SWI_SNF complex 170 kDa subunit,SWI_SNF complex subunit SMARCC2,SWI_SNF-related matrix-associated actin-dependent regulator of chrom
H3860 SWI SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B), Bovine, ELISA Kit 96T
H3861 SWI SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B), Human, ELISA Kit 96T
H3862 SWI SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B), Mouse, ELISA Kit 96T
SNF5_CHICK Chicken ELISA Kit FOR SWI per SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 96T
SMCE1_HUMAN Human ELISA Kit FOR SWI per SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 96T
E0848h Human ELISA Kit FOR SWI per SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur