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Serine/threonine-protein kinase OXI1 (EC 2.7.11.1) (AGC serine/threonine-protein kinase subfamily 2 member 1) (Protein OXIDATIVE SIGNAL-INDUCIBLE 1)

 OXI1_ARATH              Reviewed;         421 AA.
Q9LSF1; A1L4U5;
11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
22-NOV-2017, entry version 111.
RecName: Full=Serine/threonine-protein kinase OXI1;
EC=2.7.11.1;
AltName: Full=AGC serine/threonine-protein kinase subfamily 2 member 1 {ECO:0000303|PubMed:13678909};
AltName: Full=Protein OXIDATIVE SIGNAL-INDUCIBLE 1 {ECO:0000303|PubMed:14985766};
Name=OXI1 {ECO:0000303|PubMed:14985766};
Synonyms=AGC2-1 {ECO:0000303|PubMed:13678909};
OrderedLocusNames=At3g25250; ORFNames=MJL12.21;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10819329; DOI=10.1093/dnares/7.2.131;
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
features of the regions of 4,504,864 bp covered by sixty P1 and TAC
clones.";
DNA Res. 7:131-135(2000).
[2]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
The Arabidopsis Information Portal (Araport);
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
Bautista V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C.,
Ecker J.R.;
"Arabidopsis ORF clones.";
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
[4]
GENE FAMILY, AND REVIEW.
PubMed=13678909; DOI=10.1016/S1360-1385(03)00188-2;
Boegre L., Okresz L., Henriques R., Anthony R.G.;
"Growth signalling pathways in Arabidopsis and the AGC protein
kinases.";
Trends Plant Sci. 8:424-431(2003).
[5]
ENZYME REGULATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE,
INTERACTION WITH PDK1 AND PDK2, AND MUTAGENESIS OF LYS-45; SER-235;
PHE-418 AND PHE-421.
PubMed=14749726; DOI=10.1038/sj.emboj.7600068;
Anthony R.G., Henriques R., Helfer A., Meszaros T., Rios G.,
Testerink C., Munnik T., Deak M., Koncz C., Boegre L.;
"A protein kinase target of a PDK1 signalling pathway is involved in
root hair growth in Arabidopsis.";
EMBO J. 23:572-581(2004).
[6]
FUNCTION, ENZYME REGULATION, TISSUE SPECIFICITY, INDUCTION, AND
DISRUPTION PHENOTYPE.
PubMed=14985766; DOI=10.1038/nature02353;
Rentel M.C., Lecourieux D., Ouaked F., Usher S.L., Petersen L.,
Okamoto H., Knight H., Peck S.C., Grierson C.S., Hirt H., Knight M.R.;
"OXI1 kinase is necessary for oxidative burst-mediated signalling in
Arabidopsis.";
Nature 427:858-861(2004).
-!- FUNCTION: Involved in oxidative burst-mediated signaling. Required
for basal resistance to P.parasitica infection and root hair
growth. Partly required for the activation of MPK3 and MPK6 by
hydrogen peroxide and cellulase elicitor.
{ECO:0000269|PubMed:14985766}.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
-!- ENZYME REGULATION: Activated in response to hydrogen peroxide and
cellulase elicitor. Activated by PDK1 in a phosphatidic acid
dependent manner. {ECO:0000269|PubMed:14749726,
ECO:0000269|PubMed:14985766}.
-!- SUBUNIT: Interacts with PDK1 and PDK2.
{ECO:0000269|PubMed:14749726}.
-!- INTERACTION:
O80719:At2g47060; NbExp=4; IntAct=EBI-8574783, EBI-4436376;
-!- TISSUE SPECIFICITY: Expressed in roots and root hair cells.
{ECO:0000269|PubMed:14749726, ECO:0000269|PubMed:14985766}.
-!- DEVELOPMENTAL STAGE: Highly expressed in fast-growing organs and
dividing cells.
-!- INDUCTION: By wounding, hydrogen peroxide and cellulase elicitor.
{ECO:0000269|PubMed:14985766}.
-!- DOMAIN: The activation loop within the kinase domain is the target
of phosphorylation. {ECO:0000250}.
-!- DISRUPTION PHENOTYPE: Plants have enhanced susceptibility to
virulent P.parasitica pathogen and reduced root hair length.
{ECO:0000269|PubMed:14749726, ECO:0000269|PubMed:14985766}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
protein kinase family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AB026647; BAB02084.1; -; Genomic_DNA.
EMBL; CP002686; AEE77000.1; -; Genomic_DNA.
EMBL; BT029732; ABM06002.1; -; mRNA.
RefSeq; NP_189162.1; NM_113431.6.
UniGene; At.37401; -.
ProteinModelPortal; Q9LSF1; -.
BioGrid; 7450; 7.
ELM; Q9LSF1; -.
IntAct; Q9LSF1; 4.
MINT; MINT-8085713; -.
STRING; 3702.AT3G25250.1; -.
PaxDb; Q9LSF1; -.
EnsemblPlants; AT3G25250.1; AT3G25250.1; AT3G25250.
GeneID; 822119; -.
Gramene; AT3G25250.1; AT3G25250.1; AT3G25250.
KEGG; ath:AT3G25250; -.
Araport; AT3G25250; -.
TAIR; locus:2090310; AT3G25250.
eggNOG; KOG0610; Eukaryota.
eggNOG; ENOG410XQ0C; LUCA.
HOGENOM; HOG000233027; -.
InParanoid; Q9LSF1; -.
KO; K20714; -.
OMA; EYKRVSF; -.
OrthoDB; EOG09360GG4; -.
PhylomeDB; Q9LSF1; -.
PRO; PR:Q9LSF1; -.
Proteomes; UP000006548; Chromosome 3.
Genevisible; Q9LSF1; AT.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0016301; F:kinase activity; ISS:TAIR.
GO; GO:0004672; F:protein kinase activity; IDA:TAIR.
GO; GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
GO; GO:0006468; P:protein phosphorylation; IDA:TAIR.
GO; GO:0006979; P:response to oxidative stress; IEP:TAIR.
GO; GO:0009611; P:response to wounding; IEP:TAIR.
InterPro; IPR000961; AGC-kinase_C.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 2.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 2.
PROSITE; PS51285; AGC_KINASE_CTER; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
Phosphoprotein; Plant defense; Reference proteome;
Serine/threonine-protein kinase; Transferase.
CHAIN 1 421 Serine/threonine-protein kinase OXI1.
/FTId=PRO_0000245827.
DOMAIN 17 329 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
DOMAIN 330 421 AGC-kinase C-terminal.
NP_BIND 23 31 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
REGION 167 246 Activation loop. {ECO:0000250}.
MOTIF 418 421 PIF.
ACT_SITE 149 149 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 45 45 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 235 235 Phosphoserine; by PDPK1. {ECO:0000305}.
MUTAGEN 45 45 K->A: Abolishes catalytic activity.
{ECO:0000269|PubMed:14749726}.
MUTAGEN 235 235 S->A: Strongly reduces catalytic
activity. {ECO:0000269|PubMed:14749726}.
MUTAGEN 418 418 F->A: Loss of interaction with PDPK1 and
PDK2; when associated with A-421.
{ECO:0000269|PubMed:14749726}.
MUTAGEN 421 421 F->A: Loss of interaction with PDPK1 and
PDK2; when associated with A-418.
{ECO:0000269|PubMed:14749726}.
SEQUENCE 421 AA; 47560 MW; 6855585F4DC14C4D CRC64;
MLEGDEKQSR ALDFNRLEVL SLLGRGAKGV VFLVRDDDAK LLALKVILKE AIEKKKKGRE
SEDDEYKRVS FEQGVLSRFD HPLFPSLHGV LATDKVIGYA IDYCPGQNLN SLRKMQSESM
FSDEIIRFYA AELVLALDYL HNQGIVYRDL KPDNVMIQEN GHLMLIDFDL STNLAPRTPQ
PSPSLSKPSP TMKRKKRLFR FTSFCNSGIS PQESISVHSS STLAVSDSSG EKSNSFVGTE
EYVAPEVISG DGHDFAVDWW SLGVVLYEML YGATPFRGSN RKETFYRILS KPPNLTGETT
SLRDLIRRLL EKDPSRRINV EEIKGHDFFR GVDWEKVILV SRPPYIPAPD DGGDKGTDVN
TKMDVENIVQ EIFAARQERE KQSGDNNKNA NMKIKDNTSG EWVKGLNNNH DLESDNNFLV
F


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