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Short transient receptor potential channel 5 (TrpC5) (Capacitative calcium entry channel 2) (CCE2) (Transient receptor protein 5) (TRP-5) (mTRP5) (Trp-related protein 5)

 TRPC5_MOUSE             Reviewed;         975 AA.
Q9QX29; Q61059; Q9QWT1; Q9R0D4;
20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
20-JUN-2001, sequence version 2.
25-OCT-2017, entry version 158.
RecName: Full=Short transient receptor potential channel 5;
Short=TrpC5;
AltName: Full=Capacitative calcium entry channel 2;
Short=CCE2;
AltName: Full=Transient receptor protein 5;
Short=TRP-5;
Short=mTRP5;
AltName: Full=Trp-related protein 5;
Name=Trpc5; Synonyms=Trp5, Trrp5;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=9553080; DOI=10.1074/jbc.273.17.10279;
Okada T., Shimizu S., Wakamori M., Maeda A., Kurosaki T., Takada N.,
Imoto K., Mori Y.;
"Molecular cloning and functional characterization of a novel
receptor-activated TRP Ca2+ channel from mouse brain.";
J. Biol. Chem. 273:10279-10287(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
Zhu X., Peyton M., Boulay B., Birnbaumer B.;
"Molecular cloning and functional expression of mouse TRP5.";
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=10980202; DOI=10.1074/jbc.M006635200;
Tang Y., Tang J., Chen Z., Trost C., Flockerzi V., Li M., Ramesh V.,
Zhu M.X.;
"Association of mammalian trp4 and phospholipase C isozymes with a PDZ
domain-containing protein, NHERF.";
J. Biol. Chem. 275:37559-37564(2000).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-966, AND TISSUE SPECIFICITY.
TISSUE=Brain;
PubMed=9687496; DOI=10.1093/emboj/17.15.4274;
Philipp S., Hambrecht J., Braslavski L., Schroth G., Freichel M.,
Murakami M., Cavalie A., Flockerzi V.;
"A novel capacitative calcium entry channel expressed in excitable
cells.";
EMBO J. 17:4274-4282(1998).
[5]
PROTEIN SEQUENCE OF 354-361, AND IDENTIFICATION BY MASS SPECTROMETRY.
STRAIN=OF1; TISSUE=Hippocampus;
Lubec G., Sunyer B., Chen W.-Q.;
Submitted (JAN-2009) to UniProtKB.
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 515-637.
PubMed=8646775; DOI=10.1016/S0092-8674(00)81233-7;
Zhu X., Jiang M., Peyton M., Boulay G., Hurst R., Stefani E.,
Birnbaumer L.;
"trp, a novel mammalian gene family essential for agonist-activated
capacitative Ca2+ entry.";
Cell 85:661-671(1996).
[7]
INTERACTION WITH CABP1.
PubMed=15895247; DOI=10.1007/s00424-005-1419-1;
Kinoshita-Kawada M., Tang J., Xiao R., Kaneko S., Foskett J.K.,
Zhu M.X.;
"Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus
oocytes.";
Pflugers Arch. 450:345-354(2005).
[8]
INTERACTION WITH TRPC4AP.
PubMed=20458742; DOI=10.1002/jcp.22221;
Mace K.E., Lussier M.P., Boulay G., Terry-Powers J.L., Parfrey H.,
Perraud A.L., Riches D.W.H.;
"TRUSS, TNF-R1, and TRPC ion channels synergistically reverse
endoplasmic reticulum Ca2+ storage reduction in response to m1
muscarinic acetylcholine receptor signaling.";
J. Cell. Physiol. 225:444-453(2010).
-!- FUNCTION: Thought to form a receptor-activated non-selective
calcium permeant cation channel. Probably is operated by a
phosphatidylinositol second messenger system activated by receptor
tyrosine kinases or G-protein coupled receptors. Has also been
shown to be calcium-selective. May also be activated by
intracellular calcium store depletion.
-!- ENZYME REGULATION: Calcium channel activity is enhanced by MYLK,
that promotes its subcellular localization at the plasma membrane.
{ECO:0000250}.
-!- SUBUNIT: Homotetramer and heterotetramer with TRPC1 and/or TRPC4
(By similarity). Interacts (via C-terminus) with CABP1. Interacts
with NHERF (By similarity). Interacts with MX1 and RNF24 (By
similarity). Interacts with SESTD1 (via the spectrin 1 repeat) (By
similarity). Interacts with TRPC4AP. {ECO:0000250,
ECO:0000269|PubMed:15895247, ECO:0000269|PubMed:20458742}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass
membrane protein {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed almost exclusively in brain, in
mitral cells of the olfactory bulb, in lateral cerebellar nuclei
and in pyramidal neurons of the hippocampus. Very low levels
detected in liver kidney, testis, and uterus.
{ECO:0000269|PubMed:9687496}.
-!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
STrpC subfamily. TRPC5 sub-subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF029983; AAC13550.1; -; mRNA.
EMBL; AF060107; AAF02200.1; -; mRNA.
EMBL; AJ006204; CAA06912.1; -; mRNA.
CCDS; CCDS30457.1; -.
RefSeq; NP_033454.1; NM_009428.3.
UniGene; Mm.328378; -.
UniGene; Mm.82621; -.
ProteinModelPortal; Q9QX29; -.
BioGrid; 204331; 1.
DIP; DIP-40847N; -.
IntAct; Q9QX29; 2.
MINT; MINT-144678; -.
STRING; 10090.ENSMUSP00000049063; -.
GuidetoPHARMACOLOGY; 490; -.
iPTMnet; Q9QX29; -.
PhosphoSitePlus; Q9QX29; -.
MaxQB; Q9QX29; -.
PaxDb; Q9QX29; -.
PRIDE; Q9QX29; -.
Ensembl; ENSMUST00000040184; ENSMUSP00000049063; ENSMUSG00000041710.
GeneID; 22067; -.
KEGG; mmu:22067; -.
UCSC; uc009umv.1; mouse.
CTD; 7224; -.
MGI; MGI:109524; Trpc5.
eggNOG; KOG3609; Eukaryota.
eggNOG; ENOG410XQ0Y; LUCA.
GeneTree; ENSGT00760000119180; -.
HOGENOM; HOG000020589; -.
HOVERGEN; HBG068337; -.
InParanoid; Q9QX29; -.
KO; K04968; -.
OMA; GFNEYVH; -.
OrthoDB; EOG091G029I; -.
PhylomeDB; Q9QX29; -.
TreeFam; TF313147; -.
Reactome; R-MMU-3295583; TRP channels.
PRO; PR:Q9QX29; -.
Proteomes; UP000000589; Chromosome X.
Bgee; ENSMUSG00000041710; -.
ExpressionAtlas; Q9QX29; baseline and differential.
Genevisible; Q9QX29; MM.
GO; GO:0034704; C:calcium channel complex; ISO:MGI.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0030425; C:dendrite; IEA:Ensembl.
GO; GO:0030426; C:growth cone; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0045121; C:membrane raft; IEA:Ensembl.
GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO; GO:0003779; F:actin binding; IEA:Ensembl.
GO; GO:0042805; F:actinin binding; IEA:Ensembl.
GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
GO; GO:0005262; F:calcium channel activity; ISO:MGI.
GO; GO:0030276; F:clathrin binding; IEA:Ensembl.
GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IDA:BHF-UCL.
GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
GO; GO:0050774; P:negative regulation of dendrite morphogenesis; IEA:Ensembl.
GO; GO:0030182; P:neuron differentiation; IEA:Ensembl.
GO; GO:0045773; P:positive regulation of axon extension; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
GO; GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
GO; GO:1902630; P:regulation of membrane hyperpolarization; IEA:Ensembl.
CDD; cd00204; ANK; 1.
Gene3D; 1.25.40.20; -; 1.
InterPro; IPR002110; Ankyrin_rpt.
InterPro; IPR020683; Ankyrin_rpt-contain_dom.
InterPro; IPR036770; Ankyrin_rpt-contain_sf.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR004729; TRP_channel.
InterPro; IPR013555; TRP_dom.
InterPro; IPR005461; TRPC5_channel.
InterPro; IPR002153; TRPC_channel.
PANTHER; PTHR10117; PTHR10117; 1.
PANTHER; PTHR10117:SF24; PTHR10117:SF24; 1.
Pfam; PF12796; Ank_2; 1.
Pfam; PF00520; Ion_trans; 1.
Pfam; PF08344; TRP_2; 1.
PRINTS; PR01097; TRNSRECEPTRP.
PRINTS; PR01646; TRPCHANNEL5.
SMART; SM00248; ANK; 2.
SUPFAM; SSF48403; SSF48403; 1.
TIGRFAMs; TIGR00870; trp; 1.
1: Evidence at protein level;
ANK repeat; Calcium; Calcium channel; Calcium transport;
Cell membrane; Complete proteome; Direct protein sequencing;
Glycoprotein; Ion channel; Ion transport; Membrane;
Reference proteome; Repeat; Transmembrane; Transmembrane helix;
Transport.
CHAIN 1 975 Short transient receptor potential
channel 5.
/FTId=PRO_0000215319.
TOPO_DOM 1 330 Cytoplasmic. {ECO:0000255}.
TRANSMEM 331 351 Helical. {ECO:0000255}.
TOPO_DOM 352 398 Extracellular. {ECO:0000255}.
TRANSMEM 399 419 Helical. {ECO:0000255}.
TOPO_DOM 420 437 Cytoplasmic. {ECO:0000255}.
TRANSMEM 438 458 Helical. {ECO:0000255}.
TOPO_DOM 459 470 Extracellular. {ECO:0000255}.
TRANSMEM 471 491 Helical. {ECO:0000255}.
TOPO_DOM 492 512 Cytoplasmic. {ECO:0000255}.
TRANSMEM 513 533 Helical. {ECO:0000255}.
TOPO_DOM 534 603 Extracellular. {ECO:0000255}.
TRANSMEM 604 624 Helical. {ECO:0000255}.
TOPO_DOM 625 975 Cytoplasmic. {ECO:0000255}.
REPEAT 31 60 ANK 1.
REPEAT 69 97 ANK 2.
REPEAT 98 124 ANK 3.
REPEAT 141 170 ANK 4.
REGION 971 973 Essential for binding to NHERF PDZ
domain. {ECO:0000250}.
COMPBIAS 690 693 Poly-Arg.
CARBOHYD 461 461 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 975 AA; 111458 MW; DF9248168D3D2D62 CRC64;
MAQLYYKKVN YSPYRDRIPL QIVRAETELS AEEKAFLSAV EKGDYATVKQ ALQEAEIYYN
VNINCMDPLG RSALLIAIEN ENLEIMELLL NHSVYVGDAL LYAIRKEVVG AVELLLSYRK
PSGEKQVPTL MMDTQFSEFT PDITPIMLAA HTNNYEIIKL LVQKRVTIPR PHQIRCNCVE
CVSSSEVDSL RHSRSRLNIY KALASPSLIA LSSEDPILTA FRLGWELKEL SKVENEFKAE
YEELSQQCKL FAKDLLDQAR SSRELEIILN HRDDHSEELD PQKYHDLAKL KVAIKYHQKE
FVAQPNCQQL LATLWYDGFP GWRRKHWVVK LLTCMTIGFL FPMLSIAYLI SPRSNLGLFI
KKPFIKFICH TASYLTFLFM LLLASQHIVR TDLHVQGPPP TVVEWMILPW VLGFIWGEIK
EMWDGGFTEY IHDWWNLMDF AMNSLYLATI SLKIVAYVKY NGSRPREEWE MWHPTLIAEA
LFAISNILSS LRLISLFTAN SHLGPLQISL GRMLLDILKF LFIYCLVLLA FANGLNQLYF
YYETRAIDEP NNCKGIRCEK QNNAFSTLFE TLQSLFWSVF GLLNLYVTNV KARHEFTEFV
GATMFGTYNV ISLVVLLNML IAMMNNSYQL IADHADIEWK FARTKLWMSY FDEGGTLPPP
FNIIPSPKSF LYLGNWFNNT FCPKRDPDGR RRRHNLRSFT ERHADSLIQN QHYQEVIRNL
VKRYVAAMIR NSKTNEGLTE ENFKELKQDI SSFRYEVLDL LGNRKHPRRS LSTSSADFSQ
RDDTNDGSGG ARAKSKSVSF NVGCKKKACH GAPLIRTVPR ASGAQGKPKS ESSSKRSFMG
PSFKKLGLFF SKFNGQTSEP TSEPMYTISD GIAQQHCMWQ DIRYSQMEKG KAEACSQSQM
NLGEVELGEI RGAAARSSEC PLACSSSLHC ASGICSSNSK LLDSSEDVFE TWGEACDLLM
HKWGDGQEEQ VTTRL


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