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Segmentation protein Runt

 RUNT_DROME              Reviewed;         510 AA.
P22814; A0AVT9; O76551; Q6SD78; Q7KPD6; Q8MRF4; Q9TVG1; Q9TVZ7;
Q9TZQ9; Q9TZR0; Q9VRB6;
01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
25-OCT-2005, sequence version 2.
22-NOV-2017, entry version 163.
RecName: Full=Segmentation protein Runt;
Name=run; ORFNames=CG1849;
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
SPECIFICITY, AND DEVELOPMENTAL STAGE.
TISSUE=Embryo;
PubMed=2249771; DOI=10.1101/gad.4.10.1701;
Kania M.A., Bonner A.S., Duffy J.B., Gergen J.P.;
"The Drosophila segmentation gene runt encodes a novel nuclear
regulatory protein that is also expressed in the developing nervous
system.";
Genes Dev. 4:1701-1713(1990).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=OK13, OK17, OK5, OK94, Z11, Z16, Z27, Z42, Z55, Z64, and Z74;
PubMed=10368951; DOI=10.1093/oxfordjournals.molbev.a026157;
Labate J.A., Biermann C.H., Eanes W.F.;
"Nucleotide variation at the runt locus in Drosophila melanogaster and
Drosophila simulans.";
Mol. Biol. Evol. 16:724-731(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G.,
Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A.,
Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X.,
Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[4]
GENOME REANNOTATION.
STRAIN=Berkeley;
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Berkeley; TISSUE=Head;
Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W.,
Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E.,
George R.A., Gonzalez M., Guarin H., Kapadia B., Kronmiller B.,
Li P.W., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J.M.,
Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C.,
Lewis S.E., Rubin G.M., Celniker S.E.;
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 216-275.
STRAIN=Ara1, Ara10, Ara11, Ara12, Ara13, Ara15, Ara2, Ara3, Ara4,
Ara5, Ara6, Ara7, Ara8, Ara9, Cog1, Cog11, Cog12, Cog13, Cog14, Cog15,
Cog2, Cog3, Cog4, Cog5, Cog6, Cog7, Cog8, Cog9, Gh51, Gh52, Gh53,
Gh54, Gh55, Gh56, Gh57, Gh58, Gh59, Gh60, Gh61, Gh62, Gh63, Gh65, KN1,
KN10, KN11, KN12, KN13, KN15, KN2, KN3, KN4, KN5, KN6, KN7, KN8, KN9,
Mad1, Mad10, Mad11, Mad13, Mad14, Mad17, Mad2, Mad3, Mad4, Mad5, Mad6,
Mad7, Mad8, Mad9, Mif1, Mif10, Mif11, Mif12, Mif13, Mif15, Mif16,
Mif2, Mif3, Mif4, Mif6, Mif7, Mif8, Mif9, Nd1, Nd10, Nd11, Nd12, Nd13,
Nd14, Nd2, Nd3, Nd4, Nd5, Nd6, Nd7, Nd8, Nd9, Nia1, Nia10, Nia11,
Nia13, Nia16, Nia17, Nia18, Nia2, Nia20, Nia21, Nia22, Nia3, Nia6,
Nia9, Pe1, Pe12, Pe13, Pe14, Pe15, Pe16, Pe17, Pe18, Pe19, Pe2, Pe4,
Pe7, Pe8, Pe9, USA1, USA10, USA11, USA12, USA13, USA14, USA2, USA3,
USA4, USA5, USA6, USA7, USA8, USA9, Z12, Z121, Z145, Z147, Z18, Z27,
Z30, Z32, Z33, Z422, Z53, Z67, and Z75;
PubMed=15014160; DOI=10.1093/molbev/msh089;
Baudry E., Viginier B., Veuille M.;
"Non-African populations of Drosophila melanogaster have a unique
origin.";
Mol. Biol. Evol. 21:1482-1491(2004).
[7]
SIMILARITY TO AML1.
PubMed=1560822; DOI=10.1038/356484b0;
Daga A., Tighe J.E., Calabi F.;
"Leukaemia/Drosophila homology.";
Nature 356:484-484(1992).
-!- FUNCTION: Plays a pivotal role in regulating the expression of
other pair-rule genes such as eve, ftz, and h.
{ECO:0000269|PubMed:2249771}.
-!- INTERACTION:
Q24039:Bro; NbExp=6; IntAct=EBI-868309, EBI-148540;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00399, ECO:0000269|PubMed:2249771}.
-!- TISSUE SPECIFICITY: Expressed in embryonic central and peripheral
nervous system. {ECO:0000269|PubMed:2249771}.
-!- DEVELOPMENTAL STAGE: Most abundantly expressed at the blastoderm
stage of embryogenesis. {ECO:0000269|PubMed:2249771}.
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EMBL; X56432; CAA39817.1; -; mRNA.
EMBL; AF077070; AAC27776.1; -; Genomic_DNA.
EMBL; AF077071; AAC27777.1; -; Genomic_DNA.
EMBL; AF077072; AAC27778.1; -; Genomic_DNA.
EMBL; AF077073; AAC27779.1; -; Genomic_DNA.
EMBL; AF077074; AAC27780.1; -; Genomic_DNA.
EMBL; AF077075; AAC27781.1; -; Genomic_DNA.
EMBL; AF077076; AAC27782.1; -; Genomic_DNA.
EMBL; AF077077; AAC27783.1; -; Genomic_DNA.
EMBL; AF077078; AAC27784.1; -; Genomic_DNA.
EMBL; AF077079; AAC27785.1; -; Genomic_DNA.
EMBL; AF077080; AAC27786.1; -; Genomic_DNA.
EMBL; AE014298; AAF50886.1; -; Genomic_DNA.
EMBL; AY121615; AAM51942.2; -; mRNA.
EMBL; BT029257; ABK30894.1; -; mRNA.
EMBL; AY459923; AAS16109.1; -; Genomic_DNA.
EMBL; AY459924; AAS16110.1; -; Genomic_DNA.
EMBL; AY459925; AAS16111.1; -; Genomic_DNA.
EMBL; AY459926; AAS16112.1; -; Genomic_DNA.
EMBL; AY459927; AAS16113.1; -; Genomic_DNA.
EMBL; AY459928; AAS16114.1; -; Genomic_DNA.
EMBL; AY459929; AAS16115.1; -; Genomic_DNA.
EMBL; AY459930; AAS16116.1; -; Genomic_DNA.
EMBL; AY459931; AAS16117.1; -; Genomic_DNA.
EMBL; AY459932; AAS16118.1; -; Genomic_DNA.
EMBL; AY459933; AAS16119.1; -; Genomic_DNA.
EMBL; AY459934; AAS16120.1; -; Genomic_DNA.
EMBL; AY459935; AAS16121.1; -; Genomic_DNA.
EMBL; AY459936; AAS16122.1; -; Genomic_DNA.
EMBL; AY459937; AAS16123.1; -; Genomic_DNA.
EMBL; AY459938; AAS16124.1; -; Genomic_DNA.
EMBL; AY459939; AAS16125.1; -; Genomic_DNA.
EMBL; AY459940; AAS16126.1; -; Genomic_DNA.
EMBL; AY459941; AAS16127.1; -; Genomic_DNA.
EMBL; AY459942; AAS16128.1; -; Genomic_DNA.
EMBL; AY459943; AAS16129.1; -; Genomic_DNA.
EMBL; AY459944; AAS16130.1; -; Genomic_DNA.
EMBL; AY459945; AAS16131.1; -; Genomic_DNA.
EMBL; AY459946; AAS16132.1; -; Genomic_DNA.
EMBL; AY459947; AAS16133.1; -; Genomic_DNA.
EMBL; AY459948; AAS16134.1; -; Genomic_DNA.
EMBL; AY459949; AAS16135.1; -; Genomic_DNA.
EMBL; AY459950; AAS16136.1; -; Genomic_DNA.
EMBL; AY459951; AAS16137.1; -; Genomic_DNA.
EMBL; AY459952; AAS16138.1; -; Genomic_DNA.
EMBL; AY459953; AAS16139.1; -; Genomic_DNA.
EMBL; AY459954; AAS16140.1; -; Genomic_DNA.
EMBL; AY459955; AAS16141.1; -; Genomic_DNA.
EMBL; AY459956; AAS16142.1; -; Genomic_DNA.
EMBL; AY459957; AAS16143.1; -; Genomic_DNA.
EMBL; AY459958; AAS16144.1; -; Genomic_DNA.
EMBL; AY459959; AAS16145.1; -; Genomic_DNA.
EMBL; AY459960; AAS16146.1; -; Genomic_DNA.
EMBL; AY459961; AAS16147.1; -; Genomic_DNA.
EMBL; AY459962; AAS16148.1; -; Genomic_DNA.
EMBL; AY459963; AAS16149.1; -; Genomic_DNA.
EMBL; AY459964; AAS16150.1; -; Genomic_DNA.
EMBL; AY459965; AAS16151.1; -; Genomic_DNA.
EMBL; AY459966; AAS16152.1; -; Genomic_DNA.
EMBL; AY459967; AAS16153.1; -; Genomic_DNA.
EMBL; AY459968; AAS16154.1; -; Genomic_DNA.
EMBL; AY459969; AAS16155.1; -; Genomic_DNA.
EMBL; AY459970; AAS16156.1; -; Genomic_DNA.
EMBL; AY459971; AAS16157.1; -; Genomic_DNA.
EMBL; AY459972; AAS16158.1; -; Genomic_DNA.
EMBL; AY459973; AAS16159.1; -; Genomic_DNA.
EMBL; AY459974; AAS16160.1; -; Genomic_DNA.
EMBL; AY459975; AAS16161.1; -; Genomic_DNA.
EMBL; AY459976; AAS16162.1; -; Genomic_DNA.
EMBL; AY459977; AAS16163.1; -; Genomic_DNA.
EMBL; AY459978; AAS16164.1; -; Genomic_DNA.
EMBL; AY459979; AAS16165.1; -; Genomic_DNA.
EMBL; AY459980; AAS16166.1; -; Genomic_DNA.
EMBL; AY459981; AAS16167.1; -; Genomic_DNA.
EMBL; AY459982; AAS16168.1; -; Genomic_DNA.
EMBL; AY459983; AAS16169.1; -; Genomic_DNA.
EMBL; AY459984; AAS16170.1; -; Genomic_DNA.
EMBL; AY459985; AAS16171.1; -; Genomic_DNA.
EMBL; AY459986; AAS16172.1; -; Genomic_DNA.
EMBL; AY459987; AAS16173.1; -; Genomic_DNA.
EMBL; AY459988; AAS16174.1; -; Genomic_DNA.
EMBL; AY459989; AAS16175.1; -; Genomic_DNA.
EMBL; AY459990; AAS16176.1; -; Genomic_DNA.
EMBL; AY459991; AAS16177.1; -; Genomic_DNA.
EMBL; AY459992; AAS16178.1; -; Genomic_DNA.
EMBL; AY459993; AAS16179.1; -; Genomic_DNA.
EMBL; AY459994; AAS16180.1; -; Genomic_DNA.
EMBL; AY459995; AAS16181.1; -; Genomic_DNA.
EMBL; AY459996; AAS16182.1; -; Genomic_DNA.
EMBL; AY459997; AAS16183.1; -; Genomic_DNA.
EMBL; AY459998; AAS16184.1; -; Genomic_DNA.
EMBL; AY459999; AAS16185.1; -; Genomic_DNA.
EMBL; AY460000; AAS16186.1; -; Genomic_DNA.
EMBL; AY460001; AAS16187.1; -; Genomic_DNA.
EMBL; AY460002; AAS16188.1; -; Genomic_DNA.
EMBL; AY460003; AAS16189.1; -; Genomic_DNA.
EMBL; AY460004; AAS16190.1; -; Genomic_DNA.
EMBL; AY460005; AAS16191.1; -; Genomic_DNA.
EMBL; AY460006; AAS16192.1; -; Genomic_DNA.
EMBL; AY460007; AAS16193.1; -; Genomic_DNA.
EMBL; AY460008; AAS16194.1; -; Genomic_DNA.
EMBL; AY460009; AAS16195.1; -; Genomic_DNA.
EMBL; AY460010; AAS16196.1; -; Genomic_DNA.
EMBL; AY460011; AAS16197.1; -; Genomic_DNA.
EMBL; AY460012; AAS16198.1; -; Genomic_DNA.
EMBL; AY460013; AAS16199.1; -; Genomic_DNA.
EMBL; AY460014; AAS16200.1; -; Genomic_DNA.
EMBL; AY460015; AAS16201.1; -; Genomic_DNA.
EMBL; AY460016; AAS16202.1; -; Genomic_DNA.
EMBL; AY460017; AAS16203.1; -; Genomic_DNA.
EMBL; AY460018; AAS16204.1; -; Genomic_DNA.
EMBL; AY460019; AAS16205.1; -; Genomic_DNA.
EMBL; AY460020; AAS16206.1; -; Genomic_DNA.
EMBL; AY460021; AAS16207.1; -; Genomic_DNA.
EMBL; AY460022; AAS16208.1; -; Genomic_DNA.
EMBL; AY460023; AAS16209.1; -; Genomic_DNA.
EMBL; AY460024; AAS16210.1; -; Genomic_DNA.
EMBL; AY460025; AAS16211.1; -; Genomic_DNA.
EMBL; AY460026; AAS16212.1; -; Genomic_DNA.
EMBL; AY460027; AAS16213.1; -; Genomic_DNA.
EMBL; AY460028; AAS16214.1; -; Genomic_DNA.
EMBL; AY460029; AAS16215.1; -; Genomic_DNA.
EMBL; AY460030; AAS16216.1; -; Genomic_DNA.
EMBL; AY460031; AAS16217.1; -; Genomic_DNA.
EMBL; AY460032; AAS16218.1; -; Genomic_DNA.
EMBL; AY460033; AAS16219.1; -; Genomic_DNA.
EMBL; AY460034; AAS16220.1; -; Genomic_DNA.
EMBL; AY460035; AAS16221.1; -; Genomic_DNA.
EMBL; AY460036; AAS16222.1; -; Genomic_DNA.
EMBL; AY460037; AAS16223.1; -; Genomic_DNA.
EMBL; AY460038; AAS16224.1; -; Genomic_DNA.
EMBL; AY460039; AAS16225.1; -; Genomic_DNA.
EMBL; AY460040; AAS16226.1; -; Genomic_DNA.
EMBL; AY460041; AAS16227.1; -; Genomic_DNA.
EMBL; AY460042; AAS16228.1; -; Genomic_DNA.
EMBL; AY460043; AAS16229.1; -; Genomic_DNA.
EMBL; AY460044; AAS16230.1; -; Genomic_DNA.
EMBL; AY460045; AAS16231.1; -; Genomic_DNA.
EMBL; AY460046; AAS16232.1; -; Genomic_DNA.
EMBL; AY460047; AAS16233.1; -; Genomic_DNA.
EMBL; AY460048; AAS16234.1; -; Genomic_DNA.
EMBL; AY460049; AAS16235.1; -; Genomic_DNA.
EMBL; AY460050; AAS16236.1; -; Genomic_DNA.
EMBL; AY460051; AAS16237.1; -; Genomic_DNA.
EMBL; AY460052; AAS16238.1; -; Genomic_DNA.
EMBL; AY460053; AAS16239.1; -; Genomic_DNA.
EMBL; AY460054; AAS16240.1; -; Genomic_DNA.
EMBL; AY460055; AAS16241.1; -; Genomic_DNA.
EMBL; AY460056; AAS16242.1; -; Genomic_DNA.
EMBL; AY460057; AAS16243.1; -; Genomic_DNA.
EMBL; AY460058; AAS16244.1; -; Genomic_DNA.
EMBL; AY460059; AAS16245.1; -; Genomic_DNA.
EMBL; AY460060; AAS16246.1; -; Genomic_DNA.
EMBL; AY460061; AAS16247.1; -; Genomic_DNA.
EMBL; AY460062; AAS16248.1; -; Genomic_DNA.
EMBL; AY460063; AAS16249.1; -; Genomic_DNA.
EMBL; AY460064; AAS16250.1; -; Genomic_DNA.
EMBL; AY460065; AAS16251.1; -; Genomic_DNA.
EMBL; AY460066; AAS16252.1; -; Genomic_DNA.
EMBL; AY460067; AAS16253.1; -; Genomic_DNA.
EMBL; AY460068; AAS16254.1; -; Genomic_DNA.
EMBL; AY460069; AAS16255.1; -; Genomic_DNA.
EMBL; AY460070; AAS16256.1; -; Genomic_DNA.
EMBL; AY460071; AAS16257.1; -; Genomic_DNA.
EMBL; AY460072; AAS16258.1; -; Genomic_DNA.
EMBL; AY460073; AAS16259.1; -; Genomic_DNA.
EMBL; AY460074; AAS16260.1; -; Genomic_DNA.
EMBL; AY460075; AAS16261.1; -; Genomic_DNA.
PIR; A36392; A36392.
RefSeq; NP_001285501.1; NM_001298572.1.
RefSeq; NP_523424.2; NM_078700.4.
UniGene; Dm.2688; -.
ProteinModelPortal; P22814; -.
SMR; P22814; -.
BioGrid; 59347; 19.
ELM; P22814; -.
IntAct; P22814; 4.
MINT; MINT-777112; -.
STRING; 7227.FBpp0076971; -.
PaxDb; P22814; -.
PRIDE; P22814; -.
EnsemblMetazoa; FBtr0077279; FBpp0076971; FBgn0003300.
EnsemblMetazoa; FBtr0304593; FBpp0293135; FBgn0003300.
EnsemblMetazoa; FBtr0345922; FBpp0311837; FBgn0003300.
GeneID; 33059; -.
KEGG; dme:Dmel_CG1849; -.
CTD; 33059; -.
FlyBase; FBgn0003300; run.
eggNOG; KOG3982; Eukaryota.
eggNOG; ENOG4111J4Y; LUCA.
InParanoid; P22814; -.
KO; K20213; -.
OMA; HAFHPYN; -.
OrthoDB; EOG091G0CXB; -.
PhylomeDB; P22814; -.
SignaLink; P22814; -.
GenomeRNAi; 33059; -.
PRO; PR:P22814; -.
Proteomes; UP000000803; Chromosome X.
Bgee; FBgn0003300; -.
ExpressionAtlas; P22814; differential.
Genevisible; P22814; DM.
GO; GO:0005634; C:nucleus; IDA:FlyBase.
GO; GO:0005524; F:ATP binding; IEA:InterPro.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:FlyBase.
GO; GO:0007411; P:axon guidance; IMP:FlyBase.
GO; GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.
GO; GO:0048592; P:eye morphogenesis; IMP:FlyBase.
GO; GO:0007377; P:germ-band extension; IMP:FlyBase.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:FlyBase.
GO; GO:0007400; P:neuroblast fate determination; TAS:FlyBase.
GO; GO:0007366; P:periodic partitioning by pair rule gene; TAS:FlyBase.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:FlyBase.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:FlyBase.
GO; GO:0007367; P:segment polarity determination; IEA:UniProtKB-KW.
GO; GO:0007540; P:sex determination, establishment of X:A ratio; TAS:FlyBase.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0007419; P:ventral cord development; TAS:FlyBase.
Gene3D; 2.60.40.720; -; 1.
InterPro; IPR000040; AML1_Runt.
InterPro; IPR008967; p53-like_TF_DNA-bd.
InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd_sf.
InterPro; IPR013524; Runt_dom.
PANTHER; PTHR11950; PTHR11950; 1.
Pfam; PF00853; Runt; 1.
PRINTS; PR00967; ONCOGENEAML1.
SUPFAM; SSF49417; SSF49417; 1.
PROSITE; PS51062; RUNT; 1.
1: Evidence at protein level;
Complete proteome; Developmental protein; Nucleus; Pair-rule protein;
Reference proteome; Segmentation polarity protein; Transcription;
Transcription regulation.
CHAIN 1 510 Segmentation protein Runt.
/FTId=PRO_0000174664.
DOMAIN 106 234 Runt. {ECO:0000255|PROSITE-
ProRule:PRU00399}.
COMPBIAS 18 58 Ala-rich.
COMPBIAS 254 385 Ala-rich.
VARIANT 32 32 A -> P.
VARIANT 44 44 T -> A (in strain: OK17, OK94, Z42, Z55,
Z64 and Z74).
VARIANT 315 315 P -> S (in strain: OK94).
VARIANT 469 469 A -> S (in strain: Z27, OK13, OK5 and
Z16).
CONFLICT 18 18 Missing (in Ref. 1; CAA39817).
{ECO:0000305}.
CONFLICT 153 153 V -> W (in Ref. 1; CAA39817).
{ECO:0000305}.
CONFLICT 231 236 EPRSKQ -> DPR (in Ref. 5; AAM51942).
{ECO:0000305}.
CONFLICT 329 329 A -> S (in Ref. 1; CAA39817 and 2;
AAC27776/AAC27777/AAC27778/AAC27779/
AAC27780/AAC27781/AAC27782/AAC27783/
AAC27784/AAC27785/AAC27786).
{ECO:0000305}.
SEQUENCE 510 AA; 53209 MW; C32B1D344433362E CRC64;
MHLPAGPTMV ANNTQVLAAA AAAAAAAAAA VAQGPGPQQS SNATTASAIA INPAQSLANT
STHSASSTGS STPDLSTNNT SSSSNATTSP QNSAKMPSSM TDMFASLHEM LQEYHGELAQ
TGSPSILCSA LPNHWRSNKS LPGAFKVIAL DDVPDGTLVS IKCGNDENYC GELRNCTTTM
KNQVAKFNDL RFVGRSGRGK SFTLTITIAT YPVQIASYSK AIKVTVDGPR EPRSKQSYGY
PHPGAFNPFM LNPAWLDAAY MTYGYADYFR HQAAAQAAQV HHPALAKSSA SSVSPNPNPS
VATSSSSAVQ PSEYPHPAAA VAAAAGQPAA MMPSPPGAAP ATPYAIPQFP FNHVAAAAAA
KAATPHAFHP YNFAAAAGLR ARNAALHHQS EPVHVSPASS RPSSSSPTQQ HVLLKLNTSI
ETSSIHEQSA SDGDSDDEQI DVVKSEFDLD KSLDVAPLRM RCDLKAPSAM KPLYHESGPG
AVANSRQPSP ETTTKIKSAA VQQKTVWRPY


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