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Serine/threonine-protein kinase csk1 (EC 2.7.11.22) (CAK-activating kinase) (CAKAK)

 CSK1_SCHPO              Reviewed;         306 AA.
P36615;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
01-JUN-1994, sequence version 1.
28-FEB-2018, entry version 135.
RecName: Full=Serine/threonine-protein kinase csk1;
EC=2.7.11.22;
AltName: Full=CAK-activating kinase;
Short=CAKAK;
Name=csk1; ORFNames=SPAC1D4.06c;
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
Schizosaccharomycetes; Schizosaccharomycetales;
Schizosaccharomycetaceae; Schizosaccharomyces.
NCBI_TaxID=284812;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8467814;
Molz L., Beach D.;
"Characterization of the fission yeast mcs2 cyclin and its associated
protein kinase activity.";
EMBO J. 12:1723-1732(1993).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=972 / ATCC 24843;
PubMed=11859360; DOI=10.1038/nature724;
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[3]
FUNCTION.
PubMed=9857180; DOI=10.1093/emboj/17.24.7230;
Hermand D., Pihlak A., Westerling T., Damagnez V., Vandenhaute J.,
Cottarel G., Makela T.P.;
"Fission yeast Csk1 is a CAK-activating kinase (CAKAK).";
EMBO J. 17:7230-7238(1998).
-!- FUNCTION: Acts as a CAK-activating kinase that specifically
activates crk1 of the crk1-mcs2 CAK complex.
{ECO:0000269|PubMed:9857180}.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
-!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC
Ser/Thr protein kinase family. CDC2/CDKX subfamily. {ECO:0000305}.
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EMBL; S59896; AAB26194.1; -; Genomic_DNA.
EMBL; CU329670; CAA93215.1; -; Genomic_DNA.
PIR; S39151; S39151.
RefSeq; NP_593019.1; NM_001018418.1.
ProteinModelPortal; P36615; -.
SMR; P36615; -.
BioGrid; 279750; 85.
STRING; 4896.SPAC1D4.06c.1; -.
MaxQB; P36615; -.
PaxDb; P36615; -.
PRIDE; P36615; -.
EnsemblFungi; SPAC1D4.06c.1; SPAC1D4.06c.1:pep; SPAC1D4.06c.
GeneID; 2543327; -.
KEGG; spo:SPAC1D4.06c; -.
EuPathDB; FungiDB:SPAC1D4.06c; -.
PomBase; SPAC1D4.06c; csk1.
InParanoid; P36615; -.
KO; K07760; -.
OrthoDB; EOG092C3S5J; -.
PhylomeDB; P36615; -.
BRENDA; 2.7.11.22; 5613.
PRO; PR:P36615; -.
Proteomes; UP000002485; Chromosome I.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005829; C:cytosol; HDA:PomBase.
GO; GO:0005634; C:nucleus; HDA:PomBase.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0019912; F:cyclin-dependent protein kinase activating kinase activity; IDA:PomBase.
GO; GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IEA:UniProtKB-EC.
GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IMP:PomBase.
GO; GO:0030295; F:protein kinase activator activity; IDA:PomBase.
GO; GO:0004672; F:protein kinase activity; IDA:PomBase.
GO; GO:0004674; F:protein serine/threonine kinase activity; IDA:PomBase.
GO; GO:1901409; P:positive regulation of phosphorylation of RNA polymerase II C-terminal domain; IDA:PomBase.
GO; GO:0051445; P:regulation of meiotic cell cycle; ISO:PomBase.
GO; GO:0007165; P:signal transduction; IC:PomBase.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
Pfam; PF00069; Pkinase; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
3: Inferred from homology;
ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
Reference proteome; Serine/threonine-protein kinase; Transferase.
CHAIN 1 306 Serine/threonine-protein kinase csk1.
/FTId=PRO_0000085881.
DOMAIN 11 306 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 17 25 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
ACT_SITE 129 129 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
BINDING 40 40 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
SEQUENCE 306 AA; 34672 MW; E670D87547523D0C CRC64;
MKSVGHFVPW LTDIRHLTDG TISEVFVGER KNSKKLYVIK VQGLVFKRPP HDAMRGKLIL
ESIGHPHIER IVDSFIDNEA GSVYLITSFK SFVLSDVMDE ISIDTKCKIV LQISSALEYL
EKHGILHRDI HPNNILLDSM NGPAYLSDFS IAWSKQHPGE EVQELIPQIG TGHYRAIETL
FGCHSYGHEV DRWTFGILIA ELFSNQALFD DGSSEGWPSE LRLTSSIIQT LGTPNPSMWP
ELSTFPDWNK FIFHEYPPKP WSEILPSVDT SIQYIVSHLV TYSNRASPSF VIESFPKVSA
RLSQYA


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