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Secreted frizzled-related protein 2 (sFRP-2) (Protein SDF5) (Secreted apoptosis-related protein 1) (SARP-1)

 SFRP2_MOUSE             Reviewed;         295 AA.
P97299; O08862; O35297;
15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
15-MAR-2005, sequence version 2.
13-FEB-2019, entry version 155.
RecName: Full=Secreted frizzled-related protein 2;
AltName: Full=Protein SDF5;
AltName: Full=Secreted apoptosis-related protein 1;
Flags: Precursor;
Name=Sfrp2; Synonyms=Sarp1, Sdf5;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
TISSUE=Bone marrow stroma;
PubMed=8938438; DOI=10.1006/geno.1996.0560;
Shirozu M., Tada H., Tashiro K., Nakamura T., Lopez N.D., Nazarea M.,
Hamada T., Sato T., Nakano T., Honjo T.;
"Characterization of novel secreted and membrane proteins isolated by
the signal sequence trap method.";
Genomics 37:273-280(1996).
STRAIN=C57BL/6J; TISSUE=Embryonic eye;
PubMed=9096311; DOI=10.1073/pnas.94.7.2859;
Rattner A., Hsieh J.-C., Smallwood P.M., Gilbert D.J., Copeland N.G.,
Jenkins N.A., Nathans J.;
"A family of secreted proteins contains homology to the cysteine-rich
ligand-binding domain of frizzled receptors.";
Proc. Natl. Acad. Sci. U.S.A. 94:2859-2863(1997).
PubMed=9391078; DOI=10.1073/pnas.94.25.13636;
Melkonyan H.S., Chang W.C., Shapiro J.P., Mahadevappa M.,
Fitzpatrick P.A., Kiefer M.C., Tomei L.D., Umansky S.R.;
"SARPs: a family of secreted apoptosis-related proteins.";
Proc. Natl. Acad. Sci. U.S.A. 94:13636-13641(1997).
STRAIN=FVB/N; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
PubMed=9739103; DOI=10.1016/S0925-4773(98)00072-0;
Leimeister C., Bach A., Gessler M.;
"Developmental expression patterns of mouse sFRP genes encoding
members of the secreted frizzled related protein family.";
Mech. Dev. 75:29-42(1998).
PubMed=15226823; DOI=10.1371/journal.pbio.0020247;
Blackshaw S., Harpavat S., Trimarchi J., Cai L., Huang H., Kuo W.P.,
Weber G., Lee K., Fraioli R.E., Cho S.-H., Yung R., Asch E.,
Ohno-Machado L., Wong W.H., Cepko C.L.;
"Genomic analysis of mouse retinal development.";
PLoS Biol. 2:1411-1431(2004).
-!- FUNCTION: Soluble frizzled-related proteins (sFRPS) function as
modulators of Wnt signaling through direct interaction with Wnts.
They have a role in regulating cell growth and differentiation in
specific cell types. SFRP2 may be important for eye retinal
development and for myogenesis.
P13497-2:BMP1 (xeno); NbExp=2; IntAct=EBI-15892646, EBI-12509497;
-!- TISSUE SPECIFICITY: Highly expressed in the eye. Weaker expression
in heart and lung. {ECO:0000269|PubMed:9096311}.
-!- DEVELOPMENTAL STAGE: During kidney development, expressed at 10.5
dpc in the mesonephric tubules, and at 12.5 dpc strongly expressed
in the comma shaped bodies and surrounding ureter stalk. In 14.5
dpc kidney, expressed in the S-shaped bodies. In the developing
nervous system, expressed in the presumptive hindbrain and the
ventral part of the neural tube from E8.0 onwards. At E9.5,
expression is additionally detected in the mesonephros and the
optic vesicle. 10 dpc expression is found in the second and third
branchial cleft, in the eye, the ventral neural tube and specific
rhombomeres and prosomers. 10.5 dpc brain shows specific
expression in the basal and alar plate. In developing eye,
expressed at E9.0 in the optic placode, and at E9.5 in the optic
vesicle. By 10.5 dpc, expression found in the lens vesicle and the
inner layer of the invaginating optic vesicle. Strong expression
at 14.5 dpc in the anterior lens epithelium, decreasing
thereafter. Expression also found in the prospective neural
retina. In developing limbs, expression found at 11.5 dpc in the
shoulder and at the distal end of the cartilaginous condensation.
At 12.5 dpc, expressed in the foot and hand paddle extending along
the digital rays. Expressed, at 13.5 dpc and 14.5 dpc, in the
forelimb and hindlimb where the interphalangeal joints will
develop. Also expressed at 14.5 dpc between the sternal bands and
where the ribs contact the sternum. In other developing
structures, expression found at 11.5 dpc, in the maxillary and
mandibular component of the first branchial arch, and later, in
the loose mesenchyme surrounding cartilage and epithelia of the
skull as well as in the whisker follicles. Also expressed in
developing teeth, with the highest levels at 15.5 dpc and 16.5 dpc
in the mesenchyme and the dental epithelium of the developing
molars. Expressed in development smooth muscle surrounding the
esophagus at 11.5 dpc, the dorsal aorta and the ductus arteriosus
at 14.5 dpc, and the ureter stalk at 15.5 dpc.
{ECO:0000269|PubMed:15226823, ECO:0000269|PubMed:9739103}.
-!- DOMAIN: The FZ domain is involved in binding with Wnt ligands.
-!- SIMILARITY: Belongs to the secreted frizzled-related protein
(sFRP) family. {ECO:0000305}.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; D50462; BAA09053.1; -; mRNA.
EMBL; U88567; AAC53146.1; -; mRNA.
EMBL; AF017989; AAB70795.1; -; mRNA.
EMBL; BC014722; AAH14722.1; -; mRNA.
CCDS; CCDS17434.1; -.
RefSeq; NP_033170.1; NM_009144.2.
UniGene; Mm.19155; -.
ProteinModelPortal; P97299; -.
SMR; P97299; -.
BioGrid; 203142; 9.
DIP; DIP-59486N; -.
IntAct; P97299; 1.
STRING; 10090.ENSMUSP00000029625; -.
MEROPS; I93.002; -.
iPTMnet; P97299; -.
PhosphoSitePlus; P97299; -.
PaxDb; P97299; -.
PRIDE; P97299; -.
Ensembl; ENSMUST00000029625; ENSMUSP00000029625; ENSMUSG00000027996.
GeneID; 20319; -.
KEGG; mmu:20319; -.
UCSC; uc008ppl.2; mouse.
CTD; 6423; -.
MGI; MGI:108078; Sfrp2.
eggNOG; KOG3577; Eukaryota.
GeneTree; ENSGT00940000156432; -.
HOGENOM; HOG000231058; -.
HOVERGEN; HBG052928; -.
InParanoid; P97299; -.
KO; K02176; -.
OrthoDB; 1306779at2759; -.
PhylomeDB; P97299; -.
TreeFam; TF350133; -.
ChiTaRS; Sfrp2; mouse.
PRO; PR:P97299; -.
Proteomes; UP000000589; Chromosome 3.
Bgee; ENSMUSG00000027996; Expressed in 307 organ(s), highest expression level in ureter smooth muscle.
ExpressionAtlas; P97299; baseline and differential.
Genevisible; P97299; MM.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
GO; GO:0061133; F:endopeptidase activator activity; IDA:MGI.
GO; GO:0008047; F:enzyme activator activity; IDA:MGI.
GO; GO:0048018; F:receptor ligand activity; IDA:BHF-UCL.
GO; GO:0017147; F:Wnt-protein binding; IPI:MGI.
GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
GO; GO:0006915; P:apoptotic process; IMP:MGI.
GO; GO:0060349; P:bone morphogenesis; IMP:MGI.
GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IDA:BHF-UCL.
GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
GO; GO:0003214; P:cardiac left ventricle morphogenesis; ISO:MGI.
GO; GO:0051216; P:cartilage development; IMP:MGI.
GO; GO:0031668; P:cellular response to extracellular stimulus; IDA:MGI.
GO; GO:0071481; P:cellular response to X-ray; IDA:UniProtKB.
GO; GO:0002063; P:chondrocyte development; IMP:MGI.
GO; GO:0030199; P:collagen fibril organization; IMP:MGI.
GO; GO:0060028; P:convergent extension involved in axis elongation; IGI:MGI.
GO; GO:0046546; P:development of primary male sexual characteristics; IGI:MGI.
GO; GO:0048546; P:digestive tract morphogenesis; IGI:MGI.
GO; GO:0042733; P:embryonic digit morphogenesis; IMP:MGI.
GO; GO:0071425; P:hematopoietic stem cell proliferation; IDA:UniProtKB.
GO; GO:0008584; P:male gonad development; IGI:MGI.
GO; GO:0030514; P:negative regulation of BMP signaling pathway; IDA:MGI.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:MGI.
GO; GO:0010667; P:negative regulation of cardiac muscle cell apoptotic process; IDA:MGI.
GO; GO:0030308; P:negative regulation of cell growth; ISO:MGI.
GO; GO:0030336; P:negative regulation of cell migration; IDA:UniProtKB.
GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:MGI.
GO; GO:0061185; P:negative regulation of dermatome development; IDA:BHF-UCL.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISO:MGI.
GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; ISO:MGI.
GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IDA:BHF-UCL.
GO; GO:0010629; P:negative regulation of gene expression; IDA:UniProtKB.
GO; GO:0043508; P:negative regulation of JUN kinase activity; IGI:MGI.
GO; GO:0042662; P:negative regulation of mesodermal cell fate specification; IGI:MGI.
GO; GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; IDA:UniProtKB.
GO; GO:2000041; P:negative regulation of planar cell polarity pathway involved in axis elongation; IGI:MGI.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IDA:BHF-UCL.
GO; GO:0001843; P:neural tube closure; IGI:MGI.
GO; GO:0021915; P:neural tube development; IGI:MGI.
GO; GO:0035567; P:non-canonical Wnt signaling pathway; IBA:GO_Central.
GO; GO:0003151; P:outflow tract morphogenesis; ISO:MGI.
GO; GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IGI:MGI.
GO; GO:0045766; P:positive regulation of angiogenesis; IDA:BHF-UCL.
GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IDA:ParkinsonsUK-UCL.
GO; GO:0030307; P:positive regulation of cell growth; IDA:UniProtKB.
GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:UniProtKB.
GO; GO:0010950; P:positive regulation of endopeptidase activity; IDA:MGI.
GO; GO:0045600; P:positive regulation of fat cell differentiation; ISO:MGI.
GO; GO:0045669; P:positive regulation of osteoblast differentiation; IGI:MGI.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:BHF-UCL.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:BHF-UCL.
GO; GO:0036342; P:post-anal tail morphogenesis; IMP:MGI.
GO; GO:0042981; P:regulation of apoptotic process; IMP:MGI.
GO; GO:0042127; P:regulation of cell population proliferation; IMP:MGI.
GO; GO:0090175; P:regulation of establishment of planar polarity; IGI:MGI.
GO; GO:1904956; P:regulation of midbrain dopaminergic neuron differentiation; IGI:ParkinsonsUK-UCL.
GO; GO:0010975; P:regulation of neuron projection development; IDA:ParkinsonsUK-UCL.
GO; GO:2000035; P:regulation of stem cell division; IDA:UniProtKB.
GO; GO:0030111; P:regulation of Wnt signaling pathway; IDA:UniProtKB.
GO; GO:0042493; P:response to drug; IDA:UniProtKB.
GO; GO:0007584; P:response to nutrient; IEA:Ensembl.
GO; GO:0061056; P:sclerotome development; IEP:BHF-UCL.
GO; GO:0001756; P:somitogenesis; IGI:MGI.
GO; GO:0090244; P:Wnt signaling pathway involved in somitogenesis; IGI:MGI.
Gene3D; 1.10.2000.10; -; 1.
InterPro; IPR015526; Frizzled/SFRP.
InterPro; IPR020067; Frizzled_dom.
InterPro; IPR036790; Frizzled_dom_sf.
InterPro; IPR001134; Netrin_domain.
InterPro; IPR018933; Netrin_module_non-TIMP.
InterPro; IPR026558; SFRP2.
InterPro; IPR008993; TIMP-like_OB-fold.
PANTHER; PTHR11309; PTHR11309; 1.
PANTHER; PTHR11309:SF45; PTHR11309:SF45; 1.
Pfam; PF01392; Fz; 1.
Pfam; PF01759; NTR; 1.
SMART; SM00643; C345C; 1.
SMART; SM00063; FRI; 1.
SUPFAM; SSF50242; SSF50242; 1.
SUPFAM; SSF63501; SSF63501; 1.
PROSITE; PS50038; FZ; 1.
PROSITE; PS50189; NTR; 1.
1: Evidence at protein level;
Complete proteome; Developmental protein; Differentiation;
Disulfide bond; Reference proteome; Secreted; Signal;
Wnt signaling pathway.
SIGNAL 1 24 {ECO:0000255}.
CHAIN 25 295 Secreted frizzled-related protein 2.
DOMAIN 35 155 FZ. {ECO:0000255|PROSITE-
DOMAIN 172 295 NTR. {ECO:0000255|PROSITE-
DISULFID 40 103 {ECO:0000250}.
DISULFID 50 96 {ECO:0000250}.
DISULFID 87 125 {ECO:0000250}.
DISULFID 114 152 {ECO:0000250}.
DISULFID 118 142 {ECO:0000250}.
DISULFID 172 245 {ECO:0000250}.
DISULFID 175 247 {ECO:0000250}.
DISULFID 190 295 {ECO:0000250}.
CONFLICT 38 38 S -> T (in Ref. 3; AAB70795).
CONFLICT 119 119 V -> M (in Ref. 1; BAA09053).
SEQUENCE 295 AA; 33469 MW; 2D287C177C974C62 CRC64;

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