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Serine/threonine-protein kinase Aurora-3 (AtAur3) (EC 2.7.11.1) (Aurora-like kinase 3)

 AUR3_ARATH              Reviewed;         288 AA.
O64629;
09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
12-SEP-2018, entry version 137.
RecName: Full=Serine/threonine-protein kinase Aurora-3;
Short=AtAur3;
EC=2.7.11.1;
AltName: Full=Aurora-like kinase 3;
Name=AUR3; OrderedLocusNames=At2g45490; ORFNames=F17K2.2;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
STRAIN=cv. Columbia;
PubMed=16028112; DOI=10.1007/s11103-005-3454-x;
Kawabe A., Matsunaga S., Nakagawa K., Kurihara D., Yoneda A.,
Hasezawa S., Uchiyama S., Fukui K.;
"Characterization of plant Aurora kinases during mitosis.";
Plant Mol. Biol. 58:1-13(2005).
[2]
NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, INDUCTION, AND
TISSUE SPECIFICITY.
STRAIN=cv. Columbia;
PubMed=15722465; DOI=10.1105/tpc.104.029710;
Demidov D., Van Damme D., Geelen D., Blattner F.R., Houben A.;
"Identification and dynamics of two classes of aurora-like kinases in
Arabidopsis and other plants.";
Plant Cell 17:836-848(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10617197; DOI=10.1038/45471;
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L.,
Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L.,
Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H.,
Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D.,
Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M.,
Venter J.C.;
"Sequence and analysis of chromosome 2 of the plant Arabidopsis
thaliana.";
Nature 402:761-768(1999).
[4]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[6]
SUBCELLULAR LOCATION.
PubMed=15469496; DOI=10.1111/j.1365-313X.2004.02222.x;
Van Damme D., Bouget F.-Y., Van Poucke K., Inze D., Geelen D.;
"Molecular dissection of plant cytokinesis and phragmoplast structure:
a survey of GFP-tagged proteins.";
Plant J. 40:386-398(2004).
[7]
FUNCTION, AND INHIBITION BY HESPERADIN.
PubMed=17087760; DOI=10.1111/j.1365-313X.2006.02893.x;
Kurihara D., Matsunaga S., Kawabe A., Fujimoto S., Noda M.,
Uchiyama S., Fukui K.;
"Aurora kinase is required for chromosome segregation in tobacco BY-2
cells.";
Plant J. 48:572-580(2006).
-!- FUNCTION: Phosphorylates in vitro histone H3 at 'Ser-10' (H3S10ph)
and 'Ser-28' (H3S28ph), but not at 'Thr-3' (H3T3ph) or 'Thr-11'
(H3T11ph). Colocalizes with phosphorylated histone H3 during
mitosis. Associates with cytoskeletal structures that are
necessary for cytokinesis and with the microtubule spindle.
{ECO:0000269|PubMed:16028112, ECO:0000269|PubMed:17087760}.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
-!- ACTIVITY REGULATION: Inhibited by hesperadin.
-!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Nucleus.
Chromosome. Chromosome, centromere. Note=Cytoplasmic perinuclear
region or in dots around the nucleolus and at the nuclear
periphery in interphase cells, associated to centromeric regions
of condensed chromosomes at metaphase and dispersed along the
entire length of the chromosomes during anaphase
(PubMed:16028112). Nucleus (PubMed:15722465).
{ECO:0000269|PubMed:15722465, ECO:0000269|PubMed:16028112}.
-!- TISSUE SPECIFICITY: Abundant in roots, flowers and flower buds,
low or absent in expanded leaves, stems and siliques.
{ECO:0000269|PubMed:15722465}.
-!- INDUCTION: Expression peaks at mitosis.
{ECO:0000269|PubMed:15722465}.
-!- PTM: Phosphorylation at Thr-176 may regulate activity and
degradation of AUR3 in a cell cycle dependent manner.
{ECO:0000250}.
-!- MISCELLANEOUS: Overexpression of AUR3 induces mitotic spindle
defects, but the distribution of phosphorylation of histone H3 on
the chromosome is not affected.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr
protein kinase family. Aurora subfamily. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
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EMBL; AB196735; BAE00021.1; -; Genomic_DNA.
EMBL; AJ854185; CAH69534.1; -; mRNA.
EMBL; AC003680; AAC06151.1; -; Genomic_DNA.
EMBL; CP002685; AEC10561.1; -; Genomic_DNA.
EMBL; AY074653; AAL69469.1; -; mRNA.
PIR; T00862; T00862.
RefSeq; NP_182073.1; NM_130111.4.
UniGene; At.37011; -.
ProteinModelPortal; O64629; -.
SMR; O64629; -.
STRING; 3702.AT2G45490.1; -.
PaxDb; O64629; -.
EnsemblPlants; AT2G45490.1; AT2G45490.1; AT2G45490.
GeneID; 819157; -.
Gramene; AT2G45490.1; AT2G45490.1; AT2G45490.
KEGG; ath:AT2G45490; -.
Araport; AT2G45490; -.
TAIR; locus:2043624; AT2G45490.
eggNOG; KOG0580; Eukaryota.
eggNOG; ENOG410XNRB; LUCA.
HOGENOM; HOG000233016; -.
InParanoid; O64629; -.
KO; K08850; -.
OMA; MREIEIQ; -.
OrthoDB; EOG09360G97; -.
PhylomeDB; O64629; -.
PRO; PR:O64629; -.
Proteomes; UP000006548; Chromosome 2.
ExpressionAtlas; O64629; baseline and differential.
Genevisible; O64629; AT.
GO; GO:0032133; C:chromosome passenger complex; IBA:GO_Central.
GO; GO:0000775; C:chromosome, centromeric region; IDA:TAIR.
GO; GO:0000780; C:condensed nuclear chromosome, centromeric region; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IDA:TAIR.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005819; C:spindle; IDA:TAIR.
GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
GO; GO:0051233; C:spindle midzone; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0035175; F:histone kinase activity (H3-S10 specific); IDA:TAIR.
GO; GO:0044022; F:histone kinase activity (H3-S28 specific); IDA:TAIR.
GO; GO:0007059; P:chromosome segregation; IEA:InterPro.
GO; GO:0043987; P:histone H3-S10 phosphorylation; IDA:TAIR.
GO; GO:0043988; P:histone H3-S28 phosphorylation; IDA:TAIR.
GO; GO:0016572; P:histone phosphorylation; IDA:TAIR.
GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
GO; GO:0032465; P:regulation of cytokinesis; IBA:GO_Central.
InterPro; IPR030616; Aur.
InterPro; IPR030614; AUR3.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
PANTHER; PTHR24350; PTHR24350; 1.
PANTHER; PTHR24350:SF7; PTHR24350:SF7; 1.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
2: Evidence at transcript level;
ATP-binding; Centromere; Chromosome; Complete proteome; Cytoplasm;
Kinase; Nucleotide-binding; Nucleus; Phosphoprotein;
Reference proteome; Serine/threonine-protein kinase; Transferase.
CHAIN 1 288 Serine/threonine-protein kinase Aurora-3.
/FTId=PRO_0000270794.
DOMAIN 22 273 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 28 36 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
ACT_SITE 145 145 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 51 51 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 167 167 Phosphoserine.
{ECO:0000250|UniProtKB:Q93V58}.
MOD_RES 176 176 Phosphothreonine.
{ECO:0000250|UniProtKB:Q38997}.
SEQUENCE 288 AA; 33119 MW; BFB41F3E34795BD8 CRC64;
MSKKSTESDA GNTEKQWSLA DFEIGRPLGK GKFGRVYLAR EAKSKYIVAL KVIFKEQIEK
YKIHHQLRRE MEIQTSLRHP NILRLFGWFH DNERIFLILE YAHGGELYGV LKQNGHLTEQ
QAATYIASLS QALAYCHGKC VIHRDIKPEN LLLDHEGRLK IADFGWSVQS SNKRKTMCGT
LDYLAPEMVE NRDHDYAVDN WTLGILCYEF LYGNPPFEAE SQKDTFKRIL KIDLSFPLTP
NVSEEAKNLI SQLLVKDPSK RLSIEKIMQH PWIVKNADPK GVCASIDI


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