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SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 (60 kDa BRG-1/Brm-associated factor subunit C) (BRG1-associated factor 60C) (BAF60C)

 SMRD3_HUMAN             Reviewed;         483 AA.
Q6STE5; D3DX10; Q2YD86; Q75MJ2; Q75MR8; Q92926; Q9BUH1;
04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
10-OCT-2018, entry version 154.
RecName: Full=SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3;
AltName: Full=60 kDa BRG-1/Brm-associated factor subunit C;
AltName: Full=BRG1-associated factor 60C;
Short=BAF60C;
Name=SMARCD3; Synonyms=BAF60C;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND FUNCTION.
PubMed=8804307; DOI=10.1101/gad.10.17.2117;
Wang W., Xue Y., Zhou S., Kuo A., Cairns B.R., Crabtree G.R.;
"Diversity and specialization of mammalian SWI/SNF complexes.";
Genes Dev. 10:2117-2130(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION,
INTERACTION WITH SMARCA4 AND TRANSCRIPTIONAL ACTIVATORS, AND VARIANT
SER-170.
TISSUE=Adipose tissue;
PubMed=14701856; DOI=10.1074/jbc.M312288200;
Debril M.-B., Gelman L., Fayard E., Annicotte J.-S., Rocchi S.,
Auwerx J.;
"Transcription factors and nuclear receptors interact with the SWI/SNF
complex through the BAF60c subunit.";
J. Biol. Chem. 279:16677-16686(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=12853948; DOI=10.1038/nature01782;
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
Waterston R.H., Wilson R.K.;
"The DNA sequence of human chromosome 7.";
Nature 424:157-164(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Blood, and Uterus;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in
signaling networks.";
Cell 127:635-648(2006).
[7]
IDENTIFICATION IN THE BAF COMPLEX, AND IDENTIFICATION BY MASS
SPECTROMETRY.
PubMed=18765789; DOI=10.1101/gad.471408;
Lange M., Kaynak B., Forster U.B., Toenjes M., Fischer J.J., Grimm C.,
Schlesinger J., Just S., Dunkel I., Krueger T., Mebus S., Lehrach H.,
Lurz R., Gobom J., Rottbauer W., Abdelilah-Seyfried S., Sperling S.;
"Regulation of muscle development by DPF3, a novel histone acetylation
and methylation reader of the BAF chromatin remodeling complex.";
Genes Dev. 22:2370-2384(2008).
[8]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=20068231; DOI=10.1126/scisignal.2000475;
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
Mann M.;
"Quantitative phosphoproteomics reveals widespread full
phosphorylation site occupancy during mitosis.";
Sci. Signal. 3:RA3-RA3(2010).
[9]
ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22814378; DOI=10.1073/pnas.1210303109;
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
Aldabe R.;
"N-terminal acetylome analyses and functional insights of the N-
terminal acetyltransferase NatB.";
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
[10]
REVIEW ON SWI/SNF CHROMATIN REMODELING COMPLEXES.
PubMed=22952240; DOI=10.1074/jbc.R111.309302;
Euskirchen G., Auerbach R.K., Snyder M.;
"SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse
functions.";
J. Biol. Chem. 287:30897-30905(2012).
[11]
REVIEW ON SWI/SNF CHROMATIN REMODELING COMPLEXES.
PubMed=26601204; DOI=10.1126/sciadv.1500447;
Kadoch C., Crabtree G.R.;
"Mammalian SWI/SNF chromatin remodeling complexes and cancer:
Mechanistic insights gained from human genomics.";
Sci. Adv. 1:E1500447-E1500447(2015).
[12]
FUNCTION, AND IDENTIFICATION IN THE GBAF COMPLEX.
PubMed=29374058; DOI=10.1074/jbc.RA117.001065;
Alpsoy A., Dykhuizen E.C.;
"Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its
paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes.";
J. Biol. Chem. 293:3892-3903(2018).
-!- FUNCTION: Involved in transcriptional activation and repression of
select genes by chromatin remodeling (alteration of DNA-nucleosome
topology). Component of SWI/SNF chromatin remodeling complexes
that carry out key enzymatic activities, changing chromatin
structure by altering DNA-histone contacts within a nucleosome in
an ATP-dependent manner. Stimulates nuclear receptor mediated
transcription. Belongs to the neural progenitors-specific
chromatin remodeling complex (npBAF complex) and the neuron-
specific chromatin remodeling complex (nBAF complex). During
neural development a switch from a stem/progenitor to a
postmitotic chromatin remodeling mechanism occurs as neurons exit
the cell cycle and become committed to their adult state. The
transition from proliferating neural stem/progenitor cells to
postmitotic neurons requires a switch in subunit composition of
the npBAF and nBAF complexes. As neural progenitors exit mitosis
and differentiate into neurons, npBAF complexes which contain
ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous
alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits
in neuron-specific complexes (nBAF). The npBAF complex is
essential for the self-renewal/proliferative capacity of the
multipotent neural stem cells. The nBAF complex along with CREST
plays a role regulating the activity of genes essential for
dendrite growth (By similarity). {ECO:0000250|UniProtKB:Q6P9Z1,
ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:8804307,
ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
-!- SUBUNIT: Component of the multiprotein chromatin-remodeling
complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related
complexes. The canonical complex contains a catalytic subunit
(either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least
SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and
SMARCB1/SNF5/BAF47. Other subunits specific to each of the
complexes may also be present permitting several possible
combinations developmentally and tissue specific (Probable).
Component of the BAF complex, which includes at least actin
(ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM,
SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57,
SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more
SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle
cells, the BAF complex also contains DPF3 (PubMed:18765789).
Component of neural progenitors-specific chromatin remodeling
complex (npBAF complex) composed of at least, ARID1A/BAF250A or
ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C,
SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47,
SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A,
ACTL6A/BAF53A and actin. Component of neuron-specific chromatin
remodeling complex (nBAF complex) composed of at least,
ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C,
SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47,
SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B,
DPF3/BAF45C, ACTL6B/BAF53B and actin (By similarity). May be a
component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at
least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A
or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B,
perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170,
PBRM1/BAF180, ARID2/BAF200 and actin (PubMed:22952240,
PubMed:26601204). Interacts with SMARCA4/BRG1/BAF190A
(PubMed:14701856). Component of SWI/SNF (GBAF) subcomplex, which
includes at least BICRA or BICRAL (mutually exclusive), BRD9,
SS18, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53,
SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058). The precise
distribution of the related SMARCD1, SMARCD2 and SMARCD3 proteins
among these and other SWI/SNF nucleosome-remodeling complexes is
not fully known. May allow recruitment of SWI/SNF containing
complexes specifically to promoters where these factors are
located. Also interacts with several nuclear receptors including
PPARG/NR1C3, RXRA/NR1F1, ESR1, NR5A1, NR5A2/LRH1 and other
transcriptional activators including the HLH protein SREBF1/SREBP1
and the homeobox protein PBX1 (PubMed:14701856).
{ECO:0000250|UniProtKB:Q6P9Z1, ECO:0000269|PubMed:14701856,
ECO:0000269|PubMed:18765789, ECO:0000269|PubMed:29374058,
ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
-!- INTERACTION:
P37231:PPARG; NbExp=3; IntAct=EBI-488506, EBI-781384;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14701856}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=BAF60C2;
IsoId=Q6STE5-1; Sequence=Displayed;
Name=2; Synonyms=BAF60C1;
IsoId=Q6STE5-2; Sequence=VSP_012498;
-!- TISSUE SPECIFICITY: Isoform 2 and isoform 1 are expressed in
brain, heart, kidney, placenta, prostate, salivary gland, spleen,
testis, thyroid, trachea and uterus. Isoform 1 is also expressed
in skeletal muscle and adipose tissue.
-!- SIMILARITY: Belongs to the SMARCD family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAC50697.1; Type=Frameshift; Positions=41, 65, 78; Evidence={ECO:0000305};
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EMBL; U66619; AAC50697.1; ALT_FRAME; mRNA.
EMBL; AY450430; AAR88510.1; -; mRNA.
EMBL; AY450431; AAR88511.1; -; mRNA.
EMBL; AC021097; AAS00380.1; -; Genomic_DNA.
EMBL; AC005486; AAS02031.1; -; Genomic_DNA.
EMBL; CH471173; EAW54005.1; -; Genomic_DNA.
EMBL; CH471173; EAW54007.1; -; Genomic_DNA.
EMBL; CH471173; EAW54008.1; -; Genomic_DNA.
EMBL; BC002628; AAH02628.1; -; mRNA.
EMBL; BC110350; AAI10351.1; -; mRNA.
CCDS; CCDS34780.1; -. [Q6STE5-1]
CCDS; CCDS5924.1; -. [Q6STE5-2]
RefSeq; NP_001003801.1; NM_001003801.1. [Q6STE5-1]
RefSeq; NP_001003802.1; NM_001003802.1. [Q6STE5-2]
RefSeq; NP_003069.2; NM_003078.3. [Q6STE5-2]
UniGene; Hs.647067; -.
ProteinModelPortal; Q6STE5; -.
SMR; Q6STE5; -.
BioGrid; 112488; 44.
ComplexPortal; CPX-1164; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant.
ComplexPortal; CPX-1194; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant.
ComplexPortal; CPX-1201; Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant.
ComplexPortal; CPX-1202; Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant.
ComplexPortal; CPX-1204; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant.
ComplexPortal; CPX-1205; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant.
ComplexPortal; CPX-1206; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant.
ComplexPortal; CPX-1207; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant.
ComplexPortal; CPX-1209; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant.
ComplexPortal; CPX-1210; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant.
ComplexPortal; CPX-1211; SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant.
ComplexPortal; CPX-1212; Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant.
ComplexPortal; CPX-1213; Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant.
ComplexPortal; CPX-1215; Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant.
ComplexPortal; CPX-1216; Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant.
ComplexPortal; CPX-1217; Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant.
ComplexPortal; CPX-1218; Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant.
ComplexPortal; CPX-1222; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant.
ComplexPortal; CPX-1223; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant.
ComplexPortal; CPX-1224; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant.
ComplexPortal; CPX-1225; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant.
ComplexPortal; CPX-1226; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant.
ComplexPortal; CPX-1227; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant.
ComplexPortal; CPX-1228; Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant.
CORUM; Q6STE5; -.
DIP; DIP-33012N; -.
IntAct; Q6STE5; 19.
STRING; 9606.ENSP00000262188; -.
iPTMnet; Q6STE5; -.
PhosphoSitePlus; Q6STE5; -.
BioMuta; SMARCD3; -.
DMDM; 57013057; -.
EPD; Q6STE5; -.
MaxQB; Q6STE5; -.
PaxDb; Q6STE5; -.
PeptideAtlas; Q6STE5; -.
PRIDE; Q6STE5; -.
ProteomicsDB; 67360; -.
ProteomicsDB; 67361; -. [Q6STE5-2]
DNASU; 6604; -.
Ensembl; ENST00000262188; ENSP00000262188; ENSG00000082014. [Q6STE5-1]
Ensembl; ENST00000356800; ENSP00000349254; ENSG00000082014. [Q6STE5-2]
Ensembl; ENST00000392811; ENSP00000376558; ENSG00000082014. [Q6STE5-2]
GeneID; 6604; -.
KEGG; hsa:6604; -.
UCSC; uc003wjs.4; human. [Q6STE5-1]
CTD; 6604; -.
DisGeNET; 6604; -.
EuPathDB; HostDB:ENSG00000082014.16; -.
GeneCards; SMARCD3; -.
HGNC; HGNC:11108; SMARCD3.
HPA; HPA063955; -.
HPA; HPA065517; -.
MIM; 601737; gene.
neXtProt; NX_Q6STE5; -.
OpenTargets; ENSG00000082014; -.
PharmGKB; PA35958; -.
eggNOG; KOG2570; Eukaryota.
eggNOG; COG5531; LUCA.
GeneTree; ENSGT00390000017809; -.
HOVERGEN; HBG054046; -.
InParanoid; Q6STE5; -.
KO; K11650; -.
OMA; RAAFYHE; -.
OrthoDB; EOG091G06WW; -.
PhylomeDB; Q6STE5; -.
TreeFam; TF106486; -.
Reactome; R-HSA-1368082; RORA activates gene expression.
Reactome; R-HSA-1368108; BMAL1:CLOCK,NPAS2 activates circadian gene expression.
Reactome; R-HSA-1989781; PPARA activates gene expression.
Reactome; R-HSA-2151201; Transcriptional activation of mitochondrial biogenesis.
Reactome; R-HSA-2426168; Activation of gene expression by SREBF (SREBP).
Reactome; R-HSA-3214858; RMTs methylate histone arginines.
Reactome; R-HSA-381340; Transcriptional regulation of white adipocyte differentiation.
Reactome; R-HSA-400206; Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
Reactome; R-HSA-400253; Circadian Clock.
Reactome; R-HSA-8939243; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.
SIGNOR; Q6STE5; -.
ChiTaRS; SMARCD3; human.
GeneWiki; SMARCD3; -.
GenomeRNAi; 6604; -.
PRO; PR:Q6STE5; -.
Proteomes; UP000005640; Chromosome 7.
Bgee; ENSG00000082014; Expressed in 217 organ(s), highest expression level in nucleus accumbens.
CleanEx; HS_SMARCD3; -.
ExpressionAtlas; Q6STE5; baseline and differential.
Genevisible; Q6STE5; HS.
GO; GO:0005737; C:cytoplasm; IDA:BHF-UCL.
GO; GO:0071565; C:nBAF complex; ISS:UniProtKB.
GO; GO:0071564; C:npBAF complex; IDA:BHF-UCL.
GO; GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0005634; C:nucleus; IDA:BHF-UCL.
GO; GO:0016514; C:SWI/SNF complex; IDA:BHF-UCL.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0035257; F:nuclear hormone receptor binding; IPI:UniProtKB.
GO; GO:0016922; F:nuclear receptor binding; IPI:BHF-UCL.
GO; GO:0030374; F:nuclear receptor transcription coactivator activity; IMP:BHF-UCL.
GO; GO:0005102; F:signaling receptor binding; IPI:UniProtKB.
GO; GO:0003713; F:transcription coactivator activity; NAS:BHF-UCL.
GO; GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO; GO:0003219; P:cardiac right ventricle formation; IEA:Ensembl.
GO; GO:0006338; P:chromatin remodeling; IDA:BHF-UCL.
GO; GO:0042692; P:muscle cell differentiation; IEA:Ensembl.
GO; GO:0003407; P:neural retina development; IEP:BHF-UCL.
GO; GO:0006337; P:nucleosome disassembly; IDA:BHF-UCL.
GO; GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
GO; GO:0002052; P:positive regulation of neuroblast proliferation; IDA:BHF-UCL.
GO; GO:0051152; P:positive regulation of smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0019216; P:regulation of lipid metabolic process; TAS:Reactome.
GO; GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:BHF-UCL.
GO; GO:0003139; P:secondary heart field specification; IEA:Ensembl.
GO; GO:0006351; P:transcription, DNA-templated; IDA:UniProtKB.
Gene3D; 1.10.245.10; -; 1.
InterPro; IPR038043; SMARCD3.
InterPro; IPR019835; SWIB_domain.
InterPro; IPR036885; SWIB_MDM2_dom_sf.
InterPro; IPR003121; SWIB_MDM2_domain.
PANTHER; PTHR13844:SF5; PTHR13844:SF5; 1.
Pfam; PF02201; SWIB; 1.
SMART; SM00151; SWIB; 1.
SUPFAM; SSF47592; SSF47592; 1.
1: Evidence at protein level;
Acetylation; Alternative splicing; Chromatin regulator;
Complete proteome; Neurogenesis; Nucleus; Phosphoprotein;
Polymorphism; Reference proteome; Transcription;
Transcription regulation.
INIT_MET 1 1 Removed. {ECO:0000244|PubMed:22814378}.
CHAIN 2 483 SWI/SNF-related matrix-associated actin-
dependent regulator of chromatin
subfamily D member 3.
/FTId=PRO_0000071988.
DOMAIN 259 334 SWIB.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000244|PubMed:22814378}.
MOD_RES 178 178 Phosphoserine.
{ECO:0000244|PubMed:17081983}.
VAR_SEQ 1 26 MAADEVAGGARKATKSKLFEFLVHGV -> MTPGLQHPPTV
VQ (in isoform 2).
{ECO:0000303|PubMed:14701856,
ECO:0000303|PubMed:15489334,
ECO:0000303|PubMed:8804307}.
/FTId=VSP_012498.
VARIANT 170 170 P -> S (in dbSNP:rs1050101).
{ECO:0000269|PubMed:14701856}.
/FTId=VAR_020884.
CONFLICT 88 88 V -> E (in Ref. 1; AAC50697).
{ECO:0000305}.
CONFLICT 140 140 R -> G (in Ref. 1; AAC50697).
{ECO:0000305}.
CONFLICT 387 387 A -> P (in Ref. 1; AAC50697).
{ECO:0000305}.
SEQUENCE 483 AA; 55016 MW; B7B28DD11DCD0B5C CRC64;
MAADEVAGGA RKATKSKLFE FLVHGVRPGM PSGARMPHQG APMGPPGSPY MGSPAVRPGL
APAGMEPARK RAAPPPGQSQ AQSQGQPVPT APARSRSAKR RKMADKILPQ RIRELVPESQ
AYMDLLAFER KLDQTIMRKR VDIQEALKRP MKQKRKLRLY ISNTFNPAKP DAEDSDGSIA
SWELRVEGKL LDDPSKQKRK FSSFFKSLVI ELDKDLYGPD NHLVEWHRTP TTQETDGFQV
KRPGDLSVRC TLLLMLDYQP PQFKLDPRLA RLLGLHTQSR SAIVQALWQY VKTNRLQDSH
DKEYINGDKY FQQIFDCPRL KFSEIPQRLT ALLLPPDPIV INHVISVDPS DQKKTACYDI
DVEVEEPLKG QMSSFLLSTA NQQEISALDS KIHETIESIN QLKIQRDFML SFSRDPKGYV
QDLLRSQSRD LKVMTDVAGN PEEERRAEFY HQPWSQEAVS RYFYCKIQQR RQELEQSLVV
RNT


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