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Short transient receptor potential channel 3 (TrpC3) (Receptor-activated cation channel TRP3) (Transient receptor protein 3) (TRP-3) (mTrp3) (Trp-related protein 3)

 TRPC3_MOUSE             Reviewed;         836 AA.
Q9QZC1; Q61058;
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
10-OCT-2018, entry version 130.
RecName: Full=Short transient receptor potential channel 3;
Short=TrpC3;
AltName: Full=Receptor-activated cation channel TRP3;
AltName: Full=Transient receptor protein 3;
Short=TRP-3;
Short=mTrp3;
AltName: Full=Trp-related protein 3;
Name=Trpc3; Synonyms=Trp3, Trrp3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=9512398;
Mori Y., Takada N., Okada T., Wakamori M., Imoto K., Wanifuchi H.,
Oka H., Oba A., Ikenaka K., Kurosaki T.;
"Differential distribution of TRP Ca2+ channel isoforms in mouse
brain.";
NeuroReport 9:507-515(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 563-671.
PubMed=8646775; DOI=10.1016/S0092-8674(00)81233-7;
Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E.,
Birnbaumer L.;
"trp, a novel mammalian gene family essential for agonist-activated
capacitative Ca2+ entry.";
Cell 85:661-671(1996).
-!- FUNCTION: Thought to form a receptor-activated non-selective
calcium permeant cation channel. Probably is operated by a
phosphatidylinositol second messenger system activated by receptor
tyrosine kinases or G-protein coupled receptors. Activated by
diacylglycerol (DAG) in a membrane-delimited fashion,
independently of protein kinase C, and by inositol 1,4,5-
triphosphate receptors (ITPR) with bound IP3 (By similarity). May
also be activated by internal calcium store depletion.
{ECO:0000250}.
-!- SUBUNIT: Interacts with TRPC1, ITPR1, ITPR3, MX1 and RNF24.
Interacts with JPH2; the interaction is involved in maintaining
Ca(2+) homeostasis in skeletal muscle and is mediated by JPH2
'Ser-165' phosphorylation (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
protein {ECO:0000305}.
-!- TISSUE SPECIFICITY: Abundantly expressed in brain. Concentrated in
cerebellar Purkinje cells and sparsely localized in cerebellar
granule lyer, pontine nuclei and thalamus. Lower levels detected
in other tissues.
-!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
STrpC subfamily. TRPC3 sub-subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF190645; AAF01468.1; -; mRNA.
EMBL; U40982; AAC52701.1; -; mRNA.
UniGene; Mm.74363; -.
ProteinModelPortal; Q9QZC1; -.
SMR; Q9QZC1; -.
CORUM; Q9QZC1; -.
DIP; DIP-61309N; -.
IntAct; Q9QZC1; 3.
STRING; 10090.ENSMUSP00000029271; -.
iPTMnet; Q9QZC1; -.
PhosphoSitePlus; Q9QZC1; -.
MaxQB; Q9QZC1; -.
PaxDb; Q9QZC1; -.
PRIDE; Q9QZC1; -.
MGI; MGI:109526; Trpc3.
eggNOG; KOG3609; Eukaryota.
eggNOG; ENOG410XQ0Y; LUCA.
HOVERGEN; HBG068337; -.
InParanoid; Q9QZC1; -.
ChiTaRS; Trpc3; mouse.
PRO; PR:Q9QZC1; -.
Proteomes; UP000000589; Unplaced.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0005227; F:calcium activated cation channel activity; ISO:MGI.
GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; ISO:MGI.
GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
GO; GO:0070588; P:calcium ion transmembrane transport; ISO:MGI.
GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
GO; GO:0010524; P:positive regulation of calcium ion transport into cytosol; ISO:MGI.
GO; GO:1903244; P:positive regulation of cardiac muscle hypertrophy in response to stress; ISO:MGI.
GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
GO; GO:0033198; P:response to ATP; ISO:MGI.
GO; GO:0051592; P:response to calcium ion; ISO:MGI.
GO; GO:0007338; P:single fertilization; IBA:GO_Central.
CDD; cd00204; ANK; 1.
Gene3D; 1.25.40.20; -; 1.
InterPro; IPR002110; Ankyrin_rpt.
InterPro; IPR020683; Ankyrin_rpt-contain_dom.
InterPro; IPR036770; Ankyrin_rpt-contain_sf.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR004729; TRP_channel.
InterPro; IPR013555; TRP_dom.
InterPro; IPR005459; TRPC3_channel.
InterPro; IPR002153; TRPC_channel.
PANTHER; PTHR10117; PTHR10117; 1.
PANTHER; PTHR10117:SF8; PTHR10117:SF8; 1.
Pfam; PF12796; Ank_2; 1.
Pfam; PF00520; Ion_trans; 1.
Pfam; PF08344; TRP_2; 1.
PRINTS; PR01097; TRNSRECEPTRP.
PRINTS; PR01644; TRPCHANNEL3.
SMART; SM00248; ANK; 3.
SUPFAM; SSF48403; SSF48403; 1.
TIGRFAMs; TIGR00870; trp; 1.
PROSITE; PS50297; ANK_REP_REGION; 1.
2: Evidence at transcript level;
ANK repeat; Calcium; Calcium channel; Calcium transport;
Complete proteome; Glycoprotein; Ion channel; Ion transport; Membrane;
Reference proteome; Repeat; Transmembrane; Transmembrane helix;
Transport.
CHAIN 1 836 Short transient receptor potential
channel 3.
/FTId=PRO_0000215311.
TOPO_DOM 1 369 Cytoplasmic. {ECO:0000255}.
TRANSMEM 370 390 Helical. {ECO:0000255}.
TOPO_DOM 391 418 Extracellular. {ECO:0000255}.
TRANSMEM 419 439 Helical. {ECO:0000255}.
TOPO_DOM 440 451 Cytoplasmic. {ECO:0000255}.
TRANSMEM 452 472 Helical. {ECO:0000255}.
TOPO_DOM 473 523 Extracellular. {ECO:0000255}.
TRANSMEM 524 544 Helical. {ECO:0000255}.
TOPO_DOM 545 567 Cytoplasmic. {ECO:0000255}.
TRANSMEM 568 588 Helical. {ECO:0000255}.
TOPO_DOM 589 637 Extracellular. {ECO:0000255}.
TRANSMEM 638 658 Helical. {ECO:0000255}.
TOPO_DOM 659 836 Cytoplasmic. {ECO:0000255}.
REPEAT 26 55 ANK 1.
REPEAT 61 90 ANK 2.
REPEAT 92 118 ANK 3.
REPEAT 147 176 ANK 4.
CARBOHYD 404 404 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 836 AA; 95672 MW; 7B863B209B9A25F8 CRC64;
MRDKGRRQAV RGPAFMFGAR GPSLTAEEER FLDAAEYGNI PVVRKMLEES RTLNVNCVDY
MGQNALQLAV GNEHLEVTEL LLKKENLARI GDALLLAISK GYVRIVEAIL GHPGFAASRR
LTLSPCEQEL RDDDFYAYDE DGTRFSPDIT PIILAAHCHK YEVVHLLLLK GARIERAHDY
FCRCSDCAEK QRLDAFSHSR SRINAYKGLA SPAYLSLSSE DPVLTALELS NELAKLANIE
KEFKNDYRKL SMQCKDFVVG VLDLCRDSEE VEAILNGDLE SAEPLERHGH KASLSRVKLA
IKYEVKKFVA HPNCQQQLLT IWYENLSGLR EQTIAIKCLV VLVVALGLPF LAIGYWIAPC
SRLGKILRSP FMKFVAHAAS FIIFLGLLVF NASDRFEGIT TLPNITVIDY PKQIFRVKTT
QFTWTEMLIM VWVLGMMWSE CKELWLEGPR EYIVQLWNVL DFGMLSIFIA AFTARFLAFL
QATKAQQYVD SHVQESDLSE VTLPPEVQYF TYARDKWLPS DPQIISEGLY AIAVVLSFSR
IAYILPANES FGPLQISLGR TVKDIFKFMV LFIMVFLAFM IGMFILYSYY LGAKVNPAFT
TVEESFKTLF WSIFGLSEVT SVVLKYDHKF IENIGYVLYG IYNVTMVVVL LNMLIAMINS
SYQEIEDDSD VEWKFARSKL WLSYFDDGKT LPPPFSLVPS PKSFVYFIMR ITNFSKCRRR
RLQKDLELGM GNSKSRLNLF TQSNSRVFES HSFNSILNQP TRYQQIMKRL IKRYVLKAQV
DKENDEVNEG ELKEIKQDIS SLRYELLEDK SQATEELAIL IHKLSEKLNP SVLRCE


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