Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Sarcospan (K-ras oncogene-associated protein) (Kirsten-ras-associated protein)

 SSPN_HUMAN              Reviewed;         243 AA.
Q14714; B3KS67;
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 3.
28-FEB-2018, entry version 143.
RecName: Full=Sarcospan;
AltName: Full=K-ras oncogene-associated protein;
AltName: Full=Kirsten-ras-associated protein;
Name=SSPN; Synonyms=KRAG;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
TISSUE=Skeletal muscle;
PubMed=9395445; DOI=10.1074/jbc.272.50.31221;
Crosbie R.H., Heighway J., Venzke D.P., Lee J.C., Campbell K.P.;
"Sarcospan, the 25-kDa transmembrane component of the dystrophin-
glycoprotein complex.";
J. Biol. Chem. 272:31221-31224(1997).
[2]
SEQUENCE REVISION.
Crosbie R.H., Heighway J., Venzke D.P., Campbell K.P.;
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
TISSUE=Spleen;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16541075; DOI=10.1038/nature04569;
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M.,
Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B.,
Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D.,
Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z.,
Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H.,
Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H.,
Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V.,
Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J.,
Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A.,
Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M.,
Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E.,
Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M.,
Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R.,
Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J.,
Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C.,
Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M.,
Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M.,
Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P.,
Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L.,
Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E.,
Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C.,
Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F.,
Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M.,
Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S.,
Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D.,
Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I.,
Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T.,
Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S.,
Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D.,
Kucherlapati R., Weinstock G., Gibbs R.A.;
"The finished DNA sequence of human chromosome 12.";
Nature 440:346-351(2006).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Testis;
PubMed=11230166; DOI=10.1101/gr.GR1547R;
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
Wambutt R., Korn B., Klein M., Poustka A.;
"Towards a catalog of human genes and proteins: sequencing and
analysis of 500 novel complete protein coding human cDNAs.";
Genome Res. 11:422-435(2001).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Eye;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
NUCLEOTIDE SEQUENCE [MRNA] OF 27-243 (ISOFORM 1).
TISSUE=Brain, and Lung;
PubMed=8661122; DOI=10.1006/geno.1996.0340;
Heighway J., Betticher D.C., Hoban P.R., Altermatt H.J., Cowen R.;
"Coamplification in tumors of KRAS2, type 2 inositol 1,4,5
triphosphate receptor gene, and a novel human gene, KRAG.";
Genomics 35:207-214(1996).
-!- FUNCTION: Component of the dystrophin-glycoprotein complex (DGC),
a complex that spans the muscle plasma membrane and forms a link
between the F-actin cytoskeleton and the extracellular matrix.
Preferentially associates with the sarcoglycan subcomplex of the
DGC.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}. Cell membrane, sarcolemma
{ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane
{ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Note=Also found in myotendinous junctions and in the postsynaptic
membrane of neuromuscular junctions. {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1; Synonyms=SPN1;
IsoId=Q14714-1; Sequence=Displayed;
Name=2; Synonyms=SPN2;
IsoId=Q14714-2; Sequence=VSP_004431;
Name=3;
IsoId=Q14714-3; Sequence=VSP_046351;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Isoform 1 is expressed exclusively in heart
and skeletal muscle. Isoform 2 is expressed in heart, skeletal
muscle, thymus, prostate, testis, ovary, small intestine, colon
and spleen.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AF016028; AAC61660.2; -; mRNA.
EMBL; AL136756; CAB66690.1; -; mRNA.
EMBL; AK092925; BAG52629.1; -; mRNA.
EMBL; AC022509; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC055720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC062299; AAH62299.1; -; mRNA.
EMBL; X89105; CAA61479.1; -; mRNA.
CCDS; CCDS44850.1; -. [Q14714-3]
CCDS; CCDS8707.1; -. [Q14714-1]
PIR; S57712; S57712.
RefSeq; NP_001129295.1; NM_001135823.1. [Q14714-3]
RefSeq; NP_005077.2; NM_005086.4. [Q14714-1]
RefSeq; XP_011519155.1; XM_011520853.2. [Q14714-3]
RefSeq; XP_011519156.1; XM_011520854.2. [Q14714-3]
RefSeq; XP_011519157.1; XM_011520855.2. [Q14714-3]
UniGene; Hs.183428; -.
UniGene; Hs.736914; -.
ProteinModelPortal; Q14714; -.
BioGrid; 113755; 1.
CORUM; Q14714; -.
STRING; 9606.ENSP00000242729; -.
iPTMnet; Q14714; -.
PhosphoSitePlus; Q14714; -.
SwissPalm; Q14714; -.
BioMuta; SSPN; -.
DMDM; 13431900; -.
PaxDb; Q14714; -.
PeptideAtlas; Q14714; -.
PRIDE; Q14714; -.
DNASU; 8082; -.
Ensembl; ENST00000242729; ENSP00000242729; ENSG00000123096. [Q14714-1]
Ensembl; ENST00000422622; ENSP00000396087; ENSG00000123096. [Q14714-3]
Ensembl; ENST00000540266; ENSP00000442893; ENSG00000123096. [Q14714-3]
GeneID; 8082; -.
KEGG; hsa:8082; -.
UCSC; uc001rhd.4; human. [Q14714-1]
CTD; 8082; -.
DisGeNET; 8082; -.
EuPathDB; HostDB:ENSG00000123096.11; -.
GeneCards; SSPN; -.
HGNC; HGNC:11322; SSPN.
HPA; HPA066432; -.
MIM; 601599; gene.
neXtProt; NX_Q14714; -.
OpenTargets; ENSG00000123096; -.
PharmGKB; PA36146; -.
eggNOG; ENOG410IK33; Eukaryota.
eggNOG; ENOG4111WM7; LUCA.
GeneTree; ENSGT00390000007747; -.
HOGENOM; HOG000065718; -.
HOVERGEN; HBG005016; -.
InParanoid; Q14714; -.
KO; K22194; -.
OMA; YVGVRMC; -.
OrthoDB; EOG091G0MQZ; -.
PhylomeDB; Q14714; -.
TreeFam; TF332100; -.
SIGNOR; Q14714; -.
ChiTaRS; SSPN; human.
GenomeRNAi; 8082; -.
PRO; PR:Q14714; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000123096; -.
CleanEx; HS_SSPN; -.
ExpressionAtlas; Q14714; baseline and differential.
Genevisible; Q14714; HS.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0016010; C:dystrophin-associated glycoprotein complex; TAS:ProtInc.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
GO; GO:0030133; C:transport vesicle; IDA:LIFEdb.
GO; GO:0007155; P:cell adhesion; TAS:ProtInc.
GO; GO:0006936; P:muscle contraction; TAS:ProtInc.
InterPro; IPR007237; CD20-like.
InterPro; IPR030429; Sarcospan.
PANTHER; PTHR15260; PTHR15260; 1.
Pfam; PF04103; CD20; 1.
2: Evidence at transcript level;
Alternative splicing; Cell junction; Cell membrane; Complete proteome;
Membrane; Polymorphism; Postsynaptic cell membrane;
Reference proteome; Synapse; Transmembrane; Transmembrane helix.
CHAIN 1 243 Sarcospan.
/FTId=PRO_0000072226.
TOPO_DOM 1 53 Cytoplasmic. {ECO:0000255}.
TRANSMEM 54 74 Helical. {ECO:0000255}.
TOPO_DOM 75 86 Extracellular. {ECO:0000255}.
TRANSMEM 87 107 Helical. {ECO:0000255}.
TOPO_DOM 108 122 Cytoplasmic. {ECO:0000255}.
TRANSMEM 123 143 Helical. {ECO:0000255}.
TOPO_DOM 144 193 Extracellular. {ECO:0000255}.
TRANSMEM 194 214 Helical. {ECO:0000255}.
TOPO_DOM 215 243 Cytoplasmic. {ECO:0000255}.
VAR_SEQ 1 103 Missing (in isoform 3).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_046351.
VAR_SEQ 108 218 Missing (in isoform 2).
{ECO:0000303|PubMed:11230166,
ECO:0000303|PubMed:9395445}.
/FTId=VSP_004431.
VARIANT 186 186 S -> N (in dbSNP:rs12313670).
/FTId=VAR_051384.
VARIANT 228 228 V -> I (in dbSNP:rs12313736).
/FTId=VAR_051385.
CONFLICT 13 13 Missing (in Ref. 1). {ECO:0000305}.
SEQUENCE 243 AA; 26618 MW; 0D6B24B9848253F9 CRC64;
MGKNKQPRGQ QRQGGPPAAD AAGPDDMEPK KGTGAPKECG EEEPRTCCGC RFPLLLALLQ
LALGIAVTVV GFLMASISSS LLVRDTPFWA GIIVCLVAYL GLFMLCVSYQ VDERTCIQFS
MKLLYFLLSA LGLTVCVLAV AFAAHHYSQL TQFTCETTLD SCQCKLPSSE PLSRTFVYRD
VTDCTSVTGT FKLFLLIQMI LNLVCGLVCL LACFVMWKHR YQVFYVGVRI CSLTASEGPQ
QKI


Related products :

Catalog number Product name Quantity
EIAAB40040 Kirsten-Ras-associated protein,Krag,K-ras oncogene-associated protein,Mouse,Mus musculus,Sarcospan,Sspn
EIAAB40041 Homo sapiens,Human,Kirsten-ras-associated protein,KRAG,K-ras oncogene-associated protein,Sarcospan,SSPN
orb81181 Human Kirsten Rat Sarcoma Viral Oncogene protein Proteins 5
orb81181 Human Kirsten Rat Sarcoma Viral Oncogene protein KRAS Recombinant human produced in E.coli is a single, non-glycosylated polypeptide chain containing 205 amino acids (1-185 a.a.) and having a molecula 5
RPR-446 Recombinant Human Kirsten Rat Sarcoma Viral Oncogene, Isoform 2A 5
pro-854 Recombinant Human Kirsten Rat Sarcoma Viral Oncogene, Isoform 2B 5
OETPRO854 Kirsten Rat Sarcoma Viral Oncogene Human Recombinant 5
7-05446 Recombinant Human Kirsten Rat Sarcoma Viral Oncogene 5
pro-854 Recombinant Human Kirsten Rat Sarcoma Viral Oncogene KRAS 25
OETPRO854 Kirsten Rat Sarcoma Viral Oncogene Human Recombinant 25
pro-854 Recombinant Human Kirsten Rat Sarcoma Viral Oncogene KRAS 1mg
RPR-854 Recombinant Human Kirsten Rat Sarcoma Viral Oncogene, Isoform 2B 5
pro-854 Recombinant Human Kirsten Rat Sarcoma Viral Oncogene, Isoform 2B 25
pro-854 Recombinant Human Kirsten Rat Sarcoma Viral Oncogene, Isoform 2B 1mg
pro-854 Recombinant Human Kirsten Rat Sarcoma Viral Oncogene KRAS 5
7-05448 Recombinant Human Kirsten Rat Sarcoma Viral Oncogene 1mg
7-05447 Recombinant Human Kirsten Rat Sarcoma Viral Oncogene 25
pro-1446 Recombinant Human Kirsten Rat Sarcoma Viral Oncogene, Isoform 2A 20
pro-1446 Recombinant Human Kirsten Rat Sarcoma Viral Oncogene, Isoform 2A 5
pro-1446 Recombinant Human Kirsten Rat Sarcoma Viral Oncogene, Isoform 2A 1mg
PR-204 K-Ras 4B Kirsten rat sarcoma viral oncogene homolog, isoform 4Bhuman, recombinant, E. coli 50
201-20-0038 KRAS{v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog}goat.pAb 0.2ml
KRBA2 KRAS Gene v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
201-20-3014 KRAS{v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog}rabbit.pAb 0.2ml
18-003-43560 RNA-binding protein FUS - Oncogene FUS; Oncogene TLS; Translocated in liposarcoma protein; POMp75; 75 kDa DNA-pairing protein Polyclonal 0.05 mg Aff Pur


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur