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Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)

 SRRM2_HUMAN             Reviewed;        2752 AA.
Q9UQ35; A6NKB9; D3DU97; O15038; O94803; Q6NSL3; Q6PIM3; Q6PK40;
Q8IW17; Q96GY7; Q9P0G1; Q9UHA8; Q9UQ36; Q9UQ37; Q9UQ38; Q9UQ40;
05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
06-MAR-2007, sequence version 2.
18-JUL-2018, entry version 154.
RecName: Full=Serine/arginine repetitive matrix protein 2;
AltName: Full=300 kDa nuclear matrix antigen;
AltName: Full=Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa;
Short=SR-related nuclear matrix protein of 300 kDa;
Short=Ser/Arg-related nuclear matrix protein of 300 kDa;
AltName: Full=Splicing coactivator subunit SRm300;
AltName: Full=Tax-responsive enhancer element-binding protein 803;
Short=TaxREB803;
Name=SRRM2; Synonyms=KIAA0324, SRL300, SRM300; ORFNames=HSPC075;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), RNA-BINDING, TISSUE
SPECIFICITY, AND PHOSPHORYLATION.
TISSUE=Cervix carcinoma;
PubMed=11004489; DOI=10.1016/S0167-4781(00)00065-8;
Sawada Y., Miura Y., Umeki K., Tamaoki T., Fujinaga K., Ohtaki S.;
"Cloning and characterization of a novel RNA-binding protein SRL300
with RS domains.";
Biochim. Biophys. Acta 1492:191-195(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PROTEIN SEQUENCE OF 1223-1226
AND 2587-2597, AND FUNCTION.
PubMed=10668804; DOI=10.1017/S1355838200991982;
Blencowe B.J., Bauren G., Eldridge A.G., Issner R., Nickerson J.A.,
Rosonina E., Sharp P.A.;
"The SRm160/300 splicing coactivator subunits.";
RNA 6:111-120(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT
THR-804.
TISSUE=Brain;
PubMed=9205841; DOI=10.1093/dnares/4.2.141;
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N.,
Tanaka A., Kotani H., Nomura N., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. VII.
The complete sequences of 100 new cDNA clones from brain which can
code for large proteins in vitro.";
DNA Res. 4:141-150(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15616553; DOI=10.1038/nature03187;
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
Rubin E.M., Pennacchio L.A.;
"The sequence and analysis of duplication-rich human chromosome 16.";
Nature 432:988-994(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE
SEQUENCE [LARGE SCALE MRNA] OF 1-1018 (ISOFORMS 1/2), AND NUCLEOTIDE
SEQUENCE [LARGE SCALE MRNA] OF 2555-2752 (ISOFORMS 1/2).
TISSUE=Embryonic testis, Muscle, Placenta, and Retina;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
PROTEIN SEQUENCE OF 1-11; 44-51; 116-130; 137-155; 357-401; 1001-1013;
1041-1058; 1101-1111; 1119-1128; 1138-1158; 1224-1277; 1316-1352;
1394-1412; 1539-1556; 2104-2113; 2120-2129; 2132-2163; 2181-2221;
2232-2392; 2431-2460 AND 2690-2698, ACETYLATION AT MET-1, AND
IDENTIFICATION BY MASS SPECTROMETRY.
TISSUE=Colon carcinoma;
Bienvenut W.V., Heiserich L., Boulahbel H., Gottlieb E.;
Submitted (JUL-2007) to UniProtKB.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 88-185.
TISSUE=Umbilical cord blood;
Ye M., Zhang Q.-H., Zhou J., Shen Y., Wu X.-Y., Guan Z.Q., Wang L.,
Fan H.-Y., Mao Y.-F., Dai M., Huang Q.-H., Chen S.-J., Chen Z.;
"Human partial CDS from CD34+ stem cells.";
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
[9]
IDENTIFICATION IN A PRE-MRNA SPLICING COMPLEX WITH SFRS4; SFRS5;
SNRP70; SNRPA1 AND SRRM1.
PubMed=9531537; DOI=10.1101/gad.12.7.996;
Blencowe B.J., Issner R., Nickerson J.A., Sharp P.A.;
"A coactivator of pre-mRNA splicing.";
Genes Dev. 12:996-1009(1998).
[10]
IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE
SPLICEOSOMAL C COMPLEX.
PubMed=11991638; DOI=10.1017/S1355838202021088;
Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.;
"Purification and characterization of native spliceosomes suitable for
three-dimensional structural analysis.";
RNA 8:426-439(2002).
[11]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Leukemic T-cell;
PubMed=15144186; DOI=10.1021/ac035352d;
Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,
Peters E.C.;
"Robust phosphoproteomic profiling of tyrosine phosphorylation sites
from human T cells using immobilized metal affinity chromatography and
tandem mass spectrometry.";
Anal. Chem. 76:2763-2772(2004).
[12]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-440; THR-1003; SER-1132;
SER-1188; SER-1329 AND THR-1492, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in
signaling networks.";
Cell 127:635-648(2006).
[13]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-367; SER-377; SER-871;
SER-876; SER-954; SER-1072; SER-1073; SER-1102; SER-2272; THR-2291;
THR-2316; SER-2382 AND SER-2694, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=16964243; DOI=10.1038/nbt1240;
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
"A probability-based approach for high-throughput protein
phosphorylation analysis and site localization.";
Nat. Biotechnol. 24:1285-1292(2006).
[14]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1531, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=17924679; DOI=10.1021/pr070152u;
Yu L.R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
"Improved titanium dioxide enrichment of phosphopeptides from HeLa
cells and high confident phosphopeptide identification by cross-
validation of MS/MS and MS/MS/MS spectra.";
J. Proteome Res. 6:4150-4162(2007).
[15]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377 AND SER-2449, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryonic kidney;
PubMed=17525332; DOI=10.1126/science.1140321;
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,
Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,
Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
"ATM and ATR substrate analysis reveals extensive protein networks
responsive to DNA damage.";
Science 316:1160-1166(2007).
[16]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2272, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18220336; DOI=10.1021/pr0705441;
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,
Yates J.R. III;
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for
efficient phosphoproteomic analysis.";
J. Proteome Res. 7:1346-1351(2008).
[17]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295; SER-297; SER-322;
SER-323; SER-351; SER-353; SER-377; SER-387; SER-398; SER-435;
SER-440; SER-778; SER-780; SER-783; SER-857; SER-864; THR-866;
SER-950; SER-952; SER-954; SER-957; SER-968; SER-970; SER-972;
SER-974; THR-983; SER-994; THR-1003; SER-1014; SER-1028; SER-1032;
SER-1064; SER-1069; SER-1072; SER-1073; SER-1099; SER-1101; SER-1102;
SER-1103; SER-1112; SER-1179; SER-1188; THR-1208; SER-1318; SER-1320;
SER-1326; SER-1329; SER-1387; SER-1401; SER-1404; THR-1413; SER-1415;
SER-1444; SER-1451; THR-1453; THR-1472; THR-1511; SER-1522; THR-1531;
SER-1537; SER-1539; SER-1541; SER-1542; SER-1552; SER-1691; SER-1693;
SER-1694; THR-1698; SER-1876; SER-1878; THR-1880; SER-1923; SER-1925;
THR-1927; SER-1946; SER-1948; THR-1950; SER-1958; SER-1960; THR-1962;
SER-1970; SER-2100; SER-2102; THR-2104; SER-2118; SER-2121; SER-2123;
SER-2132; THR-2144; SER-2272; THR-2289; THR-2302; THR-2316; THR-2329;
SER-2382; SER-2398; SER-2407; THR-2409; SER-2412; SER-2449; SER-2581;
SER-2675; SER-2677; SER-2690; SER-2692 AND SER-2694, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[18]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19413330; DOI=10.1021/ac9004309;
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,
Mohammed S.;
"Lys-N and trypsin cover complementary parts of the phosphoproteome in
a refined SCX-based approach.";
Anal. Chem. 81:4493-4501(2009).
[19]
COMPLEMENTATION OF YEAST MUTANTS.
PubMed=19854871; DOI=10.1261/rna.1908309;
Grainger R.J., Barrass J.D., Jacquier A., Rain J.-C., Beggs J.D.;
"Physical and genetic interactions of yeast Cwc21p, an ortholog of
human SRm300/SRRM2, suggest a role at the catalytic center of the
spliceosome.";
RNA 15:2161-2173(2009).
[20]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-145; SER-322; SER-323;
SER-351; SER-353; SER-357; SER-358; THR-359; THR-367; SER-377;
SER-846; SER-857; THR-866; SER-876; SER-952; SER-954; THR-1003;
SER-1099; SER-1101; SER-1102; SER-1103; THR-1106; SER-1214; SER-1318;
SER-1320; SER-1326; SER-1329; SER-1382; SER-1387; SER-1401; SER-1403;
SER-1404; SER-2100; SER-2102; THR-2104; SER-2132; SER-2272; THR-2289;
THR-2316; THR-2381; SER-2382 AND SER-2449, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Leukemic T-cell;
PubMed=19690332; DOI=10.1126/scisignal.2000007;
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
Rodionov V., Han D.K.;
"Quantitative phosphoproteomic analysis of T cell receptor signaling
reveals system-wide modulation of protein-protein interactions.";
Sci. Signal. 2:RA46-RA46(2009).
[21]
ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-169, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19608861; DOI=10.1126/science.1175371;
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M.,
Walther T.C., Olsen J.V., Mann M.;
"Lysine acetylation targets protein complexes and co-regulates major
cellular functions.";
Science 325:834-840(2009).
[22]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-220; SER-222; THR-286;
SER-295; SER-297; SER-300; SER-351; SER-353; THR-367; SER-377;
SER-424; SER-440; SER-454; SER-484; SER-486; SER-778; THR-866;
SER-871; SER-875; SER-876; SER-950; SER-973; SER-974; THR-983;
SER-994; THR-1003; SER-1014; SER-1028; SER-1083; SER-1099; SER-1101;
SER-1103; SER-1122; SER-1124; SER-1132; SER-1152; SER-1179; SER-1188;
SER-1219; SER-1320; SER-1326; SER-1329; SER-1336; SER-1368; SER-1387;
SER-1404; THR-1413; SER-1415; SER-1421; THR-1434; SER-1460; SER-1462;
SER-1463; SER-1482; SER-1483; THR-1492; SER-1497; SER-1499; SER-1501;
SER-1502; SER-1621; SER-1762; SER-1764; SER-1854; SER-1857; SER-1890;
THR-1892; SER-1893; SER-1916; SER-1919; SER-1925; THR-1927; SER-1948;
THR-1950; SER-1960; THR-1962; SER-1972; SER-1975; SER-1984; SER-1987;
SER-1996; SER-1999; SER-2008; SER-2011; SER-2044; SER-2046; THR-2069;
SER-2071; SER-2102; THR-2104; SER-2123; SER-2132; SER-2272; THR-2289;
THR-2302; THR-2329; SER-2335; SER-2343; SER-2382; SER-2394; SER-2398;
SER-2407; THR-2409; SER-2426; SER-2449; SER-2453; SER-2581; THR-2583;
SER-2664; SER-2684; SER-2688; SER-2690; SER-2692; SER-2694; SER-2702
AND SER-2706, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=20068231; DOI=10.1126/scisignal.2000475;
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
Mann M.;
"Quantitative phosphoproteomics reveals widespread full
phosphorylation site occupancy during mitosis.";
Sci. Signal. 3:RA3-RA3(2010).
[23]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
[24]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-297; SER-351; SER-353;
SER-377; SER-398; SER-404; SER-408; SER-424; SER-440; SER-778;
SER-783; SER-876; SER-908; SER-973; SER-974; THR-977; THR-1003;
THR-1043; SER-1069; SER-1099; SER-1101; SER-1103; SER-1124; SER-1129;
SER-1132; SER-1179; SER-1188; SER-1219; SER-1320; SER-1329; SER-1382;
SER-1387; SER-1404; THR-1413; SER-1415; SER-1424; SER-1444; SER-1458;
SER-1463; SER-1497; SER-1499; SER-1502; SER-1517; SER-1519; SER-1521;
SER-1522; SER-1542; SER-1552; SER-1577; SER-1579; SER-1581; SER-1582;
SER-1598; SER-1600; SER-1601; SER-1648; SER-1658; SER-1694; SER-1727;
SER-1729; SER-1731; SER-1732; SER-1762; SER-1764; SER-1818; SER-1822;
SER-1854; SER-1878; SER-1884; SER-1890; SER-1916; SER-1919; SER-1925;
THR-1927; THR-1931; SER-1948; THR-1950; THR-1954; SER-1960; THR-1962;
THR-1966; SER-1970; SER-1972; SER-1975; THR-1978; SER-1984; SER-1987;
SER-1996; SER-1999; SER-2008; SER-2011; SER-2020; THR-2022; SER-2032;
THR-2034; SER-2044; SER-2046; SER-2067; THR-2069; SER-2071; SER-2090;
THR-2092; THR-2104; SER-2123; SER-2132; SER-2272; SER-2382; SER-2398;
SER-2407; SER-2412; SER-2415; SER-2426; SER-2429; SER-2449; SER-2581;
SER-2664; SER-2684; SER-2688; SER-2692; SER-2694; SER-2702 AND
SER-2706, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].
PubMed=21406692; DOI=10.1126/scisignal.2001570;
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
Blagoev B.;
"System-wide temporal characterization of the proteome and
phosphoproteome of human embryonic stem cell differentiation.";
Sci. Signal. 4:RS3-RS3(2011).
[25]
ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22223895; DOI=10.1074/mcp.M111.015131;
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C.,
Meinnel T., Giglione C.;
"Comparative large-scale characterisation of plant vs. mammal proteins
reveals similar and idiosyncratic N-alpha acetylation features.";
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
[26]
ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22814378; DOI=10.1073/pnas.1210303109;
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E.,
Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K.,
Aldabe R.;
"N-terminal acetylome analyses and functional insights of the N-
terminal acetyltransferase NatB.";
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
[27]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295; SER-297; SER-300;
SER-322; SER-323; THR-367; SER-377; SER-387; SER-424; SER-435;
SER-436; SER-437; SER-440; SER-506; SER-508; SER-510; SER-534;
SER-536; SER-543; SER-702; SER-704; SER-706; SER-778; SER-780;
SER-857; SER-864; THR-866; SER-876; SER-950; SER-952; SER-954;
THR-983; SER-992; SER-994; THR-1003; SER-1010; SER-1014; SER-1064;
SER-1069; SER-1083; SER-1103; SER-1112; SER-1122; SER-1124; SER-1132;
SER-1152; SER-1179; SER-1188; SER-1198; THR-1208; SER-1227; SER-1254;
SER-1257; SER-1258; SER-1318; SER-1320; SER-1326; SER-1329; SER-1382;
SER-1387; SER-1401; SER-1403; SER-1404; THR-1413; THR-1434; SER-1444;
SER-1458; SER-1463; THR-1492; SER-1499; THR-1531; SER-1537; SER-1539;
SER-1541; SER-1542; SER-1552; SER-1648; SER-1694; SER-1854; SER-1857;
SER-1876; SER-1878; THR-1880; SER-2018; SER-2020; THR-2022; SER-2030;
SER-2032; THR-2034; SER-2042; SER-2044; SER-2046; SER-2067; THR-2069;
SER-2071; SER-2100; SER-2102; THR-2104; SER-2121; SER-2123; SER-2132;
SER-2272; THR-2289; SER-2310; THR-2316; THR-2329; SER-2335; SER-2368;
SER-2376; SER-2398; SER-2407; THR-2409; SER-2412; SER-2426; SER-2449;
SER-2581; THR-2599; SER-2675; SER-2677; SER-2684; SER-2688; SER-2692;
SER-2694; SER-2702; THR-2738 AND SER-2740, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma, and Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[28]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295; SER-297; SER-300;
SER-323; SER-351; SER-353; SER-377; THR-383; THR-384; SER-387;
SER-395; SER-398; SER-404; SER-408; SER-424; SER-440; THR-866;
SER-935; THR-983; SER-994; TYR-996; THR-1003; SER-1010; SER-1014;
TYR-1049; SER-1083; SER-1124; SER-1132; SER-1152; SER-1179; SER-1188;
SER-1219; SER-1311; SER-1320; SER-1326; SER-1329; SER-1387; SER-2272;
SER-2382; SER-2581; THR-2583 AND SER-2702, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[29]
METHYLATION [LARGE SCALE ANALYSIS] AT ARG-2194; ARG-2207; ARG-2231;
ARG-2246; ARG-2274; ARG-2288; ARG-2342 AND ARG-2384, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Colon carcinoma;
PubMed=24129315; DOI=10.1074/mcp.O113.027870;
Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V.,
Aguiar M., Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C.,
Vemulapalli V., Bedford M.T., Comb M.J.;
"Immunoaffinity enrichment and mass spectrometry analysis of protein
methylation.";
Mol. Cell. Proteomics 13:372-387(2014).
[30]
SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-108; LYS-130 AND LYS-2587,
AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=28112733; DOI=10.1038/nsmb.3366;
Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
Nielsen M.L.;
"Site-specific mapping of the human SUMO proteome reveals co-
modification with phosphorylation.";
Nat. Struct. Mol. Biol. 24:325-336(2017).
-!- FUNCTION: Involved in pre-mRNA splicing. May function at or prior
to the first catalytic step of splicing at the catalytic center of
the spliceosome. May do so by stabilizing the catalytic center or
the position of the RNA substrate (By similarity). Binds to RNA.
{ECO:0000250, ECO:0000269|PubMed:10668804}.
-!- SUBUNIT: Component of the active spliceosome. Found in a pre-mRNA
splicing complex with SFRS4, SFRS5, SNRP70, SNRPA1, SRRM1 and
SRRM2. Identified in the spliceosome C complex.
{ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:9531537}.
-!- INTERACTION:
P31946:YWHAB; NbExp=2; IntAct=EBI-1050142, EBI-359815;
P61981:YWHAG; NbExp=2; IntAct=EBI-1050142, EBI-359832;
-!- SUBCELLULAR LOCATION: Nucleus speckle.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=Q9UQ35-1; Sequence=Displayed;
Name=2;
IsoId=Q9UQ35-2; Sequence=VSP_020187;
Note=No experimental confirmation available.;
Name=3;
IsoId=Q9UQ35-3; Sequence=VSP_020184, VSP_020185, VSP_020186;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Expressed in liver, placenta, and white blood
cells. {ECO:0000269|PubMed:11004489}.
-!- MISCELLANEOUS: Can functionally substitute for CWC12 in yeast.
{ECO:0000305|PubMed:19854871}.
-!- SIMILARITY: Belongs to the CWC21 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAF21439.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
Sequence=AAF28898.1; Type=Frameshift; Positions=167, 175, 179; Evidence={ECO:0000305};
Sequence=AAH70050.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Sequence=BAA20782.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AB015644; BAA34957.1; -; mRNA.
EMBL; AB016087; BAA83713.1; -; mRNA.
EMBL; AB016089; BAA83715.1; -; mRNA.
EMBL; AB016090; BAA83716.1; -; mRNA.
EMBL; AB016091; BAA83717.1; -; mRNA.
EMBL; AB016092; BAA83718.1; -; mRNA.
EMBL; AF201422; AAF21439.1; ALT_FRAME; mRNA.
EMBL; AB002322; BAA20782.3; ALT_INIT; mRNA.
EMBL; AC092117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471112; EAW85478.1; -; Genomic_DNA.
EMBL; CH471112; EAW85477.1; -; Genomic_DNA.
EMBL; CH471112; EAW85480.1; -; Genomic_DNA.
EMBL; BC007752; AAH07752.1; -; mRNA.
EMBL; BC009062; AAH09062.1; -; mRNA.
EMBL; BC041155; AAH41155.1; -; mRNA.
EMBL; BC070050; AAH70050.1; ALT_SEQ; mRNA.
EMBL; AF161338; AAF28898.1; ALT_FRAME; mRNA.
CCDS; CCDS32373.1; -. [Q9UQ35-1]
RefSeq; NP_057417.3; NM_016333.3. [Q9UQ35-1]
UniGene; Hs.433343; -.
PDB; 5MQF; EM; 5.90 A; S=1-2752.
PDB; 5XJC; EM; 3.60 A; U=1-2752.
PDBsum; 5MQF; -.
PDBsum; 5XJC; -.
ProteinModelPortal; Q9UQ35; -.
SMR; Q9UQ35; -.
BioGrid; 117071; 263.
CORUM; Q9UQ35; -.
IntAct; Q9UQ35; 81.
MINT; Q9UQ35; -.
STRING; 9606.ENSP00000301740; -.
iPTMnet; Q9UQ35; -.
PhosphoSitePlus; Q9UQ35; -.
SwissPalm; Q9UQ35; -.
BioMuta; SRRM2; -.
DMDM; 143928063; -.
EPD; Q9UQ35; -.
PaxDb; Q9UQ35; -.
PeptideAtlas; Q9UQ35; -.
PRIDE; Q9UQ35; -.
ProteomicsDB; 85503; -.
ProteomicsDB; 85504; -. [Q9UQ35-2]
ProteomicsDB; 85505; -. [Q9UQ35-3]
TopDownProteomics; Q9UQ35-3; -. [Q9UQ35-3]
Ensembl; ENST00000301740; ENSP00000301740; ENSG00000167978. [Q9UQ35-1]
Ensembl; ENST00000630499; ENSP00000487247; ENSG00000167978. [Q9UQ35-3]
GeneID; 23524; -.
KEGG; hsa:23524; -.
UCSC; uc002crk.3; human. [Q9UQ35-1]
CTD; 23524; -.
DisGeNET; 23524; -.
EuPathDB; HostDB:ENSG00000167978.16; -.
GeneCards; SRRM2; -.
H-InvDB; HIX0194349; -.
HGNC; HGNC:16639; SRRM2.
HPA; HPA041411; -.
HPA; HPA066181; -.
MIM; 606032; gene.
neXtProt; NX_Q9UQ35; -.
OpenTargets; ENSG00000167978; -.
PharmGKB; PA38178; -.
eggNOG; KOG1869; Eukaryota.
eggNOG; ENOG4111F3M; LUCA.
GeneTree; ENSGT00730000110977; -.
HOVERGEN; HBG093999; -.
InParanoid; Q9UQ35; -.
KO; K13172; -.
OMA; RNHSGSR; -.
OrthoDB; EOG091G0NRZ; -.
TreeFam; TF335721; -.
Reactome; R-HSA-72163; mRNA Splicing - Major Pathway.
ChiTaRS; SRRM2; human.
GeneWiki; SRRM2; -.
GenomeRNAi; 23524; -.
PRO; PR:Q9UQ35; -.
Proteomes; UP000005640; Chromosome 16.
Bgee; ENSG00000167978; -.
ExpressionAtlas; Q9UQ35; baseline and differential.
Genevisible; Q9UQ35; HS.
GO; GO:0015030; C:Cajal body; IDA:UniProtKB.
GO; GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.
GO; GO:0016607; C:nuclear speck; IDA:UniProtKB.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0071007; C:U2-type catalytic step 2 spliceosome; IDA:UniProtKB.
GO; GO:0070742; F:C2H2 zinc finger domain binding; IDA:UniProtKB.
GO; GO:0047485; F:protein N-terminus binding; IPI:UniProtKB.
GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
GO; GO:0000398; P:mRNA splicing, via spliceosome; IDA:UniProtKB.
InterPro; IPR013170; mRNA_splic_Cwf21_dom.
InterPro; IPR024945; Spt5_C_dom.
Pfam; PF08312; cwf21; 1.
SMART; SM01104; CTD; 1.
1: Evidence at protein level;
3D-structure; Acetylation; Alternative splicing; Coiled coil;
Complete proteome; Direct protein sequencing; Isopeptide bond;
Methylation; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
Polymorphism; Reference proteome; RNA-binding; Spliceosome;
Ubl conjugation.
CHAIN 1 2752 Serine/arginine repetitive matrix protein
2.
/FTId=PRO_0000248154.
REGION 197 259 Sufficient for RNA-binding.
COILED 60 92 {ECO:0000255}.
COMPBIAS 177 2731 Ser-rich.
COMPBIAS 186 246 Lys-rich.
COMPBIAS 350 447 Pro-rich.
COMPBIAS 462 816 Arg-rich.
COMPBIAS 1666 2089 Arg-rich.
COMPBIAS 2182 2378 Ala-rich.
COMPBIAS 2673 2750 Arg-rich.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000244|PubMed:22223895,
ECO:0000244|PubMed:22814378,
ECO:0000269|Ref.7}.
MOD_RES 101 101 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q8BTI8}.
MOD_RES 145 145 Phosphotyrosine.
{ECO:0000244|PubMed:19690332}.
MOD_RES 169 169 N6-acetyllysine.
{ECO:0000244|PubMed:19608861}.
MOD_RES 220 220 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 222 222 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 286 286 Phosphothreonine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 295 295 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 297 297 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 300 300 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 322 322 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:23186163}.
MOD_RES 323 323 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 351 351 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:24275569}.
MOD_RES 353 353 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:24275569}.
MOD_RES 357 357 Phosphoserine.
{ECO:0000244|PubMed:19690332}.
MOD_RES 358 358 Phosphoserine.
{ECO:0000244|PubMed:19690332}.
MOD_RES 359 359 Phosphothreonine.
{ECO:0000244|PubMed:19690332}.
MOD_RES 367 367 Phosphothreonine.
{ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163}.
MOD_RES 377 377 Phosphoserine.
{ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:17525332,
ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 383 383 Phosphothreonine.
{ECO:0000244|PubMed:24275569}.
MOD_RES 384 384 Phosphothreonine.
{ECO:0000244|PubMed:24275569}.
MOD_RES 387 387 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 395 395 Phosphoserine.
{ECO:0000244|PubMed:24275569}.
MOD_RES 398 398 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:24275569}.
MOD_RES 404 404 Phosphoserine.
{ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:24275569}.
MOD_RES 408 408 Phosphoserine.
{ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:24275569}.
MOD_RES 424 424 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 435 435 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163}.
MOD_RES 436 436 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 437 437 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 440 440 Phosphoserine.
{ECO:0000244|PubMed:17081983,
ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 454 454 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 484 484 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 486 486 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 506 506 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 508 508 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 510 510 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 534 534 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 536 536 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 543 543 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 702 702 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 704 704 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 706 706 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 778 778 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 780 780 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163}.
MOD_RES 783 783 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:21406692}.
MOD_RES 846 846 Phosphoserine.
{ECO:0000244|PubMed:19690332}.
MOD_RES 854 854 Phosphoserine.
{ECO:0000250|UniProtKB:Q8BTI8}.
MOD_RES 856 856 Phosphothreonine.
{ECO:0000250|UniProtKB:Q8BTI8}.
MOD_RES 857 857 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:23186163}.
MOD_RES 864 864 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163}.
MOD_RES 866 866 Phosphothreonine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 871 871 Phosphoserine.
{ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:20068231}.
MOD_RES 875 875 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 876 876 Phosphoserine.
{ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 908 908 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 935 935 Phosphoserine.
{ECO:0000244|PubMed:24275569}.
MOD_RES 950 950 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163}.
MOD_RES 952 952 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:23186163}.
MOD_RES 954 954 Phosphoserine.
{ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:23186163}.
MOD_RES 957 957 Phosphoserine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 968 968 Phosphoserine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 970 970 Phosphoserine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 972 972 Phosphoserine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 973 973 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 974 974 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 977 977 Phosphothreonine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 983 983 Phosphothreonine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 992 992 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 994 994 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 996 996 Phosphotyrosine.
{ECO:0000244|PubMed:24275569}.
MOD_RES 1003 1003 Phosphothreonine.
{ECO:0000244|PubMed:17081983,
ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 1010 1010 Phosphoserine.
{ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 1014 1014 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 1024 1024 Phosphoserine.
{ECO:0000250|UniProtKB:Q8BTI8}.
MOD_RES 1028 1028 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231}.
MOD_RES 1032 1032 Phosphoserine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 1042 1042 Phosphoserine.
{ECO:0000250|UniProtKB:Q8BTI8}.
MOD_RES 1043 1043 Phosphothreonine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1049 1049 Phosphotyrosine.
{ECO:0000244|PubMed:24275569}.
MOD_RES 1064 1064 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163}.
MOD_RES 1069 1069 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 1072 1072 Phosphoserine.
{ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:18669648}.
MOD_RES 1073 1073 Phosphoserine.
{ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:18669648}.
MOD_RES 1083 1083 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 1099 1099 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1101 1101 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1102 1102 Phosphoserine.
{ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332}.
MOD_RES 1103 1103 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 1106 1106 Phosphothreonine.
{ECO:0000244|PubMed:19690332}.
MOD_RES 1112 1112 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163}.
MOD_RES 1122 1122 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163}.
MOD_RES 1124 1124 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 1129 1129 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1132 1132 Phosphoserine.
{ECO:0000244|PubMed:17081983,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 1152 1152 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 1179 1179 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 1188 1188 Phosphoserine.
{ECO:0000244|PubMed:17081983,
ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 1198 1198 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 1208 1208 Phosphothreonine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163}.
MOD_RES 1214 1214 Phosphoserine.
{ECO:0000244|PubMed:19690332}.
MOD_RES 1219 1219 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:24275569}.
MOD_RES 1227 1227 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 1254 1254 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 1257 1257 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 1258 1258 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 1266 1266 Phosphoserine.
{ECO:0000250|UniProtKB:Q8BTI8}.
MOD_RES 1270 1270 Phosphoserine.
{ECO:0000250|UniProtKB:Q8BTI8}.
MOD_RES 1271 1271 Phosphoserine.
{ECO:0000250|UniProtKB:Q8BTI8}.
MOD_RES 1311 1311 Phosphoserine.
{ECO:0000244|PubMed:24275569}.
MOD_RES 1318 1318 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:23186163}.
MOD_RES 1320 1320 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 1326 1326 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 1329 1329 Phosphoserine.
{ECO:0000244|PubMed:17081983,
ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 1336 1336 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 1348 1348 Phosphoserine.
{ECO:0000250|UniProtKB:Q8BTI8}.
MOD_RES 1368 1368 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 1382 1382 Phosphoserine.
{ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 1383 1383 Phosphoserine.
{ECO:0000250|UniProtKB:Q8BTI8}.
MOD_RES 1384 1384 Phosphoserine.
{ECO:0000250|UniProtKB:Q8BTI8}.
MOD_RES 1387 1387 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 1401 1401 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:23186163}.
MOD_RES 1403 1403 Phosphoserine.
{ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:23186163}.
MOD_RES 1404 1404 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 1413 1413 Phosphothreonine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 1415 1415 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1421 1421 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 1423 1423 Phosphoserine.
{ECO:0000250|UniProtKB:Q8BTI8}.
MOD_RES 1424 1424 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1434 1434 Phosphothreonine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163}.
MOD_RES 1444 1444 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 1451 1451 Phosphoserine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 1453 1453 Phosphothreonine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 1458 1458 Phosphoserine.
{ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 1460 1460 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 1462 1462 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 1463 1463 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 1472 1472 Phosphothreonine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 1482 1482 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 1483 1483 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 1492 1492 Phosphothreonine.
{ECO:0000244|PubMed:17081983,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163}.
MOD_RES 1497 1497 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1499 1499 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 1501 1501 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 1502 1502 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1511 1511 Phosphothreonine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 1517 1517 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1519 1519 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1521 1521 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1522 1522 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:21406692}.
MOD_RES 1531 1531 Phosphothreonine.
{ECO:0000244|PubMed:17924679,
ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163}.
MOD_RES 1537 1537 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163}.
MOD_RES 1539 1539 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163}.
MOD_RES 1541 1541 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163}.
MOD_RES 1542 1542 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 1552 1552 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 1577 1577 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1579 1579 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1581 1581 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1582 1582 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1598 1598 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1600 1600 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1601 1601 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1616 1616 Phosphoserine.
{ECO:0000250|UniProtKB:Q8BTI8}.
MOD_RES 1620 1620 Phosphoserine.
{ECO:0000250|UniProtKB:Q8BTI8}.
MOD_RES 1621 1621 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 1648 1648 Phosphoserine.
{ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 1658 1658 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1691 1691 Phosphoserine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 1693 1693 Phosphoserine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 1694 1694 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 1698 1698 Phosphothreonine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 1727 1727 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1729 1729 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1731 1731 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1732 1732 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1762 1762 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1764 1764 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1818 1818 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1822 1822 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1854 1854 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 1857 1857 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163}.
MOD_RES 1876 1876 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163}.
MOD_RES 1878 1878 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 1880 1880 Phosphothreonine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163}.
MOD_RES 1884 1884 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1890 1890 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1892 1892 Phosphothreonine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 1893 1893 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 1916 1916 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1919 1919 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1923 1923 Phosphoserine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 1925 1925 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1927 1927 Phosphothreonine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1931 1931 Phosphothreonine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1946 1946 Phosphoserine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 1948 1948 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1950 1950 Phosphothreonine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1954 1954 Phosphothreonine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1958 1958 Phosphoserine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 1960 1960 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1962 1962 Phosphothreonine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1966 1966 Phosphothreonine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1970 1970 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:21406692}.
MOD_RES 1972 1972 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1975 1975 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1978 1978 Phosphothreonine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 1984 1984 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1987 1987 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1996 1996 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 1999 1999 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 2008 2008 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 2011 2011 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 2018 2018 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 2020 2020 Phosphoserine.
{ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2022 2022 Phosphothreonine.
{ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2030 2030 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 2032 2032 Phosphoserine.
{ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2034 2034 Phosphothreonine.
{ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2042 2042 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 2044 2044 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2046 2046 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2067 2067 Phosphoserine.
{ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2069 2069 Phosphothreonine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2071 2071 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2090 2090 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 2092 2092 Phosphothreonine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 2100 2100 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:23186163}.
MOD_RES 2102 2102 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163}.
MOD_RES 2104 2104 Phosphothreonine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2118 2118 Phosphoserine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 2121 2121 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163}.
MOD_RES 2123 2123 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2132 2132 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2144 2144 Phosphothreonine.
{ECO:0000244|PubMed:18669648}.
MOD_RES 2194 2194 Omega-N-methylarginine.
{ECO:0000244|PubMed:24129315}.
MOD_RES 2207 2207 Omega-N-methylarginine.
{ECO:0000244|PubMed:24129315}.
MOD_RES 2231 2231 Omega-N-methylarginine.
{ECO:0000244|PubMed:24129315}.
MOD_RES 2246 2246 Omega-N-methylarginine.
{ECO:0000244|PubMed:24129315}.
MOD_RES 2272 2272 Phosphoserine.
{ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:18220336,
ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 2274 2274 Omega-N-methylarginine.
{ECO:0000244|PubMed:24129315}.
MOD_RES 2288 2288 Omega-N-methylarginine.
{ECO:0000244|PubMed:24129315}.
MOD_RES 2289 2289 Phosphothreonine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163}.
MOD_RES 2291 2291 Phosphothreonine.
{ECO:0000244|PubMed:16964243}.
MOD_RES 2302 2302 Phosphothreonine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231}.
MOD_RES 2310 2310 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 2316 2316 Phosphothreonine.
{ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:23186163}.
MOD_RES 2329 2329 Phosphothreonine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163}.
MOD_RES 2335 2335 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163}.
MOD_RES 2342 2342 Omega-N-methylarginine.
{ECO:0000244|PubMed:24129315}.
MOD_RES 2343 2343 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 2368 2368 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 2376 2376 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 2381 2381 Phosphothreonine.
{ECO:0000244|PubMed:19690332}.
MOD_RES 2382 2382 Phosphoserine.
{ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:24275569}.
MOD_RES 2384 2384 Asymmetric dimethylarginine; alternate.
{ECO:0000244|PubMed:24129315}.
MOD_RES 2384 2384 Omega-N-methylarginine; alternate.
{ECO:0000244|PubMed:24129315}.
MOD_RES 2394 2394 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 2398 2398 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2407 2407 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2409 2409 Phosphothreonine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163}.
MOD_RES 2412 2412 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2415 2415 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 2426 2426 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2429 2429 Phosphoserine.
{ECO:0000244|PubMed:21406692}.
MOD_RES 2449 2449 Phosphoserine.
{ECO:0000244|PubMed:17525332,
ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2453 2453 Phosphoserine.
{ECO:0000244|PubMed:20068231}.
MOD_RES 2581 2581 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 2583 2583 Phosphothreonine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:24275569}.
MOD_RES 2599 2599 Phosphothreonine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 2664 2664 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 2675 2675 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163}.
MOD_RES 2677 2677 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:23186163}.
MOD_RES 2684 2684 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2688 2688 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2690 2690 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231}.
MOD_RES 2692 2692 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2694 2694 Phosphoserine.
{ECO:0000244|PubMed:16964243,
ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163}.
MOD_RES 2702 2702 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692,
ECO:0000244|PubMed:23186163,
ECO:0000244|PubMed:24275569}.
MOD_RES 2706 2706 Phosphoserine.
{ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:21406692}.
MOD_RES 2738 2738 Phosphothreonine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 2740 2740 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
CROSSLNK 108 108 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000244|PubMed:28112733}.
CROSSLNK 130 130 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000244|PubMed:28112733}.
CROSSLNK 2587 2587 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000244|PubMed:28112733}.
VAR_SEQ 1 96 Missing (in isoform 3).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_020184.
VAR_SEQ 394 407 PSEASPTRDRSPPK -> SPQLFMFLKGILVF (in
isoform 3).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_020185.
VAR_SEQ 408 2752 Missing (in isoform 3).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_020186.
VAR_SEQ 2023 2440 Missing (in isoform 2).
{ECO:0000303|PubMed:10668804}.
/FTId=VSP_020187.
VARIANT 804 804 P -> T (in dbSNP:rs2240140).
{ECO:0000269|PubMed:9205841}.
/FTId=VAR_027259.
VARIANT 856 856 T -> R (in dbSNP:rs12185191).
/FTId=VAR_048868.
VARIANT 883 883 S -> C (in dbSNP:rs17136053).
/FTId=VAR_027260.
CONFLICT 157 157 A -> V (in Ref. 8; AAF28898).
{ECO:0000305}.
CONFLICT 178 179 SS -> NN (in Ref. 2; AAF21439).
{ECO:0000305}.
CONFLICT 195 195 D -> K (in Ref. 6; AAH07752).
{ECO:0000305}.
CONFLICT 314 314 G -> S (in Ref. 2; AAF21439).
{ECO:0000305}.
CONFLICT 321 321 P -> A (in Ref. 2; AAF21439).
{ECO:0000305}.
CONFLICT 1474 1474 S -> F (in Ref. 1; BAA83716/BAA83718).
{ECO:0000305}.
SEQUENCE 2752 AA; 299615 MW; 7A5DCEB9B50AA912 CRC64;
MYNGIGLPTP RGSGTNGYVQ RNLSLVRGRR GERPDYKGEE ELRRLEAALV KRPNPDILDH
ERKRRVELRC LELEEMMEEQ GYEEQQIQEK VATFRLMLLE KDVNPGGKEE TPGQRPAVTE
THQLAELNEK KNERLRAAFG ISDSYVDGSS FDPQRRAREA KQPAPEPPKP YSLVRESSSS
RSPTPKQKKK KKKKDRGRRS ESSSPRRERK KSSKKKKHRS ESESKKRKHR SPTPKSKRKS
KDKKRKRSRS TTPAPKSRRA HRSTSADSAS SSDTSRSRSR SAAAKTHTTA LAGRSPSPAS
GRRGEGDAPF SEPGTTSTQR PSSPETATKQ PSSPYEDKDK DKKEKSATRP SPSPERSSTG
PEPPAPTPLL AERHGGSPQP LATTPLSQEP VNPPSEASPT RDRSPPKSPE KLPQSSSSES
SPPSPQPTKV SRHASSSPES PKPAPAPGSH REISSSPTSK NRSHGRAKRD KSHSHTPSRR
MGRSRSPATA KRGRSRSRTP TKRGHSRSRS PQWRRSRSAQ RWGRSRSPQR RGRSRSPQRP
GWSRSRNTQR RGRSRSARRG RSHSRSPATR GRSRSRTPAR RGRSRSRTPA RRRSRSRTPT
RRRSRSRTPA RRGRSRSRTP ARRRSRTRSP VRRRSRSRSP ARRSGRSRSR TPARRGRSRS
RTPARRGRSR SRTPARRSGR SRSRTPARRG RSRSRTPRRG RSRSRSLVRR GRSHSRTPQR
RGRSGSSSER KNKSRTSQRR SRSNSSPEMK KSRISSRRSR SLSSPRSKAK SRLSLRRSLS
GSSPCPKQKS QTPPRRSRSG SSQPKAKSRT PPRRSRSSSS PPPKQKSKTP SRQSHSSSSP
HPKVKSGTPP RQGSITSPQA NEQSVTPQRR SCFESSPDPE LKSRTPSRHS CSGSSPPRVK
SSTPPRQSPS RSSSPQPKVK AIISPRQRSH SGSSSPSPSR VTSRTTPRRS RSVSPCSNVE
SRLLPRYSHS GSSSPDTKVK PETPPRQSHS GSISPYPKVK AQTPPGPSLS GSKSPCPQEK
SKDSLVQSCP GSLSLCAGVK SSTPPGESYF GVSSLQLKGQ SQTSPDHRSD TSSPEVRQSH
SESPSLQSKS QTSPKGGRSR SSSPVTELAS RSPIRQDRGE FSASPMLKSG MSPEQSRFQS
DSSSYPTVDS NSLLGQSRLE TAESKEKMAL PPQEDATASP PRQKDKFSPF PVQDRPESSL
VFKDTLRTPP RERSGAGSSP ETKEQNSALP TSSQDEELME VVEKSEEPAG QILSHLSSEL
KEMSTSNFES SPEVEERPAV SLTLDQSQSQ ASLEAVEVPS MASSWGGPHF SPEHKELSNS
PLRENSFGSP LEFRNSGPLG TEMNTGFSSE VKEDLNGPFL NQLETDPSLD MKEQSTRSSG
HSSSELSPDA VEKAGMSSNQ SISSPVLDAV PRTPSRERSS SASSPEMKDG LPRTPSRRSR
SGSSPGLRDG SGTPSRHSLS GSSPGMKDIP RTPSRGRSEC DSSPEPKALP QTPRPRSRSP
SSPELNNKCL TPQRERSGSE SSVDQKTVAR TPLGQRSRSG SSQELDVKPS ASPQERSESD
SSPDSKAKTR TPLRQRSRSG SSPEVDSKSR LSPRRSRSGS SPEVKDKPRA APRAQSGSDS
SPEPKAPAPR ALPRRSRSGS SSKGRGPSPE GSSSTESSPE HPPKSRTARR GSRSSPEPKT
KSRTPPRRRS SRSSPELTRK ARLSRRSRSA SSSPETRSRT PPRHRRSPSV SSPEPAEKSR
SSRRRRSASS PRTKTTSRRG RSPSPKPRGL QRSRSRSRRE KTRTTRRRDR SGSSQSTSRR
RQRSRSRSRV TRRRRGGSGY HSRSPARQES SRTSSRRRRG RSRTPPTSRK RSRSRTSPAP
WKRSRSRASP ATHRRSRSRT PLISRRRSRS RTSPVSRRRS RSRTSVTRRR SRSRASPVSR
RRSRSRTPPV TRRRSRSRTP TTRRRSRSRT PPVTRRRSRS RTPPVTRRRS RSRTSPITRR
RSRSRTSPVT RRRSRSRTSP VTRRRSRSRT SPVTRRRSRS RTPPAIRRRS RSRTPLLPRK
RSRSRSPLAI RRRSRSRTPR TARGKRSLTR SPPAIRRRSA SGSSSDRSRS ATPPATRNHS
GSRTPPVALN SSRMSCFSRP SMSPTPLDRC RSPGMLEPLG SSRTPMSVLQ QAGGSMMDGP
GPRIPDHQRT SVPENHAQSR IALALTAISL GTARPPPSMS AAGLAARMSQ VPAPVPLMSL
RTAPAANLAS RIPAASAAAM NLASARTPAI PTAVNLADSR TPAAAAAMNL ASPRTAVAPS
AVNLADPRTP TAPAVNLAGA RTPAALAALS LTGSGTPPTA ANYPSSSRTP QAPASANLVG
PRSAHATAPV NIAGSRTAAA LAPASLTSAR MAPALSGANL TSPRVPLSAY ERVSGRTSPP
LLDRARSRTP PSAPSQSRMT SERAPSPSSR MGQAPSQSLL PPAQDQPRSP VPSAFSDQSR
CLIAQTTPVA GSQSLSSGAV ATTTSSAGDH NGMLSVPAPG VPHSDVGEPP ASTGAQQPSA
LAALQPAKER RSSSSSSSSS SSSSSSSSSS SSSSSSGSSS SDSEGSSLPV QPEVALKRVP
SPTPAPKEAV REGRPPEPTP AKRKRRSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS
SSSSSSSSPS PAKPGPQALP KPASPKKPPP GERRSRSPRK PIDSLRDSRS LSYSPVERRR
PSPQPSPRDQ QSSSSERGSR RGQRGDSRSP SHKRRRETPS PRPMRHRSSR SP


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