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Salt-mediated killer protoxin 1 [Cleaved into: Salt-mediated killer toxin 1 alpha chain (SMK toxin alpha chain); Salt-mediated killer toxin 1 gamma chain (SMK toxin gamma chain); Salt-mediated killer toxin 1 beta chain (SMK toxin beta chain)]

 TOXK_MILFA              Reviewed;         222 AA.
P19972;
01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
29-AUG-2001, sequence version 4.
28-MAR-2018, entry version 83.
RecName: Full=Salt-mediated killer protoxin 1;
Contains:
RecName: Full=Salt-mediated killer toxin 1 alpha chain;
Short=SMK toxin alpha chain;
Contains:
RecName: Full=Salt-mediated killer toxin 1 gamma chain;
Short=SMK toxin gamma chain;
Contains:
RecName: Full=Salt-mediated killer toxin 1 beta chain;
Short=SMK toxin beta chain;
Flags: Precursor;
Name=SMK1;
Millerozyma farinosa (Yeast) (Pichia farinosa).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Millerozyma.
NCBI_TaxID=4920;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
STRAIN=KK1;
PubMed=8300637;
Suzuki C., Nikkuni S.;
"The primary and subunit structure of a novel type killer toxin
produced by a halotolerant yeast, Pichia farinosa.";
J. Biol. Chem. 269:3041-3046(1994).
[2]
SEQUENCE REVISION TO 87; 137; 162; 167 AND 206.
Suzuki C., Nikkuni S.;
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
[3]
PRELIMINARY PROTEIN SEQUENCE OF 146-167.
STRAIN=KK1;
Suzuki C., Nikkuni S.;
"Purification and properties of the killer toxin produced by a
halotolerant yeast, Pichia farinosa.";
Agric. Biol. Chem. 53:2599-2604(1989).
[4]
X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
STRAIN=KK1;
PubMed=9016714; DOI=10.1016/S0969-2126(97)00168-8;
Kashiwagi T., Kunishima N., Suzuki C., Tsuchiya F., Nikkuni S.,
Arata Y., Morikawa K.;
"The novel acidophilic structure of the killer toxin from halotolerant
yeast demonstrates remarkable folding similarity with a fungal killer
toxin.";
Structure 5:81-94(1997).
-!- FUNCTION: This toxin kills sensitive strains of yeast.
-!- SUBUNIT: Heterodimer of an alpha and a beta chain. The fate of the
gamma chain is unknown.
-!- MISCELLANEOUS: The full activity of this toxin depends on NaCl or
KCL. Its maximum activity is found at 2M salt solution.
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EMBL; D14538; BAA03405.2; -; Genomic_DNA.
PIR; A49995; A49995.
PIR; PQ0007; PQ0007.
PDB; 1KVD; X-ray; 1.80 A; A/C=19-81, B/D=146-222.
PDB; 1KVE; X-ray; 1.80 A; A/C=19-81, B/D=146-222.
PDBsum; 1KVD; -.
PDBsum; 1KVE; -.
DisProt; DP00180; -.
ProteinModelPortal; P19972; -.
SMR; P19972; -.
EvolutionaryTrace; P19972; -.
GO; GO:0005576; C:extracellular region; IEA:InterPro.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
GO; GO:0008219; P:cell death; IDA:CAFA.
GO; GO:0009405; P:pathogenesis; IDA:CAFA.
CDD; cd12839; Killer_toxin_beta; 1.
Gene3D; 3.30.44.10; -; 1.
Gene3D; 4.10.420.10; -; 1.
InterPro; IPR011329; Killer_tox_Kp4/SMK.
InterPro; IPR011327; Killer_tox_SMK_b.
InterPro; IPR038431; Killer_tox_SMK_b_sf.
InterPro; IPR011328; SMK_a.
SUPFAM; SSF55221; SSF55221; 2.
1: Evidence at protein level;
3D-structure; Cleavage on pair of basic residues;
Direct protein sequencing; Disulfide bond; Glycoprotein; Signal;
Toxin.
SIGNAL 1 18
CHAIN 19 81 Salt-mediated killer toxin 1 alpha chain.
/FTId=PRO_0000022565.
CHAIN 82 145 Salt-mediated killer toxin 1 gamma chain.
/FTId=PRO_0000022566.
CHAIN 146 222 Salt-mediated killer toxin 1 beta chain.
/FTId=PRO_0000022567.
CARBOHYD 127 127 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 37 53
DISULFID 190 219
STRAND 20 28 {ECO:0000244|PDB:1KVD}.
HELIX 43 45 {ECO:0000244|PDB:1KVE}.
HELIX 49 71 {ECO:0000244|PDB:1KVD}.
STRAND 75 80 {ECO:0000244|PDB:1KVD}.
STRAND 150 159 {ECO:0000244|PDB:1KVD}.
HELIX 167 180 {ECO:0000244|PDB:1KVD}.
TURN 181 184 {ECO:0000244|PDB:1KVD}.
STRAND 187 195 {ECO:0000244|PDB:1KVD}.
STRAND 198 207 {ECO:0000244|PDB:1KVD}.
SEQUENCE 222 AA; 23000 MW; B1954761060FE24B CRC64;
MRKETLIGLA FITANVIAWS LRWRMQKSTT IAAIAGCSGA ATFGGLAGGI VGCIAAGILA
ILQGFEVNWH NGGGGDRSNP VKRSSDSFSI VNHNGEKVDS YAHLVPGKVG KVIIDNIELS
AIRYANNHTS LGYHFTSDGS GPAARGEATT IWGVGADEAI DKGTPSKNDL QNMSADLAKN
GFKGHQGVAC STVKDGNKDV YMIKFSLAGG SNDPGGSPCS DD


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