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Short transient receptor potential channel 5 (TrpC5) (Fragment)

 TRPC5_BOVIN             Reviewed;         109 AA.
Q9MYV9;
20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
25-OCT-2017, entry version 87.
RecName: Full=Short transient receptor potential channel 5;
Short=TrpC5;
Flags: Fragment;
Name=TRPC5; Synonyms=TRP5;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=10816590; DOI=10.1074/jbc.M003408200;
Philipp S., Trost C., Warnat J., Rautmann J., Himmerkus N.,
Schroth G., Kretz O., Nastainczyk W., Cavalie A., Hoth M.,
Flockerzi V.;
"TRP4 (CCE1) protein is part of native calcium release-activated Ca2+-
like channels in adrenal cells.";
J. Biol. Chem. 275:23965-23972(2000).
-!- FUNCTION: Thought to form a receptor-activated non-selective
calcium permeant cation channel. Probably is operated by a
phosphatidylinositol second messenger system activated by receptor
tyrosine kinases or G-protein coupled receptors. Has also been
shown to be calcium-selective. May also be activated by
intracellular calcium store depletion.
-!- SUBUNIT: Homotetramer and heterotetramer with TRPC1 and/or TRPC4.
Interacts with NHERF. Interacts with MX1 and RNF24. Interacts (via
C-terminus) with CABP1. Interacts with SESTD1 (via the spectrin 1
repeat). Interacts with TRPC4AP. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
protein {ECO:0000305}.
-!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
STrpC subfamily. TRPC5 sub-subfamily. {ECO:0000305}.
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EMBL; AJ271070; CAC01678.1; -; mRNA.
UniGene; Bt.29713; -.
SMR; Q9MYV9; -.
STRING; 9913.ENSBTAP00000013270; -.
PaxDb; Q9MYV9; -.
eggNOG; KOG3609; Eukaryota.
eggNOG; ENOG410XQ0Y; LUCA.
HOGENOM; HOG000020589; -.
InParanoid; Q9MYV9; -.
Proteomes; UP000009136; Unplaced.
GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
InterPro; IPR005821; Ion_trans_dom.
InterPro; IPR005461; TRPC5_channel.
InterPro; IPR002153; TRPC_channel.
PANTHER; PTHR10117; PTHR10117; 1.
PANTHER; PTHR10117:SF24; PTHR10117:SF24; 1.
Pfam; PF00520; Ion_trans; 1.
2: Evidence at transcript level;
Calcium; Calcium channel; Calcium transport; Complete proteome;
Ion channel; Ion transport; Membrane; Reference proteome;
Transmembrane; Transmembrane helix; Transport.
CHAIN <1 >109 Short transient receptor potential
channel 5.
/FTId=PRO_0000215317.
TRANSMEM 1 21 Helical. {ECO:0000255}.
TRANSMEM 83 103 Helical. {ECO:0000255}.
NON_TER 1 1
NON_TER 109 109
SEQUENCE 109 AA; 12607 MW; E0068E440512BAC9 CRC64;
FIYCLVLLAF ANGLNQLYFY YETRAIDEPN NCKGIRCEKQ NNAFSTLFET LQSLFWSVFG
LLNLYVTNVK ARHEFTEFVG ATMFGTYNVI SLVVLLNMLI AMMNNSYQL


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