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Sarcosine oxidase subunit beta (Sarcosine oxidase subunit B) (EC 1.5.3.1)

 SOXB_CORS1              Reviewed;         405 AA.
P40875; Q46335;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 2.
28-FEB-2018, entry version 96.
RecName: Full=Sarcosine oxidase subunit beta;
Short=Sarcosine oxidase subunit B;
EC=1.5.3.1;
Name=soxB;
Corynebacterium sp. (strain P-1).
Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
Corynebacterium.
NCBI_TaxID=69006;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-36.
PubMed=7543100; DOI=10.1074/jbc.270.31.18252;
Chlumsky L.J., Zhang L., Jorns M.S.;
"Sequence analysis of sarcosine oxidase and nearby genes reveals
homologies with key enzymes of folate one-carbon metabolism.";
J. Biol. Chem. 270:18252-18259(1995).
[2]
PROTEIN SEQUENCE OF 161-187 AND 334-404.
STRAIN=U-96;
PubMed=1939012;
Suzuki H., Kawamura-Konishi Y.;
"Cysteine residues in the active site of Corynebacterium sarcosine
oxidase.";
J. Biochem. 109:909-917(1991).
[3]
PARTIAL PROTEIN SEQUENCE.
STRAIN=U-96;
PubMed=3202887;
Suzuki H., Kawamura-Konishi Y.;
"Presence of AMP binding sequence in subunit B of Corynebacterium
sarcosine oxidase.";
Biochem. Int. 17:577-583(1988).
[4]
CHARACTERIZATION, AND MUTAGENESIS OF HIS-175.
PubMed=7692961; DOI=10.1021/bi00092a024;
Chlumsky L.J., Zhang L., Ramsey A.J., Jorns M.S.;
"Preparation and properties of recombinant corynebacterial sarcosine
oxidase: evidence for posttranslational modification during turnover
with sarcosine.";
Biochemistry 32:11132-11142(1993).
[5]
FMN-BINDING.
PubMed=8611516; DOI=10.1021/bi952995h;
Willie A., Edmondson D.E., Jorns M.S.;
"Sarcosine oxidase contains a novel covalently bound FMN.";
Biochemistry 35:5292-5299(1996).
[6]
PROTEIN SEQUENCE OF 174-178, FMN-BINDING AT HIS-173, AND
IDENTIFICATION BY MASS SPECTROMETRY.
PubMed=9485355; DOI=10.1021/bi972705s;
Chlumsky L.J., Sturgess A.W., Nieves E., Jorns M.S.;
"Identification of the covalent flavin attachment site in sarcosine
oxidase.";
Biochemistry 37:2089-2095(1998).
[7]
PROTEIN SEQUENCE OF 174-178, FMN-BINDING AT HIS-173, AND
IDENTIFICATION BY MASS SPECTROMETRY.
PubMed=11902668; DOI=10.1023/A:1014135216860;
Mukouyama E.B., Ohsawa H., Suzuki H.;
"Cofactors in sarcosine oxidase from Corynebacterium sp. U-96.";
J. Protein Chem. 21:59-64(2002).
-!- FUNCTION: Catalyzes the oxidative demethylation of sarcosine to
yield glycine, hydrogen peroxide and 5,10-
methylenetetrahydrofolate.
-!- CATALYTIC ACTIVITY: Sarcosine + H(2)O + O(2) = glycine +
formaldehyde + H(2)O(2).
-!- COFACTOR:
Name=FAD; Xref=ChEBI:CHEBI:57692;
Note=Binds 1 FAD per subunit.;
-!- COFACTOR:
Name=FMN; Xref=ChEBI:CHEBI:58210;
Note=Binds 1 FMN covalently.;
-!- SUBUNIT: Heterotetramer (SoxA, SoxB, SoxG and SoxD).
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- SIMILARITY: Belongs to the SoxB family. {ECO:0000305}.
-----------------------------------------------------------------------
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-----------------------------------------------------------------------
EMBL; U23955; AAC43459.1; -; Genomic_DNA.
PIR; PX0049; PX0049.
ProteinModelPortal; P40875; -.
SMR; P40875; -.
BioCyc; MetaCyc:MONOMER-8522; -.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0008115; F:sarcosine oxidase activity; IEA:UniProtKB-EC.
GO; GO:0046653; P:tetrahydrofolate metabolic process; IEA:InterPro.
Gene3D; 3.50.50.60; -; 3.
InterPro; IPR006076; FAD-dep_OxRdtase.
InterPro; IPR036188; FAD/NAD-bd_sf.
InterPro; IPR006278; SoxB.
Pfam; PF01266; DAO; 1.
SUPFAM; SSF51905; SSF51905; 2.
TIGRFAMs; TIGR01373; soxB; 1.
1: Evidence at protein level;
Cytoplasm; Direct protein sequencing; FAD; Flavoprotein; FMN;
Oxidoreductase.
INIT_MET 1 1 Removed. {ECO:0000269|PubMed:7543100}.
CHAIN 2 405 Sarcosine oxidase subunit beta.
/FTId=PRO_0000072044.
REGION 23 53 ADP binding. {ECO:0000255}.
MOD_RES 173 173 Tele-8alpha-FMN histidine.
VARIANT 167 167 R -> Y (in strain: U-96).
VARIANT 172 173 KH -> CK (in strain: U-96).
VARIANT 178 178 W -> T (in strain: U-96).
VARIANT 182 182 R -> N (in strain: U-96).
VARIANT 359 359 K -> FC (in strain: U-96).
VARIANT 366 366 F -> Y (in strain: U-96).
VARIANT 370 370 H -> E (in strain: U-96).
VARIANT 374 374 N -> A (in strain: U-96).
VARIANT 377 379 AHA -> PKK (in strain: U-96).
VARIANT 385 385 S -> A (in strain: U-96).
MUTAGEN 175 175 H->A: No effect on FMN binding.
{ECO:0000269|PubMed:7692961}.
SEQUENCE 405 AA; 43987 MW; 401141810BA60CDE CRC64;
MADLLPEHPE FLWANPEPKK SYDVVIVGGG GHGLATAYYL AKNHGITNVA VLEKGWLAGG
NMARNTTIIR SNYLWDESAG IYEKSLKLWE QLPEELDYDF LFSQRGVLNL AHTLGDVRES
VRRVEANKFN GVDAEWLTPE QVKEVCPIIN IGDDIRYPVM GATYQPRAGI AKHDHVAWAF
ARKANEMGVD IIQNCEVTGF LKDGEKVTGV KTTRGTIHAG KVALAGAGHS SVLAELAGFE
LPIQSHPLQA LVSELFEPVH PTVVMSNHIH VYVSQAHKGE LVMGAGIDSY NGYGQRGAFH
VIEEQMAAAV ELFPIFARAH VLRTWGGIVD TTMDASPIIS KTPIQNLYVN CGWGTGGFKG
TPGAGFTLAH TIANDEAHAL NAPFSLERFE TGHLIDEHGA AAVAH


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