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Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1)

 STK25_MOUSE             Reviewed;         426 AA.
Q9Z2W1; Q6IR17;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
05-JUL-2017, entry version 143.
RecName: Full=Serine/threonine-protein kinase 25;
EC=2.7.11.1;
AltName: Full=Ste20-like kinase;
AltName: Full=Sterile 20/oxidant stress-response kinase 1;
Short=SOK-1;
Short=Ste20/oxidant stress response kinase 1;
Name=Stk25; Synonyms=Sok1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J;
Melnick M.B.;
"Genetic mapping of human and mouse PAK genes.";
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Czech II; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-278, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Kidney, and Lung;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Oxidant stress-activated serine/threonine kinase that
may play a role in the response to environmental stress. Targets
to the Golgi apparatus where it appears to regulate protein
transport events, cell adhesion, and polarity complexes important
for cell migration (By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
-!- ENZYME REGULATION: Interaction with Golgi matrix protein GOLGA2
leads to autophosphorylation on Thr-174, possibly as a consequence
of stabilization of dimer formation. The C-terminal non-catalytic
region inhibits the kinase activity (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Homodimer. Interacts with CTTNBP2NL. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus
{ECO:0000250}. Note=Localizes to the Golgi apparatus.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
protein kinase family. STE20 subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF004934; AAD01208.1; -; mRNA.
EMBL; AK148041; BAE28307.1; -; mRNA.
EMBL; CH466520; EDL39941.1; -; Genomic_DNA.
EMBL; CH466520; EDL39942.1; -; Genomic_DNA.
EMBL; BC071218; AAH71218.1; -; mRNA.
CCDS; CCDS15192.1; -.
RefSeq; NP_067512.3; NM_021537.3.
RefSeq; XP_006529831.1; XM_006529768.2.
UniGene; Mm.28761; -.
ProteinModelPortal; Q9Z2W1; -.
SMR; Q9Z2W1; -.
IntAct; Q9Z2W1; 4.
MINT; MINT-4135919; -.
STRING; 10090.ENSMUSP00000027498; -.
iPTMnet; Q9Z2W1; -.
PhosphoSitePlus; Q9Z2W1; -.
MaxQB; Q9Z2W1; -.
PaxDb; Q9Z2W1; -.
PeptideAtlas; Q9Z2W1; -.
PRIDE; Q9Z2W1; -.
Ensembl; ENSMUST00000027498; ENSMUSP00000027498; ENSMUSG00000026277.
GeneID; 59041; -.
KEGG; mmu:59041; -.
UCSC; uc007ced.1; mouse.
CTD; 10494; -.
MGI; MGI:1891699; Stk25.
eggNOG; KOG0201; Eukaryota.
eggNOG; ENOG410XP9G; LUCA.
GeneTree; ENSGT00810000125395; -.
HOGENOM; HOG000234203; -.
HOVERGEN; HBG108518; -.
InParanoid; Q9Z2W1; -.
KO; K08838; -.
OMA; FSHNRNH; -.
OrthoDB; EOG091G0F24; -.
TreeFam; TF354217; -.
PRO; PR:Q9Z2W1; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000026277; -.
CleanEx; MM_STK25; -.
ExpressionAtlas; Q9Z2W1; baseline and differential.
Genevisible; Q9Z2W1; MM.
GO; GO:0005737; C:cytoplasm; ISO:MGI.
GO; GO:0070062; C:extracellular exosome; ISO:MGI.
GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0008349; F:MAP kinase kinase kinase kinase activity; IBA:GO_Central.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0042803; F:protein homodimerization activity; ISO:MGI.
GO; GO:0051683; P:establishment of Golgi localization; ISO:MGI.
GO; GO:0007163; P:establishment or maintenance of cell polarity; IMP:MGI.
GO; GO:0051645; P:Golgi localization; IMP:MGI.
GO; GO:0090168; P:Golgi reassembly; ISO:MGI.
GO; GO:0036481; P:intrinsic apoptotic signaling pathway in response to hydrogen peroxide; ISO:MGI.
GO; GO:0050772; P:positive regulation of axonogenesis; IMP:MGI.
GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISO:MGI.
GO; GO:0046777; P:protein autophosphorylation; ISO:MGI.
GO; GO:0006468; P:protein phosphorylation; IMP:MGI.
GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO; GO:0007346; P:regulation of mitotic cell cycle; IBA:GO_Central.
GO; GO:0042542; P:response to hydrogen peroxide; ISO:MGI.
GO; GO:0031098; P:stress-activated protein kinase signaling cascade; IBA:GO_Central.
CDD; cd06642; STKc_STK25; 1.
InterPro; IPR011009; Kinase-like_dom.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR035060; STK_STK25.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
1: Evidence at protein level;
ATP-binding; Complete proteome; Cytoplasm; Golgi apparatus; Kinase;
Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein;
Reference proteome; Serine/threonine-protein kinase; Transferase.
CHAIN 1 426 Serine/threonine-protein kinase 25.
/FTId=PRO_0000086714.
DOMAIN 20 270 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 26 34 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
ACT_SITE 140 140 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
BINDING 49 49 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 174 174 Phosphothreonine; by autocatalysis.
{ECO:0000250|UniProtKB:O00506}.
MOD_RES 278 278 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
CONFLICT 156 156 L -> M (in Ref. 1; AAD01208).
{ECO:0000305}.
SEQUENCE 426 AA; 48158 MW; 70B191AB55E26337 CRC64;
MAHLRGFAHQ HSRVDPEELF TKLDRIGKGS FGEVYKGIDN HTKEVVAIKI IDLEEAEDEI
EDIQQEITVL SQCDSPYITR YFGSYLKSTK LWIIMEYLGG GSALDLLKPG PLEETYIATI
LREILKGLDY LHSERKIHRD IKAANVLLSE QGDVKLADFG VAGQLTDTQI KRNTFVGTPF
WMAPEVIKQS AYDFKADIWS LGITAIELAK GEPPNSDLHP MRVLFLIPKN NPPTLEGHHS
KPFKEFVEAC LNKDPRFRPT AKELLKHKFI TRYTKKTSFL TELIDRYKRW KSEGHGEESS
SEDSDIDGEA EDGEQGPIWT FPPTIRPSPH SKLHKGTALH SSQKPAEPIK RQPRSQCLST
LVRPVFGELK EKHKQSGGSV GALEELENAF SLAEESCPGI SDKLMVHLVE RVQRFSHSRN
HLTSTR


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