Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PP2A B subunit isoform B'-alpha) (PP2A B subunit isoform B56-alpha) (PP2A B subunit isoform PR61-alpha) (PR61alpha) (PP2A B subunit isoform R5-alpha)

 2A5A_MOUSE              Reviewed;         486 AA.
Q6PD03; Q8R1U7;
05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
05-DEC-2018, entry version 123.
RecName: Full=Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform;
AltName: Full=PP2A B subunit isoform B'-alpha;
AltName: Full=PP2A B subunit isoform B56-alpha;
AltName: Full=PP2A B subunit isoform PR61-alpha;
Short=PR61alpha;
AltName: Full=PP2A B subunit isoform R5-alpha;
Name=Ppp2r5a;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Embryonic brain, and Retina;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2]
IDENTIFICATION, AND TISSUE SPECIFICITY.
PubMed=15095873; DOI=10.1016/j.jmb.2003.12.047;
Martens E., Stevens I., Janssens V., Vermeesch J., Goetz J., Goris J.,
Van Hoof C.;
"Genomic organisation, chromosomal localisation tissue distribution
and developmental regulation of the PR61/B' regulatory subunits of
protein phosphatase 2A in mice.";
J. Mol. Biol. 336:971-986(2004).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
Pancreas, and Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: The B regulatory subunit might modulate substrate
selectivity and catalytic activity, and also might direct the
localization of the catalytic enzyme to a particular subcellular
compartment.
-!- SUBUNIT: PP2A consists of a common heterodimeric core enzyme,
composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa
constant regulatory subunit (PR65 or subunit A), that associates
with a variety of regulatory subunits. Proteins that associate
with the core dimer include three families of regulatory subunits
B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56
families), the 48 kDa variable regulatory subunit, viral proteins,
and cell signaling molecules. Interacts with SGO1 (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
{ECO:0000250}. Chromosome, centromere {ECO:0000250}. Note=From
mitotic prophase to metaphase, localizes at the inner centromere
between a pair of sister kinetochores. Decreased expression at the
onset of anaphase (By similarity). {ECO:0000250}.
-!- TISSUE SPECIFICITY: Widely expressed with highest levels in thymus
and ovary. {ECO:0000269|PubMed:15095873}.
-!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B56
family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH23062.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; BC023062; AAH23062.1; ALT_INIT; mRNA.
EMBL; BC059026; AAH59026.1; -; mRNA.
EMBL; BK000647; DAA01426.1; -; mRNA.
CCDS; CCDS15620.1; -.
RefSeq; NP_659129.2; NM_144880.4.
UniGene; Mm.205569; -.
ProteinModelPortal; Q6PD03; -.
SMR; Q6PD03; -.
BioGrid; 230562; 1.
IntAct; Q6PD03; 2.
MINT; Q6PD03; -.
STRING; 10090.ENSMUSP00000070726; -.
iPTMnet; Q6PD03; -.
PhosphoSitePlus; Q6PD03; -.
EPD; Q6PD03; -.
MaxQB; Q6PD03; -.
PaxDb; Q6PD03; -.
PRIDE; Q6PD03; -.
Ensembl; ENSMUST00000067976; ENSMUSP00000070726; ENSMUSG00000026626.
GeneID; 226849; -.
KEGG; mmu:226849; -.
UCSC; uc007eci.1; mouse.
CTD; 5525; -.
MGI; MGI:2388479; Ppp2r5a.
eggNOG; KOG2085; Eukaryota.
eggNOG; ENOG410XQJW; LUCA.
GeneTree; ENSGT00940000153622; -.
HOGENOM; HOG000067326; -.
HOVERGEN; HBG000009; -.
InParanoid; Q6PD03; -.
KO; K11584; -.
OMA; TLMEMNC; -.
OrthoDB; EOG091G06HU; -.
PhylomeDB; Q6PD03; -.
TreeFam; TF105556; -.
Reactome; R-MMU-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
Reactome; R-MMU-195253; Degradation of beta-catenin by the destruction complex.
Reactome; R-MMU-196299; Beta-catenin phosphorylation cascade.
Reactome; R-MMU-2467813; Separation of Sister Chromatids.
Reactome; R-MMU-2500257; Resolution of Sister Chromatid Cohesion.
Reactome; R-MMU-389513; CTLA4 inhibitory signaling.
Reactome; R-MMU-432142; Platelet sensitization by LDL.
Reactome; R-MMU-4641262; Disassembly of the destruction complex and recruitment of AXIN to the membrane.
Reactome; R-MMU-5663220; RHO GTPases Activate Formins.
Reactome; R-MMU-5673000; RAF activation.
Reactome; R-MMU-5675221; Negative regulation of MAPK pathway.
Reactome; R-MMU-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
Reactome; R-MMU-68877; Mitotic Prometaphase.
PRO; PR:Q6PD03; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000026626; Expressed in 116 organ(s), highest expression level in brown adipose tissue.
ExpressionAtlas; Q6PD03; baseline and differential.
Genevisible; Q6PD03; MM.
GO; GO:0005813; C:centrosome; ISO:MGI.
GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
GO; GO:0005737; C:cytoplasm; ISO:MGI.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0031430; C:M band; IDA:BHF-UCL.
GO; GO:0016020; C:membrane; ISO:MGI.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0000159; C:protein phosphatase type 2A complex; ISO:MGI.
GO; GO:0030018; C:Z disc; IDA:MGI.
GO; GO:0019900; F:kinase binding; ISO:MGI.
GO; GO:0004721; F:phosphoprotein phosphatase activity; ISO:MGI.
GO; GO:0072542; F:protein phosphatase activator activity; IBA:GO_Central.
GO; GO:0090219; P:negative regulation of lipid kinase activity; ISO:MGI.
GO; GO:1903077; P:negative regulation of protein localization to plasma membrane; ISO:MGI.
GO; GO:0035307; P:positive regulation of protein dephosphorylation; ISO:MGI.
GO; GO:0006470; P:protein dephosphorylation; ISO:MGI.
GO; GO:0031952; P:regulation of protein autophosphorylation; IBA:GO_Central.
GO; GO:0007165; P:signal transduction; IEA:InterPro.
Gene3D; 1.25.10.10; -; 1.
InterPro; IPR011989; ARM-like.
InterPro; IPR016024; ARM-type_fold.
InterPro; IPR002554; PP2A_B56.
PANTHER; PTHR10257; PTHR10257; 1.
Pfam; PF01603; B56; 1.
PIRSF; PIRSF028043; PP2A_B56; 1.
SUPFAM; SSF48371; SSF48371; 1.
1: Evidence at protein level;
Acetylation; Centromere; Chromosome; Complete proteome; Cytoplasm;
Nucleus; Phosphoprotein; Reference proteome.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:Q15172}.
CHAIN 2 486 Serine/threonine-protein phosphatase 2A
56 kDa regulatory subunit alpha isoform.
/FTId=PRO_0000071449.
MOD_RES 2 2 N-acetylserine.
{ECO:0000250|UniProtKB:Q15172}.
MOD_RES 41 41 Phosphoserine.
{ECO:0000250|UniProtKB:Q15172}.
MOD_RES 42 42 Phosphoserine.
{ECO:0000250|UniProtKB:Q15172}.
MOD_RES 49 49 Phosphoserine.
{ECO:0000250|UniProtKB:Q15172}.
SEQUENCE 486 AA; 56347 MW; BC9B0B80446C1AD2 CRC64;
MSSPSPPAPV ACAAISASEK VDGFTRKSVR KAQRQKRSQG SSQFRSQGSQ AELHPLPQLK
DATSNEQQEL FCQKLQQCCV LFDFMDSVSD LKSKEIKRAT LNELVEYVST NRGVIVESAY
SDIVKMISAN IFRTLPPSDN PDFDPEEDEP TLEASWPHIQ LVYEFFLRFL ESPDFQPSIA
KRYIDQKFVQ QLLELFDSED PRERDFLKTV LHRIYGKFLG LRAFIRKQIN NIFLRFIYET
EHFNGVAELL EILGSIINGF ALPLKAEHKQ FLMKVLIPMH TAKGLALFHA QLAYCVVQFL
EKDTTLTEPV IRGLLKFWPK TCSQKEVMFL GEIEEILDVI EPTQFKKIEE PLFKQISKCV
SSSHFQVAER ALYFWNNEYI LSLIEENIDK ILPIMFASLY KISKEHWNQT IVALVYNVLK
TLMEMNGKLF DDLTSSYKAE RQREKKKELE REELWKKLEE LQLKKALEKQ NNAYNMHSIR
SSTSAK


Related products :

Catalog number Product name Quantity
EIAAB29457 Homo sapiens,Human,PP2A subunit B isoform PR72_PR130,PP2A subunit B isoform R3 isoform,PP2A subunit B isoforms B72_B130,PP2A subunit B isoforms B''-PR72_PR130,PPP2R3,PPP2R3A,Serine_threonine-protein p
EIAAB31909 Pig,PP2A-alpha,PPP2CA,Serine_threonine-protein phosphatase 2A catalytic subunit alpha isoform,Sus scrofa
EIAAB31907 PP2A-alpha,Ppp2ca,Rat,Rattus norvegicus,Serine_threonine-protein phosphatase 2A catalytic subunit alpha isoform
EIAAB31911 Bos taurus,Bovine,PP2A-alpha,PPP2CA,Serine_threonine-protein phosphatase 2A catalytic subunit alpha isoform
EIAAB31910 Mouse,Mus musculus,PP2A-alpha,Ppp2ca,Serine_threonine-protein phosphatase 2A catalytic subunit alpha isoform
EIAAB31912 Oryctolagus cuniculus,PP2A-alpha,PPP2CA,Rabbit,Serine_threonine-protein phosphatase 2A catalytic subunit alpha isoform
EIAAB31906 Homo sapiens,Human,PP2A-alpha,PPP2CA,Replication protein C,RP-C,Serine_threonine-protein phosphatase 2A catalytic subunit alpha isoform
EIAAB31908 Chicken,Gallus gallus,PP2A-alpha,PPP2CA,Serine_threonine-protein phosphatase 2A catalytic subunit alpha isoform
EIAAB29458 Homo sapiens,Human,PP2A subunit B isoform PR48,PPP2R3B,PPP2R3L,Protein phosphatase 2A 48 kDa regulatory subunit,Serine_threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
EIAAB31922 Calmodulin-dependent calcineurin A subunit alpha isoform,CALNA,CAM-PRP catalytic subunit,CNA,Homo sapiens,Human,PPP3CA,Serine_threonine-protein phosphatase 2B catalytic subunit alpha isoform
EIAAB31920 Calmodulin-dependent calcineurin A subunit alpha isoform,Calna,CAM-PRP catalytic subunit,Mouse,Mus musculus,Ppp3ca,Serine_threonine-protein phosphatase 2B catalytic subunit alpha isoform
EIAAB31921 Calmodulin-dependent calcineurin A subunit alpha isoform,Calna,CAM-PRP catalytic subunit,Ppp3ca,Rat,Rattus norvegicus,Serine_threonine-protein phosphatase 2B catalytic subunit alpha isoform
EIAAB31919 Bos taurus,Bovine,Calmodulin-dependent calcineurin A subunit alpha isoform,CAM-PRP catalytic subunit,PPP3CA,Serine_threonine-protein phosphatase 2B catalytic subunit alpha isoform
EIAAB29456 Mouse,Mus musculus,PP2A B''-PR59,PP2A PR59,Ppp2r3a,Ppp2r6,Protein phosphatase 2A, 59 kDa regulatory subunit B,Serine_threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
E1056r Pig ELISA Kit FOR Serine per threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform 96T
2ABA_RAT Rat ELISA Kit FOR Serine per threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform 96T
H0435 Serine threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A), Pig, ELISA Kit 96T
E14916h Mouse ELISA Kit FOR Serine per threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform 96T
H0415 Serine threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A), Pig, ELISA Kit 96T
E13952b Mouse ELISA Kit FOR Serine per threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform 96T
H0417 Serine threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A), Rat, ELISA Kit 96T
GWB-7124AE PROTEIN PHOSPHATASE PP2A 65 KD REGULATORY SUBUNIT BETA ISOFORM (PPP2R1B) Rabbit anti-Rat Polyclonal (aa7-19) Antibody
H0416 Serine threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A), Rabbit, ELISA Kit 96T
CSB-EL018562HU Human Serine per threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform(PPP2R1A) ELISA kit 96T
H0433 Serine threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A), Human, ELISA Kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur