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Shaggy-related protein kinase GSK1 (EC 2.7.11.1) (Glycogen synthase kinase3-like protein 1) (OsGSK1)

 GSK1_ORYSJ              Reviewed;         407 AA.
Q9LWN0; Q0JPS3;
15-FEB-2017, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
05-DEC-2018, entry version 109.
RecName: Full=Shaggy-related protein kinase GSK1 {ECO:0000305};
EC=2.7.11.1 {ECO:0000305};
AltName: Full=Glycogen synthase kinase3-like protein 1 {ECO:0000305|PubMed:17690841};
Short=OsGSK1 {ECO:0000303|PubMed:17690841};
Name=GSK1 {ECO:0000303|PubMed:17690841};
OrderedLocusNames=Os01g0205700 {ECO:0000312|EMBL:BAS70941.1},
LOC_Os01g10840 {ECO:0000305};
ORFNames=P0451C06.26 {ECO:0000312|EMBL:BAA92966.1};
Oryza sativa subsp. japonica (Rice).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BOP clade;
Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
NCBI_TaxID=39947;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Nipponbare;
PubMed=12447438; DOI=10.1038/nature01184;
Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M.,
Okamoto M., Ando T., Aoki H., Arita K., Hamada M., Harada C.,
Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M.,
Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K.,
Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I.,
Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y.,
Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M.,
Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M.,
Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K.,
Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K.,
Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y.,
Yano M., Jiang J., Gojobori T.;
"The genome sequence and structure of rice chromosome 1.";
Nature 420:312-316(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Nipponbare;
PubMed=16100779; DOI=10.1038/nature03895;
International rice genome sequencing project (IRGSP);
"The map-based sequence of the rice genome.";
Nature 436:793-800(2005).
[3]
GENOME REANNOTATION.
STRAIN=cv. Nipponbare;
PubMed=18089549; DOI=10.1093/nar/gkm978;
The rice annotation project (RAP);
"The rice annotation project database (RAP-DB): 2008 update.";
Nucleic Acids Res. 36:D1028-D1033(2008).
[4]
GENOME REANNOTATION.
STRAIN=cv. Nipponbare;
PubMed=24280374; DOI=10.1186/1939-8433-6-4;
Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H.,
McCombie W.R., Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S.,
Childs K.L., Davidson R.M., Lin H., Quesada-Ocampo L.,
Vaillancourt B., Sakai H., Lee S.S., Kim J., Numa H., Itoh T.,
Buell C.R., Matsumoto T.;
"Improvement of the Oryza sativa Nipponbare reference genome using
next generation sequence and optical map data.";
Rice 6:4-4(2013).
[5]
FUNCTION, TISSUE SPECIFICITY, INDUCTION, AND DISRUPTION PHENOTYPE.
PubMed=17690841; DOI=10.1007/s11103-007-9213-4;
Koh S., Lee S.C., Kim M.K., Koh J.H., Lee S., An G., Choe S.,
Kim S.R.;
"T-DNA tagged knockout mutation of rice OsGSK1, an orthologue of
Arabidopsis BIN2, with enhanced tolerance to various abiotic
stresses.";
Plant Mol. Biol. 65:453-466(2007).
[6]
FUNCTION, AND INTERACTION WITH LIC.
PubMed=22570626; DOI=10.1371/journal.pgen.1002686;
Zhang C., Xu Y., Guo S., Zhu J., Huan Q., Liu H., Wang L., Luo G.,
Wang X., Chong K.;
"Dynamics of brassinosteroid response modulated by negative regulator
LIC in rice.";
PLoS Genet. 8:E1002686-E1002686(2012).
-!- FUNCTION: Probable serine-threonine kinase that may act as a
negative regulator of brassinosteroid (BR) signaling during flower
development. May have physiological roles in stress signal-
transduction pathways (PubMed:17690841). Phosphorylates LIC in
response to BR perception (PubMed:22570626).
{ECO:0000269|PubMed:17690841, ECO:0000269|PubMed:22570626}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999,
ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216;
EC=2.7.11.1; Evidence={ECO:0000305};
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.1; Evidence={ECO:0000305};
-!- SUBUNIT: Interacts with LIC. {ECO:0000269|PubMed:22570626}.
-!- TISSUE SPECIFICITY: Highly expressed in the entire young panicles,
spikelets, awns, vascular bundles of palea and lemma, stigma and
rachilla. Expressed in root tips, root hairs, lamina joint in the
collar region, vascular bundles of coleoptiles.
{ECO:0000269|PubMed:17690841}.
-!- INDUCTION: Induced by cold and salt stresses. Down-regulated by
drought stress. {ECO:0000269|PubMed:22570626}.
-!- DISRUPTION PHENOTYPE: Increased length of spikelet awns and weight
of seeds. Increased sentivity to brassinolide. Enhanced tolerance
to drought, salt, cold and heat stresses.
{ECO:0000269|PubMed:17690841}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC
Ser/Thr protein kinase family. GSK-3 subfamily. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAF04255.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=BAS70941.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AP001551; BAA92966.1; -; Genomic_DNA.
EMBL; AP008207; BAF04255.1; ALT_SEQ; Genomic_DNA.
EMBL; AP014957; BAS70941.1; ALT_SEQ; Genomic_DNA.
UniGene; Os.18766; -.
ProteinModelPortal; Q9LWN0; -.
SMR; Q9LWN0; -.
STRING; 39947.LOC_Os01g10840.1; -.
eggNOG; KOG0658; Eukaryota.
eggNOG; COG0515; LUCA.
HOGENOM; HOG000233017; -.
InParanoid; Q9LWN0; -.
Proteomes; UP000059680; Chromosome 1.
ExpressionAtlas; Q9LWN0; differential.
GO; GO:1902911; C:protein kinase complex; IDA:UniProtKB.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO; GO:0009742; P:brassinosteroid mediated signaling pathway; IEA:UniProtKB-KW.
GO; GO:1900458; P:negative regulation of brassinosteroid mediated signaling pathway; IMP:UniProtKB.
CDD; cd14137; STKc_GSK3; 1.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
InterPro; IPR039192; STKc_GSK3.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
ATP-binding; Brassinosteroid signaling pathway; Complete proteome;
Kinase; Nucleotide-binding; Reference proteome;
Serine/threonine-protein kinase; Stress response; Transferase.
CHAIN 1 407 Shaggy-related protein kinase GSK1.
/FTId=PRO_0000439007.
DOMAIN 68 352 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 74 82 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
ACT_SITE 193 193 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
BINDING 97 97 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
SEQUENCE 407 AA; 45580 MW; 9D530F76C3C6BA75 CRC64;
MEAPPGPEPM ELDAPPPPAA VAAAAATAGI SEKVLQKKEE GGGDAVTGHI ISTTIGGKNG
EPKRTISYMA ERVVGTGSFG IVFQAKCLET GETVAIKKVL QDRRYKNREL QLMRAMEHPN
VICLKHCFFS TTSRDELFLN LVMEYVPETL YRVLKHYSNA NQRMPLIYVK LYIYQLFRGL
AYIHTVPGVC HRDVKPQNVL VDPLTHQVKL CDFGSAKVLV PGEPNISYIC SRYYRAPELI
FGATEYTTSI DIWSAGCVLA ELLLGQPLFP GESAVDQLVE IIKVLGTPTR EEIRCMNPNY
TEFKFPQIKA HPWHKIFHKR MPPEAIDLAS RLLQYSPSLR CTALDACAHS FFDELREPNA
RLPNGRPFPP LFNFKHELAS ASPELIHRLI PDHIRRQHGL NFAHAGS


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