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Serine hydroxymethyltransferase (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Glycosylation-related protein 1) (Maternal effect lethal protein 32) (Serine methylase)

 GLYC_CAEEL              Reviewed;         507 AA.
P50432; Q95QX8;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
02-AUG-2002, sequence version 2.
28-MAR-2018, entry version 131.
RecName: Full=Serine hydroxymethyltransferase;
Short=SHMT;
EC=2.1.2.1;
AltName: Full=Glycine hydroxymethyltransferase;
AltName: Full=Glycosylation-related protein 1;
AltName: Full=Maternal effect lethal protein 32;
AltName: Full=Serine methylase;
Name=mel-32; Synonyms=gly-1; ORFNames=C05D11.11;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE
SPLICING.
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[2]
MUTAGENESIS OF ALA-86; ARG-107; ARG-125; ALA-126; ALA-149; GLY-166;
LEU-169; GLY-172; GLY-227; SER-274; HIS-282; ALA-291; GLY-336; GLY-395
AND GLY-429.
PubMed=9497323; DOI=10.1074/jbc.273.11.6066;
Vatcher G.P., Thacker C.M., Kaletta T., Schnabel H., Schnabel R.,
Baillie D.L.;
"Serine hydroxymethyltransferase is maternally essential in
Caenorhabditis elegans.";
J. Biol. Chem. 273:6066-6073(1998).
-!- FUNCTION: Interconversion of serine and glycine.
-!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + glycine +
H(2)O = tetrahydrofolate + L-serine.
-!- COFACTOR:
Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
Evidence={ECO:0000250};
-!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
-!- SUBUNIT: Homotetramer. {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=b;
IsoId=P50432-1; Sequence=Displayed;
Note=No experimental confirmation available.;
Name=a;
IsoId=P50432-2; Sequence=VSP_006097;
Note=No experimental confirmation available.;
-!- SIMILARITY: Belongs to the SHMT family. {ECO:0000305}.
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EMBL; FO080365; CCD63201.1; -; Genomic_DNA.
EMBL; FO080365; CCD63202.1; -; Genomic_DNA.
PIR; B88483; B88483.
RefSeq; NP_741197.1; NM_171169.4. [P50432-1]
RefSeq; NP_741198.1; NM_171170.4. [P50432-2]
UniGene; Cel.17684; -.
ProteinModelPortal; P50432; -.
SMR; P50432; -.
BioGrid; 41133; 2.
DIP; DIP-26240N; -.
IntAct; P50432; 2.
MINT; P50432; -.
STRING; 6239.C05D11.11b.1; -.
iPTMnet; P50432; -.
EPD; P50432; -.
PaxDb; P50432; -.
PeptideAtlas; P50432; -.
PRIDE; P50432; -.
EnsemblMetazoa; C05D11.11b.1; C05D11.11b.1; WBGene00003214. [P50432-1]
EnsemblMetazoa; C05D11.11b.2; C05D11.11b.2; WBGene00003214. [P50432-1]
EnsemblMetazoa; C05D11.11b.3; C05D11.11b.3; WBGene00003214. [P50432-1]
GeneID; 175915; -.
KEGG; cel:CELE_C05D11.11; -.
UCSC; F44F4.6; c. elegans. [P50432-1]
CTD; 175915; -.
WormBase; C05D11.11a; CE01130; WBGene00003214; mel-32. [P50432-2]
WormBase; C05D11.11b; CE29661; WBGene00003214; mel-32. [P50432-1]
eggNOG; KOG2467; Eukaryota.
eggNOG; COG0112; LUCA.
GeneTree; ENSGT00390000002762; -.
HOGENOM; HOG000239405; -.
InParanoid; P50432; -.
KO; K00600; -.
OMA; PLEHIIA; -.
OrthoDB; EOG09370BQP; -.
PhylomeDB; P50432; -.
Reactome; R-CEL-196757; Metabolism of folate and pterines.
Reactome; R-CEL-71262; Carnitine synthesis.
UniPathway; UPA00193; -.
PRO; PR:P50432; -.
Proteomes; UP000001940; Chromosome III.
Bgee; WBGene00003214; -.
GO; GO:0005739; C:mitochondrion; HDA:WormBase.
GO; GO:0004372; F:glycine hydroxymethyltransferase activity; TAS:UniProtKB.
GO; GO:0030170; F:pyridoxal phosphate binding; TAS:UniProtKB.
GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
GO; GO:0019264; P:glycine biosynthetic process from serine; IEA:InterPro.
GO; GO:0009069; P:serine family amino acid metabolic process; TAS:UniProtKB.
GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
CDD; cd00378; SHMT; 1.
Gene3D; 3.40.640.10; -; 1.
Gene3D; 3.90.1150.10; -; 2.
HAMAP; MF_00051; SHMT; 1.
InterPro; IPR015424; PyrdxlP-dep_Trfase.
InterPro; IPR015422; PyrdxlP-dep_Trfase_dom1.
InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
InterPro; IPR001085; Ser_HO-MeTrfase.
InterPro; IPR019798; Ser_HO-MeTrfase_PLP_BS.
PIRSF; PIRSF000412; SHMT; 1.
SUPFAM; SSF53383; SSF53383; 1.
PROSITE; PS00096; SHMT; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; One-carbon metabolism;
Pyridoxal phosphate; Reference proteome; Transferase.
CHAIN 1 507 Serine hydroxymethyltransferase.
/FTId=PRO_0000113508.
MOD_RES 283 283 N6-(pyridoxal phosphate)lysine.
{ECO:0000250}.
VAR_SEQ 1 23 Missing (in isoform a). {ECO:0000305}.
/FTId=VSP_006097.
MUTAGEN 86 86 A->V: In t1473; causes recessive maternal
effect lethal (Mel) phenotype where
homozygotes are viable but offspring
display an embryonic lethal phenotype;
when associated with F-169.
{ECO:0000269|PubMed:9497323}.
MUTAGEN 107 107 R->Q: In t1597; causes recessive maternal
effect lethal (Mel) phenotype where
homozygotes are viable but offspring
display an embryonic lethal phenotype.
{ECO:0000269|PubMed:9497323}.
MUTAGEN 125 125 R->K: In t1555; causes recessive maternal
effect lethal (Mel) phenotype where
homozygotes are viable but offspring
display an embryonic lethal phenotype.
{ECO:0000269|PubMed:9497323}.
MUTAGEN 126 126 A->V: In t1666; causes recessive maternal
effect lethal (Mel) phenotype where
homozygotes are viable but offspring
display an embryonic lethal phenotype.
{ECO:0000269|PubMed:9497323}.
MUTAGEN 149 149 A->V: In s2518; causes recessive maternal
effect lethal (Mel) phenotype where
homozygotes are viable but offspring
display an embryonic lethal phenotype.
{ECO:0000269|PubMed:9497323}.
MUTAGEN 166 166 G->D: In t1679; causes recessive maternal
effect lethal (Mel) phenotype where
homozygotes are viable but offspring
display an embryonic lethal phenotype.
{ECO:0000269|PubMed:9497323}.
MUTAGEN 169 169 L->F: In t1473; causes recessive maternal
effect lethal (Mel) phenotype where
homozygotes are viable but offspring
display an embryonic lethal phenotype;
when associated with V-86.
{ECO:0000269|PubMed:9497323}.
MUTAGEN 172 172 G->E: In t1665; causes recessive maternal
effect lethal (Mel) phenotype where
homozygotes are viable but offspring
display an embryonic lethal phenotype.
{ECO:0000269|PubMed:9497323}.
MUTAGEN 227 227 G->E: In t1552; causes recessive maternal
effect lethal (Mel) phenotype where
homozygotes are viable but offspring
display an embryonic lethal phenotype.
{ECO:0000269|PubMed:9497323}.
MUTAGEN 274 274 S->F: In t1520; causes recessive maternal
effect lethal (Mel) phenotype where
homozygotes are viable but offspring
display an embryonic lethal phenotype.
{ECO:0000269|PubMed:9497323}.
MUTAGEN 282 282 H->Y: In t1607; causes recessive maternal
effect lethal (Mel) phenotype where
homozygotes are viable but offspring
display an embryonic lethal phenotype.
{ECO:0000269|PubMed:9497323}.
MUTAGEN 291 291 A->T: In t1616; causes recessive maternal
effect lethal (Mel) phenotype where
homozygotes are viable but offspring
display an embryonic lethal phenotype.
{ECO:0000269|PubMed:9497323}.
MUTAGEN 336 336 G->E: In t1456; causes recessive maternal
effect lethal (Mel) phenotype where
homozygotes are viable but offspring
display an embryonic lethal phenotype.
{ECO:0000269|PubMed:9497323}.
MUTAGEN 395 395 G->R: In t1576; causes recessive maternal
effect lethal (Mel) phenotype where
homozygotes are viable but offspring
display an embryonic lethal phenotype.
{ECO:0000269|PubMed:9497323}.
MUTAGEN 429 429 G->E: In t1632; causes recessive maternal
effect lethal (Mel) phenotype where
homozygotes are viable but offspring
display an embryonic lethal phenotype.
{ECO:0000269|PubMed:9497323}.
SEQUENCE 507 AA; 55765 MW; 693B380E77BB07D8 CRC64;
MFARIVSRRA ATGLFAGASS QCKMADRQVH TPLAKVQRHK YTNNENILVD HVEKVDPEVF
DIMKNEKKRQ RRGLELIASE NFTSKAVMDA LGSAMCNKYS EGYPGARYYG GNEFIDQMEL
LCQKRALEVF GLDPAKWGVN VQPLSGSPAN FAVYTAIVGS NGRIMGLDLP DGGHLTHGFF
TPARKVSATS EFFQSLPYKV DPTTGLIDYD KLEQNAMLFR PKAIIAGVSC YARHLDYERF
RKIATKAGAY LMSDMAHISG LVAAGLIPSP FEYSDVVTTT THKSLRGPRG ALIFYRKGVR
STNAKGVDTL YDLEEKINSA VFPGLQGGPH NHTIAGIAVA LRQCLSEDFV QYGEQVLKNA
KTLAERMKKH GYALATGGTD NHLLLVDLRP IGVEGARAEH VLDLAHIACN KNTCPGDVSA
LRPGGIRLGT PALTSRGFQE QDFEKVGDFI HEGVQIAKKY NAEAGKTLKD FKSFTETNEP
FKKDVADLAK RVEEFSTKFE IPGNETF


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