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Scytalone dehydratase-like protein mdpB (EC 4.2.1.-) (Monodictyphenone synthesis protein B)

 MDPB_EMENI              Reviewed;         214 AA.
C8VQ71; Q5BH35;
07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
03-NOV-2009, sequence version 1.
20-JUN-2018, entry version 39.
RecName: Full=Scytalone dehydratase-like protein mdpB {ECO:0000303|PubMed:20139316};
EC=4.2.1.- {ECO:0000269|PubMed:20139316};
AltName: Full=Monodictyphenone synthesis protein B {ECO:0000303|PubMed:20139316};
Name=mdpB {ECO:0000303|PubMed:20139316}; ORFNames=ANIA_10049;
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL
194 / M139) (Aspergillus nidulans).
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
NCBI_TaxID=227321;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
PubMed=16372000; DOI=10.1038/nature04341;
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R.,
Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J.,
Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J.,
Purcell S., Harris S., Braus G.H., Draht O., Busch S., D'Enfert C.,
Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S.,
Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U.,
Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T.,
Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W.,
Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
"Sequencing of Aspergillus nidulans and comparative analysis with A.
fumigatus and A. oryzae.";
Nature 438:1105-1115(2005).
[2]
GENOME REANNOTATION.
STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P.,
von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E.,
Fekete E., Flipphi M., Estrada C.G., Geysens S., Goldman G.,
de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K.,
Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S.,
Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E.,
Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A.,
Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P.,
Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R.,
Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I.,
Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B.,
van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N.,
Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J.,
de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W.,
Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.;
"The 2008 update of the Aspergillus nidulans genome annotation: a
community effort.";
Fungal Genet. Biol. 46:S2-13(2009).
[3]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=20139316; DOI=10.1128/AEM.02187-09;
Chiang Y.M., Szewczyk E., Davidson A.D., Entwistle R., Keller N.P.,
Wang C.C., Oakley B.R.;
"Characterization of the Aspergillus nidulans monodictyphenone gene
cluster.";
Appl. Environ. Microbiol. 76:2067-2074(2010).
[4]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=21351751; DOI=10.1021/ja1096682;
Sanchez J.F., Entwistle R., Hung J.H., Yaegashi J., Jain S.,
Chiang Y.M., Wang C.C., Oakley B.R.;
"Genome-based deletion analysis reveals the prenyl xanthone
biosynthesis pathway in Aspergillus nidulans.";
J. Am. Chem. Soc. 133:4010-4017(2011).
-!- FUNCTION: Scytalone dehydratase-like protein; part of the gene
cluster that mediates the biosynthesis of monodictyphenone, a
prenyl xanthone derivative (PubMed:20139316, PubMed:21351751). The
pathway begins with the synthesis of atrochrysone thioester by the
polyketide synthase (PKS) mdpG (PubMed:20139316). The atrochrysone
carboxyl ACP thioesterase mdpF then breaks the thioester bond and
releases the atrochrysone carboxylic acid from gedC
(PubMed:20139316). The atrochrysone carboxylic acid is then
converted to atrochrysone which is further transformed into emodin
anthrone (PubMed:20139316). The next step is performed by the
anthrone oxygenase mdpH that catalyzes the oxidation of
emodinanthrone to emodin (By similarity). Emodin is further
modified to yield monodictyphenone via several steps involving
mdpB, mdpC mdpJ, mdpK and mdpL (PubMed:20139316, PubMed:21351751).
{ECO:0000250|UniProtKB:Q0CCY3, ECO:0000269|PubMed:20139316,
ECO:0000269|PubMed:21351751}.
-!- PATHWAY: Secondary metabolite biosynthesis.
{ECO:0000269|PubMed:20139316, ECO:0000269|PubMed:21351751}.
-!- DISRUPTION PHENOTYPE: Impairs the production of monodictyphenone,
but still enables the synthesis of intermediates until emodin
(PubMed:20139316, PubMed:21351751). {ECO:0000269|PubMed:20139316,
ECO:0000269|PubMed:21351751}.
-!- SIMILARITY: Belongs to the scytalone dehydratase family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=EAA66018.1; Type=Erroneous gene model prediction; Note=The predicted gene AN0145 has been split into 2 genes: ANIA_10021 and ANIA_10049.; Evidence={ECO:0000305};
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EMBL; BN001308; CBF90107.1; -; Genomic_DNA.
EMBL; AACD01000005; EAA66018.1; ALT_SEQ; Genomic_DNA.
RefSeq; XP_657749.1; XM_652657.1.
SMR; C8VQ71; -.
EnsemblFungi; CBF90107; CBF90107; ANIA_10049.
EnsemblFungi; EAA66018; EAA66018; AN0145.2.
GeneID; 2875924; -.
KEGG; ani:AN0145.2; -.
HOGENOM; HOG000168763; -.
InParanoid; C8VQ71; -.
OMA; RIDYRSF; -.
OrthoDB; EOG092C4YYV; -.
Proteomes; UP000000560; Chromosome VIII.
Proteomes; UP000005890; Unassembled WGS sequence.
GO; GO:0030411; F:scytalone dehydratase activity; IEA:InterPro.
GO; GO:0006582; P:melanin metabolic process; IEA:InterPro.
GO; GO:1900815; P:monodictyphenone biosynthetic process; IMP:AspGD.
GO; GO:0044550; P:secondary metabolite biosynthetic process; IMP:AspGD.
GO; GO:2001307; P:xanthone-containing compound biosynthetic process; IMP:AspGD.
InterPro; IPR032710; NTF2-like_dom_sf.
InterPro; IPR004235; Scytalone_dehydratase.
Pfam; PF02982; Scytalone_dh; 1.
ProDom; PD022193; Scytalone_dehydratase; 1.
SUPFAM; SSF54427; SSF54427; 1.
3: Inferred from homology;
Complete proteome; Lyase; Reference proteome.
CHAIN 1 214 Scytalone dehydratase-like protein mdpB.
/FTId=PRO_0000437107.
ACT_SITE 95 95 {ECO:0000250|UniProtKB:P56221}.
ACT_SITE 120 120 {ECO:0000250|UniProtKB:P56221}.
BINDING 40 40 Substrate.
{ECO:0000250|UniProtKB:P56221}.
BINDING 60 60 Substrate.
{ECO:0000250|UniProtKB:P56221}.
SEQUENCE 214 AA; 24307 MW; 1C2ED4EEE9DD69FF CRC64;
MTLQPTFEGR TPEQCLNVHT DSHPDITGCQ AALFEWAESY DSKDWDRLKQ CIAPFLRIDY
RAFLDKLWEK MPAEEFVAMV SHPHFLGNPL LKTQHFVGTM KWEKVDDSKI VGYHQMRVAH
QKHLDSQMKE VVAKGHGHGS ATVTYRKING EWKFAGIEPN IRWTEFGGEG IFGPPEKEEN
GVAADDQVMN SNGSSEVEER NGHVVNKAVE VRSV


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