Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Serpin B13 (HaCaT UV-repressible serpin) (Hurpin) (Headpin) (Peptidase inhibitor 13) (PI-13) (Proteinase inhibitor 13)

 SPB13_HUMAN             Reviewed;         391 AA.
Q9UIV8; A8K2Q8; Q3MII2; Q9HCX1; Q9UBW1; Q9UKG0;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-DEC-2000, sequence version 2.
25-OCT-2017, entry version 143.
RecName: Full=Serpin B13;
AltName: Full=HaCaT UV-repressible serpin;
Short=Hurpin;
AltName: Full=Headpin;
AltName: Full=Peptidase inhibitor 13;
Short=PI-13;
AltName: Full=Proteinase inhibitor 13;
Name=SERPINB13; Synonyms=PI13;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Skin;
PubMed=10512713; DOI=10.1006/jmbi.1999.3159;
Abts H.F., Welss T., Mirmohammadsadegh A., Koehrer K., Michel G.,
Ruzicka T.;
"Cloning and characterization of hurpin (Protease Inhibitor 13): a new
skin specific, UV-repressible serine proteinase inhibitor of the
ovalbumin serpin family.";
J. Mol. Biol. 293:29-39(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT SER-293.
PubMed=10527881; DOI=10.1006/bbrc.1999.1453;
Spring P., Nakashima T., Frederick M., Henderson Y., Clayman G.;
"Identification and cDNA cloning of headpin, a novel differentially
expressed serpin that maps to chromosome 18q.";
Biochem. Biophys. Res. Commun. 264:299-304(1999).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
PubMed=11004515; DOI=10.1016/S0167-4781(00)00100-7;
Nakashima T., Pak S.C., Silverman G.A., Spring P.M., Frederick M.J.,
Clayman G.L.;
"Genomic cloning, mapping, structure and promoter analysis of HEADPIN,
a serpin which is down-regulated in head and neck cancer cells.";
Biochim. Biophys. Acta 1492:441-446(2000).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2).
TISSUE=Placenta;
PubMed=11313015; DOI=10.1089/104454901300068924;
Abts H.F., Welss T., Scheuring S., Scott F.L., Irving J.A., Michel G.,
Bird P.I., Ruzicka T.;
"Sequence, organization, chromosomal localization and alternative
splicing of the human serine protease inhibitor gene hurpin (PI13),
which is up-regulated in psoriasis.";
DNA Cell Biol. 20:123-131(2001).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-293.
TISSUE=Tongue;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT SER-293.
Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
-!- FUNCTION: May play a role in the proliferation or differentiation
of keratinocytes.
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q9UIV8-1; Sequence=Displayed;
Name=2;
IsoId=Q9UIV8-2; Sequence=VSP_006058;
-!- TISSUE SPECIFICITY: Skin specific.
-!- SIMILARITY: Belongs to the serpin family. Ov-serpin subfamily.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AJ001696; CAA04935.2; -; mRNA.
EMBL; AJ001697; CAA04936.2; -; mRNA.
EMBL; AJ001698; CAA04937.1; -; mRNA.
EMBL; AF169949; AAD55765.1; -; mRNA.
EMBL; AF216854; AAF72879.1; -; Genomic_DNA.
EMBL; AJ278717; CAC03569.1; -; Genomic_DNA.
EMBL; AK290323; BAF83012.1; -; mRNA.
EMBL; AK313486; BAG36269.1; -; mRNA.
EMBL; CH471096; EAW63153.1; -; Genomic_DNA.
EMBL; BC101821; AAI01822.1; -; mRNA.
CCDS; CCDS11985.1; -. [Q9UIV8-1]
PIR; JC7118; JC7118.
RefSeq; NP_001294852.1; NM_001307923.1.
RefSeq; NP_036529.1; NM_012397.3. [Q9UIV8-1]
UniGene; Hs.241407; -.
ProteinModelPortal; Q9UIV8; -.
SMR; Q9UIV8; -.
BioGrid; 111293; 32.
IntAct; Q9UIV8; 2.
STRING; 9606.ENSP00000341584; -.
MEROPS; I04.017; -.
iPTMnet; Q9UIV8; -.
PhosphoSitePlus; Q9UIV8; -.
BioMuta; SERPINB13; -.
DMDM; 12643252; -.
PaxDb; Q9UIV8; -.
PeptideAtlas; Q9UIV8; -.
PRIDE; Q9UIV8; -.
Ensembl; ENST00000344731; ENSP00000341584; ENSG00000197641. [Q9UIV8-1]
GeneID; 5275; -.
KEGG; hsa:5275; -.
UCSC; uc002ljc.4; human. [Q9UIV8-1]
CTD; 5275; -.
DisGeNET; 5275; -.
EuPathDB; HostDB:ENSG00000197641.11; -.
GeneCards; SERPINB13; -.
HGNC; HGNC:8944; SERPINB13.
HPA; HPA052630; -.
HPA; HPA057129; -.
MIM; 604445; gene.
neXtProt; NX_Q9UIV8; -.
OpenTargets; ENSG00000197641; -.
PharmGKB; PA35512; -.
eggNOG; KOG2392; Eukaryota.
eggNOG; COG4826; LUCA.
GeneTree; ENSGT00760000118789; -.
HOVERGEN; HBG005957; -.
InParanoid; Q9UIV8; -.
KO; K13963; -.
PhylomeDB; Q9UIV8; -.
TreeFam; TF352619; -.
Reactome; R-HSA-8939242; RUNX1 regulates transcription of genes involved in differentiation of keratinocytes.
ChiTaRS; SERPINB13; human.
GeneWiki; SERPINB13; -.
GenomeRNAi; 5275; -.
PRO; PR:Q9UIV8; -.
Proteomes; UP000005640; Chromosome 18.
Bgee; ENSG00000197641; -.
CleanEx; HS_SERPINB13; -.
ExpressionAtlas; Q9UIV8; baseline and differential.
Genevisible; Q9UIV8; HS.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0005829; C:cytosol; IDA:HPA.
GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0043202; C:lysosomal lumen; TAS:Reactome.
GO; GO:0016607; C:nuclear speck; IDA:HPA.
GO; GO:0005654; C:nucleoplasm; IDA:UniProtKB.
GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IDA:UniProtKB.
GO; GO:0002020; F:protease binding; IPI:UniProtKB.
GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; NAS:UniProtKB.
GO; GO:0010951; P:negative regulation of endopeptidase activity; IDA:UniProtKB.
GO; GO:1902173; P:negative regulation of keratinocyte apoptotic process; IMP:UniProtKB.
GO; GO:0045616; P:regulation of keratinocyte differentiation; TAS:Reactome.
GO; GO:0030162; P:regulation of proteolysis; NAS:UniProtKB.
GO; GO:0009411; P:response to UV; TAS:ProtInc.
InterPro; IPR023795; Serpin_CS.
InterPro; IPR023796; Serpin_dom.
InterPro; IPR000215; Serpin_fam.
InterPro; IPR036186; Serpin_sf.
PANTHER; PTHR11461; PTHR11461; 1.
Pfam; PF00079; Serpin; 1.
SMART; SM00093; SERPIN; 1.
SUPFAM; SSF56574; SSF56574; 1.
PROSITE; PS00284; SERPIN; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Cytoplasm; Polymorphism;
Protease inhibitor; Reference proteome; Serine protease inhibitor.
CHAIN 1 391 Serpin B13.
/FTId=PRO_0000094121.
SITE 356 357 Reactive bond. {ECO:0000250}.
VAR_SEQ 206 257 Missing (in isoform 2). {ECO:0000305}.
/FTId=VSP_006058.
VARIANT 293 293 G -> S (in dbSNP:rs1020694).
{ECO:0000269|PubMed:10527881,
ECO:0000269|PubMed:14702039,
ECO:0000269|Ref.6}.
/FTId=VAR_024356.
CONFLICT 8 8 S -> N (in Ref. 4; CAC03569).
{ECO:0000305}.
CONFLICT 75 75 Missing (in Ref. 1; CAA04937).
{ECO:0000305}.
CONFLICT 297 297 E -> Q (in Ref. 1; CAA04937).
{ECO:0000305}.
SEQUENCE 391 AA; 44276 MW; 2CA88558D4BC2B09 CRC64;
MDSLGAVSTR LGFDLFKELK KTNDGNIFFS PVGILTAIGM VLLGTRGATA SQLEEVFHSE
KETKSSRIKA EEKEVIENTE AVHQQFQKFL TEISKLTNDY ELNITNRLFG EKTYLFLQKY
LDYVEKYYHA SLEPVDFVNA ADESRKKINS WVESKTNEKI KDLFPDGSIS SSTKLVLVNM
VYFKGQWDRE FKKENTKEEK FWMNKSTSKS VQMMTQSHSF SFTFLEDLQA KILGIPYKNN
DLSMFVLLPN DIDGLEKIID KISPEKLVEW TSPGHMEERK VNLHLPRFEV EDGYDLEAVL
AAMGMGDAFS EHKADYSGMS SGSGLYAQKF LHSSFVAVTE EGTEAAAATG IGFTVTSAPG
HENVHCNHPF LFFIRHNESN SILFFGRFSS P


Related products :

Catalog number Product name Quantity
EIAAB39434 HaCaT UV-repressible serpin,Headpin,Homo sapiens,Human,Hurpin,Peptidase inhibitor 13,PI13,PI-13,Proteinase inhibitor 13,Serpin B13,SERPINB13
18-001-30068 Serpin B13 - Hurpin; HaCaT UV-repressible serpin; Protease inhibitor 13; Headpin Polyclonal 0.1 mg
EIAAB39425 Rat,Rattus norvegicus,Serpin B10,Serpinb10,TGF-beta-repressible serine proteinase inhibitor,Transforming growth factor beta repressible serpin,Trespin
EIAAB39439 Bos taurus,Bovine,Proteinase inhibitor 6,Serine proteinase inhibitor B-43,Serpin B6,SERPINB6
EIAAB39440 Mouse,Mus musculus,PI-6,Placental thrombin inhibitor,Proteinase inhibitor 6,Serpin B6,Serpinb6,Serpinb6a,Spi3
EIAAB29746 Homo sapiens,Human,Monocyte Arg-serpin,PAI2,PAI-2,Placental plasminogen activator inhibitor,PLANH2,Plasminogen activator inhibitor 2,Serpin B2,SERPINB2,Urokinase inhibitor
201-20-5220 SERPING1{serpin peptidase inhibitor, clade G (C1 inhibitor), member 1}rabbit.pAb 0.2ml
KP0229 Alpha-2 Plasmin Inhibitor, Serpin Peptidase Inhibitor, Clade F (40-46), human 1 mg
GS-1998a serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 primary antibody, Host: Rabbit 200ul
E1384150 Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 ELISA Kit
201-20-5218 SERPINE2{serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2}rabbit.pAb 0.2ml
201-20-5217 SERPINE1{serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1}rabbit.pAb 0.2ml
E13812282 Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) ELISA Kit 1
EIAAB27008 Mouse,Mus musculus,Neuroserpin,Peptidase inhibitor 12,Pi12,PI-12,Serine protease inhibitor 17,Serpin I1,Serpini1,Spi17
EIAAB39438 CAP,Cytoplasmic antiproteinase,Homo sapiens,Human,Peptidase inhibitor 6,PI6,PI-6,Placental thrombin inhibitor,PTI,Serpin B6,SERPINB6
EIAAB27005 Neuroserpin,Peptidase inhibitor 12,Pi12,PI-12,Rat,Rattus norvegicus,Serine protease inhibitor 17,Serpin I1,Serpini1,Spi17
CSB-EL021086RA Rat serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 (SERPING1) ELISA kit, Species Rat, Sample Type serum, plasma 96T
GS-1996a serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 primary antibody, Host: Rabbit 200ul
GS-1995a serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 primary antibody, Host: Rabbit 200ul
EIAAB39557 Homo sapiens,Human,MEPI,Myoepithelium-derived serine protease inhibitor,Pancpin,Pancreas-specific protein TSA2004,Peptidase inhibitor 14,PI14,PI-14,Serpin I2,SERPINI2
SERPINE2 SERPINE2 Gene serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINE3 SERPINE3 Gene serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
SERPINE1 SERPINE1 Gene serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
CSB-EL021086RB Rabbit serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 (SERPING1) ELISA kit, Species Rabbit, Sample Type serum, plasma 96T
CSB-EL021086MO Mouse serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 (SERPING1) ELISA kit, Species Mouse, Sample Type serum, plasma 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur