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Serpentine receptor class r-10 (Odorant response abnormal protein 10) (Olfactory receptor 10)

 ODR10_CAEEL             Reviewed;         339 AA.
Q18807; Q17376;
09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
01-OCT-2001, sequence version 3.
10-MAY-2017, entry version 101.
RecName: Full=Serpentine receptor class r-10;
AltName: Full=Odorant response abnormal protein 10;
AltName: Full=Olfactory receptor 10;
Name=odr-10; ORFNames=C53B7.5;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1] {ECO:0000305, ECO:0000312|EMBL:AAB00117.1}
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF
HIS-110.
STRAIN=Bristol N2 {ECO:0000269|PubMed:8601313};
PubMed=8601313; DOI=10.1016/S0092-8674(00)81068-5;
Sengupta P., Chou J.H., Bargmann C.I.;
"odr-10 encodes a seven transmembrane domain olfactory receptor
required for responses to the odorant diacetyl.";
Cell 84:899-909(1996).
[2] {ECO:0000312|EMBL:ACQ44039.1}
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=AB3 {ECO:0000312|EMBL:ACQ44039.1},
BO {ECO:0000312|EMBL:ACQ44040.1},
CB4855 {ECO:0000312|EMBL:ACQ44050.1},
CB4856 {ECO:0000312|EMBL:ACQ44041.1},
CB4857 {ECO:0000312|EMBL:ACQ44042.1},
CB4932 {ECO:0000312|EMBL:ACQ44043.1},
DH424 {ECO:0000312|EMBL:ACQ44049.1},
PX174 {ECO:0000312|EMBL:ACQ44045.1},
PX178 {ECO:0000312|EMBL:ACQ44044.1},
PX179 {ECO:0000312|EMBL:ACQ44046.1},
RC301 {ECO:0000312|EMBL:ACQ44047.1}, and
TR403 {ECO:0000312|EMBL:ACQ44048.1};
PubMed=19001295; DOI=10.1534/genetics.107.082651;
Jovelin R., Dunham J.P., Sung F.S., Phillips P.C.;
"High nucleotide divergence in developmental regulatory genes
contrasts with the structural elements of olfactory pathways in
caenorhabditis.";
Genetics 181:1387-1397(2009).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[4] {ECO:0000305}
FUNCTION.
PubMed=10421632; DOI=10.1101/gad.13.14.1794;
Sagasti A., Hobert O., Troemel E.R., Ruvkun G., Bargmann C.I.;
"Alternative olfactory neuron fates are specified by the LIM homeobox
gene lim-4.";
Genes Dev. 13:1794-1806(1999).
[5]
INTERACTION WITH ODR-4, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed=24603482; DOI=10.1371/journal.pgen.1004082;
Chen C., Itakura E., Weber K.P., Hegde R.S., de Bono M.;
"An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes
GPCR maturation by a Ufm1-independent mechanism.";
PLoS Genet. 10:E1004082-E1004082(2014).
[6]
SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
PubMed=26150102; DOI=10.1038/srep11855;
Xu Q., Zhang Y., Wei Q., Huang Y., Li Y., Ling K., Hu J.;
"BBS4 and BBS5 show functional redundancy in the BBSome to regulate
the degradative sorting of ciliary sensory receptors.";
Sci. Rep. 5:11855-11855(2015).
-!- FUNCTION: An odorant receptor which affects chemotaxis to the
volatile odorant diacetyl. Specifies AWA neuronal cell fate via
the odr-7 pathway. {ECO:0000269|PubMed:10421632,
ECO:0000269|PubMed:8601313}.
-!- SUBUNIT: Interacts with odr-4. {ECO:0000269|PubMed:24603482}.
-!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
{ECO:0000269|PubMed:24603482, ECO:0000269|PubMed:26150102,
ECO:0000269|PubMed:8601313}; Multi-pass membrane protein
{ECO:0000269|PubMed:24603482, ECO:0000269|PubMed:8601313}.
-!- TISSUE SPECIFICITY: Strongly expressed in the sensory cilia of AWA
olfactory neurons, and at low levels in the CEP neurons.
{ECO:0000269|PubMed:24603482, ECO:0000269|PubMed:26150102,
ECO:0000269|PubMed:8601313}.
-!- INDUCTION: Induced upon exposure to the volatile odorant diacetyl.
{ECO:0000269|PubMed:8601313}.
-!- DISRUPTION PHENOTYPE: Defective response to diacetyl with wild-
type response exhibited to other ketones and odorants sensed by
AWA. {ECO:0000269|PubMed:8601313}.
-!- SIMILARITY: Belongs to the nematode receptor-like protein str
family. {ECO:0000255}.
-----------------------------------------------------------------------
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EMBL; U49449; AAB00117.1; -; mRNA.
EMBL; FJ455649; ACQ44039.1; -; Genomic_DNA.
EMBL; FJ455650; ACQ44040.1; -; Genomic_DNA.
EMBL; FJ455651; ACQ44041.1; -; Genomic_DNA.
EMBL; FJ455652; ACQ44042.1; -; Genomic_DNA.
EMBL; FJ455653; ACQ44043.1; -; Genomic_DNA.
EMBL; FJ455654; ACQ44044.1; -; Genomic_DNA.
EMBL; FJ455655; ACQ44045.1; -; Genomic_DNA.
EMBL; FJ455656; ACQ44046.1; -; Genomic_DNA.
EMBL; FJ455657; ACQ44047.1; -; Genomic_DNA.
EMBL; FJ455658; ACQ44048.1; -; Genomic_DNA.
EMBL; FJ455659; ACQ44049.1; -; Genomic_DNA.
EMBL; FJ455660; ACQ44050.1; -; Genomic_DNA.
EMBL; FO080931; CCD67888.1; -; Genomic_DNA.
PIR; T28806; T28806.
RefSeq; NP_509157.1; NM_076756.3.
UniGene; Cel.19728; -.
ProteinModelPortal; Q18807; -.
STRING; 6239.C53B7.5; -.
PaxDb; Q18807; -.
EnsemblMetazoa; C53B7.5; C53B7.5; WBGene00003856.
GeneID; 180959; -.
KEGG; cel:CELE_C53B7.5; -.
UCSC; C53B7.5; c. elegans.
CTD; 180959; -.
WormBase; C53B7.5; CE26361; WBGene00003856; odr-10.
eggNOG; ENOG410JFEG; Eukaryota.
eggNOG; ENOG4111BUC; LUCA.
GeneTree; ENSGT00840000130347; -.
HOGENOM; HOG000017629; -.
InParanoid; Q18807; -.
KO; K08473; -.
OMA; MWASVSY; -.
OrthoDB; EOG091G0C6Y; -.
PhylomeDB; Q18807; -.
PRO; PR:Q18807; -.
Proteomes; UP000001940; Chromosome X.
Bgee; WBGene00003856; -.
GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
GO; GO:0030425; C:dendrite; IDA:WormBase.
GO; GO:0005887; C:integral component of plasma membrane; IDA:WormBase.
GO; GO:0043025; C:neuronal cell body; IDA:WormBase.
GO; GO:0097730; C:non-motile cilium; IDA:WormBase.
GO; GO:1990075; C:periciliary membrane compartment; IDA:WormBase.
GO; GO:0001965; F:G-protein alpha-subunit binding; IPI:WormBase.
GO; GO:0038022; F:G-protein coupled olfactory receptor activity; IDA:WormBase.
GO; GO:0004930; F:G-protein coupled receptor activity; ISM:WormBase.
GO; GO:0050907; P:detection of chemical stimulus involved in sensory perception; IMP:WormBase.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:WormBase.
GO; GO:0042048; P:olfactory behavior; IDA:WormBase.
GO; GO:0050918; P:positive chemotaxis; IMP:WormBase.
InterPro; IPR019428; 7TM_GPCR_serpentine_rcpt_Str.
Pfam; PF10326; 7TM_GPCR_Str; 1.
1: Evidence at protein level;
Cell membrane; Cell projection; Chemotaxis; Cilium; Complete proteome;
Glycoprotein; Membrane; Olfaction; Receptor; Reference proteome;
Sensory transduction; Transmembrane; Transmembrane helix.
CHAIN 1 339 Serpentine receptor class r-10.
/FTId=PRO_0000391384.
TOPO_DOM 1 11 Extracellular. {ECO:0000255}.
TRANSMEM 12 32 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 33 42 Cytoplasmic. {ECO:0000255}.
TRANSMEM 43 63 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 64 92 Extracellular. {ECO:0000255}.
TRANSMEM 93 113 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 114 131 Cytoplasmic. {ECO:0000255}.
TRANSMEM 132 152 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 153 201 Extracellular. {ECO:0000255}.
TRANSMEM 202 222 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 223 254 Cytoplasmic. {ECO:0000255}.
TRANSMEM 255 275 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 276 284 Extracellular. {ECO:0000255}.
TRANSMEM 285 305 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 306 339 Cytoplasmic. {ECO:0000255}.
CARBOHYD 71 71 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 83 83 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 179 179 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
MUTAGEN 110 110 H->Y: Defective in their response to
diacetyl but wild type response to other
odorants. {ECO:0000269|PubMed:8601313}.
SEQUENCE 339 AA; 39227 MW; 89AA9FE6C7644BAC CRC64;
MSGELWITLV DTADIVGVTL TFCVNIVLLG LLKTRGKNLG TYKYLMAFFS VFSIFYAIIE
FILRPIMHIE NTTFFLISRK RFNYSTKLGK INSAFYCACF ATSFVVSGVH FVYRYFATCK
PNLLRLFNLP TLLLWPLGCS VPVTMWASVS YFLYPDTEYT EAAVTNVLNN HYNWIKKENV
SYIAYVYYQY ENGVRHIYLK NLLGCFVHYF VMSMTFVVMF YCGYATWKTM NEHKDVSDRT
RALQKQLFKA LVLQTLIPTI FMYAPTGVMF IAPFFDVNLN ANANFIVFCS FLYPGLDPLI
LILIIRDFRR TIFNFLCGKK NSVDESRSTT RANLSQVPT


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