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Short neurotoxin 6 (SNTX6) (Alpha-neurotoxin 6)

 3S36_PSETE              Reviewed;          79 AA.
Q9W7J7;
01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
05-JUL-2017, entry version 66.
RecName: Full=Short neurotoxin 6;
Short=SNTX6;
AltName: Full=Alpha-neurotoxin 6;
Flags: Precursor;
Pseudonaja textilis (Eastern brown snake).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Elapidae; Acanthophiinae;
Pseudonaja.
NCBI_TaxID=8673;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TOXIC DOSE.
TISSUE=Venom gland;
PubMed=10518793; DOI=10.1046/j.1432-1327.1999.00800.x;
Gong N.L., Armugam A., Jeyaseelan K.;
"Postsynaptic short-chain neurotoxins from Pseudonaja textilis: cDNA
cloning, expression and protein characterization.";
Eur. J. Biochem. 265:982-989(1999).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Liver;
PubMed=10818230; DOI=10.1016/S0014-5793(00)01549-0;
Gong N.L., Armugam A., Jeyaseelan K.;
"Molecular cloning, characterization and evolution of the genes
encoding a new group of short-chain alpha-neurotoxins in an Australian
elapid, Pseudonaja textilis.";
FEBS Lett. 473:303-310(2000).
[3]
IDENTIFICATION BY MASS SPECTROMETRY.
TISSUE=Venom;
PubMed=16284125; DOI=10.1074/mcp.M500270-MCP200;
Birrell G.W., Earl S., Masci P.P., de Jersey J., Wallis T.P.,
Gorman J.J., Lavin M.F.;
"Molecular diversity in venom from the Australian Brown snake,
Pseudonaja textilis.";
Mol. Cell. Proteomics 5:379-389(2006).
-!- FUNCTION: Binds with high affinity to muscle nicotinic
acetylcholine receptor (nAChR) and hinders acetylcholine binding
to the receptor, thereby impairing neuromuscular transmission.
Competes with the binding of alpha-bungarotoxin on muscle AChR
(from Torpedo) with an IC(50) of 0.18 uM. Causes muscle paralysis,
spasms and increased respiration. {ECO:0000269|PubMed:10518793}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
-!- TOXIC DOSE: LD(50) is 1 mg/kg by intravenous injection into mice.
{ECO:0000269|PubMed:10518793}.
-!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-
chain subfamily. Type III alpha-neurotoxin sub-subfamily.
{ECO:0000305}.
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EMBL; AF082980; AAD40972.1; -; mRNA.
EMBL; AF204973; AAF75224.1; -; Genomic_DNA.
ProteinModelPortal; Q9W7J7; -.
SMR; Q9W7J7; -.
HOVERGEN; HBG006553; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0035792; C:other organism postsynaptic membrane; IEA:UniProtKB-KW.
GO; GO:0009405; P:pathogenesis; IEA:InterPro.
CDD; cd00206; snake_toxin; 1.
InterPro; IPR003571; Snake_3FTx.
InterPro; IPR035076; Toxin/TOLIP.
Pfam; PF00087; Toxin_TOLIP; 1.
1: Evidence at protein level;
Acetylcholine receptor inhibiting toxin; Disulfide bond;
Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin;
Secreted; Signal; Toxin.
SIGNAL 1 21 {ECO:0000250}.
CHAIN 22 79 Short neurotoxin 6.
/FTId=PRO_0000035465.
DISULFID 24 41 {ECO:0000250}.
DISULFID 34 59 {ECO:0000250}.
DISULFID 63 71 {ECO:0000250}.
DISULFID 72 77 {ECO:0000250}.
SEQUENCE 79 AA; 8570 MW; 73676636A59E947D CRC64;
MKTLLLTLVM VTIMCLDLGY TLTCYKSLSG TVVCKPHETI CYRRLIPATH GNAIIDRGCS
TSCPGGNRPV CCSTDLCNK


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