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Serine/threonine-protein kinase PLK (EC 2.7.11.21) (Polo-like kinase)

 G1PJY4_MYOLU            Unreviewed;       604 AA.
G1PJY4;
19-OCT-2011, integrated into UniProtKB/TrEMBL.
19-OCT-2011, sequence version 1.
18-JUL-2018, entry version 47.
RecName: Full=Serine/threonine-protein kinase PLK {ECO:0000256|RuleBase:RU361162};
EC=2.7.11.21 {ECO:0000256|RuleBase:RU361162};
AltName: Full=Polo-like kinase {ECO:0000256|RuleBase:RU361162};
Name=PLK1 {ECO:0000313|Ensembl:ENSMLUP00000011078};
Myotis lucifugus (Little brown bat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
Vespertilionidae; Myotis.
NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000011078, ECO:0000313|Proteomes:UP000001074};
[1] {ECO:0000313|Ensembl:ENSMLUP00000011078, ECO:0000313|Proteomes:UP000001074}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=21993624; DOI=10.1038/nature10530;
Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
Pedersen J.S., Lander E.S., Kellis M.;
"A high-resolution map of human evolutionary constraint using 29
mammals.";
Nature 478:476-482(2011).
[2] {ECO:0000313|Ensembl:ENSMLUP00000011078}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
{ECO:0000256|RuleBase:RU361162}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr
protein kinase family. CDC5/Polo subfamily.
{ECO:0000256|RuleBase:RU361162}.
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EMBL; AAPE02011390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_006085933.1; XM_006085871.2.
STRING; 59463.ENSMLUP00000011078; -.
Ensembl; ENSMLUT00000012160; ENSMLUP00000011078; ENSMLUG00000012154.
GeneID; 102441801; -.
CTD; 5347; -.
eggNOG; KOG0575; Eukaryota.
eggNOG; ENOG410XQBP; LUCA.
GeneTree; ENSGT00530000062954; -.
InParanoid; G1PJY4; -.
OMA; FEVDTWS; -.
OrthoDB; EOG091G0D89; -.
TreeFam; TF101089; -.
Proteomes; UP000001074; Unassembled WGS sequence.
GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
GO; GO:0005814; C:centriole; IEA:Ensembl.
GO; GO:0000785; C:chromatin; IEA:Ensembl.
GO; GO:0000942; C:condensed nuclear chromosome outer kinetochore; IEA:Ensembl.
GO; GO:0030496; C:midbody; IEA:Ensembl.
GO; GO:0005876; C:spindle microtubule; IEA:Ensembl.
GO; GO:0051233; C:spindle midzone; IEA:Ensembl.
GO; GO:0000922; C:spindle pole; IEA:Ensembl.
GO; GO:0000795; C:synaptonemal complex; IEA:Ensembl.
GO; GO:0010997; F:anaphase-promoting complex binding; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO; GO:0007098; P:centrosome cycle; IEA:Ensembl.
GO; GO:0045184; P:establishment of protein localization; IEA:Ensembl.
GO; GO:0016321; P:female meiosis chromosome segregation; IEA:Ensembl.
GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IEA:Ensembl.
GO; GO:0045143; P:homologous chromosome segregation; IEA:Ensembl.
GO; GO:0001578; P:microtubule bundle formation; IEA:Ensembl.
GO; GO:0000281; P:mitotic cytokinesis; IEA:Ensembl.
GO; GO:0000070; P:mitotic sister chromatid segregation; IEA:Ensembl.
GO; GO:0007094; P:mitotic spindle assembly checkpoint; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0045736; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0051081; P:nuclear envelope disassembly; IEA:Ensembl.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
GO; GO:1904668; P:positive regulation of ubiquitin protein ligase activity; IEA:Ensembl.
GO; GO:0031648; P:protein destabilization; IEA:Ensembl.
GO; GO:0071168; P:protein localization to chromatin; IEA:Ensembl.
GO; GO:0090435; P:protein localization to nuclear envelope; IEA:Ensembl.
GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
GO; GO:0032465; P:regulation of cytokinesis; IEA:Ensembl.
GO; GO:1901673; P:regulation of mitotic spindle assembly; IEA:Ensembl.
GO; GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO; GO:0072425; P:signal transduction involved in G2 DNA damage checkpoint; IEA:Ensembl.
GO; GO:0070194; P:synaptonemal complex disassembly; IEA:Ensembl.
CDD; cd13118; POLO_box_1; 1.
CDD; cd13117; POLO_box_2; 1.
CDD; cd14187; STKc_PLK1; 1.
Gene3D; 3.30.1120.30; -; 3.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR033702; PLK1_cat.
InterPro; IPR033701; POLO_box_1.
InterPro; IPR033695; POLO_box_2.
InterPro; IPR000959; POLO_box_dom.
InterPro; IPR036947; POLO_box_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
Pfam; PF00659; POLO_box; 2.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS50078; POLO_BOX; 2.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|RuleBase:RU361162};
Complete proteome {ECO:0000313|Proteomes:UP000001074};
Kinase {ECO:0000256|RuleBase:RU361162};
Nucleotide-binding {ECO:0000256|RuleBase:RU361162};
Reference proteome {ECO:0000313|Proteomes:UP000001074};
Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU361162};
Transferase {ECO:0000256|RuleBase:RU361162}.
DOMAIN 53 305 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
DOMAIN 417 480 POLO box. {ECO:0000259|PROSITE:PS50078}.
DOMAIN 515 584 POLO box. {ECO:0000259|PROSITE:PS50078}.
SEQUENCE 604 AA; 68136 MW; E4E1E641FD3D0D1D CRC64;
MSAAAAAGKL ARAPADPGRA GAPGVAAPGA PAAAPPGKEI PEVLVDPRSR RRYLRGRFLG
KGGFAKCFEI SDADTKEVFA GKIVPKSLLL KPHQKEKMSM EISIHRSLAH QHVVGFHGFF
EDNDFVFVVL ELCRRRSLLE LHKRRKALTE PEARYYLRQV VLGCQYLHRN RVIHRDLKLG
NLFLNEDLEV KIGDFGLATK VEYDGERKKT LCGTPNYIAP EVLSKKGHSF EVDVWSIGCI
MYTLLVGKPP FETSCLKETY LRIKKNEYSI PKHINPVAAS LIQKMLQSDP TARPTIHELL
SDEFFTSGYI PARLPITCLT IPPRFSIAPS SLDPSGRKPL SVLNKGTENP MPERPREKEE
PAVRETNEAV DCHLGDMLQQ LHSVNASKPS ERGLVRQEEA EDPACIPIFW VSKWVDYSDK
YGLGYQLCDN SVGVLFNDST RLILYNDGDS LQYIERDGTE SYLTVNSHPN SLIKKITLLK
YFRNYMSEHL LKAGANITPR EGDELARLPY LRTWFRTRSA IILHLSNGCV QINFFQDHTK
LILCPLMAAV TYINEKRDFR TYRLSLLEEF GCSKELASRL RYARTMVDKL LSSRSATNRL
KASS


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