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Serologically defined colon cancer antigen 8 homolog (Centrosomal colon cancer autoantigen protein) (mCCCAP)

 SDCG8_MOUSE             Reviewed;         717 AA.
Q80UF4;
10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
05-JUL-2017, entry version 97.
RecName: Full=Serologically defined colon cancer antigen 8 homolog;
AltName: Full=Centrosomal colon cancer autoantigen protein;
Short=mCCCAP;
Name=Sdccag8; Synonyms=Cccap;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
STRAIN=C57BL/6J; TISSUE=Spleen;
PubMed=12559564; DOI=10.1016/S0378-1119(02)01141-1;
Kenedy A.A., Cohen K.J., Loveys D.A., Kato G.J., Dang C.V.;
"Identification and characterization of the novel centrosome-
associated protein CCCAP.";
Gene 303:35-46(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Head, and Pituitary;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND DISRUPTION
PHENOTYPE.
PubMed=20835237; DOI=10.1038/ng.662;
Otto E.A., Hurd T.W., Airik R., Chaki M., Zhou W., Stoetzel C.,
Patil S.B., Levy S., Ghosh A.K., Murga-Zamalloa C.A., van Reeuwijk J.,
Letteboer S.J., Sang L., Giles R.H., Liu Q., Coene K.L.,
Estrada-Cuzcano A., Collin R.W., McLaughlin H.M., Held S.,
Kasanuki J.M., Ramaswami G., Conte J., Lopez I., Washburn J.,
Macdonald J., Hu J., Yamashita Y., Maher E.R., Guay-Woodford L.M.,
Neumann H.P., Obermuller N., Koenekoop R.K., Bergmann C., Bei X.,
Lewis R.A., Katsanis N., Lopes V., Williams D.S., Lyons R.H.,
Dang C.V., Brito D.A., Dias M.B., Zhang X., Cavalcoli J.D.,
Nurnberg G., Nurnberg P., Pierce E.A., Jackson P.K., Antignac C.,
Saunier S., Roepman R., Dollfus H., Khanna H., Hildebrandt F.;
"Candidate exome capture identifies mutation of SDCCAG8 as the cause
of a retinal-renal ciliopathy.";
Nat. Genet. 42:840-850(2010).
-!- FUNCTION: Plays a role in the establishment of cell polarity and
epithelial lumen formation. May play a role in ciliogenesis.
{ECO:0000269|PubMed:20835237}.
-!- SUBUNIT: Homodimer. Interacts with OFD1; the interaction is direct
(By similarity). Interacts with FAM161A (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule
organizing center, centrosome, centriole
{ECO:0000269|PubMed:12559564, ECO:0000269|PubMed:20835237}. Cell
junction {ECO:0000250}. Note=Located at the distal ends of both
centrioles and colocalizes to centrosomes throughout the cell
cycle. Pariculary prominent at the distal basal body and the
transition zone of photoreceptors.
-!- TISSUE SPECIFICITY: Expressed in liver, kidney, spleen, brain,
heart and muscle. Expressed in photoreceptor cells of the retina.
{ECO:0000269|PubMed:12559564, ECO:0000269|PubMed:20835237}.
-!- DISRUPTION PHENOTYPE: In renal epithelial cells gene knockdown
results in the formation of spheroids with architectural defects
characterized by disturbed localization of beta-catenin (CTNNB1)
at the basolateral membrane, fewer tight junctions and an
irregular lumen. {ECO:0000269|PubMed:20835237}.
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EMBL; AF250729; AAO27828.1; -; mRNA.
EMBL; AK132316; BAE21100.1; -; mRNA.
EMBL; AK133622; BAE21753.1; -; mRNA.
CCDS; CCDS35798.1; -.
RefSeq; NP_084032.1; NM_029756.3.
UniGene; Mm.171399; -.
ProteinModelPortal; Q80UF4; -.
SMR; Q80UF4; -.
BioGrid; 218334; 24.
IntAct; Q80UF4; 25.
STRING; 10090.ENSMUSP00000027785; -.
iPTMnet; Q80UF4; -.
PhosphoSitePlus; Q80UF4; -.
MaxQB; Q80UF4; -.
PaxDb; Q80UF4; -.
PRIDE; Q80UF4; -.
Ensembl; ENSMUST00000027785; ENSMUSP00000027785; ENSMUSG00000026504.
GeneID; 76816; -.
KEGG; mmu:76816; -.
UCSC; uc007duj.2; mouse.
CTD; 10806; -.
MGI; MGI:1924066; Sdccag8.
eggNOG; ENOG410IGC5; Eukaryota.
eggNOG; ENOG410XQMR; LUCA.
GeneTree; ENSGT00730000111198; -.
HOGENOM; HOG000133059; -.
HOVERGEN; HBG056806; -.
InParanoid; Q80UF4; -.
KO; K16488; -.
OMA; QQMEAQH; -.
OrthoDB; EOG091G069J; -.
PhylomeDB; Q80UF4; -.
TreeFam; TF325472; -.
Reactome; R-MMU-2565942; Regulation of PLK1 Activity at G2/M Transition.
Reactome; R-MMU-380259; Loss of Nlp from mitotic centrosomes.
Reactome; R-MMU-380270; Recruitment of mitotic centrosome proteins and complexes.
Reactome; R-MMU-5620912; Anchoring of the basal body to the plasma membrane.
Reactome; R-MMU-8854518; AURKA Activation by TPX2.
ChiTaRS; Sdccag8; mouse.
PRO; PR:Q80UF4; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000026504; -.
CleanEx; MM_SDCCAG8; -.
ExpressionAtlas; Q80UF4; baseline and differential.
Genevisible; Q80UF4; MM.
GO; GO:0005911; C:cell-cell junction; ISO:MGI.
GO; GO:0034451; C:centriolar satellite; IDA:MGI.
GO; GO:0005814; C:centriole; IDA:MGI.
GO; GO:0005813; C:centrosome; IDA:MGI.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0007098; P:centrosome cycle; IEA:InterPro.
GO; GO:0030010; P:establishment of cell polarity; IMP:UniProtKB.
GO; GO:0031023; P:microtubule organizing center organization; IMP:MGI.
GO; GO:0001764; P:neuron migration; IMP:MGI.
GO; GO:0035148; P:tube formation; IMP:UniProtKB.
InterPro; IPR031887; SDCCAG8.
PANTHER; PTHR34343; PTHR34343; 1.
Pfam; PF15964; CCCAP; 1.
1: Evidence at protein level;
Cell junction; Coiled coil; Complete proteome; Cytoplasm;
Cytoskeleton; Phosphoprotein; Reference proteome.
CHAIN 1 717 Serologically defined colon cancer
antigen 8 homolog.
/FTId=PRO_0000076311.
REGION 216 717 Sufficient for homodimerization.
COILED 129 168 {ECO:0000255}.
COILED 221 278 {ECO:0000255}.
COILED 352 590 {ECO:0000255}.
COILED 622 712 {ECO:0000255}.
COMPBIAS 352 536 Glu-rich.
COMPBIAS 509 581 Gln-rich.
MOD_RES 4 4 Phosphoserine.
{ECO:0000250|UniProtKB:Q86SQ7}.
MOD_RES 28 28 Phosphoserine.
{ECO:0000250|UniProtKB:Q86SQ7}.
SEQUENCE 717 AA; 82979 MW; C9F69DBFB3DCD59D CRC64;
MAKSPGNSTL EDSLGQYQRS LRERANRSIH QLKCALREVD VTVEEDALDP STSINVENED
TGVAWHELQH SHAVNQLKAL LRQQTNKENE TSPPRRRKLS PSRPSECDDG SMPTMHNLVP
IINDQSQYIH HLEAEVKFCK DELSGMKNRV QVVVLENERL QQELKSQRPE ETLREQTFLD
ASGNMQNSWI MTREDSRVDE AAKRPFSHGD AETGKTASTG DANKWKLELE RLKLTYEAKT
DLLESQLMLL RKDLAEYQKT CEDLKERLKH KESLLAASAS SRVGGLCLKC AQHEAVLSQT
HSNVHIQTIE RLTKERDDLM SVLVSVRSSL AEAQKRETSA YEQVKHAVQM TEEANFEKTK
ALIQCEQLKS ELERQTERLE KELASQQEKR AVEKEMIKKE VAREREDAES KMLILSQNIA
KLEAQVEKVT REKTAAVSHL EEIQNHVASQ EMDVTKVCGE MRFQLNKTKM EKDEVEKEHR
EYKAKSHKDL EMKVQEIEKL RLELSESEQH VEQEQQKAAR ARQECLRVTE LLGEAERQLH
LTRLEKDSIQ QSFSNEAKAQ ALQAQQREQE LTQKIQQMET QHDKTESEQY LLLTSQNTFL
TKLKEECCLL AKKLEKVSLK SRSQIVRLSQ EKRYLCDKLE KLQKRNDELE EQCIQHGRVH
ETMKERLRQL DKHGQATAQQ LVQLLNKQNQ LLLERQNLSE EVARLRAQLP SMPQSDC


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