Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2 )-ATPase 1) (EC 3.6.3.8) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2 ) ATPase)

 AT2A1_PELES             Reviewed;         994 AA.
Q92105;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
28-FEB-2018, entry version 126.
RecName: Full=Sarcoplasmic/endoplasmic reticulum calcium ATPase 1;
Short=SERCA1;
Short=SR Ca(2+)-ATPase 1;
EC=3.6.3.8;
AltName: Full=Calcium pump 1;
AltName: Full=Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform;
AltName: Full=Endoplasmic reticulum class 1/2 Ca(2+) ATPase;
Name=ATP2A1;
Pelophylax esculentus (Edible frog) (Rana esculenta).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae;
Pelophylax.
NCBI_TaxID=8401;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Fast-twitch skeletal muscle;
PubMed=1386027; DOI=10.1016/0014-5793(92)81003-5;
Vilsen B., Andersen J.P.;
"Deduced amino acid sequence and E1-E2 equilibrium of the sarcoplasmic
reticulum Ca(2+)-ATPase of frog skeletal muscle. Comparison with the
Ca(2+)-ATPase of rabbit fast twitch muscle.";
FEBS Lett. 306:213-218(1992).
-!- FUNCTION: Key regulator of striated muscle performance by acting
as the major Ca(2+) ATPase responsible for the reuptake of
cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the
hydrolysis of ATP coupled with the translocation of calcium from
the cytosol to the sarcoplasmic reticulum lumen. Contributes to
calcium sequestration involved in muscular excitation/contraction.
{ECO:0000250|UniProtKB:Q8R429}.
-!- CATALYTIC ACTIVITY: ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate
+ Ca(2+)(Side 2).
-!- ENZYME REGULATION: Inhibited by sarcolipin (SLN), phospholamban
(PLN) and myoregulin (MRLN) (By similarity). Enhanced by DWORF;
DWORF increases activity by displacing sarcolipin (SLN),
phospholamban (PLN) and myoregulin (MRLN) (By similarity).
{ECO:0000250|UniProtKB:P04191, ECO:0000250|UniProtKB:Q8R429}.
-!- SUBUNIT: Interacts with sarcolipin (SLN) (By similarity).
Interacts with phospholamban (PLN) (By similarity). Interacts with
myoregulin (MRLN). Interacts with DWORF (By similarity).
{ECO:0000250|UniProtKB:Q8R429}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000250|UniProtKB:P04191}; Multi-pass membrane protein
{ECO:0000255}. Sarcoplasmic reticulum membrane
{ECO:0000250|UniProtKB:P04191}; Multi-pass membrane protein
{ECO:0000255}.
-!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC
3.A.3) family. Type IIA subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; X63009; CAA44737.1; -; mRNA.
PIR; S24359; S24359.
ProteinModelPortal; Q92105; -.
SMR; Q92105; -.
PRIDE; Q92105; -.
HOVERGEN; HBG105648; -.
GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISS:UniProtKB.
GO; GO:0031673; C:H zone; ISS:UniProtKB.
GO; GO:0031674; C:I band; ISS:UniProtKB.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; ISS:UniProtKB.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
GO; GO:0016529; C:sarcoplasmic reticulum; ISS:UniProtKB.
GO; GO:0033017; C:sarcoplasmic reticulum membrane; ISS:UniProtKB.
GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
GO; GO:0016887; F:ATPase activity; ISS:UniProtKB.
GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
GO; GO:0005388; F:calcium-transporting ATPase activity; ISS:UniProtKB.
GO; GO:0006816; P:calcium ion transport; ISS:UniProtKB.
GO; GO:0045988; P:negative regulation of striated muscle contraction; ISS:UniProtKB.
GO; GO:0031448; P:positive regulation of fast-twitch skeletal muscle fiber contraction; ISS:UniProtKB.
GO; GO:0006942; P:regulation of striated muscle contraction; ISS:UniProtKB.
Gene3D; 3.40.1110.10; -; 1.
Gene3D; 3.40.50.1000; -; 2.
InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
InterPro; IPR018303; ATPase_P-typ_P_site.
InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
InterPro; IPR036412; HAD-like_sf.
InterPro; IPR023214; HAD_sf.
InterPro; IPR005782; P-type_ATPase_IIA.
InterPro; IPR001757; P_typ_ATPase.
Pfam; PF00689; Cation_ATPase_C; 1.
Pfam; PF00690; Cation_ATPase_N; 1.
PRINTS; PR00120; HATPASE.
SMART; SM00831; Cation_ATPase_N; 1.
SUPFAM; SSF56784; SSF56784; 1.
SUPFAM; SSF81653; SSF81653; 1.
SUPFAM; SSF81660; SSF81660; 1.
SUPFAM; SSF81665; SSF81665; 3.
TIGRFAMs; TIGR01116; ATPase-IIA1_Ca; 1.
TIGRFAMs; TIGR01494; ATPase_P-type; 2.
PROSITE; PS00154; ATPASE_E1_E2; 1.
2: Evidence at transcript level;
ATP-binding; Calcium; Calcium transport; Disulfide bond;
Endoplasmic reticulum; Hydrolase; Ion transport; Magnesium; Membrane;
Metal-binding; Nucleotide-binding; Phosphoprotein;
Sarcoplasmic reticulum; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 994 Sarcoplasmic/endoplasmic reticulum
calcium ATPase 1.
/FTId=PRO_0000046193.
TOPO_DOM 1 48 Cytoplasmic. {ECO:0000250}.
TRANSMEM 49 69 Helical; Name=1. {ECO:0000250}.
TOPO_DOM 70 89 Lumenal. {ECO:0000250}.
TRANSMEM 90 110 Helical; Name=2. {ECO:0000250}.
TOPO_DOM 111 253 Cytoplasmic. {ECO:0000250}.
TRANSMEM 254 273 Helical; Name=3. {ECO:0000250}.
TOPO_DOM 274 295 Lumenal. {ECO:0000250}.
TRANSMEM 296 313 Helical; Name=4. {ECO:0000250}.
TOPO_DOM 314 757 Cytoplasmic. {ECO:0000250}.
TRANSMEM 758 777 Helical; Name=5. {ECO:0000250}.
TOPO_DOM 778 787 Lumenal. {ECO:0000250}.
TRANSMEM 788 808 Helical; Name=6. {ECO:0000250}.
TOPO_DOM 809 828 Cytoplasmic. {ECO:0000250}.
TRANSMEM 829 851 Helical; Name=7. {ECO:0000250}.
TOPO_DOM 852 897 Lumenal. {ECO:0000250}.
TRANSMEM 898 917 Helical; Name=8. {ECO:0000250}.
TOPO_DOM 918 930 Cytoplasmic. {ECO:0000250}.
TRANSMEM 931 949 Helical; Name=9. {ECO:0000250}.
TOPO_DOM 950 964 Lumenal. {ECO:0000250}.
TRANSMEM 965 985 Helical; Name=10. {ECO:0000250}.
TOPO_DOM 986 994 Cytoplasmic. {ECO:0000250}.
REGION 370 400 Interaction with phospholamban 1.
{ECO:0000250|UniProtKB:P04191}.
REGION 788 808 Interaction with phospholamban 2.
{ECO:0000250|UniProtKB:P04191}.
ACT_SITE 351 351 4-aspartylphosphate intermediate.
{ECO:0000250|UniProtKB:P04191}.
METAL 304 304 Calcium 2; via carbonyl oxygen.
{ECO:0000250|UniProtKB:P04191}.
METAL 305 305 Calcium 2; via carbonyl oxygen.
{ECO:0000250|UniProtKB:P04191}.
METAL 307 307 Calcium 2; via carbonyl oxygen.
{ECO:0000250|UniProtKB:P04191}.
METAL 309 309 Calcium 2.
{ECO:0000250|UniProtKB:P04191}.
METAL 703 703 Magnesium. {ECO:0000250}.
METAL 707 707 Magnesium. {ECO:0000250}.
METAL 768 768 Calcium 1.
{ECO:0000250|UniProtKB:P04191}.
METAL 771 771 Calcium 1.
{ECO:0000250|UniProtKB:P04191}.
METAL 796 796 Calcium 2.
{ECO:0000250|UniProtKB:P04191}.
METAL 799 799 Calcium 1.
{ECO:0000250|UniProtKB:P04191}.
METAL 800 800 Calcium 1.
{ECO:0000250|UniProtKB:P04191}.
METAL 800 800 Calcium 2.
{ECO:0000250|UniProtKB:P04191}.
METAL 908 908 Calcium 1.
{ECO:0000250|UniProtKB:P04191}.
DISULFID 876 888 {ECO:0000250}.
SEQUENCE 994 AA; 109288 MW; 71ECBD003E4498A7 CRC64;
MEQAHTKTTE ECLAYFGVNE NTGLSLDQVK KNFDKFGPNE LPAEEGKSLW ELVAEQFEDL
LVRILLLAAI ISFVLAWFEE GEETVTAFVE PFVILLILIA NAVVGVWQER NAEDAIEALK
EYEPEMGKVY RSDRKSVQRI KARELVPGDI VEVAVGDKVP ADIRLISIKS TTLRIDQSIL
TGESVSVIKH TEVVPDTRAV NQDKKNMLFS GTNVGAGKAV GVVIATGPNT EIGKIRDEMA
ATEQEKTPLQ QKLDEFGEQL SKVISLICVA VWLINIGHFN DPIHGGSWIK GAIYYFKIAV
ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ
MSVCRMFVID KVEGDVTSLN EFTITGSTYA PEGDVQKNDK NVKAGQYDGL VELATICALC
NDSSLDFNES KGVFEKVGEA TETALTTLVE KMNVFNTDVK SLSKVERANA CNSVIKQLMK
KEFTLEFSRD RKSMSVYCIP AKASRAAVGN KMFVKGAPEG VIDRCNYVRV GTTRVPLTSA
IKDKILSVVK EWGTGRDTLR CLALATRDTP PKREDMVLDE ATRFIEYETD LTFVGCVGML
DPPRKEVMGS IQLCREAGIR VIMITGDNKG TAIAICRRIG IFGEDDDVSG RAFTGREFDD
LPPAEQREAC KRASCFARVE PAHKSKIVEF LQSFDEITAM TGDGVNDAPA LKKAEIGIAM
GSGTAVAKTA SEMVLADDNF STIVAAVEEG RAIYNNMKQF IRYLISSNVG EVVCIFLTAA
LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMDRP PRSPKEPLIS GWLFFRYMAI
GGYVGAATVG AAAWWFMYAD DGPNVTFYQL SHFMQCTEDN PDFEGHECEI FESPVPMTMA
LSVLVTIEMC NALNSLSENQ SLIRMPPWSN FWLLGSICLS MSLHFLILYV EPLPMIFKLT
PLNVEQWFIV LKMSFPVILL DELLKFVARN YLEG


Related products :

Catalog number Product name Quantity
E10923h Dog ELISA Kit FOR Sarcoplasmic per endoplasmic reticulum calcium ATPase 2 96T
AT2A2_PIG Pig ELISA Kit FOR Sarcoplasmic per endoplasmic reticulum calcium ATPase 2 96T
ER547 Sarcoplasmic per endoplasmic reticulum calcium ATPase 1 Elisa Kit 96T
ER700 Sarcoplasmic per endoplasmic reticulum calcium ATPase 3 Elisa Kit 96T
EH2456 Sarcoplasmic per endoplasmic reticulum calcium ATPase 3 Elisa Kit 96T
G8948 Sarcoplasmic endoplasmic reticulum calcium ATPase 3 (ATP2A3), Rat, ELISA Kit 96T
G8947 Sarcoplasmic endoplasmic reticulum calcium ATPase 3 (ATP2A3), Pig, ELISA Kit 96T
G8943 Sarcoplasmic endoplasmic reticulum calcium ATPase 2 (ATP2A2), Rat, ELISA Kit 96T
G8941 Sarcoplasmic endoplasmic reticulum calcium ATPase 2 (ATP2A2), Pig, ELISA Kit 96T
G8938 Sarcoplasmic endoplasmic reticulum calcium ATPase 2 (ATP2A2), Dog, ELISA Kit 96T
G8936 Sarcoplasmic endoplasmic reticulum calcium ATPase 2 (ATP2A2), Cat, ELISA Kit 96T
AT2A2_CHICK Chicken ELISA Kit FOR Sarcoplasmic per endoplasmic reticulum calcium ATPase 2 96T
G8935 Sarcoplasmic endoplasmic reticulum calcium ATPase 1 (ATP2A1), Rat, ELISA Kit 96T
E1077h Mouse ELISA Kit FOR Sarcoplasmic per endoplasmic reticulum calcium ATPase 2 96T
G8930 Sarcoplasmic endoplasmic reticulum calcium ATPase 1 (ATP2A1), Bovine, ELISA Kit 96T
G8942 Sarcoplasmic endoplasmic reticulum calcium ATPase 2 (ATP2A2), Rabbit, ELISA Kit 96T
G8931 Sarcoplasmic endoplasmic reticulum calcium ATPase 1 (ATP2A1), Chicken, ELISA Kit 96T
G8946 Sarcoplasmic endoplasmic reticulum calcium ATPase 3 (ATP2A3), Mouse, ELISA Kit 96T
G8945 Sarcoplasmic endoplasmic reticulum calcium ATPase 3 (ATP2A3), Human, ELISA Kit 96T
G8944 Sarcoplasmic endoplasmic reticulum calcium ATPase 3 (ATP2A3), Chicken, ELISA Kit 96T
G8932 Sarcoplasmic endoplasmic reticulum calcium ATPase 1 (ATP2A1), Human, ELISA Kit 96T
G8933 Sarcoplasmic endoplasmic reticulum calcium ATPase 1 (ATP2A1), Mouse, ELISA Kit 96T
G8934 Sarcoplasmic endoplasmic reticulum calcium ATPase 1 (ATP2A1), Rabbit, ELISA Kit 96T
G8940 Sarcoplasmic endoplasmic reticulum calcium ATPase 2 (ATP2A2), Mouse, ELISA Kit 96T
G8939 Sarcoplasmic endoplasmic reticulum calcium ATPase 2 (ATP2A2), Human, ELISA Kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur