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Shaggy-related protein kinase GSK4 (EC 2.7.11.1) (Glycogen synthase kinase3-like protein 4) (OsGSK4) (Shaggy-related protein kinase etha homolog) (OsKETHA) (SKETHA)

 GSK4_ORYSJ              Reviewed;         403 AA.
Q5Z7J0; O04401;
15-FEB-2017, integrated into UniProtKB/Swiss-Prot.
23-NOV-2004, sequence version 1.
05-DEC-2018, entry version 125.
RecName: Full=Shaggy-related protein kinase GSK4 {ECO:0000305};
EC=2.7.11.1 {ECO:0000305};
AltName: Full=Glycogen synthase kinase3-like protein 4 {ECO:0000305};
Short=OsGSK4 {ECO:0000305};
AltName: Full=Shaggy-related protein kinase etha homolog {ECO:0000305};
Short=OsKETHA {ECO:0000303|PubMed:22570626};
Short=SKETHA {ECO:0000303|PubMed:22570626};
Name=GSK4 {ECO:0000305};
OrderedLocusNames=Os06g0547900 {ECO:0000312|EMBL:BAF19738.1},
LOC_Os06g35530 {ECO:0000305};
ORFNames=OsJ_21630 {ECO:0000312|EMBL:EAZ37291.1},
OSJNBa0016D02.31 {ECO:0000312|EMBL:BAD54124.1};
Oryza sativa subsp. japonica (Rice).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BOP clade;
Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
NCBI_TaxID=39947;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Nipponbare; TISSUE=Root;
Dornelas M.C., Kreis M.;
"Oryza sativa mRNA for shaggy-like kinase etha.";
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Nipponbare;
PubMed=16100779; DOI=10.1038/nature03895;
International rice genome sequencing project (IRGSP);
"The map-based sequence of the rice genome.";
Nature 436:793-800(2005).
[3]
GENOME REANNOTATION.
STRAIN=cv. Nipponbare;
PubMed=18089549; DOI=10.1093/nar/gkm978;
The rice annotation project (RAP);
"The rice annotation project database (RAP-DB): 2008 update.";
Nucleic Acids Res. 36:D1028-D1033(2008).
[4]
GENOME REANNOTATION.
STRAIN=cv. Nipponbare;
PubMed=24280374; DOI=10.1186/1939-8433-6-4;
Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H.,
McCombie W.R., Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S.,
Childs K.L., Davidson R.M., Lin H., Quesada-Ocampo L.,
Vaillancourt B., Sakai H., Lee S.S., Kim J., Numa H., Itoh T.,
Buell C.R., Matsumoto T.;
"Improvement of the Oryza sativa Nipponbare reference genome using
next generation sequence and optical map data.";
Rice 6:4-4(2013).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Nipponbare;
PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H.,
Cong L., Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J.,
Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X.,
Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y.,
Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J.,
Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y.,
Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y.,
Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z.,
Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T.,
Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H.,
Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W.,
Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L.,
Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J.,
Samudrala R., Wang J., Wong G.K.-S., Yang H.;
"The genomes of Oryza sativa: a history of duplications.";
PLoS Biol. 3:266-281(2005).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Nipponbare;
PubMed=12869764; DOI=10.1126/science.1081288;
The rice full-length cDNA consortium;
"Collection, mapping, and annotation of over 28,000 cDNA clones from
japonica rice.";
Science 301:376-379(2003).
[7]
INTERACTION WITH LIC.
PubMed=22570626; DOI=10.1371/journal.pgen.1002686;
Zhang C., Xu Y., Guo S., Zhu J., Huan Q., Liu H., Wang L., Luo G.,
Wang X., Chong K.;
"Dynamics of brassinosteroid response modulated by negative regulator
LIC in rice.";
PLoS Genet. 8:E1002686-E1002686(2012).
-!- FUNCTION: Probable serine-threonine kinase that may regulate
brassinosteroid signaling. {ECO:0000250|UniProtKB:Q60EZ2}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999,
ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216;
EC=2.7.11.1; Evidence={ECO:0000305};
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.1; Evidence={ECO:0000305};
-!- SUBUNIT: Interacts with LIC. {ECO:0000269|PubMed:22570626}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. CMGC
Ser/Thr protein kinase family. GSK-3 subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; Y13437; CAA73848.1; -; mRNA.
EMBL; AP004731; BAD54124.1; -; Genomic_DNA.
EMBL; AP008212; BAF19738.1; -; Genomic_DNA.
EMBL; AP014962; BAS98159.1; -; Genomic_DNA.
EMBL; CM000143; EAZ37291.1; -; Genomic_DNA.
EMBL; AK100950; BAG94846.1; -; mRNA.
PIR; T03777; T03777.
RefSeq; XP_015644139.1; XM_015788653.1.
UniGene; Os.15; -.
ProteinModelPortal; Q5Z7J0; -.
SMR; Q5Z7J0; -.
STRING; 39947.LOC_Os06g35530.1; -.
iPTMnet; Q5Z7J0; -.
PaxDb; Q5Z7J0; -.
PRIDE; Q5Z7J0; -.
EnsemblPlants; Os06t0547900-01; Os06t0547900-01; Os06g0547900.
EnsemblPlants; Os06t0547900-02; Os06t0547900-02; Os06g0547900.
GeneID; 4341251; -.
Gramene; Os06t0547900-01; Os06t0547900-01; Os06g0547900.
Gramene; Os06t0547900-02; Os06t0547900-02; Os06g0547900.
KEGG; osa:4341251; -.
eggNOG; KOG0658; Eukaryota.
eggNOG; COG0515; LUCA.
InParanoid; Q5Z7J0; -.
KO; K03083; -.
OMA; VDPLSHQ; -.
OrthoDB; EOG09360BBG; -.
Reactome; R-OSA-3371453; Regulation of HSF1-mediated heat shock response.
Proteomes; UP000059680; Chromosome 6.
ExpressionAtlas; Q5Z7J0; differential.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO; GO:0009742; P:brassinosteroid mediated signaling pathway; IEA:UniProtKB-KW.
CDD; cd14137; STKc_GSK3; 1.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
InterPro; IPR039192; STKc_GSK3.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
ATP-binding; Brassinosteroid signaling pathway; Complete proteome;
Kinase; Nucleotide-binding; Reference proteome;
Serine/threonine-protein kinase; Transferase.
CHAIN 1 403 Shaggy-related protein kinase GSK4.
/FTId=PRO_0000439009.
DOMAIN 71 355 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 77 85 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
ACT_SITE 196 196 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
BINDING 100 100 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
CONFLICT 213 213 V -> L (in Ref. 1; CAA73848).
{ECO:0000305}.
SEQUENCE 403 AA; 45307 MW; 1C17C21B081E814A CRC64;
MAAMPGGPDL AGAGGAVAVA VDAMQVDDPP RASAEEKHGP TIMGGNDPVT GHIISTTIGG
KNDEPKRTIS YMAERVVGTG SFGVVFQAKC LETGETVAIK KVLQDKRYKN RELQIMRSMD
HCNVISLKHC FFSTTSRDEL FLNLVMEFVP ESLYRVLKHY KDMKQRMPLI YVKLYMYQIF
RGLAYIHTVP GVCHRDIKPQ NILVDPLTHQ VKVCDFGSAK MLIKGEANIS YICSRYYRAP
ELIFGATEYT TSIDIWSAGC VLAELLLGQP LFPGESAVDQ LVEIIKVLGT PTREEIRCMN
PNYTEFKFPQ IKACPWHKIF HKRMPPEAID LVSRLLQYSP NLRCTALEAC AHSFFDELRE
PHAKLPNGRP FPPLFNFKQE LANTHPELVS RLLPEHAQRH SGF


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